WO2008075878A1 - Composition alimentaire à utiliser en tant que substitut aux antibiotiques, à base d'inuline extraite d'artichaut de jérusalem - Google Patents

Composition alimentaire à utiliser en tant que substitut aux antibiotiques, à base d'inuline extraite d'artichaut de jérusalem Download PDF

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Publication number
WO2008075878A1
WO2008075878A1 PCT/KR2007/006634 KR2007006634W WO2008075878A1 WO 2008075878 A1 WO2008075878 A1 WO 2008075878A1 KR 2007006634 W KR2007006634 W KR 2007006634W WO 2008075878 A1 WO2008075878 A1 WO 2008075878A1
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WO
WIPO (PCT)
Prior art keywords
inulin
feed
inuloprebiotics
jerusalem artichoke
feed composition
Prior art date
Application number
PCT/KR2007/006634
Other languages
English (en)
Inventor
Duk Hwan Son
Byung Sung Park
Hwan Ku Kang
Gyum Heon Kim
Original Assignee
Taehwa Forage And Feed Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taehwa Forage And Feed Co., Ltd filed Critical Taehwa Forage And Feed Co., Ltd
Publication of WO2008075878A1 publication Critical patent/WO2008075878A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/163—Sugars; Polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
    • A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
    • A23L33/24—Cellulose or derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to a feed additive for use as a substitute for antibiotics, which contains inulin extracted from Jerusalem artichoke, and more particularly, to feed composition as a substitute for antibiotics, which contains an inuloprebiotics, which is prepared by mixing inulin, extracted from Jerusalem artichoke, with an excipient.
  • Antibiotics have been primarily used for the prevention and treatment of diseases, but the use of antibiotics as antibacterial growth promoters in feed is being gradually prohibited. Thus, there is a need to develop novel materials, which are natural materials and, at the same time, have the effect of killing harmful bacteria, like antibiotics.
  • inulin which is composed of polysaccharides and accounts for more than 50% of Jerusalem artichoke.
  • Said inulin are fructose polymers linked by /3-2,1 bonds with the chemical structure of a non-reducing terminal ⁇ -2,1 glucosidic bond.
  • inulin is not degraded by gastric juice and digestive enzymes of human beings and livestock, more than about 80% of inulin reaches the large intestine and is fermented by intestinal microorganisms, and it has a bifidogenic effect of selectively stimulating the growth of bifidobacteria, known as beneficial intestinal microorganisms, and at the same time, inhibiting the i growth of harmful microorganisms.
  • bifidobacteria known as beneficial intestinal microorganisms
  • inulin has been reported to have the effects of alleviating obesity, promoting bowel movement, reducing blood insulin and neutral lipid levels and inhibiting the development of colon cancer.
  • inulin consisting of 2-
  • FOS fructo-oligosaccharide
  • Prebiotics are novel materials receiving attention as feed additives and functional food materials capable of substituting for probiotics and antibiotics.
  • the term "prebiotics” refers to non-degradable dietary indegredients, which are not degraded in the stomach and the small intestine and move into the large intestine to selectively stimulate the growth of microorganisms such as bifidobacterium bifidum in the colon or stimulate a limited number of microorganisms, thus providing a beneficial effect to human beings and livestock.
  • Such prebiotics microbiologically produce nutrients, such as antibiotics, vitamins and growth promoting factors, in the large intestine, to improve gastrointestinal functions, increase the bioavailability of minerals and the amount of feces, prevent diarrhea, and enhance immune functions, thus promoting the growth of animals (Cummings, et ah, Brit. J. Nutr., 87:S145, 2002; Patterson et al., Poult. ScL, 82:627, 2003; George et al., Brit. Med. J., 318:999, 1999).
  • the present inventors have made many efforts to develop a feed additive for use as a substitute for antibiotics and, as a result, have prepared an inuloprebiotics-containing feed additive as a substitute for antibiotics using inulin extracted from Jerusalem artichoke, and have found that, when the feed additive is fed to livestock, it has a bifidogenic effect of inhibiting the growth of harmful microorganisms in the intestines, thereby completing the present invention.
  • the present invention provides an antibiotic-free feed composition, which comprises an inuloprebiotics containing 100 parts by weight of an excipient selected from the group consisting of barley bran, wheat middling, limestone powder, and maize powder; and 0.05-10 parts by weight of inulin extracted from Jerusalem artichoke.
  • the present invention provides a method for raising livestock, which comprises feeding said feed composition to livestock.
  • FIG. 1 shows a comparison of the growth curves of Bifidobacterium bifidum in an inulin- containing medium and an inulin-free medium.
  • FIG. 2 shows a comparison of the growth curves of Clostridium perfringens in an inulin-containing medium and an inulin-free medium.
  • inuloprebiotics which is a feed additive for use as a substitute for antibiotics
