WO2008126846A1 - Antibacterial agent for vancomycin-resistant gram-positive bacterium - Google Patents

Antibacterial agent for vancomycin-resistant gram-positive bacterium Download PDF

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Publication number
WO2008126846A1
WO2008126846A1 PCT/JP2008/056966 JP2008056966W WO2008126846A1 WO 2008126846 A1 WO2008126846 A1 WO 2008126846A1 JP 2008056966 W JP2008056966 W JP 2008056966W WO 2008126846 A1 WO2008126846 A1 WO 2008126846A1
Authority
WO
WIPO (PCT)
Prior art keywords
vancomycin
antibacterial agent
positive bacterium
resistant gram
resistant
Prior art date
Application number
PCT/JP2008/056966
Other languages
French (fr)
Japanese (ja)
Inventor
Shoichi Shirotake
Original Assignee
Yokohama City University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yokohama City University filed Critical Yokohama City University
Priority to JP2009509349A priority Critical patent/JP4696256B2/en
Publication of WO2008126846A1 publication Critical patent/WO2008126846A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

An antibacterial agent which is highly efficacious against a vancomycin-resistant bacterium and, therefore, useful in, for example, treating infection with a vancomycin-resistant bacterium. This antibacterial agent is an antibacterial agent against vancomycin-resistant gram-positive bacterium which contains cyanoacrylate polymer particles having an antibiotic enclosed therein as the active ingredient, wherein the above-described antibiotic alone does not show any antibacterial activity on the target vancomycin-resistant gram-positive bacterium as described above but exhibits an antibacterial activity in the state of being enclosed in the cyanoacrylate polymer particles.
PCT/JP2008/056966 2007-04-09 2008-04-09 Antibacterial agent for vancomycin-resistant gram-positive bacterium WO2008126846A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009509349A JP4696256B2 (en) 2007-04-09 2008-04-09 Antibacterial agent for vancomycin-resistant gram-positive bacteria

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007101610 2007-04-09
JP2007-101610 2007-04-09

Publications (1)

Publication Number Publication Date
WO2008126846A1 true WO2008126846A1 (en) 2008-10-23

Family

ID=39863943

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/056966 WO2008126846A1 (en) 2007-04-09 2008-04-09 Antibacterial agent for vancomycin-resistant gram-positive bacterium

Country Status (2)

Country Link
JP (1) JP4696256B2 (en)
WO (1) WO2008126846A1 (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009084494A1 (en) * 2007-12-27 2009-07-09 Public University Corporation Yokohama City University Antimicrobial agent for gram-positive bacteria
WO2010101178A1 (en) * 2009-03-03 2010-09-10 公立大学法人横浜市立大学 Amino acid-conjugated cyanoacrylate polymer particles
WO2012133648A1 (en) 2011-03-31 2012-10-04 Shirotake Shoichi Novel preparation technique for higher-order structure that exhibits anti-cellular effect
WO2013108871A1 (en) 2012-01-19 2013-07-25 Shirotake Shoichi Antibacterial agent against plant disease-causing bacteria
WO2016039412A1 (en) * 2014-09-11 2016-03-17 チカミミルテック株式会社 Antibacterial agent and method for producing antibacterial agent
JP2016056481A (en) * 2014-09-11 2016-04-21 チカミミルテック株式会社 Antibacterial sheet and method for producing antibacterial sheet
JP2017081852A (en) * 2015-10-28 2017-05-18 チカミミルテック株式会社 Antibacterial agent, and method for producing the antibacterial agent
CN107988095A (en) * 2017-11-27 2018-05-04 华中农业大学 A kind of microbial bacterial agent of efficient degradation tetracycline antibiotics and application
WO2018193847A1 (en) * 2017-04-18 2018-10-25 チカミミルテック株式会社 Algae growth inhibitor and method for inhibiting algae growth
US10351644B2 (en) 2014-02-27 2019-07-16 Shoichi Shirotake Antiviral drug
CN114010797A (en) * 2021-11-26 2022-02-08 上海交通大学 Bacteria-targeted nano antibacterial agent and preparation method thereof

