WO2008041045A1 - Récipient à chambres multiples pour la production et la distribution de mousse de dioxyde de carbone, procédé de production et utilisation de ladite mousse - Google Patents

Récipient à chambres multiples pour la production et la distribution de mousse de dioxyde de carbone, procédé de production et utilisation de ladite mousse Download PDF

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Publication number
WO2008041045A1
WO2008041045A1 PCT/HU2006/000113 HU2006000113W WO2008041045A1 WO 2008041045 A1 WO2008041045 A1 WO 2008041045A1 HU 2006000113 W HU2006000113 W HU 2006000113W WO 2008041045 A1 WO2008041045 A1 WO 2008041045A1
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WO
WIPO (PCT)
Prior art keywords
container
carbon dioxide
compartment
foam
carbonate
Prior art date
Application number
PCT/HU2006/000113
Other languages
English (en)
Inventor
István Piller
Original Assignee
Piller Istvan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Piller Istvan filed Critical Piller Istvan
Publication of WO2008041045A1 publication Critical patent/WO2008041045A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/046—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/22—Gas releasing
    • A61K2800/222—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/88—Two- or multipart kits

Definitions

  • the invention relates to a two-compartment container providing stable carbon dioxide foam, and by the help of this a process for production of carbon dioxide foam from two components on a skin surface. These two components fusing on the skin surface form carbon dioxide where this carbon dioxide takes on the form of stable foam in consequence of the delaying and stabilizing effect of the present surface-active
  • the invention further relates to a process for using the foam to cause vasodilatation in the subcutaneous tissues from cosmetic and/or therapeutic aim.
  • HU 220349 and HU 1974729 Hungarian patents relate to possibilities of domestic application of the carbon dioxide baths according to which carbon dioxide is introduced to the domestic bath water from a container or a siphon cartridge available in the trade.
  • U 3015 Hungarian utility model is connected with the gas chamber ("mofette") treatment which gives a solution for gas chamber treatment with carbon dioxide gas; this consists of a house applied around a part of body into which the carbon dioxide can be introduced from outside, from a gas cylinder.
  • mofette effect which is the basis of the solution of the present invention, too
  • a lot of literary data can be found on address http://hu.wikipedia.org.wiki/Mofetta.
  • a Hungarian patent application filed on N° P9000163 and published on N° 58649 deals with the insufflating treatment and its instrument; its essence is an insufflating treatment by a needle from which itself the sterile carbon dioxide gas originates from reagents of suitable composition and of suitable quality.
  • the present invention is classed among the above specified forms into the category of "direct topical intake of the carbon dioxide gas through skin”. It can really be considered as a sub-category of the solution of "staying in a room containing carbon dioxide gas” but this solution deviates in that from the other solution that it deals with carbon dioxide treatment of smaller parts of body or skin surfaces instead of the exposure of the whole body or bigger parts of body to the carbon dioxide gas.
  • Patent document US 2003/0139696 makes known an in situ applicable pillow by the help of which it is possible to place serious wounds under carbon dioxide pressure.
  • the role of the carbon dioxide is to press tightly the wound to avoid the loss of blood.
  • Both the aim (to guarantee pressure) and the technical execution (e.g. providing carbon dioxide from cylinder and using closed bandage) deviate from the solution of the present invention.
  • the essence according to the solution of the present invention is, however, that the carbon dioxide gas is formed in the skin surface in such manner that two components, staying in a two-compartment container where one of the compartments contains some kind of preferably sterile acid and the other compartment contains some kind of preferably sterile carbonate or hydrogen carbonate, are pressed out together from the container, they combine together in the skin surface and step into reaction here with each other.
  • the toxicological and microbiological quality of the carbon dioxide can be guaranteed with the purity of the starting acid and carbonate and by possible sterilising to the desired extent.
  • the surface-active materials (detergents) also placed in one or both container compartment guarantee that the formation of the carbon dioxide should be retarded and the formed foam should be preserved at least as long as the formed carbon dioxide exposes its therapeutic (vasodilator) effect under the skin surface. For this aim 5-10 minutes is sufficient, and this period can be guaranteed with the stable foam.
  • the foam containing carbon dioxide is able to give that minimal pressure surplus which facilitates the penetration of the carbon dioxide into the skin.
  • the present invention is based on the employment of the carbon dioxide gas directly evolving by the double decomposition reaction.
  • the already activating chemical reaction is maintained by the continuously releasing water on the basis of the following reaction: CO 3 " + 2H + -» CO 2 + H 2 O