  • 0.05-10 parts by weight of inulin, extracted from Jerusalem artichoke was mixed with 100 parts by weight of barley bran which is an excipient.
  • the prepared inuloprebiotics were added to feed in an amount of 0.1-0.5 parts by weight based on 100 parts by weight of the feed, thus preparing a feed composition. It was observed that, when the feed composition was fed to animals, it had the effect of substituting for antibiotics.
  • Example 1 Inulin extraction
  • Jerusalem artichoke was washed, crushed or cut thinly, and steamed in an autoclave for 30 minutes.
  • the steamed Jerusalem artichoke was mixed with water (80 "C) at a ratio of 1 ::5 and, and the mixture was stirred for 20 minutes.
  • the stirred mixture solution was filtered through cotton cloth, and the filtrate was centrifuged at 3,000 rpm. The precipitate was collected and dried, thus extracting inulin.
  • Example 1 Using the inulin extracted in Example 1, the growth rates of Bifidobacterium bifidum, known as typical beneficial intestinal bacteria, and Clostridium perfringens, known as harmful bacteria, were measured in liquid media. For this purpose, in a microbial culture medium containing 0.5 wt% of said inulin, Bifidobacterium bifidum and Clostridium perfringens were incubated at 37 ° C for 48 hours. The growth rates of the microorganisms were measured by comparing the OD value of the bacteria, grown in an inulin-free liquid medium, with the OD value of the bacteria grown in the inulin-containing liquid medium.
  • the case of using the microbial culture medium containing 0.5 wt% of inulin showed the effect of promoting the growth of Bifidobacterium bifidum after 15 hours from the start of the incubation, unlike the case of using the inulin-free culture medium.
  • the case of using microbial culture medium containing 0.5 wt% of inulin showed the effect of inhibiting the growth of the Clostridium perfringens strain after 15 hours from the start of the incubation. This suggests that the Jerusalem artichoke- derived inulin had the "prebiotic" effect of promoting the growth of Bifidobacteria.
  • Example 3 Optimum content of inulin in inuloprebiotics
  • broilers Chicken hatchery, Korea
  • 5 groups x 4 repeat pens (25 broilers/replication and fed with starter feed (Heungsung Feed Corp.,
  • Example 1 The inulin obtained in Example 1 was added to 1 kg of barely bran in various amounts of 25 g, 50 g, 75 g and 100 g to prepare inuloprebiotics, 0.3 wt% of which were then added to compound feed (containing feed additives, including antibiotics, probiotics, enzymes, vitamins and minerals, at the highest levels), thus preparing test feed samples.
  • compound feed containing feed additives, including antibiotics, probiotics, enzymes, vitamins and minerals, at the highest levels
  • test feed containing feed additives, including antibiotics, probiotics, enzymes, vitamins and minerals, at the highest levels
  • the group treated with the inuloprebiotics containing 50 g of inulin per kg of barley bran showed increases in body weight, feed efficiency and the number of Bifidobacterium bifidum bacteria, and showed a decrease in the number (CFU log 10/kg) of harmful E. coli bacteria in the cecum (p ⁇ 0.05).
  • the number of microorganisms in the ceca of the groups treated with the inuloprebiotics containing inulin in amounts of 75 g and 100 g, respectively, did not show a difference from that of the group treated with the inuloprebiotics containing 50 g of inulin.
  • Table 1 Change in growth rate (0-35 days) and number of cecal microorganisms of broilers at various levels of inuloprebiotics addition
  • Inuloprebiotics inulin g/kg excipient
  • Example 3 Based on the results of Example 3 above, an inuloprebiotics containing 1 kg of an excipient and 50 g of inulin was prepared. 500 broilers (Chicken hatchery, Korea) were divided into 5 groups x 4 repeat pens (25 broilers/replication) and fed with starter feed (Heungsung Feed Corp., Korea) for 3 days. Then, the above-prepared inuloprebiotics (50 g of inulin per kg of barley bran) was added to compound feed in amounts of 0.1 wt%, 0.2 wt% and 0.3 wt%, thus preparing test feed samples. The feed samples were compared with a control sample and a sample containing commercial antibiotics.
  • 500 broilers Chicken hatchery, Korea
  • starter feed Heungsung Feed Corp., Korea
  • the animals were raised in an animal farm, Kangwon National University, to a market age of 35 days, while the growth rate thereof was examined, and the number of microorganisms in the cecal contents and the blood immunoglobulin (IgG) level of the animals were measured in the Lipid Medical Biotechnology Laboratory, College of Animal Life Science, Kangwon National University).
  • IgG blood immunoglobulin
  • the feed intake and the blood IgG level were not significantly different between all the test groups, and the weight, the feed efficiency, the number (CFU log 10/kg) of beneficial Bifidobacterium bifidum bacteria in the cecum, and the number (CFU log 10/kg) of harmful E. coli bacteria in the cecum, were not significantly different between the control group and the group treated with 0.1 wt% of the inuloprebiotics.
  • Inuloprebiotics inulin g/kg excipient
  • the present invention provides an antibiotic-free feed composition, which comprises an inuloprebiotics containing inulin extracted from Jerusalem artichoke.
  • antibiotic-free meat can be produced by raising healthy livestock without using antibiotics.

