WO2009001950A1 - Générateur d'ondes sonores, dispositif agitateur et dispositif d'analyse automatique - Google Patents

Générateur d'ondes sonores, dispositif agitateur et dispositif d'analyse automatique Download PDF

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Publication number
WO2009001950A1
WO2009001950A1 PCT/JP2008/061789 JP2008061789W WO2009001950A1 WO 2009001950 A1 WO2009001950 A1 WO 2009001950A1 JP 2008061789 W JP2008061789 W JP 2008061789W WO 2009001950 A1 WO2009001950 A1 WO 2009001950A1
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WIPO (PCT)
Prior art keywords
sound wave
wave generator
comb
electrode
sound
Prior art date
Application number
PCT/JP2008/061789
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English (en)
Japanese (ja)
Inventor
Miyuki Murakami
Original Assignee
Olympus Corporation
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Publication date
Application filed by Olympus Corporation filed Critical Olympus Corporation
Publication of WO2009001950A1 publication Critical patent/WO2009001950A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B01F31/85—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations with a vibrating element inside the receptacle
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/80—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
    • B01F31/86—Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations with vibration of the receptacle or part of it
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B06—GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
    • B06B—METHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
    • B06B1/00—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
    • B06B1/02—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy
    • B06B1/06—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00534—Mixing by a special element, e.g. stirrer
    • G01N2035/00554—Mixing by a special element, e.g. stirrer using ultrasound

Definitions

  • the present invention relates to a sound wave generator, a stirring device, and an automatic analyzer.
  • agitation means for agitating a liquid by sound waves generated by the sound wave generation means
  • This agitating vessel uses a surface acoustic wave element in which a vibrator comprising comb electrodes (IDT) is formed on a piezoelectric substrate as a sound wave generator.
  • IDT comb electrodes
  • Patent Document 1 Japanese Unexamined Patent Application Publication No. 2006-90791
  • the sound wave generator of Patent Document 1 has a sound wave emitting surface that emits a sound wave depending on whether a surface acoustic wave or a bulk wave is used for stirring, and is generated in a liquid.
  • the usage pattern such as the mounting surface and mounting direction when mounting to the stirring vessel is determined.
  • the arrangement of the vibrator with respect to the stirring container may be restricted depending on the configuration of the stirring means provided with the sound wave generator. For this reason, it was necessary to design the sound wave generator of Patent Document 1 for each use form such as the sound wave mode used for stirring and the direction of the intended acoustic flow.
  • the present invention has been made in view of the above, and an object thereof is to provide a radiation generator, a stirrer, and an automatic analyzer that are required to be designed for each usage pattern.
  • a sound wave generator of the present invention includes a piezoelectric substrate and comb teeth formed on a plate surface of the piezoelectric substrate and excited by input of a drive signal.
  • the comb-like electrode is driven by a signal having a driving frequency different from the frequency determined by the comb-teeth spacing force, and simultaneously generates a plurality of sound waves having different oscillation modes.
  • the sound wave generator of the present invention is characterized in that the frequency of the drive signal is a single frequency, as in the above invention.
  • the sound wave generator of the present invention is characterized in that the wavelength of the drive signal is different from the wavelength determined by the comb tooth spacing force, as in the above invention.
  • the sound wave generator of the present invention is characterized in that, in the above invention, the frequency of the drive signal is a frequency determined by a comb tooth interval of the comb-like electrode and includes a harmonic component.
  • the sound wave generator of the present invention is characterized in that, in the above invention, the drive signal comprises a rectangular wave.
  • the sound wave generator of the present invention in the above invention, when the piezoelectric substrate is disposed in a liquid, the surface on which the comb-like electrode is formed and the comb-like electrode are formed. The sound wave is emitted from the back surface and the end surface of the surface.
  • the stirring device of the present invention includes the sound wave generator, a control unit that controls a drive signal input to the comb-shaped electrode, The liquid held in the container is stirred using at least one of a plurality of sound waves having different oscillation modes that are simultaneously generated by the sound wave generator.
  • the automatic analyzer of the present invention reacts by stirring a plurality of different liquids and measuring the optical characteristics of the reaction liquid.
  • An automatic analyzer for analyzing a liquid wherein a sample and a reagent are stirred using the stirring device, and the reaction solution is optically analyzed.
