WO2008140026A1 - 新規のロイコトリエン受容体アンタゴニスト - Google Patents

新規のロイコトリエン受容体アンタゴニスト Download PDF

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Publication number
WO2008140026A1
WO2008140026A1 PCT/JP2008/058581 JP2008058581W WO2008140026A1 WO 2008140026 A1 WO2008140026 A1 WO 2008140026A1 JP 2008058581 W JP2008058581 W JP 2008058581W WO 2008140026 A1 WO2008140026 A1 WO 2008140026A1
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WIPO (PCT)
Prior art keywords
leukotriene receptor
receptor antagonist
phospholipid extract
squid
novel leukotriene
Prior art date
Application number
PCT/JP2008/058581
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English (en)
French (fr)
Inventor
Teruyuki Kanada
Toru Kuyama
Takahiko Hada
Takafumi Ishihara
Original Assignee
Bizen Chemical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bizen Chemical Co., Ltd. filed Critical Bizen Chemical Co., Ltd.
Priority to EP08752467.4A priority Critical patent/EP2153736B1/en
Priority to JP2009514142A priority patent/JP5443979B2/ja
Priority to US12/599,369 priority patent/US20110065673A1/en
Publication of WO2008140026A1 publication Critical patent/WO2008140026A1/ja
Priority to US14/012,023 priority patent/US20140005144A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
    • A23L17/40—Shell-fish
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
    • A23L17/50—Molluscs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/612—Crustaceans, e.g. crabs, lobsters, shrimps, krill or crayfish; Barnacles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
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  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Zoology (AREA)
  • Pulmonology (AREA)
  • Insects & Arthropods (AREA)
  • Dermatology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

天然の供給源から簡便に調製することが可能なロイコトリエン受容体アンタゴニストを提供することを、本発明の課題とする。 イカリン脂質抽出物、アミエビリン脂質抽出物等の海産物が、ロイコトリエン受容体であるＢＬＴおよびＣｙｓＬＴ１のアンタゴニストを含有することを見出すことによって、上記課題が達成された。従って、本発明は、イカリン脂質抽出物、アミエビリン脂質抽出物を含有する、ロイコトリエン受容体の活性を阻害するための飲食用組成物および薬学的組成物を提供する。
PCT/JP2008/058581 2007-05-11 2008-05-08 新規のロイコトリエン受容体アンタゴニスト WO2008140026A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP08752467.4A EP2153736B1 (en) 2007-05-11 2008-05-08 Novel leukotriene receptor antagonist from marine sources
JP2009514142A JP5443979B2 (ja) 2007-05-11 2008-05-08 新規のロイコトリエン受容体アンタゴニスト
US12/599,369 US20110065673A1 (en) 2007-05-11 2008-05-08 Novel leukotriene receptor agonist
US14/012,023 US20140005144A1 (en) 2007-05-11 2013-08-28 Novel leukotriene receptor antagonist

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007127431 2007-05-11
JP2007-127431 2007-05-11

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/012,023 Division US20140005144A1 (en) 2007-05-11 2013-08-28 Novel leukotriene receptor antagonist

Publications (1)

Publication Number Publication Date
WO2008140026A1 true WO2008140026A1 (ja) 2008-11-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/058581 WO2008140026A1 (ja) 2007-05-11 2008-05-08 新規のロイコトリエン受容体アンタゴニスト

Country Status (4)

Country Link
US (2) US20110065673A1 (ja)
EP (1) EP2153736B1 (ja)
JP (1) JP5443979B2 (ja)
WO (1) WO2008140026A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009173556A (ja) * 2008-01-22 2009-08-06 Bizen Chemical Co Ltd プロスタグランジンｅ２受容体、ｅｐ４アゴニストおよびそれを含有する組成物
JP2013509174A (ja) * 2009-10-30 2013-03-14 タロス・リミテッド リン脂質および中性脂質が強化されたオキアミ油を得る無溶媒の方法

