WO2008027541A2 - Compositions, procédés et articles commerciaux de soins capillaires capables de donner plus de volume et d'épaisseur aux cheveux - Google Patents

Compositions, procédés et articles commerciaux de soins capillaires capables de donner plus de volume et d'épaisseur aux cheveux Download PDF

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Publication number
WO2008027541A2
WO2008027541A2 PCT/US2007/019180 US2007019180W WO2008027541A2 WO 2008027541 A2 WO2008027541 A2 WO 2008027541A2 US 2007019180 W US2007019180 W US 2007019180W WO 2008027541 A2 WO2008027541 A2 WO 2008027541A2
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WIPO (PCT)
Prior art keywords
hair
thicker
fuller
appearance
compound
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PCT/US2007/019180
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English (en)
Other versions
WO2008027541A3 (fr
Inventor
Thomas Larry Dawson, Jr.
John Erich Oblong
Robert Scott Youngquist
Sancai Xie
David Joseph Eickhoff
Original Assignee
The Procter & Gamble Company
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Publication date
Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company
Priority to MX2009001927A priority Critical patent/MX2009001927A/es
Priority to CN2007800325514A priority patent/CN101511331B/zh
Priority to MX2013009336A priority patent/MX347443B/es
Priority to AU2007290406A priority patent/AU2007290406A1/en
Priority to EP07837604.3A priority patent/EP2056783B1/fr
Priority to JP2009523870A priority patent/JP2009545633A/ja
Priority to BRPI0715932-3A2A priority patent/BRPI0715932A2/pt
Publication of WO2008027541A2 publication Critical patent/WO2008027541A2/fr
Publication of WO2008027541A3 publication Critical patent/WO2008027541A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/002—Preparations for repairing the hair, e.g. hair cure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A61Q7/02—Preparations for inhibiting or slowing hair growth
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06Q—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
    • G06Q30/00—Commerce
    • G06Q30/02—Marketing; Price estimation or determination; Fundraising
    • G06Q30/0207—Discounts or incentives, e.g. coupons or rebates
    • G06Q30/0225—Avoiding frauds

Definitions

  • the present invention relates to hair care compositions, methods, and articles of commerce that can increase the appearance of thicker and/or fuller hair.
  • the present invention also relates to methods of marketing such compositions.
  • the present invention relates to hair care compositions, methods, and articles of commerce that can help increase the appearance of fuller and/or thicker of hair, thus resulting in younger-looking hair, by increasing the diameter of hair shafts and follicles.
  • the invention also relates to methods of marketing.
  • a method comprises topically applying a hair care composition comprising an effective amount of a hair growth inhibiting agent to the scalp and/or face (e.g., beard region) of a mammal for the purpose of increasing the appearance of fuller and/or thicker hair.
  • the hair growth inhibiting agent comprises a material that up-regulates aquaporin-3 expression. 10557M/DW 2
  • the hair care composition comprises a synergistic mixture of a xanthine compound, a vitamin B3 compound, and a panthenol compound.
  • the synergistic mixture comprises caffeine, niacinamide, and panthenol.
  • the composition comprises from about 0.1% to about 10% of a xanthine compound (e.g., caffeine), in another embodiment from about 0.5% to about 5% of a xanthine compound, and in yet another embodiment from about 1% to about 2% of a xanthine compound.
  • the composition comprises from about 0.1% to about 25% of a vitamin B3 compound (e.g., niacinamide), in another embodiment from about 0.5% to about 15% of a vitamin B3 compound, and in yet another embodiment from about 3.5% to about 7.5% of a vitamin B3 compound.
  • the composition comprises from about 0.01% to about 3% of a panthenol compound (e.g., panthenol), in another embodiment from about 0.02% to about 1% of a panthenol compound, and in yet another embodiment from about 0.2% to about 0.5% of a panthenol compound.
  • the composition can optionally comprise any other suitable ingredients as desired.
  • the composition also comprises a thickener that helps to hold the active agents on the scalp, providing substantivity to the composition, such that it does not drip undesirably onto unintended areas of the body, clothing, or home furnishings.
  • compositions comprising hair growth inhibition agents have been applied to body areas where hair is not desired, in an effort to eliminate, decrease, and/or slow the growth of unwanted hair.
  • topical application of hair growth inhibitors to regions where the appearance of more hair is desired can actually increase the appearance of thicker and/or fuller hair.
