WO2008142850A1 - 成分分離デバイス及びこれを用いた成分分離方法 - Google Patents

成分分離デバイス及びこれを用いた成分分離方法 Download PDF

Info

Publication number
WO2008142850A1
WO2008142850A1 PCT/JP2008/001199 JP2008001199W WO2008142850A1 WO 2008142850 A1 WO2008142850 A1 WO 2008142850A1 JP 2008001199 W JP2008001199 W JP 2008001199W WO 2008142850 A1 WO2008142850 A1 WO 2008142850A1
Authority
WO
WIPO (PCT)
Prior art keywords
component separation
introduction
flow channel
solution
channel
Prior art date
Application number
PCT/JP2008/001199
Other languages
English (en)
French (fr)
Inventor
Makoto Takahashi
Masaya Nakatani
Soichiro Hiraoka
Hiroshi Ushio
Akiyoshi Oshima
Original Assignee
Panasonic Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panasonic Corporation filed Critical Panasonic Corporation
Priority to EP08751717.3A priority Critical patent/EP2145687B1/en
Priority to JP2009515085A priority patent/JP5018879B2/ja
Priority to US12/532,908 priority patent/US8273302B2/en
Publication of WO2008142850A1 publication Critical patent/WO2008142850A1/ja

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/28—Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
    • B01D21/283—Settling tanks provided with vibrators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0436—Moving fluids with specific forces or mechanical means specific forces vibrational forces acoustic forces, e.g. surface acoustic waves [SAW]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)

Abstract

流路と、この流路の内部に音響波を発生させる音響波発生装置と、流路に固形粒子を含む第一の溶液を導入する第一の導入路と、第二の溶液を導入する第二の導入路と、流路から溶液を導出する二つ以上の導出路を設けた成分分離デバイス。第一の導入路に前記固形粒子の濃度勾配を形成することができる濃度勾配形成装置を設けている。純度の高い溶液中に高い回収率で固形粒子を抽出できる。
PCT/JP2008/001199 2007-05-15 2008-05-14 成分分離デバイス及びこれを用いた成分分離方法 WO2008142850A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08751717.3A EP2145687B1 (en) 2007-05-15 2008-05-14 Component separation device
JP2009515085A JP5018879B2 (ja) 2007-05-15 2008-05-14 成分分離デバイス
US12/532,908 US8273302B2 (en) 2007-05-15 2008-05-14 Component separation device

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-128922 2007-05-15
JP2007-128921 2007-05-15
JP2007128922 2007-05-15
JP2007128921 2007-05-15

Publications (1)

Publication Number Publication Date
WO2008142850A1 true WO2008142850A1 (ja) 2008-11-27

Family

ID=40031569

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/001199 WO2008142850A1 (ja) 2007-05-15 2008-05-14 成分分離デバイス及びこれを用いた成分分離方法

Country Status (4)

Country Link
US (1) US8273302B2 (ja)
EP (1) EP2145687B1 (ja)
JP (1) JP5018879B2 (ja)
WO (1) WO2008142850A1 (ja)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010013238A2 (en) * 2008-07-28 2010-02-04 Technion Research & Development Foundation Ltd. Microfluidic system and method for manufacturing the same
EP2233192A1 (en) * 2007-12-05 2010-09-29 Consejo Superior De Investigaciones Científicas Micro-device and method for non-invasive and selective separation and extraction of particles in polydispersed suspensions, production method, and the applications thereof
JP2011022031A (ja) * 2009-07-16 2011-02-03 Canon Inc 反応処理装置および反応処理方法
WO2011135802A1 (ja) * 2010-04-27 2011-11-03 パナソニック株式会社 測定デバイス
JP2013252510A (ja) * 2011-11-11 2013-12-19 National Institute Of Advanced Industrial Science & Technology 粒子分別装置および粒子分別方法
JP2015512766A (ja) * 2012-01-31 2015-04-30 ザ・ペン・ステート・リサーチ・ファンデーション 可変定常的表面弾性波を用いたマイクロ流体操作及び粒子の分類
WO2019044610A1 (ja) * 2017-08-30 2019-03-07 京セラ株式会社 粒子分離デバイスおよびそれを用いた粒子分離装置
JP2021169085A (ja) * 2015-06-25 2021-10-28 サイトノーム／エスティー・エルエルシー 音響操作を用いるマイクロ流体デバイスおよびシステム