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9814256B2 (en) 2009-09-14 2017-11-14 Rimfrost Technologies As Method for processing crustaceans to produce low fluoride/low trimethyl amine products thereof
US8557297B2 (en) 2008-09-12 2013-10-15 Olympic Seafood, As Method for processing crustaceans and products thereof
LT2720701T (lt) * 2011-06-15 2017-11-10 Stable Solutions Llc Terapinis parenterinio krilių aliejaus taikymas
US8895074B2 (en) 2011-06-15 2014-11-25 Stable Solutions Llc Therapeutic application of parenteral krill oil
US10052352B2 (en) 2011-06-15 2018-08-21 Stable Solutions Llc Therapeutic application of parenteral krill oil
AU2015100022B4 (en) * 2012-01-03 2016-01-07 Rimfrost Technologies As Method for processing crustaceans to produce low fluoride/low trimethyl amine products thereof

Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
EP0036676A1 (en) 1978-03-24 1981-09-30 The Regents Of The University Of California Method of making uniformly sized liposomes and liposomes so made
EP0052322A2 (de) 1980-11-10 1982-05-26 Gersonde, Klaus, Prof. Dr. Verfahren zur Herstellung von Lipid-Vesikeln durch Ultraschallbehandlung, Anwendung des Verfahrens und Vorrichtung zur Durchführung des Verfahrens
EP0058481A1 (en) 1981-02-16 1982-08-25 Zeneca Limited Continuous release pharmaceutical compositions
JPS58118008A (ja) 1982-01-06 1983-07-13 Nec Corp デ−タ処理装置
EP0088046A2 (de) 1982-02-17 1983-09-07 Ciba-Geigy Ag Lipide in wässriger Phase
DE3218121A1 (de) 1982-05-14 1983-11-17 Leskovar, Peter, Dr.-Ing., 8000 München Arzneimittel zur tumorbehandlung
EP0102324A2 (de) 1982-07-29 1984-03-07 Ciba-Geigy Ag Lipide und Tenside in wässriger Phase
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
EP0133988A2 (de) 1983-08-02 1985-03-13 Hoechst Aktiengesellschaft Regulatorische Peptide enthaltende pharmazeutische Präparate mit protrahierter Freisetzung und Verfahren zu deren Herstellung
EP0142641A2 (de) 1983-09-26 1985-05-29 Udo Dr. Ehrenfeld Mittel und Erzeugnis für die Diagnose und Therapie von Tumoren sowie zur Behandlung von Schwächen der zelligen und humoralen Immunabwehr
EP0143949A1 (en) 1983-11-01 1985-06-12 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Pharmaceutical composition containing urokinase
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
JPH11123052A (ja) * 1997-10-24 1999-05-11 Asahi Chem Ind Co Ltd 魚介類由来の有用物質を含む組成物およびその有用物質の製造方法
JP2000239168A (ja) * 1999-02-19 2000-09-05 Bizen Kasei Kk 脳卒中予防剤およびこれを配合してなる組成物
JP2007110904A (ja) * 2005-10-17 2007-05-10 Cosmo Shokuhin Kk 有用リン脂質組成物を含む機能性素材及び機能性食品
JP2007145814A (ja) * 2005-10-28 2007-06-14 Bizen Chemical Co Ltd 血小板活性化因子受容体拮抗剤および組成物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9101642D0 (sv) * 1991-05-30 1991-05-30 Kabi Pharmacia Ab Phospholipids
JPH06231970A (ja) * 1993-01-29 1994-08-19 Toshiba Corp 静止誘導電気機器
US5444054A (en) * 1994-04-01 1995-08-22 Abbott Labatories Method of treating ulcerative colitis
JPH09194362A (ja) * 1996-01-19 1997-07-29 Bizen Kasei Kk ドコサヘキサエン酸及びエイコサペンタエン酸含有リン脂質を含む組成物
JP2000060432A (ja) * 1998-08-27 2000-02-29 Nippon Kagaku Shiryo Kk 高度不飽和脂肪酸を多量に含有する高品質リン脂質の製造法
AU2002309856B2 (en) * 2001-05-14 2008-10-23 Dsm Ip Assets B.V. Production and use of a polar lipid-rich fraction containing omega-3 and/or omega-6 highly unsaturated fatty acids from microbes, genetically modified plant seeds and marine organisms
CA2493888C (en) * 2001-07-27 2013-07-16 Neptune Technologies & Bioressources Inc. Natural marine source phospholipids comprising flavonoids, polyunsaturated fatty acids and their applications
EP1569525A1 (en) * 2002-11-26 2005-09-07 Phares Pharmaceutical Research N.V. Marine lipid compositions
JP4788990B2 (ja) * 2003-03-19 2011-10-05 洋昭 齋藤 水圏生物を原料とするスフィンゴ脂質の製造方法
US7666447B2 (en) * 2004-10-08 2010-02-23 Pharmanutrients Compositions including Krill extracts and conjugated linoleic acid and methods of using same
JP2005187476A (ja) * 2005-01-04 2005-07-14 Asahi Kasei Chemicals Corp 血中脂質改善剤及び食品添加剤
BRPI0606283A2 (pt) * 2005-03-16 2009-06-09 Elan Pharma Int Ltd formulações de antagonista de receptor de leucotrieno/corticosteróide em nanopartìcula
CA2606255C (fr) * 2005-04-18 2013-10-08 Sc Dicophar Utilisation de la lecithine comme medicament dans le traitement du psoriasis
WO2008149177A2 (en) * 2006-05-05 2008-12-11 Natural Asa Marine lipid compositions and uses thereof
MX292557B (es) * 2006-11-16 2011-11-24 Pronova Biopharma Norge As Proceso para la produccion de fosfolipidos marinos ricos en omega-3 a partir de krill.