  • reaction partners to be found in the foam-forming mixture is not too essential; it is important only that at the meeting of the reaction partners and the water carbon dioxide of suitable amount should be formed.
  • the conditions are the same as in the case of effervescent tablets, powders or granules based on similar reaction, although the point of views of the selection are not exactly the same.
  • the main thing is that the formed ions should not be caustic, toxic or bad-tasting (rather should be good to the taste, respectively), in the present situation the main point of view is that the generating ions should not exercise caustic or toxic influence to the skin; the point of views of flavour does not play role here.
  • the calcium carbonate can be advantageous not only from point of view of the costs but from the point of views of optionally necessary retardation of the foam-forming, since the generation of the carbon dioxide gas is relatively slow from the calcium carbonate granules. It is inevitably necessary to take into consideration at the selection of the ingredients that the ingredients should be able to get across the opening of a feeding equipment. Of course, it is possible to draw up reversely: such feeding equipment should be employed which fits to the physicochemical properties of the given advantageous mixture.
  • a container (bottle, tube, flacon and the like) which is provided with a separation wall and suitable dosing equipment. Its function is to receive acidic and carbonate ingredients, respectively, and foam-forming surface-active (detergent) materials, further ingredients and optionally different pharmacons, respectively, and it have to able to place the different materials onto the skin surface in a suitable proportion by the help of a suitably formed dosing equipment from the two container compartments; Neither the empty container itself nor the dosing equipment itself nor their formation constitutes the subject-matter of the invention; every solution is applicable which is able to perform the above functions.
  • the dosing equipment has not to be a complicated construction.
  • the dosing equipment e.g. can be a dosing equipment which can be screwed onto the container.
  • the outflow of the material is provided by the pressure, mainly hand-power pressure applied onto the container.
  • an extrusive roll can provide the getting out from the two container compartments in suitable proportion.
  • the formation of the two-compartment container can be solved in various ways.
  • One of the solutions can be that the separation wall is formed in advance from the container's material.
  • a bag made from some kind of plastic, preferably a polyalkylene, first of all polyethylene, can be placed into a suitable container. This is a suitable solution first of all for that reason since it is not necessary to modify the production technique of a very cheaply available container, only a filling have to be used into it.
  • the main point of view is that this equipment should be able to dispatch the materials from both container compartment in the in advance suitably adjusted proportion taking into consideration the physical condition (consistency, grain size and the like) of the individual materials (material compositions). Consequently at the selection of the two-compartment container and its dosing equipment the main point of views are the fitting to the components, the steady convej ⁇ ng of the materials as well as economic point of views.
  • Figure 1 is a section of a scheme of a possible execution example.
  • Figure 1 makes known schematically a possible solution to a suitable container.
  • the device outlined in Figure 1. is an elastic- walled 1 container (bottle, flacon) which is divided into two parts with a 2 separation wall and is supplied with a 5 dosing equipment which represents an elastic-walled compressible material.
  • the figure shows the 3 and 4 container compartments of 1 container supplied the 2 separation wall, the 6 lower closing valve, the 7 outer closing valve and the 8 outlet opening.
  • the surface-active materials (detergents) providing the foam formation and foam stability promote both the stability of the foam and necessary delaying or maybe accelerating the evolution of the carbon dioxide.
  • these materials can be sodium lauryl sulphate, triethanolamine, polysorbates (e.g. Polysorbate 20) and sterols e.g. cholesterol.
  • Delaying and accelerating the chemical reaction depends on the hydrophilic-hydrophilic combination of the ingredients. The most retarded reaction takes place in the lipophilic-lipophilic suspension combination of the materials in the two 3, 4 container compartments. The quickest reaction can be realized by the mixture of the hydrophilic-hydrophilic combination containing dissolved carbonates.
  • cosmetic basic materials which form the suitable consistence of the preparation (cream, shampoo and other cosmetic preparations) in the condition after disappearance of the formed foam.
  • These preparations i.e. should not be removed after leaving of the carbon dioxide but they can remain on the skin surface as cosmetics.
  • To these ingredients examples can be - without the intention of limitation - cetyl alcohol stearate, glycerine, methyl cellulose, vaseline, solid and/or liquid paraffin, white wax, castor oil, gelatine, xanthan gum, etc., but the water itself, too.
  • the pharmacons intensifying the healing power intensify the healing power of the preparation first of all in that 5-10 minutes until the carbon dioxide gas performs its vasodilator effect but also after removing the carbon dioxide together with the cosmetics actually as a part of the cosmetics.
