WO2008051925A2 - Seringues de mélange à mouvement alternatif - Google Patents

Seringues de mélange à mouvement alternatif Download PDF

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Publication number
WO2008051925A2
WO2008051925A2 PCT/US2007/082125 US2007082125W WO2008051925A2 WO 2008051925 A2 WO2008051925 A2 WO 2008051925A2 US 2007082125 W US2007082125 W US 2007082125W WO 2008051925 A2 WO2008051925 A2 WO 2008051925A2
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WO
WIPO (PCT)
Prior art keywords
syringe
mixing
syringes
barrel
reciprocating
Prior art date
Application number
PCT/US2007/082125
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English (en)
Other versions
WO2008051925A3 (fr
Inventor
Wilmer L. Sibbitt, Jr.
Randy R. Sibbitt
Original Assignee
Sibbitt Wilmer L Jr
Sibbitt Randy R
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sibbitt Wilmer L Jr, Sibbitt Randy R filed Critical Sibbitt Wilmer L Jr
Publication of WO2008051925A2 publication Critical patent/WO2008051925A2/fr
Publication of WO2008051925A3 publication Critical patent/WO2008051925A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/19—Syringes having more than one chamber, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3128—Incorporating one-way valves, e.g. pressure-relief or non-return valves

Definitions

  • the present invention relates to syringes used to mix two components (which could be liquids, gels, solids, powders, gases, or any combination thereof) in fixed or variable amounts, and then after mixing, to inject or extrude the mixture (mixed components) specifically for the field of diagnostic, therapeutic, or preventive medicine, nursing, or pharmacy.
  • two components which could be liquids, gels, solids, powders, gases, or any combination thereof
  • inject or extrude the mixture specifically for the field of diagnostic, therapeutic, or preventive medicine, nursing, or pharmacy.
  • each syringe alternates from being completely full to completely empty, and the plungers of each syringe alternatively go up and down, that is, they reversibly reciprocate with each other being forced to do so by the mixture moving from syringe to syringe.
  • this configuration of syringes defines reciprocating mixing syringes.
  • Reciprocating mixing syringes which are a form of double barrel syringe, differ considerably from single barrel mixing syringes which mix the two components by moving the compound through different chambers within the single barrel and plunger or have a rotating mixing device within the barrel.
  • US Patents 3411503, 3477431 , 3570486, 946732, 4031892, 4049999, 4153057, 4159570, 4254768, 4464174, 3724077, 3 881484, 3760503, 3889674, 4041945, 41 16240, and 3815878 describe such single barrel mixing syringes.
  • Reciprocating mixing syringes also differ from fixed proportion distal mixing syringes which are also double barrel mixing syringes.
  • fixed proportion distal mixing syringes the mixing occurs outside the syringe barrels, generally in a distal mixing chamber.
  • the individual components remain pure within their individual syringe barrels and only mix when simultaneous injected from their barrels and then they only mix outside the syringes themselves.
  • the plungers do not reciprocate, rather the two plungers always move in the same direction and do not move in a reversible fashion.
  • US Patent 3767085 describes this type of distal mixing syringe with two barrels where the plungers move simultaneously in the same direction and the two components mix in a mixing chamber distal to the barrels themselves and the plungers do not reciprocate with one another.
  • Reciprocating mixing syringes are also different than double barrel injection or aspiration syringes that permit successive, simultaneous, or intermittent aspiration or injection. These devices do not move fluid from one barrel to the other, nor do the plungers reversibly reciprocate with one another.
  • Reciprocating mixing syringes are also different from reciprocating syringes.
  • Reciprocating syringes are also double barrel syringes which reversibly reciprocate and with appropriate stopcocks or valves could be used for mixing.
  • the plungers on reciprocating syringes are mechanically bound together by a mechanical reciprocating mechanism, so that unlike reciprocating mixing syringes which only reciprocate when the mixture is forced from one syringe barrel to the other, the plungers on reciprocating syringes actively reciprocate with each other whether there is mixture in the syringe or not.
  • the mechanical reciprocating mechanism is a pulley, gear, or hydraulic link between the two plungers.
  • stopcocks present right angle or oppositely collinear orientations as in US patent and patent applications 6418966B, 6457488 B2, 4101 113, 6607179 B2, 7033339 B1 , 7047994 B2, 2005/0043668 A1 , and D483,497.
  • These configurations are difficult to forcefully mix with a reciprocating mixing syringe because the two syringes and plungers are held awkwardly at 90° or 180° which are extremely nonergonomic and tend to put severe mechanical stress on the stopcock and syringes and then are difficult to rotate the stopcock and inject.