  • topical application of various hair growth inhibitors stimulates aquaporin 3 ("AQP3") up-regulators, which in turn results in thicker hair shafts and follicles.
  • AQP3 aquaporin 3
  • Aquaporins are a family of water-channel proteins found in the plasma membrane. Currently, 13 AQP have been identified in humans, and they are classified into two groups: aquaporins and aquaglyceroporins. Most of the identified aquaporins belong to the aquaporin group that is selective primarily for the passage of water. AQP 3, 7, 9, and 10 belong to the aquaglyceroporin group that facilitates the movement of water, glycerol, and various other solutes.
  • AQP3 is strongly expressed in the proliferating keratinocytes of the hair follicles.
  • AQP3 immunostaining can be detected in the hair shaft. It is believed by applicants that AQP3 up-regulators increase the thickness of hair fibers and follicles by stimulating AQP3 expression, which allows more water and water-binding molecules to be transported into the cells, thus improving cellular metabolism and increasing cellular size. This leads to increased hydration of the hair's cuticle layer, which expands the cuticle, making it thicker. As a result, the diameter of the hair fiber and of the hair follicle increase, resulting in the appearance of thicker, fuller hair.
  • the present invention also provides methods of marketing that can be advantageously used to help potential consumers appreciate the benefits that they can derive from such a product and/or its method of use. Furthermore, a method of marketing a first composition by comparing it to a second composition that comprises a hair growth inhibition agent is also provided. This method helps consumers to identify products that can potentially give similar benefits.
  • hair care compositions are compositions that are applied to the hair and/or the skin underneath the hair, including compositions used to treat or care for the hair.
  • Products contemplated by the phrase “hair care composition” include, but are not limited to liquids, creams, wipes, hair conditioners (rinse-off and leave-on), hair tonics, shampoos, hair colorants, mousses, propellant lotions, emulsions, shave gels, after-shave tonics and lotions, temporary beard hair dyes, and the like.
  • Halair growth inhibiting agent or “hair growth inhibition agent” includes any material that can reduce, inhibit, attenuate, or diminish mammalian hair growth.
  • “Increase the appearance of fuller and thicker hair” means the diameters of hair follicles and/or shafts in the subject region of hair (e.g., scalp, beard) are increased by a statistically significant amount, when an effective amount of a composition of the present invention is topically applied to the desired region over a result-effective period of time.
  • “Mammalian hair,” as referenced herein, includes hair on any part of the body of a mammal, and can include but is not limited to facial, cranial, or body hair. For instance, it can include hair on the scalp, head, neck, beard, moustache, eyebrows and sideburns hair.
  • topical application means to apply or spread the compositions of the present invention onto the surface of the keratinous tissue from which the hair to be affected grows.
  • compositions or components thereof so described are suitable for use in contact with mammalian keratinous tissue without undue toxicity, incompatibility, instability, allergic response, and the like.
  • an effective amount means an amount of a compound or composition sufficient to increase the diameter of the shafts in the subject region of hair by a statistically significant amount.
  • result-effective period of time means a period of time sufficient to increase the diameter of the hair shafts in the subject region of hair by a statistically significant amount.
  • safe and effective amount means an amount of a compound or composition sufficient to increase the diameter of the hair shafts in the subject region of hair by a statistically significant amount, when used for a result-effective period of time, but low enough to avoid serious side effects, i.e., to provide a reasonable benefit to risk ratio, within the scope of sound judgment of the skilled artisan.
  • the present invention provides hair care compositions that can be used to increase the appearance of thicker and fuller hair.
  • the hair care composition comprises a hair growth inhibiting agent.
  • the hair care composition comprises two or more hair growth inhibiting agents.
  • the hair growth inhibiting agent is present in a safe and effective amount.
  • the singular term "hair growth inhibiting agent" is broad enough to include one or a combination of more than one hair growth inhibition agent.
  • the hair care compositions can comprise a dermatologically- acceptable carrier and/or any desired suitable optional ingredients.
  • the hair growth inhibition agent can be selected from the group consisting of butylated hydroxytolune, butylated hydroxyanisole, hexamidine, hexyl isobutyrate, menthyl anthranilate, methofuran, 3-burylidenepthalide, glyceryl dilaurate, hexanediol, agmatine, aminoguanidine, phenyl butyl nitrone and other spin traps, ethoxyquin, cetyl pyridinium chloride, green tea extract, catechins, phytosterols, ursolic acid, plant extracts, plant extract compounds, 3-butylidenepthalide, its salts, its derivatives, and mixtures thereof and combinations thereof.