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
EP0036676A1 (en) 1978-03-24 1981-09-30 The Regents Of The University Of California Method of making uniformly sized liposomes and liposomes so made
EP0052322A2 (de) 1980-11-10 1982-05-26 Gersonde, Klaus, Prof. Dr. Verfahren zur Herstellung von Lipid-Vesikeln durch Ultraschallbehandlung, Anwendung des Verfahrens und Vorrichtung zur Durchführung des Verfahrens
EP0058481A1 (en) 1981-02-16 1982-08-25 Zeneca Limited Continuous release pharmaceutical compositions
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
JPS58118008A (ja) 1982-01-06 1983-07-13 Nec Corp デ−タ処理装置
EP0088046A2 (de) 1982-02-17 1983-09-07 Ciba-Geigy Ag Lipide in wässriger Phase
DE3218121A1 (de) 1982-05-14 1983-11-17 Leskovar, Peter, Dr.-Ing., 8000 München Arzneimittel zur tumorbehandlung
EP0102324A2 (de) 1982-07-29 1984-03-07 Ciba-Geigy Ag Lipide und Tenside in wässriger Phase
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
EP0133988A2 (de) 1983-08-02 1985-03-13 Hoechst Aktiengesellschaft Regulatorische Peptide enthaltende pharmazeutische Präparate mit protrahierter Freisetzung und Verfahren zu deren Herstellung
EP0142641A2 (de) 1983-09-26 1985-05-29 Udo Dr. Ehrenfeld Mittel und Erzeugnis für die Diagnose und Therapie von Tumoren sowie zur Behandlung von Schwächen der zelligen und humoralen Immunabwehr
EP0143949A1 (en) 1983-11-01 1985-06-12 TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION Pharmaceutical composition containing urokinase
JPH11123052A (ja) * 1997-10-24 1999-05-11 Asahi Chem Ind Co Ltd 魚介類由来の有用物質を含む組成物およびその有用物質の製造方法
JP2000239168A (ja) * 1999-02-19 2000-09-05 Bizen Kasei Kk 脳卒中予防剤およびこれを配合してなる組成物
JP2007110904A (ja) * 2005-10-17 2007-05-10 Cosmo Shokuhin Kk 有用リン脂質組成物を含む機能性素材及び機能性食品
JP2007145814A (ja) * 2005-10-28 2007-06-14 Bizen Chemical Co Ltd 血小板活性化因子受容体拮抗剤および組成物