  • this mixing syringe is a fully integrated device, the syringes are not connected by a stopcock, but rather a valve, the syringes are not removable, and specifically a gel and liquid are intended to be prepackaged in the syringes.
  • the configuration of the finger flanges is at 90° to the two plungers causes severe interference between the plungers and fingers whether operated with either one or two hands. This is contrasted to the other double barrel syringes mentioned above that have the finger flanges collinear with the common axis of the two plungers which does not cause this type of severe negative interaction.
  • US Patent 4313440 describes a double barrel mixing syringe but the barrels are not parallel, but rather collinear - one is inside the other.
  • US Patent 3,411 ,503 Collapsible mixing syringe with extrusion casing. Santomleri, LS. Nov 19, 1968; US Patent 3,477,431. Combined mixing syringe and container. Walecka LE. Nov 11 , 1969; US Patent 3,570,486. Mixing syringe. Engelsher HJ. Mar 16, 1971 ; US Patent 3,724,077. Mixing syringe. Leonard A. Preston, Seymour J.shriver.
  • Needle-loading mulitiople barrel syringe George Kozam, Pat Romanelli. May 3, 1983; US Patent 4,464,174. Two compartment mixing syringe seal. James Ennis. Aug7, 1984; US Patent 5,445,614. Pharmaceutical storage and mixing syringe. Terry M. Haber, William H. Smedly, Clark B. Foster. Aug 29, 1995; US Patent 5,810,773. Mixing arrangement and method. Lesley Pensnicak Sep.22, 1998; US Patent 6,418,966B. Stopcock for intravenous injections and infusion and direct of flow of fluids and gases. George Loo JuI. 16, 2002; US Patent 6,457,488 B2. Stopcock having axial port for syringe twist actuation.
  • Rotatable stopcock for a male coupling having a 9OD offset connecting piece Erminio Moretti, Gilles Perrin. Aug 19, 2003; US 7,033,339 B1. Seal sealing luer receiving stopcock. Lawrence A. Lynn. Apr. 25, 2006; US 7, 047,994 B2. Stopcocks and methods of manufacture thereof. Thomas M. McPeak, John K. Moon May 23, 2006; US 2005/0043668 A1. Three-way stopcock, and liquid transfusion circuit for blood transfustion circuit either using the three way stopcock. Takehiko Yuki Feb 24, 2005; US D483,497 S Stopcock device. Weston F. Harding, Lawrence A.
  • the present invention provides methods and apparatuses that are suitable for mixing two components, and that do not suffer from the drawbacks of previous approaches described above.
  • the present invention provides a double barrel reciprocating mixing syringe that is ergonomic and in its various embodiments permits mixing of solids, powders, pastes, colloids
  • gels gases, and liquids with other solids, powders, pastes, colloids (gels), gases, and liquids, including substances of minimal or significant viscosity.
  • the present invention also provides methods for introducing substances into the various barrels, mixing these substances in a reciprocating fashion, and then injecting or extruding the mixture.
  • the present invention also provides components and methods for making the double barrel reciprocating syringe out of conventional syringes and components, which can markedly decrease the cost of manufacture of the device and permits the individual syringes to be removed and attached to introduce substances to be mixed or to remove the syringe and inject the mixture directly.
  • the present invention also provides integrated double barrel mixing syringes.
  • Figure 1 is a schematic illustration of a reciprocating mixing syringe according to the present invention.
  • Figure 2 is a schematic illustration of a reciprocating mixing syringe according to the present invention.
  • Figure 3 is a schematic illustration of a frame for a reciprocating mixing syringe according to the present invention.
  • Figure 4 is a schematic illustration of a reciprocating mixing syringe according to the present invention.
  • Figure 5 is a schematic illustration of a reciprocating mixing syringe according to the present invention.
  • Figure 6 is a schematic illustration of potential connector (in this case stopcocks) configurations for a reciprocating mixing syringe according to the present invention.
  • Figure 7 s a schematic illustration of a frame for a reciprocating mixing syringe according to the present invention.
  • Figure 8 is a schematic illustration of a reciprocating mixing syringe according to the present invention.
  • Figure 9 is a schematic illustration of a frame for a reciprocating mixing syringe according to the present invention.
  • Figure 10 is a schematic illustration of a reciprocating mixing syringe according to the present invention.
  • Figure 11 is a schematic illustration of a reciprocating mixing syringe according to the present invention.