  • the pharmacons being in question can move in a wide domain depending in the given therapeutic field; e.g. preparations recommendable to the treatment of locomotor's diseases can contain volatile oils, e.g. the volatile oils of camomile, eucalyptus and Scotch fir, but they can contain also capsaicin, camphor, menthol and methyl salicylate.
  • the acid and the carbonate should not get into the same compartment.
  • the solution that which of the further ingredients (detergents providing foam formation and foam stability, cosmetic basic materials, pharmacons intensifying healing power) gets into the acidic compartment and which of the further ingredients gets into the carbonate compartment, is decided only according to technological advantages (compatibility, the ease of getting out). It is imaginable, too, that individual ingredients can be found both in the 3 container compartment and the 4 container compartment, if this solution has a technological advantage.
  • a filled two-compartment 1 container flacon, flask, bottle, tube
  • container contains in its 3 container compartment an acid of suitable amount and its other 4 container compartment some kind of carbonate or hydrogen carbonate, it contains further in its 3 container compartment or in its 4 container compartment or in both 3, 4 container compartments surface-active materials (detergents), cosmetic basic materials and optionally different pharmacons.
  • the filled two-compartment 1 container is provided with such a 5 dosing equipment which guarantees that the ingredients should get from two 3, 4 container compartments to the selected surface, in this situation to skin surface, in an in advance adjusted proportion.
  • the said filled 1 container have to satisfy the following point of views:
  • the filling into the bottles and the closing of the bottle with the 5 dosing equipment is a well mechanized technology having almost century-old tradition.
  • the employment of the filled 1 container as a product is accomplishable easily by simple pushing a button.
  • the filled 1 container as a product is strong and firm, well storable and maintainable for a long time without quality deterioration since the ingredients being in the individual 3, 4 container compartments are not able to react with each other within the container compartment.
  • the said product however, can be » produced from cheap basic materials and by an established technology.
  • the 1 container- filled with the said ingredients and suitable for forming stable foam is not only new but it can become to a product producible cheaply and saleable well in trade.
  • the filling of the elastic-walled, two-compartment 1 containers, tubes does not imply technological problem, neither, since there are available established technologies for this aim, too.
  • Another subject-matter of the present invention is the production of a preparation including stable foam containing carbon dioxide gas for causing vasodilatation under the skin.
  • the evolving carbon dioxide gas should quickly reach to the skin surface from the site of the reaction; • the carbon dioxide gas should be in contact uniformly and continuously with the skin surface; • it is necessary that the carbon dioxide gas should evolve permanently at least during 5-10 minutes;
  • the instrument providing carbon dioxide here the preparation itself originating on the skin surface and including stable foam containing carbon dioxide gas.
  • the originating carbon dioxide gas has not to "reach" the surface of skin, either, since it originates there. For the same reason the uniform, continuous contact is guaranteed with the skin surface.
  • the stability of the foam guarantees that minimal pressure surplus compared to the atmospheric pressure which promotes the penetration of the carbon dioxide into the skin.
  • the foam containing carbon dioxide gas is suitable as a- vasodilator preparation from every point of view. Its production is easily realisable by the help of the two-compartment 1 container which is the previous subject- ⁇ matter of the invention.
  • the carbon dioxide gas prepared on this way does not contain the (first of all pyrogenic) impurities of the industrial carbon dioxide gas; the purity of the gas can be guaranteed according to the demands by the suitable purity of the reaction partners fmdable in granules or powder; by their sterilization, however, it is possible to guarantee the sterility of the gas if necessary.
  • a further subject-matter of the invention is the use of the foam containing carbon- dioxide gas for causing vasodilatation in the tissues to be found under skin.
  • the penetration of the carbon dioxide under skin surface causes vasodilatation.
  • the penetration of the carbon dioxide is promoted by the stable foam according to the invention during the necessary 5-10 minutes
  • the stable foam containing carbon dioxide can be taken up to the selected skin surfaces and only to the selected skin surfaces, by the help of this solution the skin surface to be treated can be well surrounded. This is especially advantageous where the forwarding the carbon dioxide is realizable by other means only with serious difficulties as e.g. on the hairy on non-hairy scalp, but this preparation can be utilized every other treatable skin surface, too.
  • the stable foam containing carbon dioxide gas can occur e.g. in massaging ("warming") creams used by sportsmen, in preparations used on surfaces requiring physiotherapy, in cosmetic products (e.g. face-packs) and the like.