  • the comb-shaped electrode is driven by a signal having a frequency different from the frequency determined by the comb tooth spacing force to simultaneously generate a plurality of sound waves having different oscillation modes.
  • the apparatus includes a sound wave generator and a control means for controlling a drive signal input to the comb-like electrode, and uses at least one of a plurality of sound waves having different oscillation modes that are simultaneously generated by the sound wave generator. Then, the liquid held in the container is stirred.
  • the automatic analyzer of the present invention stirs the sample and the reagent using the stirring device and optically prays the reaction solution. Therefore, only by adjusting the drive frequency, a plurality of oscillation modes having different oscillation modes can be obtained. Simultaneous sound wave Therefore, it is possible to provide a sound wave generator, a stirring device, and an automatic analyzer that do not need to be designed for each use form.
  • FIG. 1 is a perspective view of a sound wave generator according to the present invention.
  • FIG. 2 is an enlarged cross-sectional view of a portion A of the sound wave generator shown in FIG.
  • FIG. 3 is a diagram showing a charge distribution pattern on the comb-like electrode of the sound wave generator shown in FIG. 1 and a displacement of the comb-like electrode in the vibrator.
  • FIG. 4 is a cross-sectional view of a sound wave generator showing surface acoustic waves generated along the surface of a piezoelectric substrate.
  • FIG. 5 is an enlarged view of part B of the sound wave generator shown in FIG. 4, showing the energy stored in the piezoelectric substrate corresponding to both ends in the width direction of the comb-like electrode due to the energy storage effect.
  • FIG. 6 is a cross-sectional view of a sound wave generator for explaining the conditions under which only a banorek wave is generated by phase matching when a comb-like electrode is excited.
  • FIG. 7 is a sound radiation characteristic diagram of a piezoelectric substrate using a Y-cut Z-propagating lithium niobate crystal.
  • FIG. 8 is a schematic configuration diagram of a stirring device of the present invention provided with the sound wave generator of FIG.
  • FIG. 9 is a cross-sectional view showing the surface acoustic wave and bulk wave emitted from the vibrator and the sound wave leaking into the liquid when the sound wave generator of the stirring device shown in FIG. 8 is driven.
  • FIG. 10 is a cross-sectional view showing an acoustic flow generated in a liquid by sound waves leaking from a piezoelectric substrate. .
  • FIG. 11 is a cross-sectional view of the sound wave generator for explaining the behavior of the sound wave generated by the vibrator when the sound wave generator is driven in the air.
  • FIG. 12 is an isovelocity distribution diagram created by imaging the flow generated in the liquid held in the container.
  • FIG. 13 is a schematic configuration diagram showing a modified example in which the sound wave generator of the stirring device in FIG. 8 is driven by a rectangular wave.
  • FIG. 14 shows that the vibrator emits when the sound wave generator of the stirring device shown in FIG. 13 is driven. It is sectional drawing which shows the acoustic wave which leaks into the surface acoustic wave and bulk wave which perform, and a liquid.
  • FIG. 15 is a schematic configuration diagram showing an automatic analyzer according to a second embodiment provided with the stirring device of the present invention.
  • FIG. 16 is a block diagram showing configurations of an automatic analyzer and a stirrer according to the second embodiment.
  • FIG. 17 is a perspective view showing a reaction vessel, a sound wave generator of a stirring device attached to the reaction vessel, and a power transmission body having a terminal with a spring for supplying power to the sound wave generator.
  • FIG. 18 is a cross-sectional view of the reaction vessel shown in FIG.
  • FIG. 19 is an enlarged view of part C in FIG.
  • FIG. 20 is a perspective view showing a sound wave generator of the stirring device of the present invention attached to a reaction vessel and a power transmission body having a spring-equipped terminal for supplying power to the sound wave generator.
  • FIG. 21 is a cross-sectional view of the reaction vessel and the sound wave generator shown in FIG. 20 cut at the center in the width direction.
  • FIG. 22 is an enlarged view of part D in FIG.
  • FIG. 23 is a cross-sectional view corresponding to FIG. 21, showing a modification of the stirring device in which the sound wave generator is attached to the lower surface of the bottom wall at the vibrator portion.
  • FIG. 24 is an enlarged view of part E in FIG.