  • Figure 12 is a schematic illustration of a reciprocating mixing syringe according to the present invention.
  • the present invention provides apparatuses and methods for making double barrel reciprocating mixing syringes and for achieving mixing of two components and injecting or extruding the mixture.
  • FIG. 1 is a schematic illustration of an example reciprocating mixing syringe according to the present invention, which example embodiment accommodates Luer-lock or other screw fittings.
  • This example embodiment of the reciprocating mixing syringe is suited, for example, for mixing air and saline for a bubble study for echocardiography or other imaging modality, but can be used also to make sclerosing form, resuspend lyophilized drugs, mix two fluids, mix a fluid and a gel, mix a power and fluid, and many other mixing combinations.
  • this embodiment can be a prefilled two component syringe where the two components are mixed directly before use.
  • This example reciprocating mixing syringe can be used with one or two hands.
  • a frame 101 into which the Luer-lock (or other screw fitting) syringes are inserted, holds two syringes firmly so that they do not stress the inter-syringe connector which in this case is a stopcock 103 that permits the syringes to reside in a parallel, substantially parallel, or non-right angle configuration (between 89° and -11 °); the parallel configuration in the figure being 0°.
  • Finger flanges 102 of the frame permit substantial force to be applied to the mixing syringe body and plungers, and can be oriented at a substantially collinear position to the axis between the center of the two plungers so that the flanges do not permit the plungers to interfere with each other and the thumb as the syringes are cycled.
  • a connector 103 (in this example case a stopcock) permits connection between the two barrels.
  • a female fitting 104 of the connector in this example a stopcock has a female Luer fitting (or other female fitting).
  • the stopcock can have a handle 105, with a lumen of the stopcock 106, and a male needle fitting 107 (e.g., Luer lock or other screw fitting) of the connector (stopcock).
  • Syringe A 108 can be a Luer-lock or other screw fitting syringe and Syringe B 109 can be a second Luer-lock or other screw fitting syringe.
  • Syringe A 108 can be rotated off the female fitting and removed and filled partially with one component to be mixed and reattached to the female fitting 104 of the connector (stopcock);
  • Syringe B 109 can also be removed and filled partially with the second component to be mixed and reattached to the other female fitting.
  • the lumen 106 of the connector (stopcock) 103 is then moved (stopcock handle 105 rotated in this example) so that the lumen 106 is open to both barrels.
  • the plunger of syringe A 108 is then depressed forcing the first component to move through the connector into the barrel of syringe B 109 and to mix with the second component residing in the barrel of syringe B 109, forcing the plunger of syringe B 109 outward. This is the first half-cycle of the reciprocating mixing syringe.
  • the full cycle is completed when the plunger of syringe B 109 is depressed forcing the mixture back into the barrel of syringe A 108, forcing the plunger of syringe A 108 to push out of the barrel.
  • the two plungers reciprocate with each other.
  • Multiple full or partial cycles can be completed until the mixture is adequately homogeneous or mature, and fully resides in only one of the syringes.
  • the lumen 106 of the connector can be rotated using the handle 105, so that only one of the syringes is directly connected to the needle fitting 107 by way of the connector 103 lumen.
  • the mixture can then be forced out of the full syringe by depressing the plunger, moving the mixture through the connector and into and out of the needle fitting 107.
  • the syringe full of the mixture can be removed and the mixture directly injected using the full syringe.
  • This configuration can be desirable, as an example, for use with extremely viscous materials where a Luer lumen might be too narrow for efficient mixing and larger, nonconventional lumen diameters can be required.
  • Figure 2 is a schematic illustration of an example reciprocating mixing syringe according to the present invention, and in particular a version that accommodates Luer-lock or other screw fittings. It is similar to the version in Figure 1 , except that the frame 201 and connector 203 seat the syringes in a non-parallel fashion (between 89° and -11 °), that can have improved ergonomics for some applications, as an example for 2 handed mixing.
  • Figure 3 is a schematic illustration of a frame for a reciprocating mixing syringe according to the present invention.
  • a connector 31 1 stopcock in this case
  • has female screw fittings 312 Luer in this case).
  • a frame 313 accommodates two syringes, and has finger flanges 314 that are collinear with the common axis of the plungers, and provides columnar or partially columnar seating 315 for the syringes that prevent excessive motion in the syringes and prevent excessive stress in the connector fitting 312.
  • This type of frame permits conventional screw fitting (Luer-lock) syringes to be used to construct the reciprocating mixing syringe which can decrease production costs.
