WO2007146953A3 - COMPOSITIONS ET PROCÉDÉS DESTINÉS À UNE INHIBITION DE L'ANGIOGENÈSE PAR LES ARNsi - Google Patents

COMPOSITIONS ET PROCÉDÉS DESTINÉS À UNE INHIBITION DE L'ANGIOGENÈSE PAR LES ARNsi Download PDF

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Publication number
WO2007146953A3
WO2007146953A3 PCT/US2007/071029 US2007071029W WO2007146953A3 WO 2007146953 A3 WO2007146953 A3 WO 2007146953A3 US 2007071029 W US2007071029 W US 2007071029W WO 2007146953 A3 WO2007146953 A3 WO 2007146953A3
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WIPO (PCT)
Prior art keywords
methods
sirna
angiogenesis
compositions
seq
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PCT/US2007/071029
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English (en)
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WO2007146953A2 (fr
WO2007146953A8 (fr
Inventor
Samuel Jotham Reich
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Exegenics Inc D B A Opko Healt
Samuel Jotham Reich
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Publication date
Application filed by Exegenics Inc D B A Opko Healt, Samuel Jotham Reich filed Critical Exegenics Inc D B A Opko Healt
Priority to ES07812121T priority Critical patent/ES2390499T3/es
Priority to JP2009515610A priority patent/JP2009540011A/ja
Priority to DK07812121.7T priority patent/DK2029746T3/da
Priority to EP07812121A priority patent/EP2029746B1/fr
Publication of WO2007146953A2 publication Critical patent/WO2007146953A2/fr
Publication of WO2007146953A3 publication Critical patent/WO2007146953A3/fr
Priority to IL195803A priority patent/IL195803A0/en
Publication of WO2007146953A8 publication Critical patent/WO2007146953A8/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Les modes de réalisations de la présente invention concernent des procédés utilisant des ARNsi ciblant le VEGF, y compris un ARNsi défini par les séquences SEQ ID NO: 77 et SEQ ID NO: 78, pour stabiliser l'acuité visuelle chez un sujet, inhiber des lésions de néovascularisation choroïdiennes, traiter une dégénérescence maculaire liée au vieillissement, traiter un œdème maculaire diabétique, et réduire l'épaisseur fovéale chez des sujets. L'invention concerne de plus des procédés de traitement d'une dégénérescence maculaire liée au vieillissement et d'un œdème maculaire diabétique par l'administration d'une thérapie combinée contenant un ARNsi ciblant le VEGF et un antagoniste du VEGF qui n'est pas un ARNsi.
PCT/US2007/071029 2006-06-12 2007-06-12 COMPOSITIONS ET PROCÉDÉS DESTINÉS À UNE INHIBITION DE L'ANGIOGENÈSE PAR LES ARNsi WO2007146953A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
ES07812121T ES2390499T3 (es) 2006-06-12 2007-06-12 Composiciones y métodos para la inhibición de la angiogénesis por sirna
JP2009515610A JP2009540011A (ja) 2006-06-12 2007-06-12 血管新生のｓｉＲＮＡ阻害のための組成物及び方法
DK07812121.7T DK2029746T3 (da) 2006-06-12 2007-06-12 Sammensætninger og fremgangsmåder til siRNA-hæmning af angiogenese
EP07812121A EP2029746B1 (fr) 2006-06-12 2007-06-12 COMPOSITIONS ET PROCÉDÉS DESTINÉS À UNE INHIBITION DE L'ANGIOGENÉSE PAR LES ARNsi
IL195803A IL195803A0 (en) 2006-06-12 2008-12-08 Compositions and methods for sirna inhibition of angiogenesis

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US80450006P 2006-06-12 2006-06-12
US60/804,500 2006-06-12
US82497206P 2006-09-08 2006-09-08
US60/824,972 2006-09-08
US86444006P 2006-11-06 2006-11-06
US60/864,440 2006-11-06

Publications (3)

Publication Number Publication Date
WO2007146953A2 WO2007146953A2 (fr) 2007-12-21
WO2007146953A3 true WO2007146953A3 (fr) 2008-03-06
WO2007146953A8 WO2007146953A8 (fr) 2009-11-19

Family

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Family Applications (1)

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PCT/US2007/071029 WO2007146953A2 (fr) 2006-06-12 2007-06-12 COMPOSITIONS ET PROCÉDÉS DESTINÉS À UNE INHIBITION DE L'ANGIOGENÈSE PAR LES ARNsi

Country Status (9)

Country Link
US (1) US20080152654A1 (fr)
EP (2) EP2029746B1 (fr)
JP (1) JP2009540011A (fr)
CY (1) CY1113291T1 (fr)
DK (1) DK2029746T3 (fr)
ES (1) ES2390499T3 (fr)
IL (1) IL195803A0 (fr)
PT (1) PT2029746E (fr)
WO (1) WO2007146953A2 (fr)

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US20080152654A1 (en) 2008-06-26
DK2029746T3 (da) 2012-10-08
EP2029746B1 (fr) 2012-07-04
JP2009540011A (ja) 2009-11-19
ES2390499T3 (es) 2012-11-13
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