WO2008096369A3 - Préparation pharmaceutique utilisable en thérapie anti-vih - Google Patents

Préparation pharmaceutique utilisable en thérapie anti-vih Download PDF

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Publication number
WO2008096369A3
WO2008096369A3 PCT/IN2008/000068 IN2008000068W WO2008096369A3 WO 2008096369 A3 WO2008096369 A3 WO 2008096369A3 IN 2008000068 W IN2008000068 W IN 2008000068W WO 2008096369 A3 WO2008096369 A3 WO 2008096369A3
Authority
WO
WIPO (PCT)
Prior art keywords
reverse transcriptase
pharmaceutical formulation
transcriptase inhibitors
analog reverse
hiv therapy
Prior art date
Application number
PCT/IN2008/000068
Other languages
English (en)
Other versions
WO2008096369A2 (fr
Inventor
Neha Shesh Wyawahare
Ramesh A
Mahesh Mohanrao Bhadgale
Abhijit Mukund Deshmukh
Sanjeev Meharchand Sethi
Kumar Shanmugham
Prakash Balakrishna Shetiya
Chetan Murthy Rajashekara
Original Assignee
Matrix Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Limited filed Critical Matrix Laboratories Limited
Publication of WO2008096369A2 publication Critical patent/WO2008096369A2/fr
Publication of WO2008096369A3 publication Critical patent/WO2008096369A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Abstract

L'invention porte sur la formule d'un comprimé monolithique comprenant : a) un inhibiteur analogue de nucléotide de la transcriptase inverse (NtRTI); b) des inhibiteurs non nucléosides de la transcriptase inverse (NNRTIs); c) des inhibiteurs nucléosides de la transcriptase inverse (NRTIs); et d) un ou des porteurs ou excipients pharmacocompatibles. L'invention porte également sur une autre formule pharmaceutique comprenant: a) des inhibiteurs analogues de nucléotides de la transcriptase inverse (NtRTIs); b) de inhibiteurs analogues de nucléosides de la transcriptase inverse (NRTIs); et c) un ou des porteurs ou excipients pharmacocompatibles.
PCT/IN2008/000068 2007-02-05 2008-02-04 Préparation pharmaceutique utilisable en thérapie anti-vih WO2008096369A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN257CH2007 2007-02-05
IN257/CHE/2007 2007-02-05

Publications (2)

Publication Number Publication Date
WO2008096369A2 WO2008096369A2 (fr) 2008-08-14
WO2008096369A3 true WO2008096369A3 (fr) 2009-12-30

Family

ID=39682191

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000068 WO2008096369A2 (fr) 2007-02-05 2008-02-04 Préparation pharmaceutique utilisable en thérapie anti-vih

Country Status (1)

Country Link
WO (1) WO2008096369A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009106960A2 (fr) * 2008-02-27 2009-09-03 Aurobindo Pharma Limited Compositions stables de lamivudine, de ténofovir et d'éfavirenz
WO2009106954A1 (fr) * 2008-02-27 2009-09-03 Aurobindo Pharma Limited Formes pharmaceutiques stables de lamivudine et de ténofovir
CN107312039B (zh) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 一种替诺福韦前药的制备方法
CN103211826A (zh) * 2013-05-14 2013-07-24 福建广生堂药业股份有限公司 一种抗病毒药物组合物及其制备方法和用途
EA201690146A1 (ru) * 2013-08-14 2016-07-29 Ратиофарм Гмбх Лекарственное средство, содержащее фармацевтическую комбинацию долутегравира, эмтрицитабина и тенофовира
IN2013CH05288A (fr) * 2013-11-18 2015-09-11 Aurobindo Pharma Ltd
CZ2013985A3 (cs) * 2013-12-09 2015-06-17 Zentiva, K.S. Stabilní farmaceutická kompozice obsahující tenofovir disoproxil fumarát
TR201617448A2 (tr) * 2016-11-29 2018-06-21 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Tenofovi̇r ve emtri̇si̇tabi̇n i̇çeren kati oral farmasöti̇k bi̇leşi̇mler
CN106822155B (zh) * 2016-12-29 2019-10-11 东北制药集团股份有限公司 依非韦伦、拉米夫定及富马酸替诺福韦酯三联复方片中片及其制备方法
TR201713954A2 (tr) * 2017-09-20 2019-04-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Tenofovir, emtrisitabin ve efavirenzin farmasötik kombinasyonlari
BR112022010161A2 (pt) * 2019-11-26 2022-08-09 Biotron Ltd Método para tratar a infecção por hiv-1 e regular a função do sistema imunológico, e, uso de um ou mais agentes antirretrovirais e n-carbamimidoil-5-(1-metilpirazol-4-il)naftaleno-2-carboxamida

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064845A1 (fr) * 2003-01-14 2004-08-05 Gilead Sciences, Inc. Compositions et methodes destinees a une therapie de combinaison antivirale
US20060194272A1 (en) * 2005-02-25 2006-08-31 Sysmex Corporation Reference material for assaying D-dimer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064845A1 (fr) * 2003-01-14 2004-08-05 Gilead Sciences, Inc. Compositions et methodes destinees a une therapie de combinaison antivirale
US20060194272A1 (en) * 2005-02-25 2006-08-31 Sysmex Corporation Reference material for assaying D-dimer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
LIEBERT., ANTIVIRAL BRIEFS. AIDS PATIENT CARE AND STDS, vol. 20, no. 12, December 2006 (2006-12-01), pages 887 - 889 *
NIAZI.: "Handbook of Pharmaceutical Manufacturing Formulations: Compressed solid products", 2004, INFORMA HEALTH CARE, pages: 21,47,53 *

Also Published As

Publication number Publication date
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