JP2018502684A - 微細ルームマイクロ構造体及びその製造方法 - Google Patents
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Abstract
Description
(a)本発明によれば、微細ルーム内に搭載された薬物をそのまま経皮伝達に使用することによって、薬物の薬効及び安定性を担保するという長所を有する。
(b)本発明によれば、微細ルーム内に搭載された薬物を定量及び多量で経皮伝達することができる。
(c)本発明は、基質に形成されたホールの内部面に当接して形成される場合、正圧又は物理的な力を利用して人体内に適用することによって、従来、パッチ製品による副作用(紅斑・炎症・アレルギー反応など)を克服でき、人体内に搭載された薬物の確実な伝達が可能で、ユーザの使用便宜性に非常に優れている。特に、パッチなど平板の場合は、ユーザ便宜性が増大され、ピラーの場合は、人体内に搭載された薬物が100%伝達され得るという長所を有する。
本発明は、先端部を有する微細ルーム被膜構造を含む微細ルームマイクロ構造体を提供する。
本発明は、開口された上端と、開口又は閉口された下端とを有するホールが形成された基質(substrate)と、前記ホールの内部面に当接して形成され、先端部を有する微細ルーム被膜構造と、を含む微細ルームマイクロ構造体を提供する。
ホール形成基質用鋳型は、モールディング技法を利用してMEMS(Micro Electro Mechanical Systems)工程によって製作した。
固形化された円筒形態のPDMS(Polydimethylsiloxane)材質のホール形成基質の上にCalcein(蛍光染料、Sigma−aldrich)粉末試料を塗布後、振動、切削工程を通じてホール内に充填を完了した。
(1)直径500μm、長さ385μm円筒形態のPDMS(Polydimethylsiloxane)材質のホール形成基質内に10% w/v carboxymethylcellulose(CMC、low viscosity、Sigma−aldrich)高分子組成物試料を充填した後、溶媒除去工程を総二回行い、ホール内に微細ルーム被膜構造を成形した。図8(d)の左側イメージは、成形完了した微細ルーム被膜構造の上端部の写真であり、図8(d)の右側イメージは、ホール形成基質から分離した微細ルーム被膜構造である。図8(e)は、四角筒形態のホール形成基質PDMS鋳型から分離した四角筒微細ルーム被膜構造である。
直径450μm、長さ730μm、円筒形態、PDMS(Polydimethylsiloxane)材質のホール形成基質内に10% w/v CMC高分子組成物利用、2番の充填及び乾燥過程を通じて製作した直径450μm、長さ730μm、円筒形態の微細ルーム被膜構造を形成し、微細ルーム被膜構造の上部に50% w/v ヒアルロン酸(hyaluronic acid、Average Mw 28.5kDa、PrimalHyal50、Soliance、Pomacle、France)高分子組成物を塗布した後、引張力を利用して別途のマイクロ構造体を成形した(参照:図9(h))。図9(h)の左側イメージは、引張力を利用して別途のマイクロ構造体成形結果であり、図9(h)の右側イメージで別途のマイクロ構造体上の上端部を除去することによって、人体内挿入のための微細ルームマイクロ構造体を成形した。
直径450μm、長さ400μm、円筒形態、上端と下端が開口されているPDMS(Polydimethylsiloxane)材質のホール形成基質内に蛍光染料(fluorescent dye:Calcein)を含有する10% w/v CMC高分子組成物高分子組成物試料を充填した後、溶媒除去工程を総二回行い、ホール内に微細ルーム被膜構造を成形した後、ホール形成基質から分離し、平板及びピラー上に付着した(参照:図8(h))。図8(h)の左側イメージは、平板上に付着した場合、図8(h)の右側イメージは、ピラー上に付着した場合である。
Claims (16)
- 先端部を有する微細ルーム被膜構造を含む、微細ルームマイクロ構造体。
- 前記先端部は、前記微細ルーム被膜構造の上部に形成された別途の高分子組成物に外向力(outward force)を印加して形成されたものであるか、前記微細ルーム被膜構造の上部に別途のマイクロ構造体をさらに付着して形成されたものである、請求項1に記載の微細ルームマイクロ構造体。
- 前記微細ルーム被膜構造は、開口された上端と、開口又は閉口された下端とを有するホールが形成された基質(substrate)のホールの内部面に当接して形成されたものである、請求項1に記載の微細ルームマイクロ構造体。
- 前記微細ルーム被膜構造は、人体内に挿入されるための部分である、請求項1に記載の微細ルームマイクロ構造体。
- 前記微細ルーム内に搭載された薬物をさらに含む、請求項1に記載の微細ルームマイクロ構造体。
- 前記薬物を密封するために、前記微細ルーム被膜構造と結合して形成された第2被膜構造を含む、請求項5に記載の微細ルームマイクロ構造体。
- 前記微細ルーム被膜構造と前記第2被膜構造は、一体に形成されるものである、請求項6に記載の微細ルームマイクロ構造体。
- 前記微細ルームマイクロ構造体は、平板又はピラー上に形成される、請求項1に記載の微細ルームマイクロ構造体。
- 開口された上端と、開口又は閉口された下端とを有するホールが形成された基質(substrate)と、
前記ホールの内部面に当接して形成され、先端部を有する微細ルーム被膜構造と、を含む、微細ルームマイクロ構造体。 - (a)開口された上端と、開口又は閉口された下端とを有するホールが形成された基質(substrate)を製造する段階と、
(b)前記ホールの内部面に当接して形成され、先端部を有する微細ルーム被膜構造を製造する段階と、を含む、微細ルームマイクロ構造体の製造方法。 - 前記(b)段階前に、前記ホール内部に高分子組成物又は熱可塑性高分子粉末を充填させる段階をさらに含む、請求項10に記載の微細ルームマイクロ構造体の製造方法。
