WO2008146906A1 - ホルミル基含有多孔質担体、それを用いた吸着体、およびそれらの製造方法 - Google Patents

ホルミル基含有多孔質担体、それを用いた吸着体、およびそれらの製造方法 Download PDF

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Publication number
WO2008146906A1
WO2008146906A1 PCT/JP2008/059986 JP2008059986W WO2008146906A1 WO 2008146906 A1 WO2008146906 A1 WO 2008146906A1 JP 2008059986 W JP2008059986 W JP 2008059986W WO 2008146906 A1 WO2008146906 A1 WO 2008146906A1
Authority
WO
WIPO (PCT)
Prior art keywords
porous carrier
absorbent
production
carrier
formyl group
Prior art date
Application number
PCT/JP2008/059986
Other languages
English (en)
French (fr)
Inventor
Yoshikazu Kawai
Naomi Kawahara
Original Assignee
Kaneka Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corporation filed Critical Kaneka Corporation
Priority to US12/602,001 priority Critical patent/US8828905B2/en
Priority to JP2009516366A priority patent/JP5508850B2/ja
Priority to EP08764904.2A priority patent/EP2165758A4/en
Publication of WO2008146906A1 publication Critical patent/WO2008146906A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/286—Phases chemically bonded to a substrate, e.g. to silica or to polymers
    • B01J20/289—Phases chemically bonded to a substrate, e.g. to silica or to polymers bonded via a spacer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3202—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the carrier, support or substrate used for impregnation or coating
    • B01J20/3206—Organic carriers, supports or substrates
    • B01J20/3208—Polymeric carriers, supports or substrates
    • B01J20/3212—Polymeric carriers, supports or substrates consisting of a polymer obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3214—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the method for obtaining this coating or impregnating
    • B01J20/3217—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
    • B01J20/3219—Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond involving a particular spacer or linking group, e.g. for attaching an active group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3268—Macromolecular compounds
    • B01J20/3272—Polymers obtained by reactions otherwise than involving only carbon to carbon unsaturated bonds
    • B01J20/3274—Proteins, nucleic acids, polysaccharides, antibodies or antigens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

　本発明は、下記一般式（１） （Ｒ1は、－ＣＨ（ＯＨ）－ＣＨ（ＯＨ）－と一緒になって５員環または６員環をなす原子団を表す）で表される基を開裂させた、下記一般式（２） で表される構造をスペーサーに有するホルミル基含有多孔質担体、その製造方法、および該担体にリガンドを結合させた吸着体に関する。本発明によれば、高強度でかつリガンドの漏れの少ない吸着体用担体、ならびに吸着体を提供することができる。                                                                               
PCT/JP2008/059986 2007-05-30 2008-05-30 ホルミル基含有多孔質担体、それを用いた吸着体、およびそれらの製造方法 WO2008146906A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/602,001 US8828905B2 (en) 2007-05-30 2008-05-30 Porous base matrix having formyl group, adsorbent using the porous base matrix, method for production of the porous base matrix, and method for production of the adsorbent
JP2009516366A JP5508850B2 (ja) 2007-05-30 2008-05-30 ホルミル基含有多孔質担体、それを用いた吸着体、およびそれらの製造方法
EP08764904.2A EP2165758A4 (en) 2007-05-30 2008-05-30 POROUS SUPPORT COMPRISING A FORMYL GROUP, ABSORBENT PRODUCT USING THE POROUS CARRIER, PROCESS FOR PRODUCING THE POROUS CARRIER, AND PROCESS FOR PRODUCING THE ABSORBENT PRODUCT

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2007-143513 2007-05-30
JP2007143513 2007-05-30
JP2007-188878 2007-07-19
JP2007188876 2007-07-19
JP2007-188876 2007-07-19
JP2007188878 2007-07-19

Publications (1)

Publication Number Publication Date
WO2008146906A1 true WO2008146906A1 (ja) 2008-12-04

Family

ID=40075137

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/059986 WO2008146906A1 (ja) 2007-05-30 2008-05-30 ホルミル基含有多孔質担体、それを用いた吸着体、およびそれらの製造方法

Country Status (4)

Country Link
US (1) US8828905B2 (ja)
EP (1) EP2165758A4 (ja)
JP (1) JP5508850B2 (ja)
WO (1) WO2008146906A1 (ja)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010064437A1 (ja) * 2008-12-03 2010-06-10 株式会社カネカ ホルミル基含有多孔質担体、それを用いた吸着体、およびそれらの製造方法
JP2012018135A (ja) * 2010-07-09 2012-01-26 Mitsubishi Chemicals Corp 分離剤
WO2015029790A1 (ja) 2013-09-02 2015-03-05 Jnc株式会社 多孔性セルロース粒子の製造方法および多孔性セルロース粒子
WO2015056681A1 (ja) 2013-10-15 2015-04-23 株式会社カネカ 多孔質セルロースビーズの製造方法およびそれを用いた吸着体
WO2015056680A1 (ja) 2013-10-15 2015-04-23 株式会社カネカ 多孔質セルロースビーズの製造方法
WO2015056679A1 (ja) 2013-10-15 2015-04-23 株式会社カネカ 多孔質セルロースビーズの製造方法及びそれを用いた吸着体

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104001481A (zh) * 2014-06-05 2014-08-27 新疆大学 一种用于富集糖基化肽段的亲水磁性纳米材料的制备方法

Citations (6)

