JP2006501994A - 第1流体から第2流体へ粒子を移動させるための装置 - Google Patents
第1流体から第2流体へ粒子を移動させるための装置 Download PDFInfo
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- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
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- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
- B01L2400/0436—Moving fluids with specific forces or mechanical means specific forces vibrational forces acoustic forces, e.g. surface acoustic waves [SAW]
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
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- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4077—Concentrating samples by other techniques involving separation of suspended solids
- G01N2001/4094—Concentrating samples by other techniques involving separation of suspended solids using ultrasound
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00465—Separating and mixing arrangements
- G01N2035/00564—Handling or washing solid phase elements, e.g. beads
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Abstract
Description
さらに、流体が混和しないこと、又は互いに異なることさえも必要ではない。好ましい実施形態では、各流体は水からなる。
第1流体/第1入口:脱気水
第2流体/第2入口:食品用赤色着色剤(英国,リーズ,スーパークック,サンセット・イエロー,カルモイシン)を1%(v/v)含むガス抜き水に酵母細胞(英国,ノッチンガム,ブーツ,乾燥したものを元に戻した,1×108/ml)を懸濁させた液体。
第1出口16からの視覚的に透明な産出物は、第1出口での流速を、第1入口における流速よりも低い10.5%に下げることにより得られた。この結果は、分子種の拡散が重要であることを示唆している。
周波数2.91MHzで2.5Vの交流電位が変換器19に印加された。このシステムにおいては、電圧の最小値よりも位相の最小値の方が、音響共鳴を最も正確に反映する(ジェー.ジェー.ホークスら(J.J.Hawkes et al),ジャーナル・オブ・アプライド・マイクロバイオロジー(J.Applied Microbiology),1997年,82巻,p.39−47)。電流/電圧の位相最低値は、位相ロックされたループIC(フィリップスPC74HC4046AP)を含む位相比較器ブロックにより監視された。
第1流体/第1入口:脱気水
第2流体/第2入口:フルオレセイン・ナトリウム(英国,シグマ,1mM)を含むガス抜き水に懸濁した酵母細胞(1×106〜2×108ml/分)。
第1出口16からの視覚的に透明な産出物は、流速を第1入口における流速の約90%に下げることにより得られたが、分光光度計の測定は、約9.1%が依然として移動していることを示した。ここで、図4(a)を参照すると、フルオレセイン・ナトリウムの測定された移動(●)は、CFD計算とよく一致しており、移動の主なメカニズムは拡散制御であることが確認できる。
周波数2.96MHzで17VP-Pの交流電位が、信号発生器(ヒューレット・パッカード)及び増幅器(米国,ロチェスター,モデル240L)を用いて変換器19に印加された。共鳴周波数は、オッシロスコープ(アジレント,5462A)を用いて電流と電圧との間の位相角の最小値を監視することにより測定された。
Claims (13)
- 第1流体に含まれている粒子を第2流体に移動させる装置であって、
導管と、前記導管内で各流体の層流を接触させる手段と、圧力の節が前記導管内に位置するように音響定在波を発生させることができる手段と、
を有することを特徴とする装置。 - 前記層流を接触させる手段が前記2つの流体間の混合を最小限に抑制する請求項1記載の装置。
- 前記層流を接触させる手段が、各流体について、それぞれ、前記導管と連通している入口手段と出口手段とを有する請求項1又は請求項2に記載の装置。
- 前記それぞれの入口手段と出口手段とが互いに直交している請求項3記載の装置。
- 前記圧力の節が前記導管の長手方向に沿って中央に位置させられている請求項1乃至4のいずれか1項に記載の装置。
- 前記音響定在波を発生させることができる手段は、音波を発生し伝播するようになっている前記導管の第1壁と、発生した音波を反射するようになっている対向する第2壁と、を有する請求項1乃至5のいずれか1項に記載の装置。
- 前記導管の前記第1壁が、圧電セラミック材料を有する請求項6記載の装置。
- 前記圧電セラミック材料が、交番する電位源に組み合わされている請求項7記載の装置。
- 粒子を第1流体内から第2流体へ移動させる方法であって、
i)音響定在波を発生させることができる手段を有する導管内で各流体の層流を接触させること、及び
ii)前記導管内に圧力の節が位置するように定在波を発生させること、
を有することを特徴とする方法。 - 請求項9記載の方法により粒子を洗浄する方法。
- 請求項9記載の方法により試料を混合する方法。
- 添付図面に示し、該図面を参照して説明したものとほぼ同様な装置。
- 添付図面に示し、該図面を参照して説明した方法とほぼ同様な粒子を洗浄する方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0223562.0A GB0223562D0 (en) | 2002-10-10 | 2002-10-10 | Apparatus for moving particles |
PCT/GB2003/004373 WO2004033087A1 (en) | 2002-10-10 | 2003-10-10 | Apparatus for moving particles from a first fluid to a second fluid |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006501994A true JP2006501994A (ja) | 2006-01-19 |