  • FIG. 1 is a perspective view of a sound wave generator of the present invention.
  • FIG. 2 is an enlarged cross-sectional view of a part A of the sound wave generator shown in FIG.
  • FIG. 8 is a schematic configuration diagram of the stirring device of the present invention provided with the sound wave generator of FIG.
  • the sound wave generator 2 includes a plurality of comb-like electrodes (on one surface of the piezoelectric substrate 2a)
  • the vibrators 2b and 2c having IDT force are provided, and terminals 2f and 2g for supplying power are provided at the ends of the bus bars 2d and 2e.
  • Piezoelectric substrate 2a uses Y-cut Z-propagation (YZ) lithium niobate (LiNb03) crystal, vibrators 2b and 2c, bus bars 2d and 2e, and terminals 2f and 2g using gold (Au). It is formed by sputtering.
  • YZ Y-cut Z-propagation
  • LiNb03 lithium niobate
  • Au gold
  • the vibrators 2b and 2c have a line width of each comb-shaped electrode constituting Le, an interval between adjacent comb-shaped electrodes Ls, and a pair of comb teeth
  • the comb-shaped electrode thickness t is formed so as to satisfy the following equation.
  • the sound wave generator 2 distributes electric charge on each comb-shaped electrode constituting the vibrators 2b and 2c, and is shown on the upper side of FIG.
  • a pattern of charge distribution that increases at both ends in the width direction of each comb-like electrode is shown, and the plus and minus in this pattern alternately change according to the frequency of the AC voltage.
  • the comb-like electrodes constituting the vibrators 2b and 2c are arranged so that when the vibrator 2b is displaced upward as shown in the lower side of FIG. 3, the vibrator 2c is displaced downward. Excited while moving in opposite directions according to the frequency of the AC voltage.
  • the charge distribution shown on the upper side is drawn according to the positions of the vibrators 2b and 2c shown on the lower side.
  • F the drive frequency
  • 2c in the present embodiment, F 40 MHz
  • a sound wave is generated that propagates along the surface of the piezoelectric substrate 2a.
  • This sound wave is generated from each comb-like electrode constituting the vibrators 2b and 2c, and when reflected on the adjacent comb-like electrode, a part of it is reflected and the remaining part is transmitted. Interfering with each other.
  • equation (1) is derived by transforming the left side of this equation.
  • equation (2) is obtained.
  • the surface inertia wave is converted into a bulk wave and emitted from the sound wave generator 2.
  • Surface acoustic waves and bulk waves are mixed in the sound wave.
  • the sound wave generator 2 does not radiate a bulk wave in the vicinity of the Bragg frequency with respect to the surface acoustic wave.
  • the bulk wave is canceled by the periodic structure of the comb-like electrodes forming the vibrators 2b and 2c, and does not radiate.
  • the excited energy is applied to the vibrators 2b and 2c, for example, As shown in FIG. 5, the energy is accumulated in a portion surrounded by a dotted line of the piezoelectric substrate 2a corresponding to both ends in the width direction of each comb-like electrode constituting the vibrator 2b (energy accumulation effect).
  • phase matching condition can be rewritten as the following equation using a reverse velocity SB that is the reciprocal of the velocity VB of the bulk wave.
  • the reverse speed SB is not a perfect circle but a function of the radiation angle ⁇ ⁇ .
  • ⁇ lithium niobate
  • the sound radiation characteristic (Slowness Curve) which is the reverse velocity curve of sound in the piezoelectric substrate 2a, is asymmetric.
  • a bulk wave is emitted in the direction in which the drive frequency increases, that is, in the direction of the group velocity that is the normal direction of the reverse velocity curve inside the piezoelectric substrate 2a.
  • the sound radiation characteristic (Slowness Curve) is defined as follows.
  • the reverse velocity along the surface of the piezoelectric substrate 2a is SX
  • the reverse velocity along the thickness direction of the piezoelectric substrate 2a is SZ. It shows the distribution of the reverse velocity in the case.
  • the piezoelectric substrate 2a using a Y-cut Z-propagation (YZ) lithium niobate (LiNb03) crystal exhibits the sound radiation characteristics (slowness curve) shown in FIG.