  • Figure 4 is a schematic illustration of an example reciprocating mixing syringe according to the present invention.
  • the example embodiment of Figure 4 comprises a much-reduced frame 417 and reduced seatings 418 for the screw fitting (Luer-lock in this example) syringes, but retain the connector 416 (in this case a stopcock).
  • This embodiment can be less bulky than other example embodiments, but makes use of the smaller finger flanges of the conventional syringes, which can make this embodiment less stable and more difficult to use with one hand, and which can make it more difficult to mix very viscous materials and pastes.
  • FIG. 5 is a schematic illustration of an example embodiment of a reciprocating mixing syringe according to the present invention.
  • This example embodiment comprises the connector 519 (in this case a stopcock) and syringes with screw fittings 520 (in this case Luer- lock). It can be less stable than the other example embodiments, but has very little bulk and the connector can be provided separately.
  • FIG. 6 is a schematic illustration of several example connector (in this case stopcocks) configurations for a reciprocating mixing syringe according to the present invention.
  • these connectors When engaged with their respective syringes, these connectors permit the syringes to orient themselves at non-right angle configurations ranging from between 89° and -10°, with configurations 70° and 0° being preferred for many applications.
  • the connectors generally are desired to (1 ) permit movement of material and fluids between syringe A and syringe B, and (2) to permit the two syringes to reside in a angular configuration to each other as described above, between 89° and -10°.
  • An example connector 621 (stopcock) with a 120° lumen and female fittings provides the desired configuration of the syringes to each other in the syringe A open to syringe B but closed to the needle fitting position position.
  • the same connector 622 can be configured in the syringe A open to the needle fitting position but closed to syringe B.
  • the same connector 623 can be configured in the syringe B open to needle fitting but both closed to syringe A.
  • a similar connector 624 can ne reinforced to permit greater forces across the connector.
  • An alternative right angled 2-way stopcock connector 625 provides syringe A open to syringe B, syringe B open to the needle fitting, but does not permit syringe A open to the needle fitting.
  • a similar right angle 3-way stopcock 626 connector of the same configuration can permit all possible connector possibilities, but can make mixing and injection mistakes more likely.
  • FIG. 7 is a schematic illustration of an example frame for a reciprocating mixing syringe according to the present invention.
  • a double barrel mixing syringe 727 comprising a rigid U-tube connector or a pressure resistant flexible tubing connector with female fittings to accommodate pressure screw (or Luer-lock) fittings.
  • FIG. 8 is a schematic illustration of an example embodiment of a reciprocating mixing syringe according to the present invention.
  • This embodiment incorporates a non-screw fitting syringe (Luer slip in this case).
  • a frame 828 into which the Luer slip (or other non-screw fitting) syringes are inserted hold the syringes firmly so that they do not stress the inter-syringe connector, which in this example is a stopcock 830 that permits the syringes to reside in a parallel, substantially parallel, or non-right angle configuration (between 89° and -10°), the parallel configuration illustrated being about 0°.
  • a finger flange 829 of the frame permits substantial force to be applied to the mixing syringe body and plungers, and is oriented substantially parallel to the common axis between the two plungers so that the flanges do not permit the plungers to interfere with each other and the thumb as the syringes are cycled.
  • a connector 830 (in this case a stopcock) permits connection between the two barrels.
  • a female fitting 831 of the connector in this case a stopcock
  • the stopcock has a handle 832 and a lumen 833, and a male needle fitting 834 (Luer lock or other screw fitting).
  • Syringe A 835 is a Luer-slip or other non-screw fitting syringe and Syringe B 836 is a second Luer-slip or other non-screw fitting syringe.
  • Syringe A 835 can be pulled off the female fitting, pulled out of the frame, and removed and filled partially with one component to be mixed and reattached to the female fitting of the connector 830 (stopcock) and fitted back into the frame 828;
  • syringe B 836 can also be removed and filled partially with the second component to be mixed and reattached to the other female fitting and fitted back into the frame.
  • the syringe full of the mixture can be removed and the mixture directly injected using the full syringe.
  • FIG. 8 is a schematic illustration of an example frame for a reciprocating mixing syringe according to the present invention.
  • a connector (stopcock in this case) 938 has female fittings 939 (Luer in this case).
  • a frame 937 accommodates two syringes, and has finger flanges 940, and seatings 941 for two Luer slip syringes, which seatings prevent excessive motion in the syringes and prevent excessive stress in the connector fitting 939.
