WO2008156095A1 - 光学活性トランス－２－アミノシクロヘキサノールの製造方法およびその中間体 - Google Patents

光学活性トランス－２－アミノシクロヘキサノールの製造方法およびその中間体 Download PDF

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Publication number
WO2008156095A1
WO2008156095A1 PCT/JP2008/061088 JP2008061088W WO2008156095A1 WO 2008156095 A1 WO2008156095 A1 WO 2008156095A1 JP 2008061088 W JP2008061088 W JP 2008061088W WO 2008156095 A1 WO2008156095 A1 WO 2008156095A1
Authority
WO
WIPO (PCT)
Prior art keywords
optically active
aminocyclohexanol
active trans
trans
producing
Prior art date
Application number
PCT/JP2008/061088
Other languages
English (en)
French (fr)
Inventor
Ryuji Ogawa
Toshihiro Fujino
Kenichi Sakai
Original Assignee
Toray Fine Chemicals Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toray Fine Chemicals Co., Ltd. filed Critical Toray Fine Chemicals Co., Ltd.
Priority to EP08765705.2A priority Critical patent/EP2168943B1/en
Priority to JP2008542953A priority patent/JP5287250B2/ja
Priority to CA002684476A priority patent/CA2684476A1/en
Priority to CN2008800204637A priority patent/CN101743218B/zh
Priority to US12/664,164 priority patent/US20100185012A1/en
Publication of WO2008156095A1 publication Critical patent/WO2008156095A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/42—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/44—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton bound to carbon atoms of the same ring or condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/02—Preparation of carboxylic acids or their salts, halides or anhydrides from salts of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

　ラセミ体のトランス－２－アミノシクロヘキサノールと光学活性２－メトキシフェニル酢酸を反応させ、生成する光学活性トランス－２－アミノシクロヘキサノールの光学活性－２－メトキシフェニル酢酸塩を分離することを特徴とする光学活性トランス－２－アミノシクロヘキサノールの製造方法および光学活性トランス－２－アミノシクロヘキサノールの光学活性２－メトキシフェニル酢酸塩。本発明は、光学活性トランス－２－アミノシクロヘキサノールを、工業的に有利で安価な原料から、簡便かつ高収率で製造する方法を提供する。
PCT/JP2008/061088 2007-06-19 2008-06-18 光学活性トランス－２－アミノシクロヘキサノールの製造方法およびその中間体 WO2008156095A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP08765705.2A EP2168943B1 (en) 2007-06-19 2008-06-18 Method for producing optically active trans-2-aminocyclohexanol and intermediate of optically active trans-2-aminocyclohexanol
JP2008542953A JP5287250B2 (ja) 2007-06-19 2008-06-18 光学活性トランス−２−アミノシクロヘキサノールの製造方法およびその中間体
CA002684476A CA2684476A1 (en) 2007-06-19 2008-06-18 Method for producing optically active trans-2-aminocyclohexanol and intermediate of optically active trans-2-aminocyclohexanol
CN2008800204637A CN101743218B (zh) 2007-06-19 2008-06-18 光学活性反式-2-氨基环己醇的制备方法及其中间体
US12/664,164 US20100185012A1 (en) 2007-06-19 2008-06-18 Method for producing optically active trans-2-aminocyclohexanol and intermediate of optically active trans-2-aminocyclohexanol

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007161963 2007-06-19
JP2007-161963 2007-06-19

Publications (1)

Publication Number Publication Date
WO2008156095A1 true WO2008156095A1 (ja) 2008-12-24

Family

ID=40156254

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/061088 WO2008156095A1 (ja) 2007-06-19 2008-06-18 光学活性トランス－２－アミノシクロヘキサノールの製造方法およびその中間体

Country Status (7)

Country Link
US (1) US20100185012A1 (ja)
EP (1) EP2168943B1 (ja)
JP (1) JP5287250B2 (ja)
KR (1) KR20100021404A (ja)
CN (1) CN101743218B (ja)
CA (1) CA2684476A1 (ja)
WO (1) WO2008156095A1 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6623042B2 (ja) * 2015-11-24 2019-12-18 公益財団法人微生物化学研究会 触媒、及びその製造方法、並びに光学活性アンチ−１，２−ニトロアルカノール化合物の製造方法
CN111989514A (zh) 2018-07-09 2020-11-24 株式会社富士金 流体控制设备
CN111039803A (zh) * 2018-10-12 2020-04-21 中国石油化工股份有限公司 自环己烷氧化副产物制备氨基取代环己醇的方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0959252A (ja) 1995-08-22 1997-03-04 Eisai Co Ltd アミノ酸誘導体の製造方法
JP2846770B2 (ja) 1992-08-21 1999-01-13 旭化成工業株式会社 光学活性なトランス−２−アミノシクロヘキサノール誘導体を取得するための光学分割法
JPH1160543A (ja) * 1997-08-19 1999-03-02 Ichikawa Gosei Kagaku Kk １−アミノテトラリン−２−オールの光学分割方法と分割の過程で生じるジアステレオマー塩
JP2001139528A (ja) * 1999-11-17 2001-05-22 Toray Ind Inc 光学活性２−アミノシクロヘキサノール誘導体の製造方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2846770B2 (ja) 1992-08-21 1999-01-13 旭化成工業株式会社 光学活性なトランス−２−アミノシクロヘキサノール誘導体を取得するための光学分割法
JPH0959252A (ja) 1995-08-22 1997-03-04 Eisai Co Ltd アミノ酸誘導体の製造方法
JPH1160543A (ja) * 1997-08-19 1999-03-02 Ichikawa Gosei Kagaku Kk １−アミノテトラリン−２−オールの光学分割方法と分割の過程で生じるジアステレオマー塩
JP2001139528A (ja) * 1999-11-17 2001-05-22 Toray Ind Inc 光学活性２−アミノシクロヘキサノール誘導体の製造方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
SAKAI K. ET AL.: "Resolution of 1-cyclohexylethylamine via diastereomeric salt formation", TETRAHEDRON ASYMMETRY, vol. 17, no. 10, 19 June 2006 (2006-06-19), pages 1541 - 1543, XP005526156 *
See also references of EP2168943A4
TETRAHEDRON ASYMMETRY, vol. 14, 2003, pages 3297 - 3300

Also Published As

Publication number Publication date
EP2168943A4 (en) 2014-04-16
JP5287250B2 (ja) 2013-09-11
JPWO2008156095A1 (ja) 2010-08-26
EP2168943B1 (en) 2015-08-12
CN101743218B (zh) 2013-05-29
CA2684476A1 (en) 2008-12-24
KR20100021404A (ko) 2010-02-24
US20100185012A1 (en) 2010-07-22
CN101743218A (zh) 2010-06-16
EP2168943A1 (en) 2010-03-31

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