WO2008155612A1 - Procédé pour humidifier une lentille de contact - Google Patents

Procédé pour humidifier une lentille de contact Download PDF

Info

Publication number
WO2008155612A1
WO2008155612A1 PCT/IB2008/001473 IB2008001473W WO2008155612A1 WO 2008155612 A1 WO2008155612 A1 WO 2008155612A1 IB 2008001473 W IB2008001473 W IB 2008001473W WO 2008155612 A1 WO2008155612 A1 WO 2008155612A1
Authority
WO
WIPO (PCT)
Prior art keywords
liquid solution
contact lens
eye
humidifying
liquid
Prior art date
Application number
PCT/IB2008/001473
Other languages
English (en)
Inventor
Alessandro Filippo
Original Assignee
Alessandro Filippo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alessandro Filippo filed Critical Alessandro Filippo
Publication of WO2008155612A1 publication Critical patent/WO2008155612A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears

Definitions

  • the present invention relates to a method for humidifying a contact lens, having the features set forth in the preamble of the main claim. It is also directed to a kit comprising at least one contact lens and a spray device, as set forth in the preamble of the independent claim 9.
  • Technological Background The present invention is applicable to all types of contact lens but is preferably applied to soft contact lenses. These are composed of a solid matrix which is generally constituted by a polymer having high hydrophilic properties and in which a liquid component is dispersed in a relatively large amount of, for example, from 20% to 80% with respect to the total weight of the lens.
  • the liquid component is typically composed of a 0.9% sodium chloride solution in purified water, generally known as a physiological solution or saline solution.
  • the fraction of liquid component present in the contact lens in addition to improving the wearability characteristics of the lens, also contributes to the correct definition of the geometrical and optical properties thereof. It is therefore necessary for the liquid component of the lens always to be maintained at the intended levels, compensating for any losses of liquid with suitable humidifying. There is also a requirement to maintain correct humidifying of the lens in other types of lens, for example in silicone-based contact lenses, which have a coating or surface treatment which renders them hydrophilic.
  • Losses of liquid fraction attributable to evaporation phenomena take place when the contact lens is in position on the user's eye, for example, in particular climatic situations, such as excessive wind, excessive exposure to the sun or excessive heat, or in air-conditioned or heated environments, or also in conditions of visual stress caused, for example, by the intensive use of a video terminal.
  • this operation may consist in removing the contact lens from the eye and immersing it in a saline solution for a predetermined time, or applying to the contact Jens a few drops of saline solution, always after having removed it from the eye.
  • this procedure involves the necessity of removing the lenses from the eye.
  • the object of the present invention is to provide a method which is devised functionally to overcome the limits explained above with reference to the mentioned prior art.
  • the method described here provides that a contact lens 1 is moistened while it is in position on an eye 2 of the user, thus avoiding all of the complications mentioned above caused by any removal thereof.
  • the contact lens 1 is moistened by applying a liquid solution 3 thereto by spraying.
  • the liquid solution 3 is advantageously contained within a spray device 4, by acting on which the user is able to bring about the delivery of a defined amount of liquid solution 3 through a nozzle 5 of the spray device 4.
  • the spray it is desirable for the spray to be directed towards the contact lens 1 in such a manner as to cover the entire surface thereof, endeavouring at the same time not to affect areas outside the eye 2, thus limiting to the maximum extent any possible losses of liquid solution.
  • the parameters contributing to achieving this effect are the distance from which the liquid solution 3 is sprayed towards the eye 2 and the angulation at which the liquid solution 3 is emitted from the nozzle 5.
  • the first parameter is preferably selected in such a manner that the spray device 4 is sufficiently close to ensure that the spray is directed accurately without, however, running the risk of coming into contact with the eye 2, even if only accidentally.
  • the distance at which the spray device 4 is preferably held during the stage of spraying the liquid solution 3 is from approximately 30 to approximately 150 mm.
  • the nozzle 5 of the spray device 4 is dimensioned in such a manner as to spray the liquid solution 3 at an angulation of from approximately 5° to approximately 20°.
  • the liquid solution 3 is any substance in liquid form capable of humidifying the contact lens 1.
  • liquid solution is not limited to the strictly chemical definition of “mixture in completely homogeneous liquid phase” but extends to its more general meaning, which is moreover usual in the technical field of reference, of "liquid mixture”, and therefore also includes emulsions and suspensions in liquid phase.
  • the liquid solution 3 Since it is desirable for contact between the liquid solution 3 and the eye 2 to cause as little discomfort as possible, it is preferable for the liquid solution 3 to have a composition which is as similar as possible to that present on the ocular surface on which the contact lens 1 is positioned.
  • the liquid solution 3 is formed from purified water in which 0.9% sodium chloride is dissolved (physiological solution).
  • the liquid solution 3 is formed from a lachrymal substitute, that is to say, from an aqueous solution containing an effective amount of compounds, typically polymers, that confer on the liquid solution chemico-physical properties that are as similar as possible to those of natural tears.
  • Polymers of this type are already kn ⁇ wn in the field of ophthalmic treatments and include polysaccharides and the derivatives thereof, such as dextrans, galactoxyloglucans and glucosaminoglycans. Of these, hyaluronic acid and the derivatives thereof, or galactoxyloglucan extracted from tamarind seed (abbreviation TSP) are especially preferred.
  • TSP galactoxyloglucan extracted from tamarind seed
  • the amounts of polymer present in the aqueous solution are calibrated in accordance with the specific chemico-physical characteristics desired, for example the percentage of hyaluronic acid (in the form of the sodium salt) or of TSP may be from 0.1% to 1%. Still with the aim of minimizing the sensory impact on the eye of the liquid solution sprayed towards the lens, it is advantageous if the size of the droplets is as small as possible, as far as allowed by the opposing requirement of keeping substantially all of the sprayed liquid solution within a predefined spray angle (in order to prevent it affecting in an uncontrolled manner a surface which is much larger than the exposed surface of the contact lens 1).
  • the liquid solution 3 is preferably contained inside the spray device 4 without the addition of propellants, in order to prevent such substances from coming into contact with the eye 2.
  • the liquid solution 3 is advantageously free from preservatives, which are not necessary in the case of a spray-type application given that the liquid solution is closed off in an almost hermetic manner from the external environment. In a completely surprising manner, it is found that the spray application of the liquid solution 3 to the contact lens 1 while the latter is in position on the eye 2 does not cause any appreciable or substantial sensation of discomfort to the user.
  • a possible explanation for this phenomenon consists in the fact that the contact lens 1 towards which the humidifying action is directed acts substantially as a shield for the subjacent corneal area of the eye which is extremely rich in nerve endings and therefore particularly sensitive to contact and temperature variation.
  • the liquid solution 3 is supplied inside the spray device 4 and can be sold separately or together with the contact lenses.
  • the present invention thus achieves the object discussed above with reference to the mentioned prior art.