  • the syringes can be inserted from the side, into the seatings 941 for the syringe barrel and the seatings 942 for the syringe finger flanges and plungers for the Luer-slip syringes.
  • This type of frame permits conventional non-screw fitting (Luer-Slip in this case) syringes to be used to construct the reciprocating mixing syringe that can decrease production costs.
  • Figure 10 is a schematic illustration of an example embodiment of a reciprocating mixing syringe according to the present invention.
  • the lumen of a needle fitting and the lumen of a connector can provide too much resistance, for example in the mixing of pastes, gels, and high viscosity substances.
  • Figure 10 demonstrates an embodiment that facilitates the mixing of pastes, hydrated particles, and high viscosity mixtures.
  • substance A can be placed in one syringe and substance B can be placed in the other syringe.
  • An example configuration is shown in Figure 10.
  • a screw or high pressure fitting 43 mounts with syringe A 44 with a barrel and plunger, and syringe B 45 with barrel and plunger and with a needle fitting with a plug or stopcock or without a needle fitting (shown without a needle fitting), with a fistula 46 or connection or lumen between barrel A and barrel B with or without a rupturable membrane over the fistula or a valve, and a plunger lock 47.
  • plunger B can be completely depressed, forcing the mixture into syringe A.
  • the plunger lock 47 can be placed 48 on the plunger and barrel of syringe B restricting motion of plunger B.
  • a valve can be used to close the fistula between the two syringes.
  • the Luer plug can be removed, or the stopcock opened, and the mixture injected or extruded out of syringe A by depressing plunger A.
  • This device can be produced using two conventional syringe barrels, making a fistula as shown, with or without a membrane or a valve and connecting the two barrels together by welding, gluing, or fittings.
  • the device can be injection molded in one piece.
  • it can reside in a frame as previously shown in other embodiments with or without a stopcock.
  • a rupturable membrane over the fistula permits the two components to be prefilled and separated, until force is applied on one of the plungers rupturing the membrane and permitting mixing.
  • An open-close valve at the fistula can also function in this way.
  • mating irreversible dentates can be present on the plunger and barrel of syringe B, or mating devices on the stopper and needle fitting of syringe B, or an engagable screw on the plunger and barrel of syringe B to accomplish the same locking of the plunger.
  • FIG 11 is a schematic illustration of an example embodiment of a reciprocating mixing syringe according to the present invention.
  • a screw or high pressure fitting 50 mounts with syringe A 51 with a barrel and plunger, syringe B 52 with barrel and plunger and with a needle fitting with a plug or without a needle fitting (shown without a needle fitting).
  • a fistula 53 or connection or lumen is between barrel A and barrel B with our without a rupturable membrane over the fistula, and a large stopper 54 than can obstruct the fistula.
  • plunger B can be completely depressed, forcing the mixture into syringe A.
  • the large stopper 55 closes the fistula completely.
  • the Luer plug is then removed and the mixture injected or extruded out of the syringe by depressing plunger A.
  • FIG 12 is a schematic illustration of an example embodiment of a reciprocating mixing syringe according to the present invention.
  • This embodiment replaces the two conventional syringes described in connection with other example embodiments with two reciprocating syringes.
  • the plungers on reciprocating syringes are mechanically bound together by a mechanical reciprocating mechanism, so the plungers on reciprocating syringes actively reciprocate with each other whether there is mixture in the syringe or not.
  • the mechanical reciprocating mechanism is a pulley, gear, or hydraulic link between the two plungers.
  • the large plunger of syringe A is pushed with the right thumb (generating pressure in barrel A while the smaller plunger of syringe B is pushed with the left thumb (generating vacuum in barrel B).
  • This can create a larger pressure differential between barrel A and barrel B than can be achieved with an individual non-reciprocating syringe.
  • the small plunger of syringe A is pushed with the right thumb (generating vacuum) while the larger plunger of syringe B is pushed with the left thumb (generating pressure).
  • the other example embodiments can similarly have reciprocating syringes replace one or both of the conventional syringes and realize the advantage of increasing the pressure differential which makes mixing easier with less muscle fatigue.
  • embodiments of the reciprocating mixing syringe made with individual reciprocating syringes can be less desirable for a bubble study (gas-liquid mixture) because the vacuum part of the cycle can tend to make the bubbles larger and they tend to coalesce which is undesirable.
  • embodiments of a reciprocating mixing syringe made with reciprocating syringes can be more desirable for mixing for high viscosity substances or large volumes because the pressure differential is greater and mixing is accomplished with less muscle exertion. Mixing biological gels, pastes, polymers, cements, bone fillers or large volume mixing are typical examples where this embodiment employing individual reciprocating syringes can be desirable.