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4984849B2 (ja) * 2006-11-27 2012-07-25 パナソニック株式会社 成分分離デバイスと、この成分分離デバイスを用いた化学分析デバイス
US8387803B2 (en) * 2008-08-26 2013-03-05 Ge Healthcare Bio-Sciences Ab Particle sorting
US8691145B2 (en) 2009-11-16 2014-04-08 Flodesign Sonics, Inc. Ultrasound and acoustophoresis for water purification
US8714360B2 (en) * 2010-05-12 2014-05-06 Ethicon Endo-Surgery, Inc. Tissue processing device with ultrasonic tissue particle separator
WO2011159957A2 (en) 2010-06-16 2011-12-22 Flodesign Sonics, Inc. Phononic crystal desalination system and method of use
US8679338B2 (en) 2010-08-23 2014-03-25 Flodesign Sonics, Inc. Combined acoustic micro filtration and phononic crystal membrane particle separation
US9421553B2 (en) 2010-08-23 2016-08-23 Flodesign Sonics, Inc. High-volume fast separation of multi-phase components in fluid suspensions
US9821310B2 (en) * 2011-03-31 2017-11-21 The University Of Akron Two-stage microfluidic device for acoustic particle manipulation and methods of separation
US8727129B2 (en) * 2011-08-16 2014-05-20 Lawrence Livermore National Security, Llc. Microfluidic ultrasonic particle separators with engineered node locations and geometries
WO2013033232A1 (en) * 2011-08-29 2013-03-07 The Charles Stark Draper Laboratory, Inc. System and method for blood separation by microfluidic acoustic focusing
US9656263B2 (en) * 2011-09-28 2017-05-23 Acousort Ab System and method to separate cells and/or particles
US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
US9796956B2 (en) 2013-11-06 2017-10-24 Flodesign Sonics, Inc. Multi-stage acoustophoresis device
US9950282B2 (en) 2012-03-15 2018-04-24 Flodesign Sonics, Inc. Electronic configuration and control for acoustic standing wave generation
US9752113B2 (en) 2012-03-15 2017-09-05 Flodesign Sonics, Inc. Acoustic perfusion devices
US9272234B2 (en) 2012-03-15 2016-03-01 Flodesign Sonics, Inc. Separation of multi-component fluid through ultrasonic acoustophoresis
US9688958B2 (en) 2012-03-15 2017-06-27 Flodesign Sonics, Inc. Acoustic bioreactor processes
US9822333B2 (en) 2012-03-15 2017-11-21 Flodesign Sonics, Inc. Acoustic perfusion devices
US10322949B2 (en) 2012-03-15 2019-06-18 Flodesign Sonics, Inc. Transducer and reflector configurations for an acoustophoretic device
US9623348B2 (en) 2012-03-15 2017-04-18 Flodesign Sonics, Inc. Reflector for an acoustophoretic device
US10370635B2 (en) 2012-03-15 2019-08-06 Flodesign Sonics, Inc. Acoustic separation of T cells
US9416344B2 (en) 2012-03-15 2016-08-16 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US9745548B2 (en) 2012-03-15 2017-08-29 Flodesign Sonics, Inc. Acoustic perfusion devices
US9340435B2 (en) 2012-03-15 2016-05-17 Flodesign Sonics, Inc. Separation of multi-component fluid through ultrasonic acoustophoresis
US9458450B2 (en) 2012-03-15 2016-10-04 Flodesign Sonics, Inc. Acoustophoretic separation technology using multi-dimensional standing waves
US9752114B2 (en) 2012-03-15 2017-09-05 Flodesign Sonics, Inc Bioreactor using acoustic standing waves
US10689609B2 (en) 2012-03-15 2020-06-23 Flodesign Sonics, Inc. Acoustic bioreactor processes