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Birds (AREA)
  • Health & Medical Sciences (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Nutrition Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Fodder In General (AREA)

Abstract

La présente invention concerne un additif alimentaire à utiliser en tant que substitut aux antibiotiques, qui contient de l'inuline extraite d'artichaut de Jérusalem. L'invention concerne plus particulièrement une composition alimentaire sans antibiotiques qui contient un inuloprébiotique préparé par mélange d'inuline extraite d'artichaut de Jérusalem à un excipient.
PCT/KR2007/006634 2006-12-21 2007-12-18 Composition alimentaire à utiliser en tant que substitut aux antibiotiques, à base d'inuline extraite d'artichaut de jérusalem WO2008075878A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20060132077 2006-12-21
KR10-2006-0132077 2006-12-21

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WO2008075878A1 true WO2008075878A1 (fr) 2008-06-26

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PCT/KR2007/006634 WO2008075878A1 (fr) 2006-12-21 2007-12-18 Composition alimentaire à utiliser en tant que substitut aux antibiotiques, à base d'inuline extraite d'artichaut de jérusalem

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010092661A1 (fr) 2009-02-10 2010-08-19 トヨタ自動車株式会社 Mécanisme de transmission à variation continue et boîte de vitesses utilisant un mécanisme de transmission à variation continue

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0850569B1 (fr) * 1996-12-24 2000-07-12 Societe Des Produits Nestle S.A. Produit céréalier gélatinisé contenant un ologisaccharide
US20050281910A1 (en) * 1999-09-22 2005-12-22 Eduardo Schiffrin Method for increasing pet activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0850569B1 (fr) * 1996-12-24 2000-07-12 Societe Des Produits Nestle S.A. Produit céréalier gélatinisé contenant un ologisaccharide
US20050281910A1 (en) * 1999-09-22 2005-12-22 Eduardo Schiffrin Method for increasing pet activity

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010092661A1 (fr) 2009-02-10 2010-08-19 トヨタ自動車株式会社 Mécanisme de transmission à variation continue et boîte de vitesses utilisant un mécanisme de transmission à variation continue
CN102216653A (zh) * 2009-02-10 2011-10-12 丰田自动车株式会社 无级变速机构以及使用该无级变速机构的变速器

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