  • the application consists in that the stable foam containing carbon dioxide and prepared on the way introduced previously is carried up to the selected areas (surfaces) where the carbon dioxide to be found in the foam displays its vasodilator effect under the skin surface during 5-10 minutes.
  • the question whether the foam containing carbon dioxide should be carried up in what thickness onto the surface to be treated is very difficult to be decided since it strongly depend on the nature of the ingredients. The essence is that this thickness of layer should guarantee the penetration of the carbon dioxide gas for 5- 10 minutes. After leaving the carbon dioxide gas the preparation can remain on the skin surface and can display its further therapeutic- and cosmetic effect.
  • Example 1 Filled two-compartment container as a commercial product for preparing a stable shampoo containing carbon dioxide gas
  • the above prescription relates to 1000 g of product; the concrete amount is decided depending on whether the two-compartment 1 container putting on the market has what dimension. The proportions of the ingredients, however, are acceptable at whatever dimension, consequently at this packaging of 300 g, too.
  • the two-compartment 1 container is supplied with a suitable 5 dosing equipment.
  • the 5 dosing equipment indicates such a solution which can be opened by pressing down an usual springy closing valve.
  • An expanded spring moves the piston placed at the end of 1 container which empties uniformly the content of the two 3, 4 container compartments.
  • the product obtained in this manner and being able to put into the trade is the subject-matter of the invention.
  • Example 2 Filled two-compartment container as a commercial product for preparing massaging ("warming") sport cream containing carbon dioxide
  • a two-compartment, elastic-walled 1 container (tube) of 200 millilitre available in the trade is filled. Into the two 3, 4 container compartments the followings are fed:
  • the above prescription relates to 1000 g of product, the concrete amount is decided depending on whether what dimension has the two-compartment 1 container putting on the market.
  • the proportions of the ingredients are acceptable at whatever dimension, consequently at this tube of 200 ml, too.
  • the material can be helped to get out by manual pressure from the tube, from the two 3, 4 container compartments.
  • the product obtained in this manner is the subject-matter of the invention.
  • Example 3 Process for production of a medicinal shampoo including stable foam containing carbon dioxide on a skin surface to be treated
  • the ingredients from the 3, 4 container compartments of the two-compartment 1 container introduced in Example 1. are helped onto the hairy skin (scalp) surface to get out in a suitable amount in thickness of layer of 2-3 centimetres by the help of the 5 dosing equipment by pressing the 9 press-button of the 5 dosing equipment, where the ingredients stepping into reaction form carbon dioxide gas, this causes vasodilatation during 5-10 minutes in the venous network under the skin. After leaving of the carbon dioxide it is not necessary to wash down the shampoo immediately from the hairy scalp but it is possible to leave on it until it is reasonable according to the therapeutic and/or cosmetic effect.
  • Example 4 Process for the production of a massaging (“warming") cream including stable foam containing carbon dioxide on a skin surface to be treated
  • the ingredients from the 3, 4 container compartments of the two-compartment 1 container (tube) introduced in Example 2 are helped onto the skin surface covering a group of muscles to be massaged to get out in a suitable amount in thickness of layer of 1,5 - 2 centimetres by manual pressure of the 10 side wall; these ingredients stepping into reaction form carbon dioxide which causes vasodilatation during 5-10 minutes in the venous network under the skin. After leaving of the carbon dioxide it is not necessary to wash down the cream immediately from the covered skin surface but it is possible to leave on it until it is reasonable according to the therapeutic and/or cosmetic effect.
  • the group of muscles prepared by the dilatation of the blood vessels can be effectively massaged.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne un récipient à deux compartiments remplis fournissant une mousse de dioxyde de carbone. L'invention se caractérise en ce que l'un des compartiments (3) contient un acide et l'autre compartiment (4) contient un carbonate ou un carbonate d'hydrogène. En outre, le récipient contient également (dans au moins l'un des compartiments (3)) un matériau tensioactif (détergeant), des matériaux de bases cosmétiques, de l'eau et éventuellement des produits pharmaceutiques. La libération des ingrédients sur une surface donnée, de préférence la peau, est facilitée par le biais de l'équipement de dosage (5). L'invention concerne également un procédé de préparation d'une composition de mousse contenant du gaz carbonique.
PCT/HU2006/000113 2006-10-06 2006-12-15 Récipient à chambres multiples pour la production et la distribution de mousse de dioxyde de carbone, procédé de production et utilisation de ladite mousse WO2008041045A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP-06-00765 2006-10-06
HU0600765A HUP0600765A2 (en) 2006-10-06 2006-10-06 Container for stable carbondioxide foam, process for producing stable carbondioxide foam and method for using of foam

Publications (1)

Publication Number Publication Date
WO2008041045A1 true WO2008041045A1 (fr) 2008-04-10

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PCT/HU2006/000113 WO2008041045A1 (fr) 2006-10-06 2006-12-15 Récipient à chambres multiples pour la production et la distribution de mousse de dioxyde de carbone, procédé de production et utilisation de ladite mousse

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HU (1) HUP0600765A2 (fr)
WO (1) WO2008041045A1 (fr)

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DE102008029357A1 (de) * 2008-06-20 2009-12-24 Schwan-Stabilo Cosmetics Gmbh & Co. Kg Schäumende kosmetische Zubereitung
CN102764478A (zh) * 2011-05-04 2012-11-07 抛罗根有限公司 使用泡腾片剂用于美容护理的装置和方法
US8343945B2 (en) 2007-12-07 2013-01-01 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
US8362091B2 (en) 2003-08-04 2013-01-29 Foamix Ltd. Foamable vehicle and pharmaceutical compositions thereof
US8435498B2 (en) 2002-10-25 2013-05-07 Foamix Ltd. Penetrating pharmaceutical foam
US8486374B2 (en) 2003-08-04 2013-07-16 Foamix Ltd. Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses
US8486376B2 (en) 2002-10-25 2013-07-16 Foamix Ltd. Moisturizing foam containing lanolin
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US8512718B2 (en) 2000-07-03 2013-08-20 Foamix Ltd. Pharmaceutical composition for topical application
US8518376B2 (en) 2007-12-07 2013-08-27 Foamix Ltd. Oil-based foamable carriers and formulations
US8518378B2 (en) 2003-08-04 2013-08-27 Foamix Ltd. Oleaginous pharmaceutical and cosmetic foam
US8618081B2 (en) 2009-10-02 2013-12-31 Foamix Ltd. Compositions, gels and foams with rheology modulators and uses thereof
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
WO2013096425A3 (fr) * 2011-12-19 2014-03-27 Colgate-Palmolive Company Système d'activation de liquide
US8709385B2 (en) 2008-01-14 2014-04-29 Foamix Ltd. Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
US8722021B2 (en) 2002-10-25 2014-05-13 Foamix Ltd. Foamable carriers
US8795635B2 (en) 2006-11-14 2014-08-05 Foamix Ltd. Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
US8795693B2 (en) 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US8900554B2 (en) 2002-10-25 2014-12-02 Foamix Pharmaceuticals Ltd. Foamable composition and uses thereof
US8978936B2 (en) 2010-07-12 2015-03-17 Foamix Pharmaceuticals Ltd. Apparatus and method for releasing a unit dose of content from a container
US9072667B2 (en) 2009-07-29 2015-07-07 Foamix Pharmaceuticals Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
US9167813B2 (en) 2009-07-29 2015-10-27 Foamix Pharmaceuticals Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
EP2886625A4 (fr) * 2012-08-16 2016-01-20 Toyo Aerosol Ind Co Produit aérosol de formation de mousse
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US9320705B2 (en) 2002-10-25 2016-04-26 Foamix Pharmaceuticals Ltd. Sensation modifying topical composition foam
US9439857B2 (en) 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
US9516877B2 (en) 2012-03-30 2016-12-13 Gojo Industries, Inc. Antimicrobial alcohol foam compositions and methods of preparation
US9539208B2 (en) 2002-10-25 2017-01-10 Foamix Pharmaceuticals Ltd. Foam prepared from nanoemulsions and uses
US9622947B2 (en) 2002-10-25 2017-04-18 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
US9884017B2 (en) 2009-04-28 2018-02-06 Foamix Pharmaceuticals Ltd. Foamable vehicles and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
WO2019025115A1 (fr) * 2017-08-02 2019-02-07 Beiersdorf Ag Produit cosmétique pour le nettoyage du visage
US10398641B2 (en) 2016-09-08 2019-09-03 Foamix Pharmaceuticals Ltd. Compositions and methods for treating rosacea and acne

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