US9783775B2 (en) 2012-03-15 2017-10-10 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US10967298B2 (en) 2012-03-15 2021-04-06 Flodesign Sonics, Inc. Driver and control for variable impedence load
US10040011B2 (en) 2012-03-15 2018-08-07 Flodesign Sonics, Inc. Acoustophoretic multi-component separation technology platform
US9567559B2 (en) 2012-03-15 2017-02-14 Flodesign Sonics, Inc. Bioreactor using acoustic standing waves
US10953436B2 (en) 2012-03-15 2021-03-23 Flodesign Sonics, Inc. Acoustophoretic device with piezoelectric transducer array
US9422328B2 (en) 2012-03-15 2016-08-23 Flodesign Sonics, Inc. Acoustic bioreactor processes
KR101387662B1 (ko) 2012-04-18 2014-04-22 한국전기연구원 입자 필터링 장치 및 이를 포함하는 바이오칩
US10737953B2 (en) 2012-04-20 2020-08-11 Flodesign Sonics, Inc. Acoustophoretic method for use in bioreactors
US11324873B2 (en) 2012-04-20 2022-05-10 Flodesign Sonics, Inc. Acoustic blood separation processes and devices
JP6025982B2 (ja) 2012-08-01 2016-11-16 ザ・ペン・ステート・リサーチ・ファンデーション 粒子および細胞の高効率分離およびマニピュレーション
WO2014046605A1 (en) * 2012-09-21 2014-03-27 Acousort Ab A method for separating cells-bead complexes
US9757699B2 (en) 2012-11-27 2017-09-12 The Penn State Research Foundation Spatiotemporal control of chemical microenvironment using oscillating microstructures
KR101356933B1 (ko) * 2012-12-28 2014-01-29 고려대학교 산학협력단 표면탄성파를 이용한 미세유동 크로마토 그래피 기반 미세입자 분리 장치 및 방법
US9504780B2 (en) 2013-01-30 2016-11-29 The Charles Stark Draper Laboratory, Inc. Extracorporeal clearance of organophosphates from blood on an acoustic separation device
WO2014138739A1 (en) 2013-03-08 2014-09-12 The Charles Stark Draper Laboratory, Inc. System and method for blood separation by microfluidic acoustic focusing
EP2972212B1 (en) 2013-03-14 2022-12-21 Cytonome/ST, LLC Hydrodynamic focusing apparatus and methods
US9725690B2 (en) 2013-06-24 2017-08-08 Flodesign Sonics, Inc. Fluid dynamic sonic separator
US9745569B2 (en) 2013-09-13 2017-08-29 Flodesign Sonics, Inc. System for generating high concentration factors for low cell density suspensions
WO2015058265A1 (en) * 2013-10-25 2015-04-30 Monash University Virtual deterministic lateral displacement for particle separation using surface acoustic waves
US9725710B2 (en) 2014-01-08 2017-08-08 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
KR102450509B1 (ko) 2014-05-08 2022-10-04 프로디자인 소닉스, 인크. 압전 트랜듀서 어레이를 구비한 음파영동 장치
WO2015191534A2 (en) * 2014-06-09 2015-12-17 Ascent Bio-Nano Technologies, Inc. System for manipulation and sorting of particles
US9827511B2 (en) 2014-07-02 2017-11-28 Flodesign Sonics, Inc. Acoustophoretic device with uniform fluid flow
US9744483B2 (en) 2014-07-02 2017-08-29 Flodesign Sonics, Inc. Large scale acoustic separation device
US10946133B2 (en) 2014-07-31 2021-03-16 The Charles Stark Draper Laboratory, Inc. Systems and methods for parallel channel microfluidic separation
US10099002B2 (en) 2014-07-31 2018-10-16 The Charles Stark Draper Laboratory, Inc. Systems and methods for parallel channel microfluidic separation
WO2016054192A1 (en) 2014-09-30 2016-04-07 Flodesign Sonics, Inc. Acoustophoretic clarification of particle-laden non-flowing fluids