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DOUGLAS S.J. ET AL.: "Particle Size and Size Distribution of Poly(butyl2-cyanoacrylate) Nanoparticles", J. COLLOID INTERFACE SCI., vol. 103, no. 1, January 1985 (1985-01-01), pages 154 - 163 *
HODOKI N. ET AL.: "Nanotechnology o Mochiita Yakuzaigakuteki Kiban Kenkyu XV -Nano Setsugo Kaimen ga Motarasu Vancomycin Taisei Kiko no Choetsu-", DAI 56 KAI HIGASHINIHON BRANCH OF JAPANESE ASSOCIATION FOR INFECTIOUS DISEASES AND DAI 54 KAI HIGASHINIHON BRANCH OF JAPAN SOCIETY OF CHEMOTHERAPY, 10 September 2007 (2007-09-10), pages 136 *
HODOKI N. ET AL.: "Nanotechnology of Mochiita Yakuzaigakuteki Kiban Kenkyu XV -Nano Setsugo Kaimen ga Motarasu Vancomycin Taisei Kiko no Choetsu-", JAPANESE JOURNAL OF CHEMOTHERAPY, vol. 56, no. 2, 10 March 2008 (2008-03-10), pages 248 *
NAKAMURA J. ET AL.: "Nanotechnology o Mochiita Yakuzaigakuteki Kiban Kenkyu -IX. Kokin Kassei no Fine Tuning to Taisei Chiryo eno Senryaku-", THE PHARMACEUTICAL SOCIETY OF JAPAN DAI 127 NENKAI YOSHISHU, no. 3, 5 March 2007 (2007-03-05), pages 132 *
SHIROTAKE S. ET AL.: "Preparation of Cyanoacrylate Nanoparticles Using Monosaccharides or Disaccharides", CHEM. PHARM. BULL., vol. 56, no. 1, January 2008 (2008-01-01), pages 137 - 138 *
TONEGAWA A. ET AL.: "Nanotechnology o Mochiita Yakuzaigakuteki Kiban Kenkyu -VI. Kokin Kassei no Fine Tuning-", DAI 55 KAI HIGASHINIHON BRANCH OF JAPANESE ASSOCIATION FOR INFECTIOUS DISEASES AND DAI 53 KAI HIGASHINIHON BRANCH OF JAPAN SOCIETY OF CHEMOTHERAPY, 2006, pages 121 *
TONEGAWA J. ET AL.: "Nanotechnology o Mochiita Takuzaigakuteki Kiban Kenkyu -VIII. Kokinyaku Hogo Nano Cupsule no Gosei to Kokin Kassei no Tansaku-", THE PHARMACEUTCIAL SOCIETY OF JAPAN DAI 127 NENKAI YOSHISHU, no. 3, 5 March 2007 (2007-03-05), pages 132 *

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009084494A1 (en) * 2007-12-27 2009-07-09 Public University Corporation Yokohama City University Antimicrobial agent for gram-positive bacteria
JP5618284B2 (en) * 2007-12-27 2014-11-05 昇一 城武 Antibacterial agent for Gram-positive bacteria
WO2010101178A1 (en) * 2009-03-03 2010-09-10 公立大学法人横浜市立大学 Amino acid-conjugated cyanoacrylate polymer particles
CN102361636A (en) * 2009-03-03 2012-02-22 公立大学法人横浜市立大学 Amino acid-conjugated cyanoacrylate polymer particles
JP5663741B2 (en) * 2009-03-03 2015-02-04 株式会社ナノカム Amino acid conjugated cyanoacrylate polymer particles
WO2012133648A1 (en) 2011-03-31 2012-10-04 Shirotake Shoichi Novel preparation technique for higher-order structure that exhibits anti-cellular effect
WO2013108871A1 (en) 2012-01-19 2013-07-25 Shirotake Shoichi Antibacterial agent against plant disease-causing bacteria
US10351644B2 (en) 2014-02-27 2019-07-16 Shoichi Shirotake Antiviral drug
JP2016056481A (en) * 2014-09-11 2016-04-21 チカミミルテック株式会社 Antibacterial sheet and method for producing antibacterial sheet
JPWO2016039412A1 (en) * 2014-09-11 2017-07-13 チカミミルテック株式会社 Antibacterial agent and method for producing antibacterial agent
WO2016039412A1 (en) * 2014-09-11 2016-03-17 チカミミルテック株式会社 Antibacterial agent and method for producing antibacterial agent
JP2017081852A (en) * 2015-10-28 2017-05-18 チカミミルテック株式会社 Antibacterial agent, and method for producing the antibacterial agent
WO2018193847A1 (en) * 2017-04-18 2018-10-25 チカミミルテック株式会社 Algae growth inhibitor and method for inhibiting algae growth
JPWO2018193847A1 (en) * 2017-04-18 2020-03-05 チカミミルテック株式会社 Algae growth inhibitor and method for suppressing algae growth
JP7134442B2 (en) 2017-04-18 2022-09-12 チカミミルテック株式会社 Algae growth inhibitor and method for inhibiting algae growth
CN107988095A (en) * 2017-11-27 2018-05-04 华中农业大学 A kind of microbial bacterial agent of efficient degradation tetracycline antibiotics and application
CN107988095B (en) * 2017-11-27 2020-06-02 华中农业大学 Microbial agent for efficiently degrading tetracycline antibiotics and application
CN114010797A (en) * 2021-11-26 2022-02-08 上海交通大学 Bacteria-targeted nano antibacterial agent and preparation method thereof

Also Published As

Publication number Publication date
JP4696256B2 (en) 2011-06-08
JPWO2008126846A1 (en) 2010-07-22

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