  • Bulk wave Wb is emitted in a specific direction radiation range of 35 to 40 ° (left side in the figure) or 60 to 65 ° (right side in the figure) with respect to the surface of 2a, and the emission direction does not change even if the drive frequency changes slightly .
  • the curve CL indicates the longitudinal wave
  • the curve CFS indicates the fast transverse wave
  • the curve CSS indicates the slow transverse wave.
  • the piezoelectric substrate 2a using the Y-cut Z-propagation (YZ) lithium niobate (LiNb03) crystal has both end portions in the width direction of each comb-like electrode when the driving frequency is above the Bragg frequency ⁇ .
  • the energy accumulated in the piezoelectric substrate 2a is emitted as a bulk wave. That is, the sound wave generator 2 sets the drive frequency F to the frequency f0 (defined by the pitch p of the comb-like electrode. ; if adjusted to 1.5 to 2.5 times i 0), a bulk wave Wb is emitted in a specific direction of 35 to 40 ° or 60 to 65 ° shown in FIG.
  • the sound wave generator 2 behaves as if the surface acoustic wave Wa is generated only in the comb-like electrode due to the excitation of the comb-like electrode.
  • the sound wave generator 2 includes the comb-like electrode as described above.
  • the sound wave generator 2 configured as described above is combined with the control unit 3 and the drive circuit 4 to form the stirring device 1.
  • the sound wave generator 2 is inserted into the liquid L to be stirred, which is supported by the support member 5 at the top of the piezoelectric substrate 2 a and held in the container 6.
  • the stirring device 1 applies, for example, a high-frequency AC electric field (sine wave, continuous drive) of about several MHz to several hundred MHz to the sound wave generator 2 from the drive circuit 4 controlled by the control unit 3. Sound waves are generated in the vibrators 2b and 2c, and the liquid L in the container 6 is stirred.
  • the sound wave generator 2 is a force that shows a state of being immersed in the liquid L in Fig. 8.
  • the vibrators 2b and 2c emit surface acoustic waves Wa along the surface of the piezoelectric substrate 2a as shown in FIG.
  • the liquid L has an acoustic impedance substantially equal to that of the piezoelectric substrate 2a (120 or more), the liquid L has a surface wave wave transverse wave force, a component that has undergone mode conversion to a longitudinal wave, and a bulk wave in the liquid L
  • the sound wave WL including a component that emits at an angle ⁇ L satisfying the above Bragg condition leaks from the piezoelectric substrate 2a.
  • the surface acoustic wave Wa is weaker than the bulk wave Wb.
  • the liquid L held in the container 6 is caused by the sound wave WL as shown in FIG.
  • the acoustic stream FL and the acoustic stream Fb are locally generated around the piezoelectric substrate 2a, and the entire liquid L is effectively agitated by the acoustic stream FL and the acoustic stream Fb.
  • the dotted line indicates the longitudinal wave WL obtained by mode conversion of the bulk wave Wb leaking from the piezoelectric substrate 2a to the liquid L out of the bulk wave Wb propagating in the piezoelectric substrate 2a while being reflected. Yes.
  • the acoustic impedance of the air is too small compared to the acoustic impedance of the piezoelectric substrate 2a (less than 1Z500). For this reason, the surface waves emitted from the vibrators 2b and 2c do not leak into the air.As shown in FIG. 11, the bulk wave Wb is also reflected in the piezoelectric substrate 2a while propagating in the air. Will not leak.
  • the sound wave generator 2 emits sound waves into the liquid L not only from the surface of the piezoelectric substrate 2a on which the vibrators 2b and 2c are formed and the back surface thereof, but also from the lower end surface of the piezoelectric substrate 2a. It was confirmed that an acoustic flow was generated with these sound waves.
  • one scale on the vertical axis indicates 2 mm, and one scale force mm on the horizontal axis.
  • the stirring device 1 may drive the sound wave generator 2 with a rectangular wave having a frequency f0.
  • a rectangular wave includes a harmonic component in a signal. Therefore, when the sound wave generator 2 is driven by a square wave, the stirring device 1 can simultaneously generate the bulk wave Wb while being in the excitation mode of the surface anisotropy wave Wa as shown in FIG.
  • the sound wave generator 2 has been described in the case where the vibrators 2b and 2c have a pair, two or more pairs may be formed. Further, the sound wave generator 2 can obtain the same effect by setting tZ 0 optimally even if the material, cut, and electrode material of the piezoelectric body forming the piezoelectric substrate 2a are changed.
