WO2008093678A1 - ヒアルロニダーゼ阻害剤 - Google Patents

ヒアルロニダーゼ阻害剤 Download PDF

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Publication number
WO2008093678A1
WO2008093678A1 PCT/JP2008/051316 JP2008051316W WO2008093678A1 WO 2008093678 A1 WO2008093678 A1 WO 2008093678A1 JP 2008051316 W JP2008051316 W JP 2008051316W WO 2008093678 A1 WO2008093678 A1 WO 2008093678A1
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Prior art keywords
agent
hyaluronidase
skin
extract
active ingredient
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PCT/JP2008/051316
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English (en)
French (fr)
Inventor
Junji Tanaka
Hiroshi Shimoda
Hiromichi Murai
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Oryza Oil & Fat Chemical Co., Ltd.
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Publication date
Application filed by Oryza Oil & Fat Chemical Co., Ltd. filed Critical Oryza Oil & Fat Chemical Co., Ltd.
Priority to JP2008556111A priority Critical patent/JPWO2008093678A1/ja
Publication of WO2008093678A1 publication Critical patent/WO2008093678A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/64—Orobanchaceae (Broom-rape family)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Rheumatology (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Nutrition Science (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Saccharide Compounds (AREA)
  • Cosmetics (AREA)

Abstract

【課題】新規なヒアルロニダーゼ阻害活性剤及びそれらを含有する皮膚老化防止剤、抗炎症剤等を提供する。 【解決手段】本発明のヒアルロニダーゼ阻害剤は、フェニルエタノイド配糖体を有効成分として含有することを特徴とする。フェニルエタノイド配糖体としてはエキナコサイド及びアクテオサイドのうちの少なくとも１種を含有することが好ましい。また、本発明のヒアルロニダーゼ阻害剤は、ハマウツボ科の植物抽出物を有効成分とすることを特徴とする。ハマウツボ科の植物抽出物は、カンカニクジュヨウの茎由来抽出物であることが好ましい。上記ヒアルロニダーゼ阻害剤は、皮膚老化防止剤または抗炎症剤の有効成分としてヒトを含む哺乳類動物の医薬品、皮膚外用剤、飲食品、哺乳類動物用飼料に含有させることができる。
PCT/JP2008/051316 2007-01-29 2008-01-29 ヒアルロニダーゼ阻害剤 WO2008093678A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008556111A JPWO2008093678A1 (ja) 2007-01-29 2008-01-29 ヒアルロニダーゼ阻害剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-017502 2007-01-29
JP2007017502 2007-01-29

Publications (1)

Publication Number Publication Date
WO2008093678A1 true WO2008093678A1 (ja) 2008-08-07

Family

ID=39673987

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/051316 WO2008093678A1 (ja) 2007-01-29 2008-01-29 ヒアルロニダーゼ阻害剤

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JP (1) JPWO2008093678A1 (ja)
WO (1) WO2008093678A1 (ja)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008280271A (ja) * 2007-05-09 2008-11-20 Oriza Yuka Kk 皮膚光老化予防剤
JP2009091280A (ja) * 2007-10-05 2009-04-30 Pola Chem Ind Inc マトリックスメタロプロテアーゼ及びこれを含有する組成物
JP2009263279A (ja) * 2008-04-25 2009-11-12 Oriza Yuka Kk エラスターゼ阻害剤
JP2011102270A (ja) * 2009-11-11 2011-05-26 Rohto Pharmaceutical Co Ltd 抗糖化剤
CN102670436A (zh) * 2012-03-13 2012-09-19 珈侬生化科技(中国)有限公司 含管花肉苁蓉提取物的美白抗衰老化妆品及其制备方法
JP2016113460A (ja) * 2014-12-15 2016-06-23 ライオン株式会社 口腔用抗菌剤及び口腔用組成物
US9993509B2 (en) 2013-05-30 2018-06-12 Sinphar Pharmaceutical Co., Ltd. Method for regulating blood glucose level
JP2023145053A (ja) * 2022-03-28 2023-10-11 株式会社ナリス化粧品 ヒアルロニダーゼ阻害剤

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0648934A (ja) * 1992-06-02 1994-02-22 Sansho Seiyaku Co Ltd 皮膚外用剤
JPH06508601A (ja) * 1991-03-21 1994-09-29 パフューム クリスチャン ディオール 新規なコーヒー酸誘導体であるオラポシド、およびそれを含有する化粧品用組成物、又は薬剤用組成物、特に皮膚科学用組成物
JPH0797312A (ja) * 1993-09-29 1995-04-11 Pola Chem Ind Inc 化粧料
JPH07215834A (ja) * 1994-02-03 1995-08-15 Pola Chem Ind Inc 化粧料
JP2000128730A (ja) * 1998-10-28 2000-05-09 Ichimaru Pharcos Co Ltd 保湿性植物抽出物を含有する化粧料組成物
JP2003032966A (ja) * 2001-05-10 2003-01-31 Mitsuba Corp 電動モータ
JP2003238432A (ja) * 2002-02-15 2003-08-27 Fancl Corp ヒアルロン酸蓄積促進剤
JP2004250449A (ja) * 2003-02-18 2004-09-09 Sinphar Pharmaceutical Co Ltd 草本植物である、ハマウツボ科の全寄生植物［ｃｉｓｔａｎｃｈｅｔｕｂｕｌｏｓａ（ｓｃｈｅｎｋ．）ｗｉｇｈｔ］から抽出されるフェニルエタノイド配糖体を含む医薬調製物、これの製造方法およびこれの使用
JP2007191416A (ja) * 2006-01-18 2007-08-02 Univ Kinki カンカニクジュヨウの抽出物より得られる強壮剤又は強精剤、配糖体化合物及びそれらの用途

