WO2008096416A1 - 前立腺がんの悪性度判定キット及びその方法 - Google Patents

前立腺がんの悪性度判定キット及びその方法 Download PDF

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Publication number
WO2008096416A1
WO2008096416A1 PCT/JP2007/052025 JP2007052025W WO2008096416A1 WO 2008096416 A1 WO2008096416 A1 WO 2008096416A1 JP 2007052025 W JP2007052025 W JP 2007052025W WO 2008096416 A1 WO2008096416 A1 WO 2008096416A1
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WO
WIPO (PCT)
Prior art keywords
malignancy
prostate cancer
kit
same
gleason
Prior art date
Application number
PCT/JP2007/052025
Other languages
English (en)
French (fr)
Inventor
Hitoshi Endou
Isao Okayasu
Takeshi Sakata
Original Assignee
Fuji Biomedix Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fuji Biomedix Co., Ltd. filed Critical Fuji Biomedix Co., Ltd.
Priority to US12/526,062 priority Critical patent/US20100112596A1/en
Priority to EP20070713854 priority patent/EP2146208A4/en
Priority to CN200780052524A priority patent/CN101680895A/zh
Priority to JP2008556938A priority patent/JPWO2008096416A1/ja
Priority to PCT/JP2007/052025 priority patent/WO2008096416A1/ja
Priority to EP15168745.6A priority patent/EP2977761A1/en
Publication of WO2008096416A1 publication Critical patent/WO2008096416A1/ja

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57434—Specifically defined cancers of prostate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

本発明は、Gleasons分類、TMN分類に加え、新たな診断法である分子マーカーの手法を提供すると共に、手術前の早期段階において生検材料を用いてGleasons分類と組み合わせることによって、手術時に摘出した材料でなく細胞針検査で採取した材料を用いた場合でも、前立腺がんの悪性度がより高精度かつ容易に判定可能な手段を提供することを目的とする、前立腺がんの悪性度を判定（診断）して患者の予後を予測するための判定キット及び判定法に関する。  
PCT/JP2007/052025 2007-02-06 2007-02-06 前立腺がんの悪性度判定キット及びその方法 WO2008096416A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US12/526,062 US20100112596A1 (en) 2007-02-06 2007-02-06 Kit for deciding degree of malignancy in prostate cancer and method of using the same
EP20070713854 EP2146208A4 (en) 2007-02-06 2007-02-06 KIT FOR DETERMINING THE MALIGNICITY OF PROSTATE CANCER AND METHOD FOR USE THEREOF
CN200780052524A CN101680895A (zh) 2007-02-06 2007-02-06 前列腺癌的恶性程度判定试剂盒和其方法
JP2008556938A JPWO2008096416A1 (ja) 2007-02-06 2007-02-06 前立腺がんの悪性度判定キット及びその方法
PCT/JP2007/052025 WO2008096416A1 (ja) 2007-02-06 2007-02-06 前立腺がんの悪性度判定キット及びその方法
EP15168745.6A EP2977761A1 (en) 2007-02-06 2007-02-06 Antibody for determining prostate cancer malignancy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/052025 WO2008096416A1 (ja) 2007-02-06 2007-02-06 前立腺がんの悪性度判定キット及びその方法

Publications (1)

Publication Number Publication Date
WO2008096416A1 true WO2008096416A1 (ja) 2008-08-14

Family

ID=39681336

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/052025 WO2008096416A1 (ja) 2007-02-06 2007-02-06 前立腺がんの悪性度判定キット及びその方法

Country Status (5)

Country Link
US (1) US20100112596A1 (ja)
EP (2) EP2977761A1 (ja)
JP (1) JPWO2008096416A1 (ja)
CN (1) CN101680895A (ja)
WO (1) WO2008096416A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012163332A (ja) * 2011-01-28 2012-08-30 J-Pharma Co Ltd 胃癌の悪性度診断用キット
JP2015134778A (ja) * 2015-02-06 2015-07-27 ジェイファーマ株式会社 抗ヒトｌａｔ１モノクローナル抗体及び前立腺がんの悪性度判定キット

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2698634B1 (en) * 2011-04-15 2017-11-08 J-Pharma Co., Ltd. Biomarker for breast cancer
CN102866052A (zh) * 2012-10-16 2013-01-09 百奥迈科生物技术有限公司 一种细胞染色试剂盒及其使用方法
JPWO2016103761A1 (ja) * 2014-12-22 2017-11-02 ジェイファーマ株式会社 癌の血中バイオマーカー
WO2016143356A1 (en) * 2015-03-11 2016-09-15 J-Pharma Co., Ltd. Kit and method for determining prostate cancer malignancy

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11299489A (ja) 1998-04-22 1999-11-02 Japan Science & Technology Corp 中性アミノ酸トランスポーター及びその遺伝子
JP2000157286A (ja) 1998-09-03 2000-06-13 Japan Science & Technology Corp アミノ酸輸送蛋白及びその遺伝子
JP2005265531A (ja) 2004-03-17 2005-09-29 Tama Tlo Kk 中性アミノ酸トランスポーターによる癌の検出法、及びそのためのキット
WO2005121787A2 (en) 2004-06-04 2005-12-22 Xenoport, Inc. Lat1 transporters expressed in cancer cells

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7462459B2 (en) * 2004-01-30 2008-12-09 Xenoport, Inc. LAT1 transporters expressed in blood brain barrier cells
CA2657886A1 (en) * 2005-07-26 2007-02-01 Procure Therapeutics Limited Stem cell markers

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11299489A (ja) 1998-04-22 1999-11-02 Japan Science & Technology Corp 中性アミノ酸トランスポーター及びその遺伝子
JP2000157286A (ja) 1998-09-03 2000-06-13 Japan Science & Technology Corp アミノ酸輸送蛋白及びその遺伝子
JP2005265531A (ja) 2004-03-17 2005-09-29 Tama Tlo Kk 中性アミノ酸トランスポーターによる癌の検出法、及びそのためのキット
WO2005121787A2 (en) 2004-06-04 2005-12-22 Xenoport, Inc. Lat1 transporters expressed in cancer cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2146208A4 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012163332A (ja) * 2011-01-28 2012-08-30 J-Pharma Co Ltd 胃癌の悪性度診断用キット
JP2015134778A (ja) * 2015-02-06 2015-07-27 ジェイファーマ株式会社 抗ヒトｌａｔ１モノクローナル抗体及び前立腺がんの悪性度判定キット

Also Published As

Publication number Publication date
US20100112596A1 (en) 2010-05-06
CN101680895A (zh) 2010-03-24
EP2977761A1 (en) 2016-01-27
EP2146208A1 (en) 2010-01-20
JPWO2008096416A1 (ja) 2010-05-20
EP2146208A4 (en) 2010-09-01

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