WO2008021394A2 - Formulations pharmaceutiques d'agonistes cannabinoïdes et procédé d'utilisation - Google Patents

Formulations pharmaceutiques d'agonistes cannabinoïdes et procédé d'utilisation Download PDF

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Publication number
WO2008021394A2
WO2008021394A2 PCT/US2007/018062 US2007018062W WO2008021394A2 WO 2008021394 A2 WO2008021394 A2 WO 2008021394A2 US 2007018062 W US2007018062 W US 2007018062W WO 2008021394 A2 WO2008021394 A2 WO 2008021394A2
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WO
WIPO (PCT)
Prior art keywords
dosage form
cannabinoid
hours
oral dosage
agonist
Prior art date
Application number
PCT/US2007/018062
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English (en)
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WO2008021394A3 (fr
Inventor
Najib Babul
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Theraquest Biosciences, Llc
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Publication of WO2008021394A2 publication Critical patent/WO2008021394A2/fr
Publication of WO2008021394A3 publication Critical patent/WO2008021394A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compositions pharmaceutiques d'agonistes cannabinoïdes et utilisation correspondante permettant de prévenir ou de réduire au minimum le risque d'abus de ce produit et/ou de toxicité de ce produit par manipulation illicite intentionnelle ou non intentionnelle. Également, procédé permettant de prévenir ou de réduire au minimum le risque d'abus de ce produit et/ou de toxicité de ce produit par manipulation illicite intentionnelle ou non intentionnelle.
PCT/US2007/018062 2006-08-15 2007-08-15 Formulations pharmaceutiques d'agonistes cannabinoïdes et procédé d'utilisation WO2008021394A2 (fr)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US83760706P 2006-08-15 2006-08-15
US83760606P 2006-08-15 2006-08-15
US60/837,607 2006-08-15
US60/837,606 2006-08-15
US84235906P 2006-09-06 2006-09-06
US60/842,359 2006-09-06
US84900606P 2006-10-04 2006-10-04
US60/849,006 2006-10-04

Publications (2)

Publication Number Publication Date
WO2008021394A2 true WO2008021394A2 (fr) 2008-02-21
WO2008021394A3 WO2008021394A3 (fr) 2008-12-31

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WO (1) WO2008021394A2 (fr)

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JP2011190259A (ja) * 2010-03-11 2011-09-29 Wyeth Llc メチルナルトレキソンの経口製剤および親油性塩
WO2011141241A1 (fr) * 2010-05-14 2011-11-17 Ethypharm Forme pharmaceutique orale alcoolo-resistante
CN103338768A (zh) * 2010-12-13 2013-10-02 托马斯·朱利叶斯·波洛迪 胃和结肠的配制剂及其制备和使用方法
WO2014022541A1 (fr) * 2012-08-01 2014-02-06 Acura Pharmaceuticals, Inc. Stabilisation de systèmes de synthèse de la méthamphétamine en enceinte unique
US20140220146A1 (en) * 2008-07-07 2014-08-07 Euro-Celtique S.A. Use of opioid antagonists for treating urinary retention
CN104010642A (zh) * 2011-10-27 2014-08-27 萨利克斯药品有限公司 电解质泻药
US9132096B1 (en) 2014-09-12 2015-09-15 Alkermes Pharma Ireland Limited Abuse resistant pharmaceutical compositions
CN104940165A (zh) * 2015-07-23 2015-09-30 北京康远制药有限公司 一种含有多库酯钠和丹蒽醌的胶囊剂及其制备方法
AU2013203559B2 (en) * 2010-03-11 2015-12-03 Wyeth Llc Oral formulations and lipophilic salts of methylnaltrexone
WO2016010771A1 (fr) * 2014-07-17 2016-01-21 Pharmaceutical Manufacturing Research Services, Inc. Forme posologique remplie de liquide anti-abus à libération immédiate
WO2016029215A1 (fr) * 2014-08-22 2016-02-25 Medipath, Inc. Compositions et procédés d'enrobages en cannabinoïdes utilisés dans l'administration de médicaments
WO2015153984A3 (fr) * 2014-04-04 2016-03-03 Pharmaquest International Center, LLC Comprimés monolithiques à libération modifiée se désintégrant, contenant des granules à libération prolongée quadri-couches
WO2016105498A1 (fr) 2014-12-23 2016-06-30 Synthetic Biologics, Inc. Méthodes et compositions pour inhiber ou prévenir les effets néfastes des antibiotiques oraux
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
AU2016200133B2 (en) * 2010-03-11 2017-09-07 Wyeth Llc Oral formulations and lipophilic salts of methylnaltrexone
US9877925B2 (en) 2010-05-14 2018-01-30 Ethypharm Alcohol-resistant oral pharmaceutical form
US10159268B2 (en) 2013-02-08 2018-12-25 General Mills, Inc. Reduced sodium food products
US10166219B2 (en) 2012-07-27 2019-01-01 Redhill Bipharma Ltd. Formulations and methods of manufacturing formulations for use in colonic evacuation
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US10195153B2 (en) 2013-08-12 2019-02-05 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
CN109419665A (zh) * 2017-08-25 2019-03-05 汉义生物科技（北京）有限公司 一种含有大麻提取物或大麻二酚的活性物快速渗透体系
US10376584B2 (en) 2003-04-08 2019-08-13 Progenics Pharmaceuticals, Inc. Stable pharmaceutical formulations of methylnaltrexone
WO2019198001A1 (fr) * 2018-04-11 2019-10-17 Ghs Patents Limited Procede de fabrication d'un spheroide comprenant du cannabidiol
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Cited By (133)

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US10376584B2 (en) 2003-04-08 2019-08-13 Progenics Pharmaceuticals, Inc. Stable pharmaceutical formulations of methylnaltrexone
US10561649B2 (en) 2007-07-03 2020-02-18 Sucampo Ag Pharmaceutical combination of opioid and prostaglandin compound
US20140220146A1 (en) * 2008-07-07 2014-08-07 Euro-Celtique S.A. Use of opioid antagonists for treating urinary retention
US10376505B2 (en) 2010-03-11 2019-08-13 Wyeth, Llc Oral formulations and lipophilic salts of methylnaltrexone
JP2017206553A (ja) * 2010-03-11 2017-11-24 ワイス・エルエルシー メチルナルトレキソンの経口製剤および親油性塩
EP3178472A1 (fr) * 2010-03-11 2017-06-14 Wyeth LLC Formulations orales de la méthylnaltrexone
US8524276B2 (en) 2010-03-11 2013-09-03 Wyeth, Llc Oral formulations and lipophilic salts of methylnaltrexone
US10307417B2 (en) 2010-03-11 2019-06-04 Wyeth, Llc Oral formulations and lipophilic salts of methylnaltrexone
JP2016029054A (ja) * 2010-03-11 2016-03-03 ワイス・エルエルシー メチルナルトレキソンの経口製剤および親油性塩
CN107308125A (zh) * 2010-03-11 2017-11-03 惠氏有限责任公司 甲基纳曲酮的口服制剂和亲脂盐
AU2016200133B2 (en) * 2010-03-11 2017-09-07 Wyeth Llc Oral formulations and lipophilic salts of methylnaltrexone
US8956651B2 (en) 2010-03-11 2015-02-17 Wyeth, Llc Oral formulations and lipophilic salts of methylnal trexone
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