  • FIG. 15 is a schematic configuration diagram showing the automatic analyzer according to the second embodiment provided with the stirring device of the present invention.
  • FIG. 16 is a block diagram showing the configuration of the automatic analysis device and the stirring device of the second embodiment.
  • FIG. 17 is a perspective view showing a sound wave generator of a stirrer attached to a reaction vessel and a power transmission body having a spring-equipped terminal for supplying power to the sound wave generator.
  • the automatic analyzer 10 includes a reagent table 11, 12, a reaction table 13, a specimen container transfer mechanism 17, an analysis optical system 21, a cleaning mechanism 22, and a control unit. 24 and 30 stirring devices.
  • the reagent tables 11 and 12 hold a plurality of reagent containers 11a and 12a arranged in the circumferential direction, respectively, and are rotated by the driving means to surround the reagent containers 11a and 12a. Transport in the direction.
  • the reaction table 13 has a plurality of reaction vessels 14 arranged in the circumferential direction, and can be rotated forward by driving means different from the driving means of the reagent tables 11 and 12. Is reversed and transports the reaction vessel 14.
  • the reaction table 13 rotates in the clockwise direction in one cycle (one reaction container per turn) / 4 turn, and rotates in four cycles (one reaction container per turn).
  • the reaction container 14 is a very small container having a capacity of several nL to several tens of ⁇ L, and transmits 80% or more of the light contained in the analysis light emitted from the light emitting part 21a of the analysis optical system 21.
  • Transparent materials such as glass containing heat-resistant glass, synthetic resins such as cyclic olefin and polystyrene are used.
  • the reaction vessel 14 has a side wall 14a, 14b and a bottom wall to form a liquid holding portion having a rectangular horizontal section for holding the liquid, and has an opening 14c at the top of the liquid holding portion. It is a square tube-shaped cuvette.
  • the reaction container 14 is arranged on the reaction table 13 with the sound wave generator 33 facing radially outward, and the reagent containers 11a, 16 of the reagent tables 11 and 12 by the reagent dispensing mechanisms 15 and 16 provided in the vicinity of the reaction table 13. Reagents are dispensed from 12a.
  • each of the reagent dispensing mechanisms 15 and 16 is provided with probes 15b and 16b for dispensing a reagent on arms 15a and 16a that rotate in the direction of an arrow in a horizontal plane, respectively. It has cleaning means for cleaning the 15b and 16b.
  • the specimen container transfer mechanism 17 is a transfer means for transferring a plurality of racks 19 arranged in the feeder 18 one by one along the direction of the arrow. Transport.
  • the rack 19 holds a plurality of sample containers 19a containing samples.
  • the sample container 19a includes a sample dispensing mechanism 20 having a drive arm 20a and a probe 20b that rotate in the horizontal direction each time the step of the rack 19 transferred by the sample container transfer mechanism 17 stops. The sample is dispensed into each reaction container 14 by. For this reason, the specimen dispensing mechanism 20 has a cleaning means for cleaning the probe 20b with cleaning water.
  • the analysis optical system 21 emits analysis light (340 to 800 nm) for analyzing the liquid in the reaction vessel 14 in which the reagent and the sample have reacted. As shown in FIG. a, It has a spectroscopic unit 21b and a light receiving unit 21c. The analysis light emitted from the light emitting part 21a passes through the liquid in the reaction container 14 and is received by the light receiving part 21c provided at a position facing the spectroscopic part 21b. The light receiving unit 21c is connected to the control unit 24 and outputs a light amount signal of the received analysis light to the control unit 24.
  • the cleaning mechanism 22 has a plurality of nozzles 22a. After the liquid in the reaction container 14 is sucked and discharged by the first nozzle 22a, the detergent and the cleaning water are discharged from the second and subsequent nozzles 22a. The inside of the reaction vessel 14 in which photometry by the analysis optical system 21 has been completed is washed by repeating the operation of injecting and aspirating a washing solution such as a plurality of times. .
