WO2007088537A3 - Procédés et trousses pour la détection précoce du cancer ou d'une prédisposition au cancer - Google Patents

Procédés et trousses pour la détection précoce du cancer ou d'une prédisposition au cancer Download PDF

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Publication number
WO2007088537A3
WO2007088537A3 PCT/IL2007/000122 IL2007000122W WO2007088537A3 WO 2007088537 A3 WO2007088537 A3 WO 2007088537A3 IL 2007000122 W IL2007000122 W IL 2007000122W WO 2007088537 A3 WO2007088537 A3 WO 2007088537A3
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WO
WIPO (PCT)
Prior art keywords
kits
methods
cancer
determining
predisposition
Prior art date
Application number
PCT/IL2007/000122
Other languages
English (en)
Other versions
WO2007088537A2 (fr
Inventor
Nadir Arber
Original Assignee
Medical Res Fund Of Tel Aviv S
Nadir Arber
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Res Fund Of Tel Aviv S, Nadir Arber filed Critical Medical Res Fund Of Tel Aviv S
Priority to DK07706065.5T priority Critical patent/DK1994410T3/da
Priority to JP2008552953A priority patent/JP5091163B2/ja
Priority to AT07706065T priority patent/ATE486285T1/de
Priority to US12/223,315 priority patent/US9394569B2/en
Priority to EP07706065A priority patent/EP1994410B1/fr
Priority to SI200730466T priority patent/SI1994410T1/sl
Priority to DE602007010108T priority patent/DE602007010108D1/de
Priority to PL07706065T priority patent/PL1994410T3/pl
Publication of WO2007088537A2 publication Critical patent/WO2007088537A2/fr
Publication of WO2007088537A3 publication Critical patent/WO2007088537A3/fr
Priority to IL193097A priority patent/IL193097A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57419—Specifically defined cancers of colon
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne des procédés et des trousses permettant de diagnostiquer un cancer ou une lésion prémaligne par l'établissement de la présence et/ou du taux de CD24 circulants chez un sujet. L'invention concerne aussi des procédés et des trousses permettant de déterminer si un sujet présente une prédisposition au cancer gastro-intestinal par l'établissement de la présence ou de l'absence, sous la forme homozygote ou hétérozygote, de génotype(s) associé(s) au cancer dans des séquences d'acide nucléique de CD24 et/ou d'APC. L'invention concerne aussi des procédés et des trousses permettant de surveiller l'efficacité d'un traitement anticancéreux par l'établissement de la présence et/ou du taux de CD24 circulants chez un sujet.
PCT/IL2007/000122 2006-01-31 2007-01-31 Procédés et trousses pour la détection précoce du cancer ou d'une prédisposition au cancer WO2007088537A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
DK07706065.5T DK1994410T3 (da) 2006-01-31 2007-01-31 Fremgangsmåder og kits til tidlig påvisning af cancer eller disposition derfor
JP2008552953A JP5091163B2 (ja) 2006-01-31 2007-01-31 癌またはその素因の早期検出のための方法およびキット
AT07706065T ATE486285T1 (de) 2006-01-31 2007-01-31 Verfahren zur früherkennung von krebs
US12/223,315 US9394569B2 (en) 2006-01-31 2007-01-31 Methods and kits for early detection of cancer or predisposition thereto
EP07706065A EP1994410B1 (fr) 2006-01-31 2007-01-31 Procédés pour la détection précoce du cancer
SI200730466T SI1994410T1 (sl) 2006-01-31 2007-01-31 Metode in kompleti za zgodnje odkrivanje raka ali predispozicije zanj
DE602007010108T DE602007010108D1 (fr) 2006-01-31 2007-01-31
PL07706065T PL1994410T3 (pl) 2006-01-31 2007-01-31 Sposoby wczesnego wykrywania raka
IL193097A IL193097A (en) 2006-01-31 2008-07-28 Methods and kits for early diagnosis of cancer or predisposition to cancer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76337806P 2006-01-31 2006-01-31
US60/763,378 2006-01-31

Publications (2)

Publication Number Publication Date
WO2007088537A2 WO2007088537A2 (fr) 2007-08-09
WO2007088537A3 true WO2007088537A3 (fr) 2007-10-25

Family

ID=38001788

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2007/000122 WO2007088537A2 (fr) 2006-01-31 2007-01-31 Procédés et trousses pour la détection précoce du cancer ou d'une prédisposition au cancer

Country Status (12)

Country Link
US (1) US9394569B2 (fr)
EP (1) EP1994410B1 (fr)
JP (1) JP5091163B2 (fr)
AT (1) ATE486285T1 (fr)
DE (1) DE602007010108D1 (fr)
DK (1) DK1994410T3 (fr)
ES (1) ES2355388T3 (fr)
IL (1) IL193097A (fr)
PL (1) PL1994410T3 (fr)
PT (1) PT1994410E (fr)
SI (1) SI1994410T1 (fr)
WO (1) WO2007088537A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7897356B2 (en) 2008-11-12 2011-03-01 Caris Life Sciences Methods and systems of using exosomes for determining phenotypes

