WO2007125173A2 - Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease - Google Patents

Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease Download PDF

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Publication number
WO2007125173A2
WO2007125173A2 PCT/FI2007/050231 FI2007050231W WO2007125173A2 WO 2007125173 A2 WO2007125173 A2 WO 2007125173A2 FI 2007050231 W FI2007050231 W FI 2007050231W WO 2007125173 A2 WO2007125173 A2 WO 2007125173A2
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WO
WIPO (PCT)
Prior art keywords
compound
nucleic acid
oligonucleotide
target nucleic
nucleobases
Prior art date
Application number
PCT/FI2007/050231
Other languages
English (en)
French (fr)
Other versions
WO2007125173A3 (en
Inventor
Mati Karelson
Mart Saarma
Mehis Pilv
Original Assignee
Baltic Technology Development, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baltic Technology Development, Ltd. filed Critical Baltic Technology Development, Ltd.
Priority to AU2007245599A priority Critical patent/AU2007245599B2/en
Priority to BRPI0711182-7A priority patent/BRPI0711182A2/pt
Priority to MX2008014005A priority patent/MX2008014005A/es
Priority to CA002651031A priority patent/CA2651031A1/en
Priority to JP2009508407A priority patent/JP2009535383A/ja
Priority to EP07730718A priority patent/EP2013344B1/en
Publication of WO2007125173A2 publication Critical patent/WO2007125173A2/en
Publication of WO2007125173A3 publication Critical patent/WO2007125173A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/333—Modified A
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/335—Modified T or U
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/336—Modified G
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3511—Conjugate intercalating or cleaving agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
PCT/FI2007/050231 2006-05-03 2007-04-26 Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease WO2007125173A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU2007245599A AU2007245599B2 (en) 2006-05-03 2007-04-26 Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease
BRPI0711182-7A BRPI0711182A2 (pt) 2006-05-03 2007-04-26 agentes anti-sentido combinando base fortemente ligada-oligonucleotìdeo modificado e nuclease artificial
MX2008014005A MX2008014005A (es) 2006-05-03 2007-04-26 Agentes antisentido que combinan un oligonucleotido modificado con base fuertemente unida y nucleasa artificial.
CA002651031A CA2651031A1 (en) 2006-05-03 2007-04-26 Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease
JP2009508407A JP2009535383A (ja) 2006-05-03 2007-04-26 強く結合した塩基で修飾されたオリゴヌクレオチドと人工ヌクレアーゼを組み合わせたアンチセンス作用物質
EP07730718A EP2013344B1 (en) 2006-05-03 2007-04-26 Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79744806P 2006-05-03 2006-05-03
US60/797,448 2006-05-03

Publications (2)

Publication Number Publication Date
WO2007125173A2 true WO2007125173A2 (en) 2007-11-08
WO2007125173A3 WO2007125173A3 (en) 2008-01-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FI2007/050231 WO2007125173A2 (en) 2006-05-03 2007-04-26 Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease

Country Status (10)

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US (2) US7786292B2 (US07786292-20100831-C00023.png)
EP (1) EP2013344B1 (US07786292-20100831-C00023.png)
JP (1) JP2009535383A (US07786292-20100831-C00023.png)
CN (1) CN101437943A (US07786292-20100831-C00023.png)
AU (1) AU2007245599B2 (US07786292-20100831-C00023.png)
BR (1) BRPI0711182A2 (US07786292-20100831-C00023.png)
CA (1) CA2651031A1 (US07786292-20100831-C00023.png)
MX (1) MX2008014005A (US07786292-20100831-C00023.png)
WO (1) WO2007125173A2 (US07786292-20100831-C00023.png)
ZA (1) ZA200809048B (US07786292-20100831-C00023.png)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009060122A2 (en) * 2007-11-05 2009-05-14 Baltic Technology Development, Ltd. Use of oligonucleotides with modified bases as antiviral agents
WO2009060124A2 (en) * 2007-11-05 2009-05-14 Baltic Technology Development, Ltd. Use of oligonucleotides with modified bases in hybridization of nucleic acids
WO2009144365A1 (en) * 2008-05-30 2009-12-03 Baltic Technology Development, Ltd. Use of oligonucleotides with modified bases as antiviral agents
KR20220025587A (ko) * 2020-08-24 2022-03-03 수원대학교산학협력단 Erm 단백질과 상호작용하는 Helix 73 유래 RNA 분자 및 이의 이용 방법

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EE200600004A (et) * 2006-03-03 2007-10-15 O� Raidenil Infrapunakiirgusele tundlik komposiitmaterjal
US10260089B2 (en) 2012-10-29 2019-04-16 The Research Foundation Of The State University Of New York Compositions and methods for recognition of RNA using triple helical peptide nucleic acids
US20180036335A1 (en) * 2015-03-03 2018-02-08 Ionis Pharmaceuticals, Inc. Compositions for modulating mecp2 expression
US11129844B2 (en) 2015-03-03 2021-09-28 Ionis Pharmaceuticals, Inc. Compositions and methods for modulating MECP2 expression
EP3833762A4 (en) 2018-08-09 2022-09-28 Verseau Therapeutics, Inc. OLIGONUCLEOTIDE COMPOSITIONS FOR TARGETING CCR2 AND CSF1R AND THEIR USES
GB202117314D0 (en) 2021-11-30 2022-01-12 Clarke David John Cyclic nucleic acid fragmentation

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