  • control unit 24 For example, a microcomputer or the like is used as the control unit 24. As shown in FIGS. 15 and 16, the control unit 24 is connected to each component of the automatic analyzer 10 to control the operation thereof, and the light emitting unit 21a. The component concentration of the sample is analyzed on the basis of the absorbance of the liquid in the reaction container 14 based on the amount of emitted light and the amount of light received by the light receiving unit 21c.
  • the control unit 24 performs an analysis operation while controlling the operation of each component of the automatic analyzer 10 based on an analysis command input from the input unit 25 such as a keyboard, as well as analysis results and warning information. Various information based on the display command input from the input unit 25 is displayed on the display unit 26 such as a display panel.
  • the stirrer 30 stirs the liquid held in the reaction vessel 14 by the sound waves generated by driving the sound wave generator 33. As shown in FIGS. 15 and 16, the power transmitter 31 and the sound wave Departure A living body 33.
  • the power transmission body 31 is disposed in a position opposite to the reaction vessel 14 in the horizontal direction at positions opposite to each other on the outer periphery of the reaction table 13, and generates high-frequency AC power from about several MHz to several hundred MHz by generating sound waves. Power is transmitted to body 33.
  • the power transmission body 31 includes the same drive circuit and control unit as the stirrer of Embodiment 1, and as shown in FIG. 17, the spring-loaded terminal 31a that abuts against the terminals 33f and 33g of the sound wave generator 33, respectively. have. At this time, as shown in FIG. 15, the power transmission body 31 is supported by the arrangement determining member 32, and transmits power from the spring-loaded terminal 31a to the terminals 33f and 33g when the rotation of the reaction table 13 stops.
  • the arrangement determining member 32 is configured to bring each spring-equipped terminal 31a into contact with the corresponding terminal 33f, 33g when transmitting power from the power transmitting body 31 to the terminals 33f, 33g, and the rack 32a and the pinion 32b. have.
  • the arrangement determining member 32 rotates the reaction table 13 and transmits power from the power transmission body 31 to the terminals 33f and 33g, and stops operation when there is no power transmission, and the power transmission body 31 and the terminals 33f and 33g Are separated by a certain distance.
  • the arrangement determining member 32 moves the power transmission body 31 under the control of the control unit 24, so that the power transmission body 31 and the terminals 33f and 33g face each other.
  • the position along the circumferential direction of the response table 13 is adjusted and the relative arrangement is determined.
  • the power transmission body 31 transmits power to the sound wave generator 33 by bringing the spring-loaded terminals 31a into contact with the terminals 33f and 33g.
  • the sound wave generator 33 has the same configuration as the sound wave generator 2, and as shown in FIG. 17, the Y-cut Z transmission (YZ) lithium niobate (LiNb03) crystal force of the piezoelectric substrate 33a
  • vibrators 33b and 33c composed of a plurality of comb-like electrodes (IDT) are provided, and terminals 33f and 33g serving as power receiving means are provided at the ends of the bus bars 33d and 33e.
  • the transducers 33b and 33c generate sound waves by the electric power transmitted from the power transmission body 31, but the same drive conditions as the sound wave generation body 2 of the first embodiment ⁇ F ⁇ (l. 5 to 2. O) X F0 ⁇ Driven down. As shown in FIGS.
  • the sound wave generator 33 is provided with an acoustic matching layer 34 such as an epoxy resin or an ultraviolet curable resin with the vibrators 33b and 33c, the bus bars 33d and 33e, and the terminals 33f and 33g facing outward. And attached to the side wall 14b of the reaction vessel 14.
  • an acoustic matching layer 34 such as an epoxy resin or an ultraviolet curable resin with the vibrators 33b and 33c, the bus bars 33d and 33e, and the terminals 33f and 33g facing outward. And attached to the side wall 14b of the reaction vessel 14.
  • the automatic analyzer 10 configured as described above operates under the control of the control unit 24 and rotates.
  • the reagent dispensing mechanisms 15 and 16 sequentially dispense the reagents from the reagent containers lla and 12a to the plurality of reaction containers 14 that are transported along the circumferential direction by the reaction table 13 to be performed.
  • the specimen is sequentially dispensed from a plurality of specimen containers 19 a held in the rack 19 by the specimen dispensing mechanism 20.