JP4504193B2 JP4504193B2 (ja) | 2010-07-14 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004542643A Expired - Fee Related JP4504193B2 (ja) | 2002-10-10 | 2003-10-10 | 第1流体から第2流体へ粒子を移動させるための装置 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20060163166A1 (ja) |
EP (1) | EP1549430A1 (ja) |
JP (1) | JP4504193B2 (ja) |
CN (1) | CN100434157C (ja) |
AU (1) | AU2003274312B2 (ja) |
CA (1) | CA2501612A1 (ja) |
GB (1) | GB0223562D0 (ja) |
WO (1) | WO2004033087A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008142850A1 (ja) * | 2007-05-15 | 2008-11-27 | Panasonic Corporation | 成分分離デバイス及びこれを用いた成分分離方法 |
JP2009058461A (ja) * | 2007-09-03 | 2009-03-19 | Panasonic Corp | 分注装置 |
US10290490B2 (en) | 2016-02-25 | 2019-05-14 | Toshiba Memory Corporation | Dust collecting apparatus, substrate processing system, and method of manufacturing semiconductor device |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
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US7340957B2 (en) | 2004-07-29 | 2008-03-11 | Los Alamos National Security, Llc | Ultrasonic analyte concentration and application in flow cytometry |
JP4770251B2 (ja) * | 2005-04-25 | 2011-09-14 | パナソニック株式会社 | 成分分離デバイスおよびこれを用いた成分の分離方法 |
GB0619016D0 (en) * | 2006-09-27 | 2006-11-08 | Secr Defence | Ultrasound method |
US7835000B2 (en) * | 2006-11-03 | 2010-11-16 | Los Alamos National Security, Llc | System and method for measuring particles in a sample stream of a flow cytometer or the like |
EP2156178B1 (en) | 2007-04-02 | 2011-12-21 | Acoustic Cytometry Systems, Inc. | Methods for enhanced analysis of acoustic field focused cells and particles |
US8083068B2 (en) | 2007-04-09 | 2011-12-27 | Los Alamos National Security, Llc | Apparatus for separating particles utilizing engineered acoustic contrast capture particles |
US7837040B2 (en) | 2007-04-09 | 2010-11-23 | Los Alamos National Security, Llc | Acoustic concentration of particles in fluid flow |
US8263407B2 (en) | 2007-10-24 | 2012-09-11 | Los Alamos National Security, Llc | Method for non-contact particle manipulation and control of particle spacing along an axis |
US8528406B2 (en) * | 2007-10-24 | 2013-09-10 | Los Alamos National Security, LLP | Method for non-contact particle manipulation and control of particle spacing along an axis |
WO2009063198A2 (en) * | 2007-11-14 | 2009-05-22 | Prokyma Technologies Limited | Extraction and purification of biological cells using ultrasound |
US8266950B2 (en) | 2007-12-19 | 2012-09-18 | Los Alamos National Security, LLP | Particle analysis in an acoustic cytometer |
US8714014B2 (en) | 2008-01-16 | 2014-05-06 | Life Technologies Corporation | System and method for acoustic focusing hardware and implementations |
US9480935B2 (en) * | 2008-02-01 | 2016-11-01 | Lawrence Livermore National Security, Llc | Systems and methods for separating particles and/or substances from a sample fluid |
US8387803B2 (en) * | 2008-08-26 | 2013-03-05 | Ge Healthcare Bio-Sciences Ab | Particle sorting |