RU2689582C2 (ru) 2014-10-24 2019-05-28 Лайф Текнолоджиз Корпорейшн Система жидкостно-жидкостной очистки образца с акустическим осаждением
CN105987870A (zh) * 2015-02-10 2016-10-05 博奥生物集团有限公司 一种流式细胞分选系统及其聚焦检测方法及其流体芯片
US10106770B2 (en) 2015-03-24 2018-10-23 Flodesign Sonics, Inc. Methods and apparatus for particle aggregation using acoustic standing waves
US11420136B2 (en) 2016-10-19 2022-08-23 Flodesign Sonics, Inc. Affinity cell extraction by acoustics
US11021699B2 (en) 2015-04-29 2021-06-01 FioDesign Sonics, Inc. Separation using angled acoustic waves
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
CA2984492A1 (en) 2015-04-29 2016-11-03 Flodesign Sonics, Inc. Acoustophoretic device for angled wave particle deflection
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US9550134B2 (en) 2015-05-20 2017-01-24 Flodesign Sonics, Inc. Acoustic manipulation of particles in standing wave fields
US9663756B1 (en) 2016-02-25 2017-05-30 Flodesign Sonics, Inc. Acoustic separation of cellular supporting materials from cultured cells
CA2995043C (en) 2015-07-09 2023-11-21 Bart Lipkens Non-planar and non-symmetrical piezoelectric crystals and reflectors
US11459540B2 (en) 2015-07-28 2022-10-04 Flodesign Sonics, Inc. Expanded bed affinity selection
US11474085B2 (en) 2015-07-28 2022-10-18 Flodesign Sonics, Inc. Expanded bed affinity selection
JP6657379B2 (ja) * 2015-08-27 2020-03-04 プレジデント アンド フェローズ オブ ハーバード カレッジ 弾性波による分離
KR101807256B1 (ko) * 2016-01-26 2017-12-08 한양대학교 에리카산학협력단 입자 분리 장치 및 입자 분리 방법
JP6554045B2 (ja) 2016-02-25 2019-07-31 東芝メモリ株式会社 集塵装置および基板処理システム
US10710006B2 (en) 2016-04-25 2020-07-14 Flodesign Sonics, Inc. Piezoelectric transducer for generation of an acoustic standing wave
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
CN114891635A (zh) 2016-05-03 2022-08-12 弗洛设计声能学公司 利用声泳的治疗细胞洗涤、浓缩和分离
US11085035B2 (en) 2016-05-03 2021-08-10 Flodesign Sonics, Inc. Therapeutic cell washing, concentration, and separation utilizing acoustophoresis
CN109416314A (zh) 2016-07-01 2019-03-01 生命技术公司 用于浓缩颗粒的方法、系统和装置
US10933429B2 (en) * 2017-03-13 2021-03-02 New Mexico Tech University Research Park Corporation Separation of nanoparticles via acoustofluidic flow relocation
KR102439221B1 (ko) 2017-12-14 2022-09-01 프로디자인 소닉스, 인크. 음향 트랜스듀서 구동기 및 제어기
US20190270084A1 (en) 2018-03-03 2019-09-05 Yuchen Zhou Methods and apparatus to separate biological entities
US11571696B2 (en) 2018-03-03 2023-02-07 Applied Cells Inc. Biological entity separation device and method of use
US20190292565A1 (en) * 2018-03-20 2019-09-26 The Charles Stark Draper Laboratory, Inc. Acoustically-Driven Buffer Switching for Microparticles
DE102019110748B3 (de) * 2019-04-25 2020-09-03 Leibniz-Institut Für Festkörper- Und Werkstoffforschung Dresden E.V. Einrichtung und Verfahren zum Sortieren und Trennen von in Fluiden dispergierten Mikropartikeln und/oder Zellen
US11701658B2 (en) 2019-08-09 2023-07-18 President And Fellows Of Harvard College Systems and methods for microfluidic particle selection, encapsulation, and injection using surface acoustic waves
US12090481B2 (en) 2020-11-03 2024-09-17 Applied Cells Inc. Microfluidic system including cooling device