  • the reaction container 14 into which the reagent and the sample have been dispensed is sequentially stirred by the stirring device 30 so that the reagent and the sample react, and the reaction table 13 rotates again. Sometimes it passes through the analysis optics 21. At this time, the reaction liquid in the reaction vessel 14 is measured by the light receiving unit 21c, and the concentration of the component is analyzed by the control unit 24. Then, after the photometry of the reaction solution is completed, the reaction vessel 14 is washed by the washing mechanism 22 and then used again for analyzing the specimen.
  • the stirrer 30 generates the surface acoustic wave and the bulk wave simultaneously by driving the sound wave generator 33.
  • the side wall 14 from the piezoelectric substrate 33a is obtained.
  • the acoustic wave Fb is generated in the liquid sample L containing the reagent and the sample dispensed into the reaction vessel 14 by the bulk wave Wb emitted to b, and the liquid sample L is stirred.
  • the sound wave generator 33 used in the stirrer 30 has the same configuration as the sound wave generator 2 used in the first embodiment, and if the sound wave generator 2 is used, a new sound wave generator for the stirrer 30 is used. Since there is no need to design the product, the manufacturing price can be reduced, and there is an advantage that the labor can be saved in terms of inventory use and management.
  • FIG. 20 is a perspective view showing a sound wave generator of the stirrer of the present invention attached to a reaction vessel and a power transmission body having a spring-equipped terminal for supplying power to the sound wave generator.
  • FIG. 21 is a cross-sectional view of the reaction container and the sound wave generator shown in FIG. 20 cut at the center in the width direction.
  • the stirrer and the automatic analyzer of the third embodiment are the same as the stirrer and the automatic analyzer of the second embodiment except for the configuration of the stirrer. I use it.
  • the stirrer 40 has a power transmission body 31 and a sound wave generator 33 that also serves as the bottom wall of the reaction vessel 14.
  • the power transmitting body 31 transmits power by connecting and disconnecting the spring-loaded terminal 31a to the sound wave generating body 33 from above.
  • a rack 32a and a pinion 32b are arranged upward and downward.
  • the sound wave generator 33 also serves as the bottom wall of the reaction vessel 14, and as shown in FIG. 20, the piezoelectric substrate 33a with the vibrators 33b and 33c, the bus bars 33d and 33e, and the terminals 33f and 33g facing upward. Is attached to the bottom of the side walls 14a and 14b of the reaction vessel 14. At this time, in the sound wave generator 33, the vibrators 33b and 33c are arranged inside the side walls 14a and 14b, and the transducers 33b and 33c on the upper surface of the piezoelectric substrate 33a, the bus bars 33d and 33e, and the terminals 33f and 33g have a reaction container. Insulate the liquid sample held by 14 in advance.
  • the stirrer 40 configured as described above simultaneously generates the surface acoustic wave Wa and the bulk wave Wb that are apparently generated only in the comb-shaped electrode due to the excitation of the comb-shaped electrode. These occur and permeate or leak into the liquid sample L held by the reaction vessel 14 as indicated by the dotted line in FIG. For this reason, as shown in FIG. 21, the liquid sample L generates a local acoustic flow F inside and is stirred by the acoustic flow F.
  • the stirrer 40 of the third embodiment generates both the apparent surface acoustic wave Wa and the bulk wave W b at the same time, and these sound waves are transmitted from the upper surface in contact with the liquid sample L to the liquid sample L. Since it permeates or leaks, the liquid sample L held in the reaction vessel 14 can be efficiently stirred.
  • the stirrer 40 uses the sound wave generators 2 and 33 having the same configuration as those of the first and second embodiments, the manufacturing price is not required to newly design the sound wave generator for the stirrer 40. In addition, it is advantageous in that it is possible to reduce labor in terms of inventory use and management.
  • the stirrer 40 attaches the sound wave generator 33 to the lower surface of the bottom wall 14d at the portions of the vibrators 33b and 33c with an adhesive or the like that also serves as an acoustic matching layer. May be. Even in this case, when the sound generator 33 is driven, the stirrer 40 generates the apparent surface inertia wave Wa and the bulk wave Wb at the same time. As shown by the dotted line in FIG. 1 Permeated or leaked from 4d into the liquid sample L held in the reaction vessel 14. For this reason In the liquid sample L, as shown in FIG. 23, a local acoustic flow F is generated and is stirred by this acoustic flow F.