US8865003B2 (en) * | 2008-09-26 | 2014-10-21 | Abbott Laboratories | Apparatus and method for separation of particles suspended in a liquid from the liquid in which they are suspended |
EP2331230A1 (en) * | 2008-10-08 | 2011-06-15 | FOSS Analytical A/S | Separation of particles in liquids by use of a standing ultrasonic wave |
CN103906496B (zh) | 2011-09-30 | 2018-03-06 | 贝克顿·迪金森公司 | 流体交换方法与装置 |
WO2015191534A2 (en) | 2014-06-09 | 2015-12-17 | Ascent Bio-Nano Technologies, Inc. | System for manipulation and sorting of particles |
KR20170063882A (ko) * | 2014-09-30 | 2017-06-08 | 프로디자인 소닉스, 인크. | 비-유동성 유체 내의 입자의 음향 영동 정화 |
US10933429B2 (en) * | 2017-03-13 | 2021-03-02 | New Mexico Tech University Research Park Corporation | Separation of nanoparticles via acoustofluidic flow relocation |
CN114252377B (zh) * | 2021-12-28 | 2024-05-03 | 聪明猪检测技术(成都)有限公司 | 基于多传感器管道介质中颗粒含量检测方法及系统 |
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JPH11197491A (ja) * | 1998-01-13 | 1999-07-27 | Hitachi Ltd | 微粒子処理方法および微粒子処理装置 |
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2002
- 2002-10-10 GB GBGB0223562.0A patent/GB0223562D0/en not_active Ceased
-
2003
- 2003-10-10 US US10/530,131 patent/US20060163166A1/en not_active Abandoned
- 2003-10-10 EP EP03758301A patent/EP1549430A1/en not_active Withdrawn
- 2003-10-10 AU AU2003274312A patent/AU2003274312B2/en not_active Ceased
- 2003-10-10 CA CA002501612A patent/CA2501612A1/en not_active Abandoned
- 2003-10-10 CN CNB2003801012561A patent/CN100434157C/zh not_active Expired - Fee Related
- 2003-10-10 JP JP2004542643A patent/JP4504193B2/ja not_active Expired - Fee Related
- 2003-10-10 WO PCT/GB2003/004373 patent/WO2004033087A1/en active Application Filing
Patent Citations (3)
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JP2001525722A (ja) * | 1997-05-03 | 2001-12-11 | ユニバーシティ カレッジ カーディフ コンサルタンツ リミテッド | 粒子マニピュレーション |
JPH11197491A (ja) * | 1998-01-13 | 1999-07-27 | Hitachi Ltd | 微粒子処理方法および微粒子処理装置 |
WO2000041794A1 (en) * | 1999-01-15 | 2000-07-20 | University College Cardiff Consultants Ltd. | Particle manipulation |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2008142850A1 (ja) * | 2007-05-15 | 2008-11-27 | Panasonic Corporation | 成分分離デバイス及びこれを用いた成分分離方法 |
JP5018879B2 (ja) * | 2007-05-15 | 2012-09-05 | パナソニック株式会社 | 成分分離デバイス |
US8273302B2 (en) | 2007-05-15 | 2012-09-25 | Panasonic Corporation | Component separation device |
JP2009058461A (ja) * | 2007-09-03 | 2009-03-19 | Panasonic Corp | 分注装置 |
US10290490B2 (en) | 2016-02-25 | 2019-05-14 | Toshiba Memory Corporation | Dust collecting apparatus, substrate processing system, and method of manufacturing semiconductor device |
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Publication number | Publication date |
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AU2003274312A1 (en) | 2004-05-04 |
AU2003274312B2 (en) | 2008-01-31 |
CA2501612A1 (en) | 2004-04-22 |
WO2004033087A1 (en) | 2004-04-22 |
JP4504193B2 (ja) | 2010-07-14 |
EP1549430A1 (en) | 2005-07-06 |
GB0223562D0 (en) | 2002-11-20 |
CN100434157C (zh) | 2008-11-19 |
CN1703271A (zh) | 2005-11-30 |
US20060163166A1 (en) | 2006-07-27 |
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