WO2008155891A1 - 新規な動脈硬化性疾患マーカー - Google Patents

新規な動脈硬化性疾患マーカー Download PDF

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Publication number
WO2008155891A1
WO2008155891A1 PCT/JP2008/001527 JP2008001527W WO2008155891A1 WO 2008155891 A1 WO2008155891 A1 WO 2008155891A1 JP 2008001527 W JP2008001527 W JP 2008001527W WO 2008155891 A1 WO2008155891 A1 WO 2008155891A1
Authority
WO
WIPO (PCT)
Prior art keywords
arteriosclerotic disease
novel marker
mammal
evaluating
arteriosclerotic
Prior art date
Application number
PCT/JP2008/001527
Other languages
English (en)
French (fr)
Inventor
Masanao Matsuo
Hiroyuki Ebinuma
Isamu Fukamachi
Hideaki Bujo
Yasushi Saito
Original Assignee
Sekisui Medical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sekisui Medical Co., Ltd. filed Critical Sekisui Medical Co., Ltd.
Priority to US12/665,055 priority Critical patent/US20110177610A1/en
Priority to JP2009520303A priority patent/JP5415946B2/ja
Priority to EP08764122A priority patent/EP2159577B1/en
Publication of WO2008155891A1 publication Critical patent/WO2008155891A1/ja

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/323—Arteriosclerosis, Stenosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

　新たな動脈硬化性疾患のマーカーを提供することにある。 　哺乳動物から採取された試料中の可溶性ＬＲ１１を検出することを特徴とする、該動物における動脈硬化性疾患の存在・程度の評価方法、予防並びに治療効果の評価方法。
PCT/JP2008/001527 2007-06-18 2008-06-13 新規な動脈硬化性疾患マーカー WO2008155891A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/665,055 US20110177610A1 (en) 2007-06-18 2008-06-13 Novel marker for arteriosclerotic disease
JP2009520303A JP5415946B2 (ja) 2007-06-18 2008-06-13 新規な動脈硬化性疾患マーカー
EP08764122A EP2159577B1 (en) 2007-06-18 2008-06-13 Novel marker for arteriosclerotic disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-160225 2007-06-18
JP2007160225 2007-06-18

Publications (1)

Publication Number Publication Date
WO2008155891A1 true WO2008155891A1 (ja) 2008-12-24

Family

ID=40156055

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/001527 WO2008155891A1 (ja) 2007-06-18 2008-06-13 新規な動脈硬化性疾患マーカー

Country Status (4)

Country Link
US (1) US20110177610A1 (ja)
EP (1) EP2159577B1 (ja)
JP (1) JP5415946B2 (ja)
WO (1) WO2008155891A1 (ja)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009116268A1 (ja) * 2008-03-21 2009-09-24 積水メディカル株式会社 可溶性ｌｒ１１の定量方法
WO2011074594A1 (ja) 2009-12-16 2011-06-23 積水メディカル株式会社 悪性腫瘍の診断方法
WO2012008594A1 (ja) * 2010-07-15 2012-01-19 積水メディカル株式会社 悪性腫瘍細胞の検出方法
WO2012008595A1 (ja) * 2010-07-15 2012-01-19 積水メディカル株式会社 抗ｌｒ１１抗体の製造法及び免疫学的測定用標準品
WO2012153773A1 (ja) 2011-05-09 2012-11-15 積水メディカル株式会社 可溶性ｌｒ１１の免疫学的測定方法
JP2014167428A (ja) * 2013-02-28 2014-09-11 Juntendo 新規な肺高血圧症のマーカー
JP2014167446A (ja) * 2013-02-28 2014-09-11 Sekisui Medical Co Ltd 肝臓疾患の評価方法及び診断キット

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016123163A2 (en) 2015-01-27 2016-08-04 Kardiatonos, Inc. Biomarkers of vascular disease
WO2017141980A1 (ja) * 2016-02-16 2017-08-24 公立大学法人横浜市立大学 動脈硬化を検出するための血中バイオマーカー

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09163988A (ja) 1995-10-09 1997-06-24 Kowa Co 新規なｌｄｌ受容体類似蛋白質及び遺伝子
WO2001064874A2 (en) 2000-03-02 2001-09-07 Boston Heart Foundation, Inc. Low density liprotein binding proteins and their use in diagnosing and treating atherosclerosis