- 前記高分子組成物を充填させる場合、前記(b)段階で微細ルーム被膜構造の製造は、高分子組成物の溶媒を除去して行われる、請求項11に記載の微細ルームマイクロ構造体の製造方法。
- 前記熱可塑性高分子粉末を充填させる場合、前記(b)段階で微細ルーム被膜構造の製造は、熱可塑性高分子粉末に熱を加えて仮焼化した後、硬化させて行われる、請求項11に記載の微細ルームマイクロ構造体の製造方法。
- 前記(b)段階で先端部は、前記微細ルーム被膜構造の上部に形成された別途の高分子組成物に外向力(outward force)を印加して形成するか、前記微細ルーム被膜構造の上部に別途のマイクロ構造体をさらに結合して形成する、請求項10に記載の微細ルームマイクロ構造体の製造方法。
- (c)前記微細ルーム内に薬物を搭載する段階をさらに含む、請求項10に記載の微細ルームマイクロ構造体の製造方法。
- 前記薬物は、第2被膜構造により密封される、請求項16に記載の微細ルームマイクロ構造体の製造方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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KR20140181796 | 2014-12-16 | ||
KR10-2014-0181796 | 2014-12-16 | ||
PCT/KR2015/013826 WO2016099159A1 (ko) | 2014-12-16 | 2015-12-16 | 미세방 마이크로구조체 및 이의 제조방법 |
Publications (2)
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JP2018502684A true JP2018502684A (ja) | 2018-02-01 |
JP6622818B2 JP6622818B2 (ja) | 2019-12-18 |
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WO2020045933A1 (ko) * | 2018-08-28 | 2020-03-05 | 연세대학교 산학협력단 | 타공판 마이크로 구조체 모듈 |
WO2020153802A1 (ko) * | 2019-01-25 | 2020-07-30 | 주식회사 페로카 | 3층 이상 구조의 마이크로 니들 및 이의 제조방법 |
KR102235155B1 (ko) * | 2019-01-25 | 2021-04-02 | 주식회사 페로카 | 3층 이상 구조의 액체 주입형 마이크로 니들 및 이의 제조방법 |
KR102289566B1 (ko) * | 2019-03-08 | 2021-08-13 | 주식회사 페로카 | 고체형 약물을 포함하는 3층 이상 구조의 마이크로 니들 및 이의 제조방법 |
US20220176095A1 (en) * | 2019-03-08 | 2022-06-09 | Feroka Inc. | Microneedle having structure of three or more layers, and method for manufacturing same |
US20220177819A1 (en) * | 2019-03-12 | 2022-06-09 | MxT Biotech | Microfluidic system for intracellular delivery of materials and method therefor |
KR20220003800A (ko) * | 2020-07-02 | 2022-01-11 | 연세대학교 산학협력단 | 멀티 레이어 마이크로니들 구조체 및 이의 제조 방법 |
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JP2008069342A (ja) * | 2006-08-14 | 2008-03-27 | Sumitomo Electric Fine Polymer Inc | 生分解性樹脂複合体粉末からなる成形材料、成形品及びそれらの製造方法 |
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JP2010233674A (ja) * | 2009-03-30 | 2010-10-21 | Fujifilm Corp | マイクロニードルシート及びその使用方法並びに製造方法 |
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KR20160073337A (ko) | 2016-06-24 |
WO2016099159A1 (ko) | 2016-06-23 |
KR20170073581A (ko) | 2017-06-28 |
US10441545B2 (en) | 2019-10-15 |
CN107405476A (zh) | 2017-11-28 |
JP6622818B2 (ja) | 2019-12-18 |
KR101827739B1 (ko) | 2018-02-09 |
EP3235539B1 (en) | 2024-06-05 |
KR101853308B1 (ko) | 2018-04-30 |
EP3235539A1 (en) | 2017-10-25 |
US20170354610A1 (en) | 2017-12-14 |
EP3235539A4 (en) | 2018-07-18 |
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