Landscapes

  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Eyeglasses (AREA)
  • Encapsulation Of And Coatings For Semiconductor Or Solid State Devices (AREA)

Abstract

L'invention porte sur un procédé pour humidifier une lentille de contact pour l'application d'une solution liquide à une lentille de contact positionnée sur un œil d'un utilisateur, la solution liquide étant appliquée à la lentille de contact par pulvérisation.
PCT/IB2008/001473 2007-06-19 2008-06-09 Procédé pour humidifier une lentille de contact WO2008155612A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITPD20070208 ITPD20070208A1 (it) 2007-06-19 2007-06-19 Metodo di umidificazione di una lente a contatto
ITPD2007A000208 2007-06-19

Publications (1)

Publication Number Publication Date
WO2008155612A1 true WO2008155612A1 (fr) 2008-12-24

Family

ID=39865210

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/001473 WO2008155612A1 (fr) 2007-06-19 2008-06-09 Procédé pour humidifier une lentille de contact

Country Status (2)

Country Link
IT (1) ITPD20070208A1 (fr)
WO (1) WO2008155612A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0535545A1 (fr) * 1991-10-02 1993-04-07 Ocular Research Of Boston Inc. Larmes artificielles contenant de l'huile et de la cire
WO1999013863A1 (fr) * 1997-09-18 1999-03-25 Bausch & Lomb Incorporated Compositions ophtalmiques a glycoside cationique et agent therapeutique anionique
US20050202097A1 (en) * 2004-03-12 2005-09-15 Melbj Holdings, Llc, Florida Lubricant for the ocular surface
DE102005055275A1 (de) * 2005-11-17 2007-05-24 Ursapharm Arzneimittel Gmbh & Co. Kg Phosphatfreie pharmazeutische Zusammensetzung sowie deren Verwendung

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0535545A1 (fr) * 1991-10-02 1993-04-07 Ocular Research Of Boston Inc. Larmes artificielles contenant de l'huile et de la cire
WO1999013863A1 (fr) * 1997-09-18 1999-03-25 Bausch & Lomb Incorporated Compositions ophtalmiques a glycoside cationique et agent therapeutique anionique
US20050202097A1 (en) * 2004-03-12 2005-09-15 Melbj Holdings, Llc, Florida Lubricant for the ocular surface
DE102005055275A1 (de) * 2005-11-17 2007-05-24 Ursapharm Arzneimittel Gmbh & Co. Kg Phosphatfreie pharmazeutische Zusammensetzung sowie deren Verwendung

Also Published As

Publication number Publication date
ITPD20070208A1 (it) 2008-12-20

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