  • the devices described herein can be constructed and assembled from individual components, or can be injection molded in one or only a few components.
  • the devices can be formed from construction materials such as plastic, polymers, metal, and glass or combinations of these materials with appropriate biologically compatible lubricants and surface treatments as is known to the art.
  • Reciprocating mixing syringes according to the present invention can be used for mixing a gas and a liquid which can be used for a bubble study in echocardiography, ultrasound, magnetic resonance imaging, computed tomography, and other diagnostic imaging.
  • Reciprocating mixing syringes according to the present invention can be used for mixing other contrast media for echocardiography, ultrasound, magnetic resonance imaging, computed tomography, and other diagnostic imaging.
  • Reciprocating mixing syringes can be used for mixing a gas and a liquid for creating therapeutic sclerosing foams (for vascular ablation), antimicrobial foams for wound care, organic and protein foams, surfactant foams, and foam polymers.
  • Reciprocating mixing syringes according to the present invention can be used for mixing two liquids, a liquid and a gel, or two gels as a two-component drug that has a short-half life, or that must be diluted, or that must be activated.
  • Reciprocating mixing syringes according to the present invention can be used for making hydrophobic-hydrophilic emulsions, micelles, or other lipid-aqueous fine suspensions and emulsions.
  • Reciprocating mixing syringes can be used for hydrating and mixing collagen, proteins, coagulant proteins, anticoagulant proteins, carbohydrates, complex biological combination compounds, fillers, synthetic and non-synthetic and mixtures to create solutions, emulsions, suspensions, pastes, gels, and soft solids for to treat bone defects, wounds, cosmetic defects, and other medical applications.
  • Reciprocating mixing syringes according to the present invention can be used mixing a powder, a solid, or a paste with a liquid especially for the purpose of medical treatment.
  • Reciprocating mixing syringes according to the present invention can be used for hydrating and suspending embolic particles to be used to treat vascular abnormalities, hemorrhage, tumors, and cosmetic defects.
  • Reciprocating mixing syringes can be used to resuspend or mix living cells (blood cells, bone marrow cells, transplant cells, etc) with each other or a solution or gel or other processing or therapeutic modality.
  • Reciprocating mixing syringes according to the present invention can be used to mix polymers, glues, and cements.
  • Reciprocating mixing syringes according to the present invention can also be used for non-mixing purposes including intermittent injection and aspiration of individual drugs and/or aspiration of body fluids during medical syringe procedures including arthrocentesis, amniocentesis, thoracentesis, pericardiocentesis, anesthesia, and injection of other therapeutic agents.
  • Reciprocating mixing syringes according to the present invention can be prefilled with the components to be mixed.
  • the particular sizes and equipment discussed above are cited merely to illustrate particular embodiments of the invention. It is contemplated that the use of the invention can involve components having different sizes and characteristics. It is intended that the scope of the invention be defined by the claims appended hereto.

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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Infusion, Injection, And Reservoir Apparatuses (AREA)
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Abstract

L'invention concerne des appareils à seringues de mélange à mouvement alternatif et des procédés adaptés à l'utilisation, par exemple, pour mélanger deux composants et pour distribuer le mélange produit. Les appareils à seringues de mélange à mouvement alternatif comprennent des seringues à deux composants avec des corps et des plongeurs respectifs reliés entre eux de sorte que deux composants à mélanger et le mélange obtenu puissent être alors déplacés de manière réversible entre les deux chambres des seringues. Pendant ce processus, les plongeurs des seringues sont animés d'un mouvement de va et vient. Les deux corps de seringue sont orientés physiquement l'un par rapport à l'autre suivant des angles compris entre 89° et -10° pour permettre un accès ergonomique, et disposent de brides à doigts orientées de manière à empêcher une interaction défavorable entre les deux plongeurs et les doigts. La connexion entre les deux seringues comprend un tube, un robinet d'arrêt, une valve ou une fistule. Les seringues peuvent être logées dans un cadre, être intégrées au cadre, ou être reliées l'une à l'autre uniquement par le connecteur. Le dispositif doit être utilisé principalement pour des applications médicales, dentaires, d'infirmerie et pharmaceutiques.