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06508601A (ja) * 1991-03-21 1994-09-29 パフューム クリスチャン ディオール 新規なコーヒー酸誘導体であるオラポシド、およびそれを含有する化粧品用組成物、又は薬剤用組成物、特に皮膚科学用組成物
JPH0648934A (ja) * 1992-06-02 1994-02-22 Sansho Seiyaku Co Ltd 皮膚外用剤
JPH0797312A (ja) * 1993-09-29 1995-04-11 Pola Chem Ind Inc 化粧料
JPH07215834A (ja) * 1994-02-03 1995-08-15 Pola Chem Ind Inc 化粧料
JP2000128730A (ja) * 1998-10-28 2000-05-09 Ichimaru Pharcos Co Ltd 保湿性植物抽出物を含有する化粧料組成物
JP2003032966A (ja) * 2001-05-10 2003-01-31 Mitsuba Corp 電動モータ
JP2003238432A (ja) * 2002-02-15 2003-08-27 Fancl Corp ヒアルロン酸蓄積促進剤
JP2004250449A (ja) * 2003-02-18 2004-09-09 Sinphar Pharmaceutical Co Ltd 草本植物である、ハマウツボ科の全寄生植物［ｃｉｓｔａｎｃｈｅｔｕｂｕｌｏｓａ（ｓｃｈｅｎｋ．）ｗｉｇｈｔ］から抽出されるフェニルエタノイド配糖体を含む医薬調製物、これの製造方法およびこれの使用
JP2007191416A (ja) * 2006-01-18 2007-08-02 Univ Kinki カンカニクジュヨウの抽出物より得られる強壮剤又は強精剤、配糖体化合物及びそれらの用途

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
NAKAMURA T. ET AL.: "Seizaichu de Kakunin ga Konnan na Shoyaku no Shihyo Seibun no Tansaku (second report): Shoyaku Seizai (Naiyo Ekizai) Chu no Cistanchis Herba no Shihyo Seibun", JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 120, no. 2, 2000, pages 238 - 243 *
ROUSSEAU B. ET AL.: "Investigation of anti-hyaluronidase treatment on vocal fold wound healing", JOURNAL OF VOICE: OFFICIAL JOURNAL OF THE VOICE FOUNDATION, vol. 20, no. 3, September 2006 (2006-09-01), pages 443 - 451, XP005603288, DOI: doi:10.1016/j.jvoice.2005.06.002 *
TAKEDA Y. ET AL.: "Chorogi Stachys sieboldi MIQ. no Haitotai Seibun to Sono Hyaluronidase Kassei ni Oyobosu Eikyo", JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, vol. 105, no. 10, 1985, pages 955 - 959 *
TAMURA Y. ET AL.: "Changes in the concentrations of bioactive compounds in plantain leaves", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 50, no. 9, 2002, pages 2514 - 2518 *

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008280271A (ja) * 2007-05-09 2008-11-20 Oriza Yuka Kk 皮膚光老化予防剤
JP2009091280A (ja) * 2007-10-05 2009-04-30 Pola Chem Ind Inc マトリックスメタロプロテアーゼ及びこれを含有する組成物
JP2009263279A (ja) * 2008-04-25 2009-11-12 Oriza Yuka Kk エラスターゼ阻害剤
JP2011102270A (ja) * 2009-11-11 2011-05-26 Rohto Pharmaceutical Co Ltd 抗糖化剤
CN102670436A (zh) * 2012-03-13 2012-09-19 珈侬生化科技(中国)有限公司 含管花肉苁蓉提取物的美白抗衰老化妆品及其制备方法
CN102670436B (zh) * 2012-03-13 2013-09-25 珈侬生化科技(中国)有限公司 含管花肉苁蓉提取物的美白抗衰老化妆品及其制备方法
US9993509B2 (en) 2013-05-30 2018-06-12 Sinphar Pharmaceutical Co., Ltd. Method for regulating blood glucose level
JP2016113460A (ja) * 2014-12-15 2016-06-23 ライオン株式会社 口腔用抗菌剤及び口腔用組成物
JP2023145053A (ja) * 2022-03-28 2023-10-11 株式会社ナリス化粧品 ヒアルロニダーゼ阻害剤
JP7395637B2 (ja) 2022-03-28 2023-12-11 株式会社ナリス化粧品 ヒアルロニダーゼ阻害剤

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