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001525722A (ja) * 1997-05-03 2001-12-11 ユニバーシティ カレッジ カーディフ コンサルタンツ リミテッド 粒子マニピュレーション
JP2004283828A (ja) * 2003-03-21 2004-10-14 Steag Microparts Gmbh 粒子を含む液体から液体成分を分離するための微細構造型分離装置およびマイクロ流体方法
JP2004535912A (ja) 2001-03-09 2004-12-02 エリーセーブ・アクチボラグ 分離のための装置及び方法
JP2004354364A (ja) * 2002-12-02 2004-12-16 Nec Corp 微粒子操作ユニット、それを搭載したチップと検出装置、ならびにタンパク質の分離、捕獲、および検出方法
JP2005319407A (ja) * 2004-05-10 2005-11-17 Hitachi Ltd 圧電デバイスを用いた機器
JP2006501994A (ja) * 2002-10-10 2006-01-19 イギリス国 第１流体から第２流体へ粒子を移動させるための装置

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT390739B (de) * 1988-11-03 1990-06-25 Ewald Dipl Ing Dr Benes Verfahren und einrichtung zur separation von teilchen, welche in einem dispersionsmittel dispergiert sind
JP2004042012A (ja) * 2001-10-26 2004-02-12 Nec Corp 分離装置、分析システム、分離方法および分離装置の製造方法
US7453202B2 (en) * 2001-11-28 2008-11-18 Samsung Sdi Co., Ltd. Organic EL display device having organic soluble derivative layer
US7846382B2 (en) * 2002-06-04 2010-12-07 Protasis Corporation Method and device for ultrasonically manipulating particles within a fluid
KR100500455B1 (ko) * 2003-08-11 2005-07-18 삼성전자주식회사 산화된 버퍼층을 갖는 자기터널 접합 구조체 및 그 제조방법
DE102004040785B4 (de) 2004-08-23 2006-09-21 Kist-Europe Forschungsgesellschaft Mbh Mikrofluidisches System zur Isolierung biologischer Partikel unter Verwendung der immunomagnetischen Separation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001525722A (ja) * 1997-05-03 2001-12-11 ユニバーシティ カレッジ カーディフ コンサルタンツ リミテッド 粒子マニピュレーション
JP2004535912A (ja) 2001-03-09 2004-12-02 エリーセーブ・アクチボラグ 分離のための装置及び方法
JP2006501994A (ja) * 2002-10-10 2006-01-19 イギリス国 第１流体から第２流体へ粒子を移動させるための装置
JP2004354364A (ja) * 2002-12-02 2004-12-16 Nec Corp 微粒子操作ユニット、それを搭載したチップと検出装置、ならびにタンパク質の分離、捕獲、および検出方法
JP2004283828A (ja) * 2003-03-21 2004-10-14 Steag Microparts Gmbh 粒子を含む液体から液体成分を分離するための微細構造型分離装置およびマイクロ流体方法
JP2005319407A (ja) * 2004-05-10 2005-11-17 Hitachi Ltd 圧電デバイスを用いた機器