  • the composition comprises a xanthine compound, a vitamin B3 compound, a panthenol compound, or mixture
  • compositions of the present invention can include a xanthine compound.
  • xanthine compound means one or more xanthines, derivatives therof, and mixtures thereof.
  • Xanthine Compounds that can be useful herein include, but are not limited to, caffeine, xanthine, 1 -methyl xanthine, theophylline, theobromine, derivatives thereof, and mixtures thereof.
  • the composition comprises from about 0.1% to about 10% of a 10557M/DW 6 xanthine compound, in another embodiment from about 0.5% to about 5% of a xanthine compound, and in yet another embodiment from about 1% to about 2% of a xanthine compound.
  • Vitamin B 3 Compounds
  • the compositions of the present invention can include a vitamin B3 compound.
  • vitamin B3 compounds are particularly useful for regulating skin conditions, as described in U.S. Patent No. 5,939,082.
  • the composition comprises from about 0.1% to about 25% of a vitamin B3 compound, in another embodiment from about 0.5% to about 15% of a vitamin B3 compound, and in yet another embodiment from about 3.5% to about 7.5% of a vitamin B3 compound.
  • vitamin B3 compound means a one or more compounds having the formula:
  • R is - CONH2 (i.e., niacinamide), - COOH (i.e., nicotinic acid) or - CH2OH (i.e., nicotinyl alcohol); derivatives thereof; mixtures thereof; and salts of any of the foregoing.
  • CONH2 i.e., niacinamide
  • COOH i.e., nicotinic acid
  • CH2OH i.e., nicotinyl alcohol
  • Exemplary derivatives of the foregoing vitamin B3 compounds include nicotinic acid esters, including non-vasodilating esters of nicotinic acid (e.g, tocopherol nicotinate, myristyl nicotinate), nicotinyl amino acids, nicotinyl alcohol esters of carboxylic acids, nicotinic acid N- oxide and niacinamide N-oxide.
  • non-vasodilating esters of nicotinic acid e.g, tocopherol nicotinate, myristyl nicotinate
  • nicotinyl amino acids e.g, nicotinyl amino acids
  • nicotinyl alcohol esters of carboxylic acids nicotinic acid N- oxide and niacinamide N-oxide.
  • Suitable esters of nicotinic acid include nicotinic acid esters of C ⁇ -C22- > preferably Cj- C 16, more preferably CJ-CQ alcohols.
  • the alcohols are suitably straight-chain or branched chain, cyclic or acyclic, saturated or unsaturated (including aromatic), and substituted or unsubstituted.
  • the esters are preferably non-vasodilating.
  • non-vasodilating means that the ester does not commonly yield a visible flushing response after application to the skin in the subject compositions (the majority of the general population would not experience a visible flushing response, although such compounds may cause vasodilation not visible to the naked eye, i.e., the ester is non-rubifacient).
  • Non-vasodilating esters of nicotinic acid include tocopherol nicotinate and inositol hexanicotinate; tocopherol nicotinate is preferred.
  • derivatives of the vitamin B3 compound are derivatives of niacinamide resulting from substitution of one or more of the amide group hydrogens.
  • Nonlimiting examples of derivatives of niacinamide useful herein include nicotinyl amino acids, derived, for example, from the reaction of an activated nicotinic acid compound (e.g., nicotinic acid azide or nicotinyl 10557M/DW 7 chloride) with an amino acid, and nicotinyl alcohol esters of organic carboxylic acids (e.g., Cl - C 18).
  • Specific examples of such derivatives include nicotinuric acid (C8H8N2O3) and nicotinyl hydroxamic acid (C6H6N2O2), which have the following chemical structures: nicotinuric acid:
  • nicotinyl alcohol esters include nicotinyl alcohol esters of the carboxylic acids salicylic acid, acetic acid, glycolic acid, palmitic acid and the like.
  • vitamin B3 compounds useful herein are 2-chloronicotinamide, 6-aminonicotinamide, 6- methylnicotinamide, n-methyl-nicotinamide, n,n-diethylnicotinamide, n-(hydroxymethyl)- nicotinamide, quinolinic acid imide, nicotinanilide, n-benzylnicotinamide, n-ethylnicotinamide, nifenazone, nicotinaldehyde, isonicotinic acid, methyl isonicotinic acid, thionicotinamide, nialamide, l-(3-pyridylmethyl) urea, 2-mercaptonicotinic acid, nicomol, and
  • vitamin B3 compounds are well known in the art and are commercially available from a number of sources, e.g., the Sigma Chemical Company (St. Louis, MO); ICN Biomedicals, Inc. (Irvin, CA) and Aldrich Chemical Company (Milwaukee, WI).
  • One or more vitamin B3 compounds may be used herein.
  • Preferred vitamin B3 compounds are niacinamide and tocopherol nicotinate. Niacinamide is more preferred.
  • salts, derivatives, and salt derivatives of niacinamide are preferably those having substantially the same efficacy as niacinamide.
  • Salts of the vitamin B3 compound are also useful herein.
  • Nonlimiting examples of salts of the vitamin B3 compound useful herein include organic or inorganic salts, such as inorganic 10557M/DW 8 salts with anionic inorganic species (e.g., chloride, bromide, iodide, carbonate, preferably chloride), and organic carboxylic acid salts (including mono-, di- and tri- Cl - C18 carboxylic acid salts, e.g., acetate, salicylate, glycolate, lactate, malate, citrate, preferably monocarboxylic acid salts such as acetate).
  • anionic inorganic species e.g., chloride, bromide, iodide, carbonate, preferably chloride
  • organic carboxylic acid salts including mono-, di- and tri- Cl - C18 carboxylic acid salts, e.g., acetate, salicylate, glycolate, lactate, malate, citrate, preferably monocar
  • Wenner "The Reaction of L- Ascorbic and D-Iosascorbic Acid with Nicotinic Acid and Its Amide", J. Organic Chemistry, Vol. 14, 22-26 (1949). Wenner describes the synthesis of the ascorbic acid salt of niacinamide.
  • the ring nitrogen of the vitamin B3 compound is substantially chemically free (e.g., unbound and/or unhindered), or after delivery to the skin becomes substantially chemically free ("chemically free” is hereinafter alternatively referred to as "uncomplexed”). More preferably, the vitamin B3 compound is essentially uncomplexed. Therefore, if the composition contains the vitamin B3 compound in a salt or otherwise complexed form, such complex is preferably substantially reversible, more preferably essentially reversible, upon delivery of the composition to the skin. For example, such complex should be substantially reversible at a pH of from about 5.0 to about 6.0. Such reversibility can be readily determined by one having ordinary skill in the art.
  • the vitamin B3 compound is substantially uncomplexed in the composition prior to delivery to the keratinous tissue.
  • Exemplary approaches to minimizing or preventing the formation of undesirable complexes include omission of materials which form substantially irreversible or other complexes with the vitamin B3 compound, pH adjustment, ionic strength adjustment, the use of surfactants, and formulating wherein the vitamin B3 compound and materials which complex therewith are in different phases. Such approaches are well within the level of ordinary skill in the art.
  • the vitamin B3 compound contains a limited amount of the salt form and is more preferably substantially free of salts of a vitamin B3 compound.
  • the vitamin B3 compound contains less than about 50% of such salt, and is more preferably essentially free of the salt form.
  • the vitamin B3 compound in the compositions hereof having a pH of from about 4 to about 7 typically contain less than about 50% of the salt form.
  • the vitamin B3 compound may be included as the substantially pure material, or as an extract obtained by suitable physical and/or chemical isolation from natural (e.g., plant) sources.
  • the vitamin B3 compound is preferably substantially pure, more preferably essentially pure. 10557M/DW 9
  • compositions of the present invention may comprise a panthenol compound.
  • panthenol compound is broad enough to include panthenol, one or more pantothenic acid derivatives, and mixtures thereof.
  • Panthenol and its derivatives can include D- panthenol ([R]-2,4-dihydroxy-N-[3-hydroxypropyl)]-3,3-dimethylbutamide), DL-panthenol, pantothenic acids and their salts, preferably the calcium salt, panthenyl triacetate, royal jelly, panthetine, pantotheine, panthenyl ethyl ether, pangamic acid, pantoyl lactose, Vitamin B complex, or mixtures thereof.
  • compositions comprising pantothenic acid derivatives that remain more stable than panthenol and other similar materials in acidic compositions or in compositions containing acid- producing materials such as aluminum-containing actives, can also be suitable for use herein.
  • the selected pantothenic acid derivatives are most typically in liquid form and dispersed throughout or otherwise solubilized within the liquid carrier component of the composition.
  • pantothenic acid derivative refers to those materials that conform to the formula:
  • Ri, R 2 and R3 are hydrogen, C2-C20 hydrocarbons, C2-C20 carboxylic acid esters, or combinations thereof, provided that not more than two of Rl, R2 and R3 are hydrogen.
  • R), R 2 and R 3 are independently selected from hydrogen, C2-C8 hydrocarbons, C2- C8 carboxylic acid esters, or combinations thereof; in another embodiment, Ri and R 2 are hydrogen, and R 3 is a C2-C8 hydrocarbon, C2-C8 carboxylic acid ester, or combinations thereof; in yet another embodiment, Ri and R 2 are hydrogen and R 3 is ethyl.
  • the selected pantothenic acid derivatives may be derived or otherwise obtained from any known source, which may include pantothenic acid or materials other than pantothenic acid, so long as the resulting material has the above defined chemical formula.
  • pantothenic acid derivatives for use herein include ethyl panthenol, panthenyl triacetate, and combinations thereof.
  • a pantothenic acid derivative comprises the d-isomeric form(s) of such derivative form(s), such as d-ethyl panthenol. 10557M/DW 10
  • compositions of the present invention can also additionally comprise any suitable optional ingredients as desired.
  • the composition can optionally include other active or inactive ingredients.
  • the present invention may include additional skin care actives selected from the group consisting of sugar amines, retinoids, peptides, dialkanoyl hydroxyproline, hexamidine, salicylic acid, phytosterol, sunscreen actives, water soluble vitamins, oil-soluble vitamins, their derivatives, their precursors, and combinations thereof.
  • the composition may include suitable ingredients that are conventionally used in given product types.
  • CTFA Cosmetic Ingredient Handbook
  • abrasives absorbents
  • aesthetic components such as fragrances, pigments, colorings/colorants, essential oils, skin sensates, astringents, etc.
  • anti-acne agents e.g., clove oil, menthol, camphor, eucalyptus oil, eugenol, menthyl lactate, witch hazel distillate
  • anti-acne agents e.g., clove oil, menthol, camphor, eucalyptus oil, eugenol, menthyl lactate, witch hazel distillate
  • antimicrobial agents e.g., iodopropyl butylcarbamate
  • antioxidants e.g., iodopropyl butylcarbamate
  • binders biological additives, buffering agents, bulking agents, chelating agents, chemical additives, colorants, cosmetic astringents, cosmetic biocides, denaturants, drug astringents, external analgesics, film formers or materials, e.g., polymers, for aiding the film-forming properties and substantivity of the composition (e.g., copolymer of
  • hydroquinone kojic acid, ascorbic acid, magnesiuim ascorbyl phosphate, ascorbyl glucoside, pyridoxine
  • skin-conditioning agents e.g. humectants and occlusive agents
  • skin treating agents e.g. vitamin D compounds, mono-,di-, and tri-terpenoids, beta-ionol, cedrol
  • thickeners e.g. vitamin D compounds, mono-,di-, and tri-terpenoids, beta-ionol, cedrol
  • the composition comprises a thickener to increase the substantivity of the composition, such that it does not drip undesirably onto other areas of the body, onto clothing, or onto home furnishings.
  • a thickener can be used, for example, a cellulose- based thickener such as hydroxypropylmethylcellulose.
  • the composition comprises alcohol and/or water.
  • the composition comprises from 10-90% alcohol, alternatively from 15-75% alcohol, or alternatively from 25-50% alcohol. Any suitable alcohol, such as ethanol, can be used. 10557M/DW 11
  • the composition can comprise at least one nitrone derivative.
  • Nitrones are capable of irreversibly capturing electrons and/or free radicals, thereby reducing the relative amount of oxidative potential in a microenvironment.
  • spin traps these materials have been referred to as "spin traps" since the ability to detect a free radical via spectroscopic means involves monitoring the spin resonance of free radicals.
  • the spectroscopic signal becomes reduced due to the free radical becoming trapped by a nitrone such as ⁇ -phenyl butyl nitrone (PBN).