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2355388T3 (es) 2006-01-31 2011-03-25 Medical Research Fund Of Tel Aviv Sourasky Medical Center Métodos para la detección precoz de cáncer.
EP2220505B1 (fr) 2007-12-10 2015-10-28 The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center Procédés de diagnostic du cancer
BRPI0919882A8 (pt) * 2008-10-30 2017-09-19 Caris Life Sciences Luxembourg Holdings Métodos para avaliar padrões de rna
EP2524059A4 (fr) 2010-01-13 2013-11-20 Caris Life Sciences Luxembourg Holdings Détection d'affections gastro-intestinales
AU2011223789A1 (en) 2010-03-01 2012-09-20 Caris Life Sciences Switzerland Holdings Gmbh Biomarkers for theranostics
CA2795776A1 (fr) 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Biomarqueurs circulants pour une maladie
CA3025123C (fr) 2010-05-21 2022-10-11 The Governors Of The University Of Alberta Methodes de diagnostic du cancer colorectal et des polypes colorectaux faisant appel au dosage de metabolites urinaires
CN105849276B (zh) * 2013-10-01 2020-07-24 生命技术公司 用于检测结构变异体的系统和方法
ES2939298T3 (es) 2017-05-21 2023-04-20 Medical Res Infrastructure & Health Services Fund Tel Aviv Medical Ct Combinación de marcadores para el diagnóstico del cáncer
EP3759493A1 (fr) 2018-02-28 2021-01-06 The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center Méthodes de diagnostic et de traitement du cancer de la vessie
EP4369356A2 (fr) 2018-11-30 2024-05-15 Caris MPI, Inc. Profilage moléculaire de nouvelle génération
CN110777213A (zh) * 2019-11-05 2020-02-11 武汉科技大学 一种潜伏期胃癌诊断试剂盒
CA3163319A1 (fr) 2019-12-02 2021-06-10 Caris Mpi, Inc. Predicteur de reponse au platine dans une approche pan-cancer
US11840720B2 (en) 2019-12-23 2023-12-12 Metabolomic Technologies Inc. Urinary metabolomic biomarkers for detecting colorectal cancer and polyps

Citations (2)

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Publication number Priority date Publication date Assignee Title
US20040005596A1 (en) * 2002-03-19 2004-01-08 Jing Li Gene amplification in cancer
CA2453198A1 (fr) * 2004-01-07 2005-07-07 Wei-Ping Min Quantification et production d'exosomes immunosuppresseurs

Family Cites Families (8)

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CA2101943A1 (fr) * 1991-02-05 1992-08-06 Kamal Bahar Test simple pour le depistage d'un antigene carcino-embryonnaire
US5741650A (en) * 1996-01-30 1998-04-21 Exact Laboratories, Inc. Methods for detecting colon cancer from stool samples
US7081516B2 (en) * 2002-08-26 2006-07-25 Case Western Reserve University Methods for categorizing patients
US20040097448A1 (en) * 2002-11-19 2004-05-20 Isis Pharmaceuticals Inc. Modulation of CD24 expression
US20050130193A1 (en) * 2003-09-10 2005-06-16 Luxon Bruce A. Methods for detecting, diagnosing and treating human renal cell carcinoma
WO2005054810A2 (fr) * 2003-11-26 2005-06-16 The Ohio State University Research Foundation Genotypes cd24 polymorphes indicateurs d'un risque et d'une progression de sclerose en plaques
JP4912894B2 (ja) * 2004-02-19 2012-04-11 イェール ユニバーシティー プロテオーム技術を使用した癌タンパク質バイオマーカーの同定
ES2355388T3 (es) 2006-01-31 2011-03-25 Medical Research Fund Of Tel Aviv Sourasky Medical Center Métodos para la detección precoz de cáncer.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040005596A1 (en) * 2002-03-19 2004-01-08 Jing Li Gene amplification in cancer
CA2453198A1 (fr) * 2004-01-07 2005-07-07 Wei-Ping Min Quantification et production d'exosomes immunosuppresseurs

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SAGIV ET AL: "CD24 plays an important role in the carcinogenesis process of the pancreas", BIOMEDICINE AND PHARMACOTHERAPY, ELSEVIER, PARIS, FR, vol. 60, no. 6, July 2006 (2006-07-01), pages 280 - 284, XP005605585, ISSN: 0753-3322 *
WEICHERT WILKO ET AL: "Cytoplasmic CD24 expression in colorectal cancer independently correlates with shortened patient survival.", CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 15 SEP 2005, vol. 11, no. 18, 15 September 2005 (2005-09-15), pages 6574 - 6581, XP002433544, ISSN: 1078-0432 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7897356B2 (en) 2008-11-12 2011-03-01 Caris Life Sciences Methods and systems of using exosomes for determining phenotypes

Also Published As

Publication number Publication date
IL193097A0 (en) 2009-02-11
EP1994410B1 (fr) 2010-10-27
SI1994410T1 (sl) 2011-03-31
DE602007010108D1 (fr) 2010-12-09
IL193097A (en) 2013-03-24
US20100062450A1 (en) 2010-03-11
DK1994410T3 (da) 2011-01-31
WO2007088537A2 (fr) 2007-08-09
PL1994410T3 (pl) 2011-12-30
ATE486285T1 (de) 2010-11-15
ES2355388T3 (es) 2011-03-25
PT1994410E (pt) 2011-01-10
US9394569B2 (en) 2016-07-19
JP2009525041A (ja) 2009-07-09
JP5091163B2 (ja) 2012-12-05
EP1994410A2 (fr) 2008-11-26

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