WO2008093679A1 - 温度感受性物質製のマイクロニードルの製造方法 - Google Patents

温度感受性物質製のマイクロニードルの製造方法 Download PDF

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Publication number
WO2008093679A1
WO2008093679A1 PCT/JP2008/051317 JP2008051317W WO2008093679A1 WO 2008093679 A1 WO2008093679 A1 WO 2008093679A1 JP 2008051317 W JP2008051317 W JP 2008051317W WO 2008093679 A1 WO2008093679 A1 WO 2008093679A1
Authority
WO
WIPO (PCT)
Prior art keywords
jig
thermosensitive substance
substance
thermosensitive
contact
Prior art date
Application number
PCT/JP2008/051317
Other languages
English (en)
French (fr)
Inventor
Hidetoshi Hamamoto
Masaki Ishibashi
Katsunori Kobayashi
Original Assignee
Medrx Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medrx Co., Ltd. filed Critical Medrx Co., Ltd.
Priority to EP08704099A priority Critical patent/EP2127693A1/en
Priority to US12/524,829 priority patent/US20100004608A1/en
Priority to JP2008556112A priority patent/JP5190382B2/ja
Publication of WO2008093679A1 publication Critical patent/WO2008093679A1/ja

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C67/00—Shaping techniques not covered by groups B29C39/00 - B29C65/00, B29C70/00 or B29C73/00
    • B29C67/0048—Local deformation of formed objects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2995/00—Properties of moulding materials, reinforcements, fillers, preformed parts or moulds
    • B29K2995/0037—Other properties
    • B29K2995/0059—Degradable
    • B29K2995/006—Bio-degradable, e.g. bioabsorbable, bioresorbable or bioerodible
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/756—Microarticles, nanoarticles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/759—Needles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29L—INDEXING SCHEME ASSOCIATED WITH SUBCLASS B29C, RELATING TO PARTICULAR ARTICLES
    • B29L2031/00—Other particular articles
    • B29L2031/765—Articles provided with piles, e g. nap on cloth

Abstract

　マイクロニードルを安価且つ量産規模で製造し得る、新規なマイクロニードルの製造方法を提供すること。治具の温度を熱塑性変形する温度感受性物質が粘塑性状態になる温度以上に加熱し、その治具を温度感受性物質に接触させ、その後、治具と温度感受性物質を引き離すことで、治具と接着した温度感受性物質が引き伸ばされて針状突起が形成される。好適には、以下の工程(i)～(iv)を含む方法。 (i)治具の温度を熱塑性変形する温度感受性物質が粘塑性状態になる温度以上に設定する。 (ii)治具を上記温度感受性物質に接触させ、接触部位の温度感受性物質を粘塑性状態にする。 (iii)治具と温度感受性物質を引き離し、粘塑性状態の温度感受性物質を糸状に引き伸ばす。 (iv)治具と温度感受性物質の引き離しを停止又は引き離し速度を減速させることにより、糸状の温度感受性物質を切断して、針状突起を形成させる。
PCT/JP2008/051317 2007-01-29 2008-01-29 温度感受性物質製のマイクロニードルの製造方法 WO2008093679A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP08704099A EP2127693A1 (en) 2007-01-29 2008-01-29 Process for producing microneedle of thermosensitive substance
US12/524,829 US20100004608A1 (en) 2007-01-29 2008-01-29 Process for producing microneedle of thermosensitive substance
JP2008556112A JP5190382B2 (ja) 2007-01-29 2008-01-29 温度感受性物質製のマイクロニードルの製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-018006 2007-01-29
JP2007018006 2007-01-29

Publications (1)

Publication Number Publication Date
WO2008093679A1 true WO2008093679A1 (ja) 2008-08-07

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PCT/JP2008/051317 WO2008093679A1 (ja) 2007-01-29 2008-01-29 温度感受性物質製のマイクロニードルの製造方法

Country Status (5)

Country Link
US (1) US20100004608A1 (ja)
EP (1) EP2127693A1 (ja)
JP (1) JP5190382B2 (ja)
CN (1) CN101594905A (ja)
WO (1) WO2008093679A1 (ja)

Cited By (18)

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WO2010039006A2 (ko) * 2008-10-02 2010-04-08 연세대학교 산학협력단 송풍에 의한 솔리드 마이크로구조체의 제조방법 및 이로부터 제조된 솔리드 마이크로구조체
WO2010095456A1 (ja) 2009-02-23 2010-08-26 株式会社メドレックス 剣山型マイクロニードルのアプリケーター
WO2010122816A1 (ja) 2009-04-24 2010-10-28 株式会社メドレックス 薬液担持用治具とそれを用いたマイクロニードルへの薬剤塗布方法
WO2010137319A1 (ja) * 2009-05-27 2010-12-02 株式会社メドレックス 剣山型マイクロニードルの製造方法およびマイクロニードル
WO2011089907A1 (ja) 2010-01-22 2011-07-28 株式会社メドレックス マイクロニードル貼付剤の貼付補助具
JP2013094662A (ja) * 2012-05-02 2013-05-20 Kosumedei Seiyaku Kk マイクロニードル溶着法
WO2016060020A1 (ja) * 2014-10-17 2016-04-21 花王株式会社 微細中空突起物の製造方法
JP2017038903A (ja) * 2015-08-17 2017-02-23 花王株式会社 微細中空突起物の製造方法
JP2017532086A (ja) * 2014-08-29 2017-11-02 コリウム インターナショナル， インコーポレイテッド 活性剤の送達のための微細構造アレイ
KR20170129731A (ko) 2015-03-23 2017-11-27 코스메드 파마소티컬 씨오 쩜 엘티디 마이크로니들 및 그의 제조 방법
JP2018502684A (ja) * 2014-12-16 2018-02-01 チュビック インコーポレイテッドＪｕｖｉｃ Ｉｎｃ． 微細ルームマイクロ構造体及びその製造方法
WO2019230175A1 (ja) * 2018-05-30 2019-12-05 花王株式会社 微細中空突起具の製造方法、及び微細中空突起具
US10632653B2 (en) 2014-10-17 2020-04-28 Kao Corporation Fine hollow protrusion manufacturing method
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US11052231B2 (en) 2012-12-21 2021-07-06 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
US11123530B2 (en) 2016-01-27 2021-09-21 Kao Corporation Method for producing fine, hollow projection tool
US11419816B2 (en) 2010-05-04 2022-08-23 Corium, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
US11565097B2 (en) 2013-03-15 2023-01-31 Corium Pharma Solutions, Inc. Microarray for delivery of therapeutic agent and methods of use