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AUGUSTSSON P, PETERSSON F., LAURELL T.: "IMPROVED CARRIER MEDIUM EXCHANGE EFFICIENCY IN ACOUSTIC STANDING WAVE PARTICLE WASHING", THE 10TH INTERNATIONAL CONFERENCE ON MINIATURISED SYSTEMS FOR CHEMISTRY AND LIFE SCIENCES, 2006, pages 627 - 629 *
LAURELL T., PETERSSON F., NILSSON A.: "Chip integrated for acoustic separation and manipulation of cells and particles", CHEMICAL SOCIETY REVIEWS, vol. 36, no. 3, March 2007 (2007-03-01), pages 492 - 506, XP008117651 *
PER AUGUSTSSON ET AL., UTAS, 2006, pages 627 - 629
See also references of EP2145687A4

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2233192A4 (en) * 2007-12-05 2012-01-04 Consejo Superior Investigacion MICRODISPOSITIVE AND METHOD FOR SELECTIVE AND NON-INVASIVE SEPARATION AND EXTRACTION OF POLYDISPERSED SUSPENSION PARTICLES, MANUFACTURING METHOD AND CORRESPONDING APPLICATIONS
EP2233192A1 (en) * 2007-12-05 2010-09-29 Consejo Superior De Investigaciones Científicas Micro-device and method for non-invasive and selective separation and extraction of particles in polydispersed suspensions, production method, and the applications thereof
WO2010013238A3 (en) * 2008-07-28 2010-04-15 Technion Research & Development Foundation Ltd. Microfluidic system and method for manufacturing the same
WO2010013238A2 (en) * 2008-07-28 2010-02-04 Technion Research & Development Foundation Ltd. Microfluidic system and method for manufacturing the same
JP2011022031A (ja) * 2009-07-16 2011-02-03 Canon Inc 反応処理装置および反応処理方法
JP5899438B2 (ja) * 2010-04-27 2016-04-06 パナソニックＩｐマネジメント株式会社 測定デバイス
US8966960B2 (en) 2010-04-27 2015-03-03 Panasonic Intellectual Property Management Co., Ltd. Measuring device
WO2011135802A1 (ja) * 2010-04-27 2011-11-03 パナソニック株式会社 測定デバイス
JP2013252510A (ja) * 2011-11-11 2013-12-19 National Institute Of Advanced Industrial Science & Technology 粒子分別装置および粒子分別方法
JP2015512766A (ja) * 2012-01-31 2015-04-30 ザ・ペン・ステート・リサーチ・ファンデーション 可変定常的表面弾性波を用いたマイクロ流体操作及び粒子の分類
JP2021169085A (ja) * 2015-06-25 2021-10-28 サイトノーム／エスティー・エルエルシー 音響操作を用いるマイクロ流体デバイスおよびシステム
JP7308885B2 (ja) 2015-06-25 2023-07-14 サイトノーム／エスティー・エルエルシー 音響操作を用いるマイクロ流体デバイスおよびシステム
WO2019044610A1 (ja) * 2017-08-30 2019-03-07 京セラ株式会社 粒子分離デバイスおよびそれを用いた粒子分離装置
JPWO2019044610A1 (ja) * 2017-08-30 2020-09-24 京セラ株式会社 粒子分離デバイスおよびそれを用いた粒子分離装置

Also Published As

Publication number Publication date
EP2145687B1 (en) 2014-12-03
JPWO2008142850A1 (ja) 2010-08-05
US8273302B2 (en) 2012-09-25
EP2145687A1 (en) 2010-01-20
US20100126922A1 (en) 2010-05-27
EP2145687A4 (en) 2010-10-27
JP5018879B2 (ja) 2012-09-05

Similar Documents

Publication Publication Date Title
WO2008142850A1 (ja) 成分分離デバイス及びこれを用いた成分分離方法
MX2009010711A (es) Sistemas y metodos para la separacion de fluidos.
EP4285957A3 (en) Perfusion apparatus with reduced pressure fluctuations, and bubble trap
PT1800753E (pt) Método e dispositivo para separar partículas sólidas com base numa diferença de densidade
EA201070765A1 (ru) Анализ частиц в акустическом цитометре
SG10201703938WA (en) Fluidic device and method for separation of neutrally buoyant particles
GB2495258A (en) Screening methods and apparatus
WO2012015600A3 (en) Fluid gasification/degasification apparatuses, systems, and processes
GB2477602A8 (en) Method of coating a monolith substrate with catalyst component
WO2010036667A3 (en) Apparatus and method for separation of particles from a suspension by means of standing ultrasonic waves
CA2459261A1 (en) Apparatus and system for concentrating slurry solids
WO2016069403A3 (en) Methods and apparatuses for reforming of hydrocarbons including recovery of products using a recovery zone, a pressure swing adsorption zone, and a membrane separation zone
WO2007082031A3 (en) Methods and apparatus for purging a substrate carrier
PH12014501583A1 (en) Methods and apparatuses for water purification
EP2128082A4 (en) HYDROGEN PURIFICATION METHOD, HYDROGEN SEPARATION MEMBRANE, AND HYDROGEN PURIFICATION APPARATUS
GB2447395A (en) Apparatus and method for separating immiscible fluid components
MX2009006510A (es) Preconcentrador de gas para aparatos de deteccion.
WO2008134355A3 (en) High pressure intraosseous bag and method
WO2006113543A3 (en) Separation of fatty materials to produce lean meat products
GB2548418A8 (en) Apparatus and method using ultrasounds for gas conversion
WO2010138233A3 (en) Membrane separation
MX2015013106A (es) Metodo y aparato para la desorcion empleando membrana microporosa manejada en el modo humedecido.
AU2003298024A1 (en) Inlet baffle arrangement for gas/liquid separation; apparatus; and methods
EP2317016A3 (en) Underwater excavation apparatus
WO2011112563A3 (en) Acoustic transducer with a liquid-filled porous medium backing and methods of making and using same

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08751717

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2009515085

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 12532908

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2008751717

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE