WO2008093700A1 - トレハロース化合物、その製造方法、及び該化合物を含有する免疫賦活剤 - Google Patents

トレハロース化合物、その製造方法、及び該化合物を含有する免疫賦活剤 Download PDF

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Publication number
WO2008093700A1
WO2008093700A1 PCT/JP2008/051355 JP2008051355W WO2008093700A1 WO 2008093700 A1 WO2008093700 A1 WO 2008093700A1 JP 2008051355 W JP2008051355 W JP 2008051355W WO 2008093700 A1 WO2008093700 A1 WO 2008093700A1
Authority
WO
WIPO (PCT)
Prior art keywords
compound
trehalose
immuno
trehalose compound
production
Prior art date
Application number
PCT/JP2008/051355
Other languages
English (en)
French (fr)
Inventor
Mugio Nishizawa
Hiroshi Imagawa
Hirofumi Yamamoto
Jun Sakurai
Masataka Oda
Original Assignee
Otsuka Chemical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Chemical Co., Ltd. filed Critical Otsuka Chemical Co., Ltd.
Priority to JP2008556127A priority Critical patent/JP5258582B2/ja
Priority to US12/525,184 priority patent/US20100093993A1/en
Priority to EP08704137.2A priority patent/EP2123662B1/en
Publication of WO2008093700A1 publication Critical patent/WO2008093700A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/04—Disaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

　本発明は、優れた免疫賦活作用を有し、工業的に大量供給が可能な新規トレハロース化合物及び該トレハロース化合物の製造方法を提供することを目的とする。本発明のトレハロース化合物は、一般式（１） ［式中、Ｒ１、Ｒ２、Ｒ３及びＲ４は、同一又は異なって、Ｃ１０－１６アルキル基を示す。］で表され、免疫賦活活性に優れている。本発明のトレハロース化合物は、一般式（５） ［式中、Ｒ１、Ｒ２、Ｒ３及びＲ４は、前記に同じ。Ｒ５は水酸基の保護基を示す。］で表されるトレハロース化合物から水酸基の保護基（Ｒ５）を脱保護することにより製造される。
PCT/JP2008/051355 2007-01-31 2008-01-30 トレハロース化合物、その製造方法、及び該化合物を含有する免疫賦活剤 WO2008093700A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2008556127A JP5258582B2 (ja) 2007-01-31 2008-01-30 トレハロース化合物、その製造方法、及び該化合物を含有する免疫賦活剤
US12/525,184 US20100093993A1 (en) 2007-01-31 2008-01-30 Trehalose compound, process for production of the compound, and immuno-stimulative agent comprising the compound
EP08704137.2A EP2123662B1 (en) 2007-01-31 2008-01-30 Trehalose compound, process for production of the compound, and immuno-stimulative agent comprising the compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-021227 2007-01-31
JP2007021227 2007-01-31

Publications (1)

Publication Number Publication Date
WO2008093700A1 true WO2008093700A1 (ja) 2008-08-07

Family

ID=39674009

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/051355 WO2008093700A1 (ja) 2007-01-31 2008-01-30 トレハロース化合物、その製造方法、及び該化合物を含有する免疫賦活剤

Country Status (5)

Country Link
US (1) US20100093993A1 (ja)
EP (1) EP2123662B1 (ja)
JP (1) JP5258582B2 (ja)
TW (1) TWI410432B (ja)
WO (1) WO2008093700A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010050178A1 (ja) 2008-10-31 2010-05-06 大塚化学株式会社 トレハロース化合物、その製造方法、及び該化合物を含有する医薬
US12064480B2 (en) 2018-04-13 2024-08-20 Glaxosmithkline Biologicals Sa Immunigenic alpha-branched trehalose-diesters

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9084720B2 (en) 2013-05-07 2015-07-21 BioBlast Pharma Ltd. Compositions and methods for treating oculopharyngeal muscular dystrophy
US10493023B2 (en) 2013-05-07 2019-12-03 Seelos Therapeutics, Inc. Treatment of protein aggregation myopathic and neurodegenerative diseases by parenteral administration of trehalose
TWI505276B (zh) * 2014-02-13 2015-10-21 Au Optronics Corp 移位暫存電路及移位暫存器

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61130298A (ja) * 1984-11-30 1986-06-18 Ss Pharmaceut Co Ltd α，α−トレハロ−ス脂肪酸ジアミド誘導体およびその製造法
JPH03251537A (ja) * 1990-02-28 1991-11-11 Eisai Co Ltd マクロファージ及び好中球活性化剤
JPH1072478A (ja) * 1996-08-28 1998-03-17 Mitsubishi Chem Corp 新規糖脂質
JP2005281298A (ja) * 2004-03-04 2005-10-13 Fancl Corp メリビオースを有効成分とするｔ細胞免疫調節剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101412082B1 (ko) * 2006-03-27 2014-06-26 가부시키가이샤 도우사 고가쿠 겐큐쇼 트레할로스 화합물 및 그 화합물을 함유하는 의약

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61130298A (ja) * 1984-11-30 1986-06-18 Ss Pharmaceut Co Ltd α，α−トレハロ−ス脂肪酸ジアミド誘導体およびその製造法
JPH03251537A (ja) * 1990-02-28 1991-11-11 Eisai Co Ltd マクロファージ及び好中球活性化剤
JPH1072478A (ja) * 1996-08-28 1998-03-17 Mitsubishi Chem Corp 新規糖脂質
JP2005281298A (ja) * 2004-03-04 2005-10-13 Fancl Corp メリビオースを有効成分とするｔ細胞免疫調節剤

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
"Protecting Groups in Organic Chemistry", 1991, JOHN WILEY & SONS, INC.
CHEM. PHARM. BULL., vol. 33, 1985, pages 4544
J. CARBOHYDR. CHEM., vol. 5, 1986, pages 127
JOURNAL OF AMERICAN CHEMICAL SOCIETY, vol. 92, 1970, pages 1397
NUMATA FUMIO ET AL.: "Lethal and adjuvant activities of cord factor (trehalose 6,6'-dimycolate) and synthetic analogs in mice", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 33, no. 10, 1985, pages 4544 - 4555, XP008111645 *
SAKURAI T.; KAISE T.; MATSUBARA C., CHEM. RES. TOXICOL., vol. 11, 1998, pages 273 - 283
See also references of EP2123662A4 *
SYNLETT, 1996, pages 452

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010050178A1 (ja) 2008-10-31 2010-05-06 大塚化学株式会社 トレハロース化合物、その製造方法、及び該化合物を含有する医薬
US8741871B2 (en) 2008-10-31 2014-06-03 Glytech, Inc. Trehalose compound, method for producing same, and pharmaceutical product containing the compound
US12064480B2 (en) 2018-04-13 2024-08-20 Glaxosmithkline Biologicals Sa Immunigenic alpha-branched trehalose-diesters

Also Published As

Publication number Publication date
JPWO2008093700A1 (ja) 2010-05-20
EP2123662A1 (en) 2009-11-25
TW200836756A (en) 2008-09-16
TWI410432B (zh) 2013-10-01
JP5258582B2 (ja) 2013-08-07
US20100093993A1 (en) 2010-04-15
EP2123662A4 (en) 2010-03-24
EP2123662B1 (en) 2013-12-04

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