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KR20080068679A (ko) 2005-10-07 2008-07-23 더 유니버시티 오브 알라바마 활성 약학적, 생물학적, 영양학적 및 에너지적 조성의다형성 극복 및 향상된 특성 부여를 위한 다관능성 이온성액체 조성물
KR101254240B1 (ko) * 2010-12-17 2013-04-12 주식회사 라파스 마이크로구조체 제조방법
KR101635292B1 (ko) * 2011-10-28 2016-06-30 도판 인사츠 가부시키가이샤 중공 바늘 형상체의 제조 방법 및 중공 바늘 형상체
CN109011131B (zh) * 2018-07-03 2020-08-28 华中科技大学 一种温度响应释放药物的可溶性微针及其应用
CN109879242B (zh) * 2019-03-13 2021-09-14 中山大学 一种应力辅助定位纳米加工方法及其制备的纳米结构

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Cited By (28)

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JP2012504034A (ja) * 2008-10-02 2012-02-16 ヌリ−エム ウェルネス カンパニー リミテッド 送風によるソリッドマイクロ構造体の製造方法及びこれから製造されたソリッドマイクロ構造体
WO2010039006A3 (ko) * 2008-10-02 2010-07-22 연세대학교 산학협력단 송풍에 의한 솔리드 마이크로구조체의 제조방법 및 이로부터 제조된 솔리드 마이크로구조체
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WO2010095456A1 (ja) 2009-02-23 2010-08-26 株式会社メドレックス 剣山型マイクロニードルのアプリケーター
JP5709137B2 (ja) * 2009-02-23 2015-04-30 株式会社 メドレックス 剣山型マイクロニードルのアプリケーター
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JPWO2010095456A1 (ja) * 2009-02-23 2012-08-23 株式会社 メドレックス 剣山型マイクロニードルのアプリケーター
US9067048B2 (en) 2009-04-24 2015-06-30 Medrx Co., Ltd. Medication liquid supporting jig and method of applying medication to micro-needle using same
WO2010122816A1 (ja) 2009-04-24 2010-10-28 株式会社メドレックス 薬液担持用治具とそれを用いたマイクロニードルへの薬剤塗布方法
JP2011005245A (ja) * 2009-05-27 2011-01-13 Kagawa Univ 剣山型マイクロニードルの製造方法およびマイクロニードル
WO2010137319A1 (ja) * 2009-05-27 2010-12-02 株式会社メドレックス 剣山型マイクロニードルの製造方法およびマイクロニードル
WO2011089907A1 (ja) 2010-01-22 2011-07-28 株式会社メドレックス マイクロニードル貼付剤の貼付補助具
US11419816B2 (en) 2010-05-04 2022-08-23 Corium, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
JP2013094662A (ja) * 2012-05-02 2013-05-20 Kosumedei Seiyaku Kk マイクロニードル溶着法
US11052231B2 (en) 2012-12-21 2021-07-06 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
US11565097B2 (en) 2013-03-15 2023-01-31 Corium Pharma Solutions, Inc. Microarray for delivery of therapeutic agent and methods of use
JP2017532086A (ja) * 2014-08-29 2017-11-02 コリウム インターナショナル， インコーポレイテッド 活性剤の送達のための微細構造アレイ
JP7109188B2 (ja) 2014-08-29 2022-07-29 コリウム， インコーポレイテッド 活性剤の送達のための微細構造アレイ
US10632653B2 (en) 2014-10-17 2020-04-28 Kao Corporation Fine hollow protrusion manufacturing method
WO2016060020A1 (ja) * 2014-10-17 2016-04-21 花王株式会社 微細中空突起物の製造方法
JP2018502684A (ja) * 2014-12-16 2018-02-01 チュビック インコーポレイテッドＪｕｖｉｃ Ｉｎｃ． 微細ルームマイクロ構造体及びその製造方法
US10589006B2 (en) 2015-03-23 2020-03-17 Cosmed Pharmaceutical Co., Ltd. Microneedle and method for producing same
KR20170129731A (ko) 2015-03-23 2017-11-27 코스메드 파마소티컬 씨오 쩜 엘티디 마이크로니들 및 그의 제조 방법
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
JP2017038903A (ja) * 2015-08-17 2017-02-23 花王株式会社 微細中空突起物の製造方法
US11123530B2 (en) 2016-01-27 2021-09-21 Kao Corporation Method for producing fine, hollow projection tool
JP2019205767A (ja) * 2018-05-30 2019-12-05 花王株式会社 微細中空突起具の製造方法、及び微細中空突起具
WO2019230175A1 (ja) * 2018-05-30 2019-12-05 花王株式会社 微細中空突起具の製造方法、及び微細中空突起具

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US20100004608A1 (en) 2010-01-07
EP2127693A1 (en) 2009-12-02
CN101594905A (zh) 2009-12-02
JPWO2008093679A1 (ja) 2010-05-20
JP5190382B2 (ja) 2013-04-24

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