PCT/US2007/082125 2006-10-23 2007-10-22 Seringues de mélange à mouvement alternatif WO2008051925A2 (fr)

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US60/853,713 2006-10-23

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Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110184357A1 (en) * 2010-01-22 2011-07-28 Kci Licensing, Inc. Devices, systems, and methods for instillation of foamed fluid with negative pressure wound therapy
WO2011143560A1 (fr) * 2010-05-13 2011-11-17 Ethicon Endo-Surgery, Inc. Instrument de débridement d'un tissu et d'application de cellules thérapeutiques
WO2012167003A2 (fr) * 2011-06-02 2012-12-06 32304.96 Patent Trust Interventions chirurgicales orales et nasales multiples, procédé et trousse
WO2013188931A1 (fr) * 2012-06-20 2013-12-27 Vermeylen Jan Gustaaf M Récipient rempli d'un anesthésique local et procédé de préparation d'un mélange constitué d'un anesthésique local et d'un second liquide
US8647115B2 (en) 2009-02-13 2014-02-11 3M Innovative Properties Company Syringes for dispensing multi-component material
WO2016073764A1 (fr) * 2014-11-05 2016-05-12 National Jewish Health Dispositif et procédé pour faciliter une pleurodèse pour la gestion de drainage de fluide
EP3003428A4 (fr) * 2013-06-05 2017-05-31 The Regents of the University of California Système d'obturation sous pression à base d'hydrogel
WO2018107126A1 (fr) * 2016-12-08 2018-06-14 Blackswan Vascular, Inc. Dispositifs, systèmes et procédés d'embolisation de lumières corporelles
CN108303663A (zh) * 2018-01-23 2018-07-20 中国科学院电工研究所无锡分所 一种双气隙开放式磁共振成像磁体
CN108489780A (zh) * 2018-03-02 2018-09-04 中国科学院深海科学与工程研究所 一种用于高压下进行化学固定的装置
KR101909255B1 (ko) 2017-09-08 2018-10-17 주식회사 삼양바이오팜 실란트 실린지 어셈블리
KR101909259B1 (ko) 2017-09-08 2018-10-17 주식회사 삼양바이오팜 실란트 실린지 어셈블리
CN109332059A (zh) * 2018-11-29 2019-02-15 华南理工大学 一种全自动智能高分子材料胶体涂覆系统及方法
CN109984772A (zh) * 2019-05-20 2019-07-09 广东省人民医院(广东省医学科学院) 一种左心造影检查装置
EP3435889A4 (fr) * 2016-04-27 2020-01-01 Vanderbilt University Système et méthode de recherche de fuites après une anastomose
CN111991629A (zh) * 2020-09-02 2020-11-27 刘军光 一种胃肠外科用胃肠液减压装置
US20210015964A1 (en) * 2019-07-18 2021-01-21 United Health Products, Inc. Method of forming and using a hemostatic hydrocolloid
FR3109318A1 (fr) * 2020-04-15 2021-10-22 Syrengy Seringue d’injection
US20220001112A1 (en) * 2020-05-29 2022-01-06 Windgap Medical, Inc. Dynamic mixing and delivery system for mixing a therapeutic agent in an injector or autoinjector
CN115770212A (zh) * 2022-11-24 2023-03-10 杭州德柯医疗科技有限公司 载有消融剂的可注射型凝胶组合物及其制备方法
WO2023150544A1 (fr) * 2022-02-01 2023-08-10 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Méthode simplifiée de préparation de cellules pour administration à un patient
US11771841B2 (en) 2020-12-23 2023-10-03 Tolmar International Limited Systems and methods for mixing syringe valve assemblies
WO2024044402A1 (fr) * 2022-08-26 2024-02-29 Georgia Tech Research Corporation Micro-aiguille de perfusion multicanal
USD1029245S1 (en) 2022-06-22 2024-05-28 Tolmar International Limited Syringe connector

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US8647115B2 (en) 2009-02-13 2014-02-11 3M Innovative Properties Company Syringes for dispensing multi-component material
US20110184357A1 (en) * 2010-01-22 2011-07-28 Kci Licensing, Inc. Devices, systems, and methods for instillation of foamed fluid with negative pressure wound therapy
US10918527B2 (en) 2010-01-22 2021-02-16 Kci Licensing, Inc. Devices, systems, and methods for instillation of foamed fluid with negative pressure wound therapy
US9974693B2 (en) * 2010-01-22 2018-05-22 Kci Licensing, Inc. Devices, systems, and methods for instillation of foamed fluid with negative pressure wound therapy
WO2011143560A1 (fr) * 2010-05-13 2011-11-17 Ethicon Endo-Surgery, Inc. Instrument de débridement d'un tissu et d'application de cellules thérapeutiques
US8702644B2 (en) 2010-05-13 2014-04-22 Ethicon Endo-Surgery, Inc. Instrument for debriding tissue and applying therapeutic cells
WO2012167003A2 (fr) * 2011-06-02 2012-12-06 32304.96 Patent Trust Interventions chirurgicales orales et nasales multiples, procédé et trousse
WO2012167003A3 (fr) * 2011-06-02 2013-03-14 32304.96 Patent Trust Interventions chirurgicales orales et nasales multiples, procédé et trousse
WO2013188931A1 (fr) * 2012-06-20 2013-12-27 Vermeylen Jan Gustaaf M Récipient rempli d'un anesthésique local et procédé de préparation d'un mélange constitué d'un anesthésique local et d'un second liquide
BE1020761A3 (nl) * 2012-06-20 2014-04-01 Jan Gustaaf M Vermeylen Houder gevuld met een lokaal anestheticum en werkwijze om een mengsel van een lokaal anestheticum met een tweede vloeistof aan te maken.