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5529898A (en) * 1993-08-19 1996-06-25 Duke University Methods of detecting disorders of the central nervous system by detecting autoantibodies which specifically bind ionotropic glutamate receptors
CA2228970A1 (en) * 1995-08-18 1997-02-27 Donald W. Landry Detection of organic compounds through regulation of antibody-catalyzed reactions
WO2005117561A2 (en) * 2004-06-04 2005-12-15 Icell Therapeutics Compositions and methods for diagnosing and treating diseases using low density lipoprotein-like lipid emulsions
WO2006031592A1 (en) * 2004-09-09 2006-03-23 University Of Massachusetts Disease markers for early stage atherosclerosis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09163988A (ja) 1995-10-09 1997-06-24 Kowa Co 新規なｌｄｌ受容体類似蛋白質及び遺伝子
WO2001064874A2 (en) 2000-03-02 2001-09-07 Boston Heart Foundation, Inc. Low density liprotein binding proteins and their use in diagnosing and treating atherosclerosis

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ARTERIOSCLER. THROMB. VASC. BIOL., vol. 19, 1999, pages 2687 - 2695
CIRC. RES., vol. 94, 2004, pages 752 - 758
J. BIOL. CHEM., vol. 271, 1996, pages 24761 - 24768
J. BIOL. CHEM., vol. 271, 1996, pages 31379 - 31383
KENJI OHWAKI ETAL.: "A secreted soluble from of LR11,l specifically expressed in intimal smooth muscle cells, accelerated formation of lipid-laden macrophages", ARTER. THROMB. VASC. BIOL., vol. 27, no. 5, 16 May 2007 (2007-05-16), pages 1050 - 1056, XP009134179 *
OHWAKI ET AL., ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, vol. 27, 2007, pages 1050 - 1056
OHWAKI ET AL., CIRCULATION, vol. 114, 2006
See also references of EP2159577A4
TAKESHIRO H.: "Kekkan no Lipidology LDL Juyotai Family to Kekkan", VASCULAR BIOLOGY & MEDICINE, vol. 5, no. 5, 2004, pages 469 - 474 *
YANJUAN ZHU ET AL.: "LR11, an LDL receptor gene family member, is a novel regulator of smooth muscle cell migration", CIRCULAT. RES., vol. 94, no. 6, 2004, pages 752 - 758, XP009134177 *

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9261443B2 (en) 2008-03-21 2016-02-16 Sekisui Medical Co., Ltd. Method for quantification of soluble LR 11
WO2009116268A1 (ja) * 2008-03-21 2009-09-24 積水メディカル株式会社 可溶性ｌｒ１１の定量方法
US9097714B2 (en) 2009-12-16 2015-08-04 Sekisui Medical Co., Ltd. Method for diagnosing malignant tumor
WO2011074594A1 (ja) 2009-12-16 2011-06-23 積水メディカル株式会社 悪性腫瘍の診断方法
JP5783909B2 (ja) * 2009-12-16 2015-09-24 積水メディカル株式会社 悪性腫瘍の診断方法
JP2012144550A (ja) * 2010-07-15 2012-08-02 Sekisui Medical Co Ltd 悪性腫瘍細胞の検出方法
KR20130091720A (ko) 2010-07-15 2013-08-19 세키스이 메디칼 가부시키가이샤 악성종양 세포의 검출방법
JPWO2012008595A1 (ja) * 2010-07-15 2013-09-09 積水メディカル株式会社 抗ｌｒ１１抗体の製造法及び免疫学的測定用標準品
WO2012008595A1 (ja) * 2010-07-15 2012-01-19 積水メディカル株式会社 抗ｌｒ１１抗体の製造法及び免疫学的測定用標準品
WO2012008594A1 (ja) * 2010-07-15 2012-01-19 積水メディカル株式会社 悪性腫瘍細胞の検出方法
US9969802B2 (en) 2010-07-15 2018-05-15 Sekisui Medical Co., Ltd. Method for detecting malignant tumor cells
KR101879225B1 (ko) * 2010-07-15 2018-07-17 세키스이 메디칼 가부시키가이샤 악성종양 세포의 검출방법
KR20140033365A (ko) 2011-05-09 2014-03-18 세키스이 메디칼 가부시키가이샤 가용성 lr11의 면역학적 측정방법
WO2012153773A1 (ja) 2011-05-09 2012-11-15 積水メディカル株式会社 可溶性ｌｒ１１の免疫学的測定方法
US9541550B2 (en) 2011-05-09 2017-01-10 Sekisui Medical Co., Ltd. Method for immunologically measuring soluble LR11
JP2014167428A (ja) * 2013-02-28 2014-09-11 Juntendo 新規な肺高血圧症のマーカー
JP2014167446A (ja) * 2013-02-28 2014-09-11 Sekisui Medical Co Ltd 肝臓疾患の評価方法及び診断キット

Also Published As

Publication number Publication date
JP5415946B2 (ja) 2014-02-12
EP2159577A1 (en) 2010-03-03
US20110177610A1 (en) 2011-07-21
EP2159577A4 (en) 2010-08-04
JPWO2008155891A1 (ja) 2010-08-26
EP2159577B1 (en) 2012-08-08

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