WO2008099561A1 - 抗菌性ペプチドを用いた細胞増殖促進剤及び該細胞増殖促進剤を含有する無血清培地を用いる細胞増殖促進方法 - Google Patents

抗菌性ペプチドを用いた細胞増殖促進剤及び該細胞増殖促進剤を含有する無血清培地を用いる細胞増殖促進方法 Download PDF

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Publication number
WO2008099561A1
WO2008099561A1 PCT/JP2007/073912 JP2007073912W WO2008099561A1 WO 2008099561 A1 WO2008099561 A1 WO 2008099561A1 JP 2007073912 W JP2007073912 W JP 2007073912W WO 2008099561 A1 WO2008099561 A1 WO 2008099561A1
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WO
WIPO (PCT)
Prior art keywords
cell proliferation
acid sequence
amino acid
promoting cell
arg
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PCT/JP2007/073912
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English (en)
French (fr)
Inventor
Hiroki Nikawa
Masahiro Nishimura
Koichiro Tsuji
Nobue Hiromoto
Original Assignee
Japan Science And Technology Agency
Hiroshima University
Two Cells Co., Ltd.
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Publication date
Application filed by Japan Science And Technology Agency, Hiroshima University, Two Cells Co., Ltd. filed Critical Japan Science And Technology Agency
Priority to JP2008557989A priority Critical patent/JPWO2008099561A1/ja
Publication of WO2008099561A1 publication Critical patent/WO2008099561A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

本発明の目的は、軟骨細胞への分化や神経細胞への分化という点で、幹細胞よりも優れている滑膜細胞および羊膜由来細胞を大量に増殖させるために、生体に対しての副作用や阻害作用がきわめて小さく、かつ、有用な活性を有するペプチドを提供することである。 本発明は、以下のアミノ酸配列から成るペプチドから成る羊膜由来細胞又は滑膜細胞増殖促進剤に関する： （１）以下のアミノ酸配列： Lys-Arg-Leu-Phe-Arg-Arg-Trp-Gln-Trp-Arg-Met-Lys-Lys-Tyr（配列番号１）、又は （２）上記配列番号１のアミノ酸配列において、１～数個のアミノ酸が欠失、置換、又は付加し、配列番号１のアミノ酸配列から成るペプチドと実質的に同等の細胞増殖促進活性を有するアミノ酸配列。
PCT/JP2007/073912 2007-02-14 2007-12-12 抗菌性ペプチドを用いた細胞増殖促進剤及び該細胞増殖促進剤を含有する無血清培地を用いる細胞増殖促進方法 WO2008099561A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008557989A JPWO2008099561A1 (ja) 2007-02-14 2007-12-12 抗菌性ペプチドを用いた細胞増殖促進剤及び該細胞増殖促進剤を含有する無血清培地を用いる細胞増殖促進方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007033318 2007-02-14
JP2007-033318 2007-12-05

Publications (1)

Publication Number Publication Date
WO2008099561A1 true WO2008099561A1 (ja) 2008-08-21

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ID=39689811

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PCT/JP2007/073912 WO2008099561A1 (ja) 2007-02-14 2007-12-12 抗菌性ペプチドを用いた細胞増殖促進剤及び該細胞増殖促進剤を含有する無血清培地を用いる細胞増殖促進方法

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JP (1) JPWO2008099561A1 (ja)
WO (1) WO2008099561A1 (ja)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002179698A (ja) * 2000-12-08 2002-06-26 Univ Hiroshima 新規ペプチド、及び当該ペプチドを用いた組成物
JP2003231639A (ja) * 2001-12-06 2003-08-19 Sankyo Co Ltd ヒト羊膜由来細胞含有医薬組成物
JP2005154338A (ja) * 2003-11-26 2005-06-16 Japan Science & Technology Agency 塩基性抗菌性ペプチドを有効成分とする細胞増殖剤
JP2006000059A (ja) * 2004-06-17 2006-01-05 Two Cells Co Ltd 細胞外基質を用いた動物細胞の増殖及び分化促進方法
JP2006034118A (ja) * 2004-07-23 2006-02-09 Kaneka Corp 間葉系幹細胞の効率的保存または調製方法
JP2006511201A (ja) * 2002-06-14 2006-04-06 カルテラ、アクチボラグ 幹細胞のマーカーおよびその使用
JP2007037426A (ja) * 2005-08-01 2007-02-15 Two Cells Co Ltd 動物幹細胞培養用無血清培地

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002179698A (ja) * 2000-12-08 2002-06-26 Univ Hiroshima 新規ペプチド、及び当該ペプチドを用いた組成物
JP2003231639A (ja) * 2001-12-06 2003-08-19 Sankyo Co Ltd ヒト羊膜由来細胞含有医薬組成物
JP2006511201A (ja) * 2002-06-14 2006-04-06 カルテラ、アクチボラグ 幹細胞のマーカーおよびその使用
JP2005154338A (ja) * 2003-11-26 2005-06-16 Japan Science & Technology Agency 塩基性抗菌性ペプチドを有効成分とする細胞増殖剤
JP2006000059A (ja) * 2004-06-17 2006-01-05 Two Cells Co Ltd 細胞外基質を用いた動物細胞の増殖及び分化促進方法
JP2006034118A (ja) * 2004-07-23 2006-02-09 Kaneka Corp 間葉系幹細胞の効率的保存または調製方法
JP2007037426A (ja) * 2005-08-01 2007-02-15 Two Cells Co Ltd 動物幹細胞培養用無血清培地

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