  • PBN ⁇ -phenyl butyl nitrone
  • PBN ⁇ -phenyl butyl nitrone
  • PBN doxylcyclohexane radicals 5,5-dimethyl pyrroline N-oxide (DMPO), ⁇ -(4-pyridyl l-oxide)-N- tert-butylnitrone (POBN), 2,2,6,6-tetramethylpiperidine 1 -oxide, 4-hydroxytetramethylpiperidine 1 -oxide, and the salts of N-(l-oxido-2,2,6,6-tetramethyl-4-piperidyl)-N,N-dimethyl-N- hydroxyethylammonium, 3,5-dibromo-4-nitrosobenzenesulfonic acid, 2-methyl-2- nitrosopropane, nitrosodisulfonic acid, ⁇ -(4-pyridyl-l-oxide)-N-t-butylnitrone, 3,3,5,5- tetramethylpyrrol
  • the present invention also provides a method for increasing the diameter of the hair shaft and follicle, leading to an appearance of thicker and/or fuller hair.
  • the method comprises applying a hair care composition comprising a hair growth inhibiting agent to a skin surface from which a region of styled hair grows.
  • the hair care composition can be applied to the scalp and/or face (e.g., beard or moustache area).
  • the method comprises topically applying a hair care composition comprising an effective amount of a hair growth inhibiting agent to a region of skin of a mammal seeking to increase the appearance of thicker and/or fuller hair.
  • the invention provides use of a hair care composition comprising a hair growth reduction agent for increasing the diameter of the hair shaft and/or follicle.
  • the region of hair can be located on any part of the body. For instance, it can grow from a skin surface located on at least a portion of the scalp or the face.
  • the method comprises applying the composition according to a regimen, wherein said regimen comprises:
  • the present invention provides articles of commerce and methods of marketing hair care compositions that can be used to increase the appearance of thicker and fuller hair.
  • the article of commerce comprises: (1) a container;
  • said hair care composition comprises a hair growth inhibition agent
  • the present invention provides methods of marketing hair care compositions that can be used to increase the appearance of thicker and fuller hair.
  • the method comprises:
  • the invention provides a marketing method that utilizes a comparison of a first hair care composition to a second hair care composition, in order to market the first hair care composition.
  • the method comprises offering for sale a first article of commerce, wherein said first article of commerce comprises:
  • said second hair care composition comprising a hair growth inhibition agent
  • the invention provides a marketing method that utilizes at least one visual cue to communicate that a first hair care composition is similar to or the same as a second hair care composition, in order to market the first hair care composition.
  • the 10557M/DW 13 visual cue comprises a message.
  • the message can comprise words such as "compare,” “compare to", “like”, “similar", “try instead of,” or the like.
  • the visual cue can comprise the same or similar graphics as those included on or near the packaging of the second hair care composition.
  • a visual cue can be located at or on any suitable location. For instance, a visual cue can be located on or near product packaging, or on or near a store shelf.
  • the first hair care composition is marketed in a container having at least two of the same colors as the container in which the second hair care composition is marketed.
  • the method comprises a method of marketing a first hair care composition, wherein said method comprises:
  • the term "potential consumer” means an actual or potential purchaser and/or an actual or potential user of the article of commerce and/or hair care composition.
  • Any container from which the hair care composition can be stored and/or contained can be used herein. Suitable containers can include, but are not limited to, bottles, tottles, tubes, pouches, boxes, tubs, and cans.
  • containers can include primary containers, which contain the hair care composition itself, or secondary containers, which contain at least one primary container that contains the composition. 10557M/DW 14
  • set of graphics refers to the text and/or pictorial images that are disposed on a container.
  • disposed on means integral with and/or located on the container and can include, but is not limited to, disposed directly thereon (e.g., printed directly on the container), disposed indirectly thereon (e.g., printed on a sticker that is affixed to the outer portion of the container), and/or applied to the container by any other suitable means (e.g., sprayed, bonded, drawn, painted, printed, or molded).
  • “communication” means a message, and can include but is not limited to a printed (e.g., printed material attached directly or indirectly to the container), electronic, or broadcast message.
  • said first article of commerce and said second article of commerce can be located within visual sight of one another.
  • said first article of commerce and said second article of commerce can be located adjacent to one another on a retail shelf or other retail display.
  • first article of commerce and the second article of commerce are located in proximity to one another such that a human with unassisted 20/20 vision can see both the first article of commerce and the second article of commerce at the same time.