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
BUCHWALD ET AL., SURGERY, vol. 88, 1980, pages 507
CAPRA V; AMBROSIO M; RICCIONI G; ROVATI GE: "Cysteinyl-Leukotriene receptor antagonists: Present Situation and Future Opportunities", CURR MED CHEM., vol. 13, no. 26, 2006, pages 3213 - 26
EPSTEIN ET AL., PROC. NATL. ACAD. SCI. USA, vol. 82, 1985, pages 3688 - 3692
HWANG ET AL., PROC. NATL. ACAD. SCI. USA, vol. 77, 1980, pages 4030 - 4034
INOUE Y. ET AL.: "Manufacturing and Physiological properties of phosoholipids containing DHA", OLEOSCIENCE, vol. 2, no. 2, 2002, pages 67 - 74, XP008122958 *
KANEDA T. ET AL.: "DHA wa Choju ni Kiyo Dekiruka Phospholipid to Triglyceride no Sa ni Tsuite", FOOD PROCESSING AND INGREDIENTS, vol. 34, no. 8, 1999, pages 41 - 43, XP008122920 *
LANGER ET AL., J. BIOMED. MATER. RES., vol. 15, 1981, pages 167 - 277
LANGER, CHEM. TECH., vol. 12, 1982, pages 98 - 105
LANGER, SCIENCE, vol. 249, 1990, pages 1527 - 1533
MASAYOSHI ABE; TANIHIRO YOSHIMOTO: "Leukotriene Lipoxygenase: Metabolic System and Drug Discovery", FOLIA PHARMACOLOGICA JAPONICA, vol. 124, 2004, pages 415 - 425
SAUDEK ET AL., N. ENGL. J. MED., vol. 321, 1989, pages 574
SEFTON, CRC CRIT. REF. BIOMED. ENG., vol. 14, 1987, pages 201
SIDMAN ET AL., BIOPOLYMERS, vol. 22, 1983, pages 547 - 556
TAGER AM; LUSTER AD: "BLT1 and BLT2: The Leukotriene B4 Receptors", PROSTAGLANDINS LEUKOT ESSENT FATTY ACID., vol. 69, no. 2-3, August 2003 (2003-08-01), pages 123 - 34, XP009119720, DOI: doi:10.1016/S0952-3278(03)00073-5
TREAT ET AL.: "Liposomes in the Therapy of Infectious Disease and Cancer", 1989, LISS, pages: 317 - 327,353-

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009173556A (ja) * 2008-01-22 2009-08-06 Bizen Chemical Co Ltd プロスタグランジンｅ２受容体、ｅｐ４アゴニストおよびそれを含有する組成物
JP2013509174A (ja) * 2009-10-30 2013-03-14 タロス・リミテッド リン脂質および中性脂質が強化されたオキアミ油を得る無溶媒の方法
US8865236B2 (en) 2009-10-30 2014-10-21 Tharos Ltd. Solvent-Free Process for Obtaining Phospholipids and Neutral Enriched Krill Oils
US9011942B2 (en) 2009-10-30 2015-04-21 Tharos, Ltd. Solvent-free process for obtaining phospholipids and neutral enriched krill oils

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Publication number Publication date
EP2153736A1 (en) 2010-02-17
EP2153736A4 (en) 2011-08-24
US20110065673A1 (en) 2011-03-17
JP5443979B2 (ja) 2014-03-19
JPWO2008140026A1 (ja) 2010-08-05
US20140005144A1 (en) 2014-01-02
EP2153736B1 (en) 2017-04-19

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