WO2007100913A2 - Gènes exprimés de façon différentielle dans les troubles bipolaires et/ou dans la schizophrénie - Google Patents

Gènes exprimés de façon différentielle dans les troubles bipolaires et/ou dans la schizophrénie Download PDF

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Publication number
WO2007100913A2
WO2007100913A2 PCT/US2007/005404 US2007005404W WO2007100913A2 WO 2007100913 A2 WO2007100913 A2 WO 2007100913A2 US 2007005404 W US2007005404 W US 2007005404W WO 2007100913 A2 WO2007100913 A2 WO 2007100913A2
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WO
WIPO (PCT)
Prior art keywords
genes
screening
expression
group
human
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Application number
PCT/US2007/005404
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English (en)
Other versions
WO2007100913A3 (fr
Inventor
Marquis P. Vawter
Ling Shao
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The Regents Of The University Of California
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Publication date
Application filed by The Regents Of The University Of California filed Critical The Regents Of The University Of California
Priority to GB0817080A priority Critical patent/GB2449819A/en
Publication of WO2007100913A2 publication Critical patent/WO2007100913A2/fr
Publication of WO2007100913A3 publication Critical patent/WO2007100913A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Abstract

L'invention concerne des marqueurs moléculaires qui sont des marqueurs pronostiques et/ou diagnostiques d'un trouble psychiatrique. En particulier, on a identifié des gènes dont l'expression est modifiée dans la schizophrénie et/ou dans les troubles bipolaires, constituant ainsi des marqueurs pronostiques et/ou diagnostiques du trouble. On a en outre identifié des gènes dont la dérégulation permet d'obtenir des marqueurs qui permettent la distinction diagnostique entre la schizophrénie et les troubles bipolaires.
PCT/US2007/005404 2006-02-28 2007-02-28 Gènes exprimés de façon différentielle dans les troubles bipolaires et/ou dans la schizophrénie WO2007100913A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB0817080A GB2449819A (en) 2006-02-28 2007-02-28 Genes differentially expressed in bipolar disorder and/or schizophrenia

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US77794506P 2006-02-28 2006-02-28
US60/777,945 2006-02-28
US84024806P 2006-08-25 2006-08-25
US60/840,248 2006-08-25

Publications (2)

Publication Number Publication Date
WO2007100913A2 true WO2007100913A2 (fr) 2007-09-07
WO2007100913A3 WO2007100913A3 (fr) 2008-12-04

Family

ID=38459686

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/005404 WO2007100913A2 (fr) 2006-02-28 2007-02-28 Gènes exprimés de façon différentielle dans les troubles bipolaires et/ou dans la schizophrénie

Country Status (3)

Country Link
US (2) US20080075789A1 (fr)
GB (1) GB2449819A (fr)
WO (1) WO2007100913A2 (fr)

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WO2009140665A2 (fr) * 2008-05-16 2009-11-19 Vanda Pharmaceuticals, Inc. Procédé de traitement
WO2009082743A3 (fr) * 2007-12-24 2009-11-19 Suregene Llc Marqueurs génétiques de la schizophrénie et des troubles bipolaires
CN104120172A (zh) * 2013-04-28 2014-10-29 上海交通大学 精神分裂症的基因标志物及其使用方法和应用

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US20130166320A1 (en) * 2011-09-15 2013-06-27 Nextbio Patient-centric information management
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GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
WO2020212948A1 (fr) 2019-04-17 2020-10-22 Compass Pathfinder Limited Procédés pour traiter les troubles neurocognitifs, la douleur chronique, et pour réduire l'inflammation

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009082743A3 (fr) * 2007-12-24 2009-11-19 Suregene Llc Marqueurs génétiques de la schizophrénie et des troubles bipolaires
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CN104120172A (zh) * 2013-04-28 2014-10-29 上海交通大学 精神分裂症的基因标志物及其使用方法和应用
CN104120172B (zh) * 2013-04-28 2018-11-09 上海交通大学 精神分裂症的基因标志物及其使用方法和应用

Also Published As

Publication number Publication date
US20080075789A1 (en) 2008-03-27
US20100305103A1 (en) 2010-12-02
WO2007100913A3 (fr) 2008-12-04
GB0817080D0 (en) 2008-10-29
GB2449819A (en) 2008-12-03

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