  • said first article of commerce and said second article of commerce are located within 2 meters of each other.
  • said first article of commerce and said second article of commerce are located within 1 meter of each other.
  • said first article of commerce and said second article of commerce are located within 0.5 meter of each other.
  • similar means providing one or more of the same consumer benefits (e.g., thicker hair) or comprising one or more of the same ingredients.
  • Example 5-7 Conditioner examples
  • Dimethicone/Cyclomethicone a blend dimethicone having a viscosity of 18,000,000mPas and cyclopentasiloxane available from GE Toshiba
  • Dimethicone blend a blend of dimethicone having a viscosity of 18,000,000mPas and dimethicone having a viscosity of 200mPas available from GE Toshiba
  • Lexamine S- 13 available from Inolex
  • Cetyl alcohol Konol series available from Shin Nihon Rika.
  • Example 11 Method of Marketing The shampoo of Example 1 is packaged into a blue and white container and offered for sale to consumers at a retail store. A label on the container communicates that when this shampoo is used to wash hair, it will help to increase the appearance of thicker and fuller hair.
  • Example 12 Method of Marketing A shampoo contained in a blue and white bottle (herein “Subject Shampoo”) is located on a shelf next to the shampoo of Example 1 1. A label is attached to the Subject Shampoo's bottle which directs the consumer to compare the Subject Shampoo to the shampoo of Example 1 1.
  • Subject Shampoo a blue and white bottle
  • a composition comprising a mixture of Caffeine, Niacinamide and Panthenol demonstrated a clinically significant increase in hair width versus a placebo.
  • a 10557M/DW 19 scalp tonic containing 5% Niacinamide, 1.5% Caffeine, and 0.3% D-Panthenol in a water/alcohol matrix (25% ethanol, q.s. water) was evaluated.
  • This formula also included 0.3% hydroxypropylmethylcellulose as a thickening agent.
  • 1.5 ml of the tonic was applied to one side of the head two times per day, and 1.5ml of the placebo was applied to the other side of the head two times daily.
  • subjects Upon arriving at the test site, subjects were acclimated in an environmentally controlled room (70 0 F + 2 and 30-45% relative humidity) for 30 minutes prior to having their scalp evaluated by a qualified skin grader to assess skin health.
  • a licensed cosmetologist identified two scalp sites for clipping (areas of approximately 1.8 cm x 1.8 cm), one on the top left lateral scalp, approximately 4-5" back into the hairline and the other was symmetrically placed on the top right lateral scalp.
  • a template was used to mark the 4 corners and a notch slightly below center of each treatment site.
  • the clipped sites were approximately 2" lateral to either of their respective sides from the midline of the head/scalp.
  • the licensed cosmetologist then cut the hair within each of the scalp clipping sites with a small battery operated hair clipper to about lmm in length.
  • a trained clinical assistant placed a small, permanent dot tattoo approximately 1 mm above the marked notch (located slightly below center of the treatment site) on each treatment site to provide a reference for identification of these sites for digital imaging that was performed at designated study time points.
  • the clipped scalp sites were identified using the template and marking the 4 corners of the template with a Sharpie® marker or equivalent.
  • the licensed cosmetologist then evenly clipped the short hairs within the 2 clipped sites to 1 mm as previously conducted.
  • a technician captured a baseline image of each clipped scalp site using a Hi-Scope® digitized imaging system.
  • the tattoo that was placed within each lower treatment site was used as a reference point to position the image for capture and storage. This baseline image was used when blending post-treatment images during the study.
  • the next day, approximately 24 hours following the hair clipping visit a technician captured an image of each lower scalp clipping site using a Hi-Scope® digitized imaging system.
  • the tattoo that was 10557M/DW 20 placed within each lower treatment site was used as a reference point to position the image for capture and storage after aligning the hair follicle openings with the image captured at Baseline, Day 1. This procedure was used for Week 4, 8 and 12.
  • An image analysis algorithm was used to measure the hair diameter from the digital micrographs.
  • the algorithm automatically carried out several steps to isolate and characterize hairs in each digital image.
  • the algorithm performed a local background leveling function and enhancement of the red component in the color image.
  • Automatic thresholding of the color image was performed to obtain a binary image (black and white) of the hairs on the background.
  • the algorithm then identified hairs as continuous black lines and broke the lines into individual hairs at branch points and points of high curvature.
  • the algorithm eliminated very short objects and retained the remaining objects as 'hairs'.
