WO2008087884A1 - 薬物投与量の予測方法及びそのプログラム - Google Patents

薬物投与量の予測方法及びそのプログラム Download PDF

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Publication number
WO2008087884A1
WO2008087884A1 PCT/JP2008/050175 JP2008050175W WO2008087884A1 WO 2008087884 A1 WO2008087884 A1 WO 2008087884A1 JP 2008050175 W JP2008050175 W JP 2008050175W WO 2008087884 A1 WO2008087884 A1 WO 2008087884A1
Authority
WO
WIPO (PCT)
Prior art keywords
migration
membrane
amount
medicament ions
ion exchange
Prior art date
Application number
PCT/JP2008/050175
Other languages
English (en)
French (fr)
Inventor
Kentaro Kogure
Kaoru Kigasawa
Naoki Nakamura
Original Assignee
Tti Ellebeau, Inc.
National University Corporation Hokkaido University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tti Ellebeau, Inc., National University Corporation Hokkaido University filed Critical Tti Ellebeau, Inc.
Priority to JP2008554014A priority Critical patent/JPWO2008087884A1/ja
Publication of WO2008087884A1 publication Critical patent/WO2008087884A1/ja

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0444—Membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body

Abstract

【課題】　膜型イオントフォレーシス装置における薬物イオンの移行量を予測する。 【解決手段】　第１イオン交換膜を介して薬物イオンの投与を行う膜型イオントフォレーシス装置における薬物イオンの移行量Ｍを、膜型イオントフォレーシス装置を用い、第１イオン交換膜を生体皮膚に接触させない条件で電極への電圧の印加を行った場合の第１イオン交換膜から装置外部への薬物イオンの移行量Ｃと、所定濃度のリポソーム溶液と所定濃度の薬物イオンを含む薬液とを混合することにより生じる薬物イオンのリポソームへの移行量Ｒに基づいて予測する。
PCT/JP2008/050175 2007-01-16 2008-01-10 薬物投与量の予測方法及びそのプログラム WO2008087884A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2008554014A JPWO2008087884A1 (ja) 2007-01-16 2008-01-10 薬物投与量の予測方法及びそのプログラム

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-007328 2007-01-16
JP2007007328 2007-01-16
US88621007P 2007-01-23 2007-01-23
US60/886,210 2007-01-23

Publications (1)

Publication Number Publication Date
WO2008087884A1 true WO2008087884A1 (ja) 2008-07-24

Family

ID=39635888

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/JP2008/050175 WO2008087884A1 (ja) 2007-01-16 2008-01-10 薬物投与量の予測方法及びそのプログラム
PCT/US2008/051215 WO2008089273A2 (en) 2007-01-16 2008-01-16 Methods of predicting dose of drug and program for predicting dose of drug

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2008/051215 WO2008089273A2 (en) 2007-01-16 2008-01-16 Methods of predicting dose of drug and program for predicting dose of drug

Country Status (13)

Country Link
US (1) US7925520B2 (ja)
EP (1) EP2104531A2 (ja)
JP (1) JPWO2008087884A1 (ja)
KR (1) KR20100014764A (ja)
CN (1) CN101631588A (ja)
AU (1) AU2008206295A1 (ja)
BR (1) BRPI0806511A2 (ja)
CA (1) CA2672875A1 (ja)
IL (1) IL199865A0 (ja)
MX (1) MX2009007554A (ja)
NZ (1) NZ577718A (ja)
RU (1) RU2009131069A (ja)
WO (2) WO2008087884A1 (ja)

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* Cited by examiner, † Cited by third party
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EP2061553A2 (en) * 2006-09-05 2009-05-27 Tti Ellebeau, Inc. Impedance systems, devices and methods for evaluating iontophoretic properties of compounds
EP2061552A2 (en) * 2006-09-05 2009-05-27 Tti Ellebeau, Inc. Non-destructive systems, devices, and methods for evaluating iontophoresis drug delivery devices
CN102475683B (zh) * 2010-11-30 2013-10-30 沈阳药科大学 利用离子交换纤维制备具内外水相梯度差的脂质体及其应用
CN104383634A (zh) * 2014-12-09 2015-03-04 沈阳药科大学 一种经皮离子导入给药系统及其制备方法

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Also Published As

Publication number Publication date
AU2008206295A1 (en) 2008-07-24
US20080208106A1 (en) 2008-08-28
WO2008089273A2 (en) 2008-07-24
RU2009131069A (ru) 2011-02-27
NZ577718A (en) 2012-05-25
KR20100014764A (ko) 2010-02-11
US7925520B2 (en) 2011-04-12
BRPI0806511A2 (pt) 2011-09-13
IL199865A0 (en) 2010-04-15
JPWO2008087884A1 (ja) 2010-05-06
WO2008089273A3 (en) 2008-10-16
CN101631588A (zh) 2010-01-20
EP2104531A2 (en) 2009-09-30
MX2009007554A (es) 2009-10-13
CA2672875A1 (en) 2008-07-24

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