EP3003428A4 (fr) * 2013-06-05 2017-05-31 The Regents of the University of California Système d'obturation sous pression à base d'hydrogel
WO2016073764A1 (fr) * 2014-11-05 2016-05-12 National Jewish Health Dispositif et procédé pour faciliter une pleurodèse pour la gestion de drainage de fluide
US11452481B2 (en) 2016-04-27 2022-09-27 Vanderbilt University System and method of testing for leaks after anastomosis
EP3435889A4 (fr) * 2016-04-27 2020-01-01 Vanderbilt University Système et méthode de recherche de fuites après une anastomose
WO2018107126A1 (fr) * 2016-12-08 2018-06-14 Blackswan Vascular, Inc. Dispositifs, systèmes et procédés d'embolisation de lumières corporelles
KR101909255B1 (ko) 2017-09-08 2018-10-17 주식회사 삼양바이오팜 실란트 실린지 어셈블리
KR101909259B1 (ko) 2017-09-08 2018-10-17 주식회사 삼양바이오팜 실란트 실린지 어셈블리
CN108303663A (zh) * 2018-01-23 2018-07-20 中国科学院电工研究所无锡分所 一种双气隙开放式磁共振成像磁体
CN108489780A (zh) * 2018-03-02 2018-09-04 中国科学院深海科学与工程研究所 一种用于高压下进行化学固定的装置
CN109332059A (zh) * 2018-11-29 2019-02-15 华南理工大学 一种全自动智能高分子材料胶体涂覆系统及方法
CN109984772A (zh) * 2019-05-20 2019-07-09 广东省人民医院(广东省医学科学院) 一种左心造影检查装置
WO2021011940A1 (fr) * 2019-07-18 2021-01-21 United Health Products, Inc. Méthode de formation et d'utilisation d'un hydrocolloïde hémostatique
US20210015964A1 (en) * 2019-07-18 2021-01-21 United Health Products, Inc. Method of forming and using a hemostatic hydrocolloid
FR3109318A1 (fr) * 2020-04-15 2021-10-22 Syrengy Seringue d’injection
EP4157403A4 (fr) * 2020-05-29 2024-01-10 Windgap Medical Inc Système de mélange et de distribution dynamique pour mélanger un agent thérapeutique dans un injecteur ou un auto-injecteur
US20220001112A1 (en) * 2020-05-29 2022-01-06 Windgap Medical, Inc. Dynamic mixing and delivery system for mixing a therapeutic agent in an injector or autoinjector
CN111991629A (zh) * 2020-09-02 2020-11-27 刘军光 一种胃肠外科用胃肠液减压装置
US11771841B2 (en) 2020-12-23 2023-10-03 Tolmar International Limited Systems and methods for mixing syringe valve assemblies
US11931559B2 (en) 2020-12-23 2024-03-19 Tolmar International Limited Systems and methods for mixing syringe valve assemblies
WO2023150544A1 (fr) * 2022-02-01 2023-08-10 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Méthode simplifiée de préparation de cellules pour administration à un patient
USD1029245S1 (en) 2022-06-22 2024-05-28 Tolmar International Limited Syringe connector
WO2024044402A1 (fr) * 2022-08-26 2024-02-29 Georgia Tech Research Corporation Micro-aiguille de perfusion multicanal
CN115770212A (zh) * 2022-11-24 2023-03-10 杭州德柯医疗科技有限公司 载有消融剂的可注射型凝胶组合物及其制备方法

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