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Publication number Priority date Publication date Assignee Title
JPS62155300A (ja) * 1985-12-27 1987-07-10 Sugiyama Sangyo Kagaku Kenkyusho 固定化生理活性物質の製造法
JPH01217041A (ja) 1988-02-26 1989-08-30 Chisso Corp 耐圧密性架橋セルロースの製造方法
US5151350A (en) 1982-10-27 1992-09-29 Repligen Corporation Cloned genes encoding recombinant protein a
JPH06281638A (ja) 1993-03-25 1994-10-07 Ngk Insulators Ltd アフィニティクロマトグラフィー用充填剤
JP2000508361A (ja) 1996-04-11 2000-07-04 アメルシャム・ファルマシア・バイオテック・アクチボラグ 多孔性架橋多糖ゲルの製造方法並びにゲル濾過媒質としておよびクロマトグラフィーにおけるその用途
WO2006004067A1 (ja) 2004-07-06 2006-01-12 Kaneka Corporation ブレビバチルス属細菌を用いたプロテインａ様蛋白質の生産方法

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GB2184732B (en) * 1985-12-26 1990-07-11 Showa Denko Kk Active support substance and adsorbent for chromatography
JPS62153752A (ja) * 1985-12-27 1987-07-08 Showa Denko Kk クロマトグラフイ−用吸着担体
US4882226A (en) * 1986-09-23 1989-11-21 Akzo N.V. Carrier material for use in chromatography or carrying out enzymatic reactions
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JPH0518950A (ja) * 1991-07-09 1993-01-26 Showa Denko Kk アフイニテイクロマトグラフイー用吸着担体
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JP4270038B2 (ja) 2004-06-16 2009-05-27 株式会社デンソーウェーブ 制御装置及びコンピュータプログラム

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5151350A (en) 1982-10-27 1992-09-29 Repligen Corporation Cloned genes encoding recombinant protein a
JPS62155300A (ja) * 1985-12-27 1987-07-10 Sugiyama Sangyo Kagaku Kenkyusho 固定化生理活性物質の製造法
JPH01217041A (ja) 1988-02-26 1989-08-30 Chisso Corp 耐圧密性架橋セルロースの製造方法
JPH06281638A (ja) 1993-03-25 1994-10-07 Ngk Insulators Ltd アフィニティクロマトグラフィー用充填剤
JP2000508361A (ja) 1996-04-11 2000-07-04 アメルシャム・ファルマシア・バイオテック・アクチボラグ 多孔性架橋多糖ゲルの製造方法並びにゲル濾過媒質としておよびクロマトグラフィーにおけるその用途
WO2006004067A1 (ja) 2004-07-06 2006-01-12 Kaneka Corporation ブレビバチルス属細菌を用いたプロテインａ様蛋白質の生産方法

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"Protective Group in Organic Synthesis", JOHN WILEY & SONS, INC.
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GREG T. HERMANSON ET AL., IMMOBILIZED AFFINITY LIGAND TECHNIQUES, 1992
IMMUNOLOGY, vol. 20, 1971, pages 1061
KASAI KENICHI ET AL.: "Affinity Chromatography", 1991, TOKYO KAGAKU DOZIN CO., LTD.
SANDERSON C.J.: "A Simple Method for Coupling Proteins to Insoluble Polysaccharides", IMMUNOLOGY, vol. 20, 1971, pages 1061 - 1065, XP008131449 *
See also references of EP2165758A4 *
STEINDL F. ET AL., JOURNAL OF IMMUNOLOGICAL METHODS, vol. 235, 2000, pages 61 - 69

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010064437A1 (ja) * 2008-12-03 2010-06-10 株式会社カネカ ホルミル基含有多孔質担体、それを用いた吸着体、およびそれらの製造方法
US9149794B2 (en) 2008-12-03 2015-10-06 Kaneka Corporation Formyl group-containing porous support, adsorbent using same, method for producing same, and method for producing the adsorbent
US9932415B2 (en) 2008-12-03 2018-04-03 Kaneka Corporation Formyl group-containing porous support, adsorbent using same, method for producing same, and method for producing the adsorbent
JP2012018135A (ja) * 2010-07-09 2012-01-26 Mitsubishi Chemicals Corp 分離剤
WO2015029790A1 (ja) 2013-09-02 2015-03-05 Jnc株式会社 多孔性セルロース粒子の製造方法および多孔性セルロース粒子
US11685793B2 (en) 2013-09-02 2023-06-27 Jnc Corporation Method for producing porous cellulose particles, and porous cellulose particles
WO2015056681A1 (ja) 2013-10-15 2015-04-23 株式会社カネカ 多孔質セルロースビーズの製造方法およびそれを用いた吸着体
WO2015056680A1 (ja) 2013-10-15 2015-04-23 株式会社カネカ 多孔質セルロースビーズの製造方法
WO2015056679A1 (ja) 2013-10-15 2015-04-23 株式会社カネカ 多孔質セルロースビーズの製造方法及びそれを用いた吸着体
JPWO2015056679A1 (ja) * 2013-10-15 2017-03-09 株式会社カネカ 多孔質セルロースビーズの製造方法及びそれを用いた吸着体
US10040053B2 (en) 2013-10-15 2018-08-07 Kaneka Corporation Production method for porous cellulose beads, and adsorbent employing same

Also Published As

Publication number Publication date
EP2165758A1 (en) 2010-03-24
US20100184957A1 (en) 2010-07-22
US8828905B2 (en) 2014-09-09
JPWO2008146906A1 (ja) 2010-08-19
EP2165758A4 (en) 2016-08-03
JP5508850B2 (ja) 2014-06-04

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