  • stirrers 30 and 40 have the sound wave generator 33 attached to the reaction vessel 14 via the sound matching layer 34 such as an epoxy resin or an ultraviolet curable resin, an acoustic matching layer such as liquid gel is used. It may be brought into contact with the reaction vessel 14 via the sound matching layer 34 such as an epoxy resin or an ultraviolet curable resin, an acoustic matching layer such as liquid gel is used. It may be brought into contact with the reaction vessel 14 via the sound matching layer 34 such as an epoxy resin or an ultraviolet curable resin, an acoustic matching layer such as liquid gel is used. It may be brought into contact with the reaction vessel 14 via the sound matching layer 34 such as an epoxy resin or an ultraviolet curable resin, an acoustic matching layer such as liquid gel is used. It may be brought into contact with the reaction vessel 14 via the sound matching layer 34 such as an epoxy resin or an ultraviolet curable resin, an acoustic matching layer such as liquid gel is used. It may be brought into contact with the reaction vessel 14 via the sound matching layer 34 such as an epoxy resin or an ultraviolet curable
  • the sound wave generator of the present invention is useful for an agitator and an automatic analyzer that do not need to be designed for each usage pattern.

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Abstract

La présente invention concerne un générateur d'ondes sonores (2), comprenant un substrat piézoélectrique (2a) et des électrodes en forme de peigne (2b et 2c) formées sur la face du substrat piézoélectrique et excitées sous l'effet d'un signal de commande, les électrodes en forme de peigne étant commandées par un signal d'une fréquence de commande différente de la fréquence déterminée à partir de l'espacement entre les dents du peigne, ce qui génère une pluralité d'ondes sonores présentant simultanément différents modes oscillatoires, ainsi qu'un dispositif agitateur et un dispositif d'analyse automatique. Le dispositif agitateur comprend le générateur d'ondes sonores et une unité de commande permettant de faire en sorte qu'un signal de commande soit envoyé aux électrodes en forme de peigne, de façon à agiter un liquide contenu dans un réservoir, en utilisant au moins l'une des ondes sonores présentant différents modes oscillatoires, qui sont simultanément générées par le générateur d'ondes sonores.
PCT/JP2008/061789 2007-06-25 2008-06-23 Générateur d'ondes sonores, dispositif agitateur et dispositif d'analyse automatique WO2009001950A1 (fr)

Applications Claiming Priority (2)

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JP2007166840A JP2009002918A (ja) 2007-06-25 2007-06-25 音波発生体、攪拌装置及び自動分析装置
JP2007-166840 2007-06-25

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120097752A1 (en) * 2009-06-22 2012-04-26 Panasonic Electric Works Co., Ltd. Generating method and generator for generating mist or fine-bubble by using surface acoustic wave

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5638777B2 (ja) * 2009-08-03 2014-12-10 国立大学法人埼玉大学 超音波発生装置及び超音波発生方法
JP7061525B2 (ja) * 2018-06-29 2022-04-28 株式会社日立ハイテク 化学分析装置

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Publication number Priority date Publication date Assignee Title
JPH0496413A (ja) * 1990-08-09 1992-03-27 Murata Mfg Co Ltd 表面波装置
JP2005164549A (ja) * 2003-12-05 2005-06-23 Canon Inc 撹拌素子および撹拌方法
JP2006349380A (ja) * 2005-06-13 2006-12-28 Olympus Corp 攪拌装置、攪拌方法、反応容器及び攪拌装置を備えた分析装置

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
JPH0496413A (ja) * 1990-08-09 1992-03-27 Murata Mfg Co Ltd 表面波装置
JP2005164549A (ja) * 2003-12-05 2005-06-23 Canon Inc 撹拌素子および撹拌方法
JP2006349380A (ja) * 2005-06-13 2006-12-28 Olympus Corp 攪拌装置、攪拌方法、反応容器及び攪拌装置を備えた分析装置

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120097752A1 (en) * 2009-06-22 2012-04-26 Panasonic Electric Works Co., Ltd. Generating method and generator for generating mist or fine-bubble by using surface acoustic wave
US10232329B2 (en) 2009-06-22 2019-03-19 Panasonic Intellectual Property Management Co., Ltd. Generating method and generator for generating mist or fine-bubble by using surface acoustic wave

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