  • the algorithm measured and recorded position and diameter (width) of each detected hair.
  • An in vitro model consisting of primary human dermal papilla cells in culture, demonstrates a surprising synergistic increase in the survival of metabolically stressed dermal papilla cells.
  • Primary human dermal papilla cells were metabolically stressed for 48 hours in reduced standard tissue culture media. During this period of stress the cells were treated with the mixtures below. After 48 hr the metabolic activity of the cells was measured by the amount of ATP using the Cell Titer GloTM kit (Promega).
  • the individual components provided little or no benefit in increasing the survival of stressed dermal papilla cells, the mixture of the three components resulted in a synergistic effect that produced a statistically significant increase in cell survival, not only above the calculated average but also above the expected additive effect of the individual components.
  • the investigators demonstrated that the combination provided a significantly greater increase in cell survival than one would expect, given the effects of the individual components alone or in addition to one another.
  • the dermal papilla in normal human hair, is the control center for hair diameter. Increasing survival of dermal papilla cells in situ leads to increased hair diameter. Accordingly, an increase in survival of dermal papilla cells correlates with an increase in hair diameter.

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Abstract

L'invention concerne des compositions, des procédés et des articles commerciaux de soins capillaires capables de donner plus de volume et d'épaisseur aux cheveux. De telles compositions peuvent être appliquées dans chaque zone dans laquelle les cheveux nécessitent plus de volume et d'épaisseur, par exemple le cuir chevelu ou le visage (zone de la barbe). L'invention concerne également des procédés de commercialisation de telles compositions.
PCT/US2007/019180 2006-08-30 2007-08-30 Compositions, procédés et articles commerciaux de soins capillaires capables de donner plus de volume et d'épaisseur aux cheveux WO2008027541A2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
MX2009001927A MX2009001927A (es) 2006-08-30 2007-08-30 Composiciones para el cuidado del pelo que pueden mejorar la apariencia de pelo espeso y abundante.
CN2007800325514A CN101511331B (zh) 2006-08-30 2007-08-30 可使毛发看上去更浓密且更丰厚的毛发护理组合物
MX2013009336A MX347443B (es) 2006-08-30 2007-08-30 Composiciones para el cuidado del pelo que pueden mejorar la apariencia de pelo espeso y abundante.
AU2007290406A AU2007290406A1 (en) 2006-08-30 2007-08-30 Hair care compositions that can increase the appearance of thicker and fuller hair
EP07837604.3A EP2056783B1 (fr) 2006-08-30 2007-08-30 Compositions, procédés et articles commerciaux de soins capillaires capables de donner plus de volume et d'épaisseur aux cheveux
JP2009523870A JP2009545633A (ja) 2006-08-30 2007-08-30 より濃く、より豊かな毛髪の外観を向上させることができるヘアケア組成物
BRPI0715932-3A2A BRPI0715932A2 (pt) 2006-08-30 2007-08-30 composiÇÕes para tratamentos dos cabelos ou pÊlos que podem melhorar a aparÊncia dos cabelos ou pÊlos, tornando-os mais espessos e mais cheios

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84109506P 2006-08-30 2006-08-30
US60/841,095 2006-08-30

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WO2008027541A2 true WO2008027541A2 (fr) 2008-03-06
WO2008027541A3 WO2008027541A3 (fr) 2008-10-09

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US (2) US20080059313A1 (fr)
EP (2) EP2574328A3 (fr)
JP (1) JP2009545633A (fr)
CN (1) CN101511331B (fr)
AU (1) AU2007290406A1 (fr)
BR (1) BRPI0715932A2 (fr)
MX (2) MX2009001927A (fr)
WO (1) WO2008027541A2 (fr)

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CN101511331B (zh) 2012-03-21
US20120258185A1 (en) 2012-10-11
MX347443B (es) 2017-04-25
BRPI0715932A2 (pt) 2013-09-24
JP2009545633A (ja) 2009-12-24
EP2056783B1 (fr) 2017-11-22
WO2008027541A3 (fr) 2008-10-09
CN101511331A (zh) 2009-08-19
EP2574328A3 (fr) 2015-04-22
EP2574328A2 (fr) 2013-04-03
MX2009001927A (es) 2009-03-06
EP2056783A2 (fr) 2009-05-13
AU2007290406A1 (en) 2008-03-06

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