WO2007077140A1 - Derives d’hydroxy-norephedrine et leur procede de fabrication - Google Patents

Derives d’hydroxy-norephedrine et leur procede de fabrication Download PDF

Info

Publication number
WO2007077140A1
WO2007077140A1 PCT/EP2006/070058 EP2006070058W WO2007077140A1 WO 2007077140 A1 WO2007077140 A1 WO 2007077140A1 EP 2006070058 W EP2006070058 W EP 2006070058W WO 2007077140 A1 WO2007077140 A1 WO 2007077140A1
Authority
WO
WIPO (PCT)
Prior art keywords
formula
preparation
optically active
compound
racemic
Prior art date
Application number
PCT/EP2006/070058
Other languages
German (de)
English (en)
Inventor
Daniela Herzberg
Wolfgang Siegel
Stefan Orsten
Original Assignee
Basf Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Aktiengesellschaft filed Critical Basf Aktiengesellschaft
Publication of WO2007077140A1 publication Critical patent/WO2007077140A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
    • C07C217/70—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring

Abstract

La présente invention concerne des dérivés de tert-butoxy-noréphédrine ou -éphédrine, ainsi que leur procédé de fabrication. L'invention concerne également un procédé de fabrication de 4-hydroxy-noréphédrine, notamment de 4-hydroxy-(1R, 2S)-noréphédrine, selon lequel des dérivés de tert-butoxy-noréphédrine sont utilisés dans une étape intermédiaire.
PCT/EP2006/070058 2006-01-06 2006-12-21 Derives d’hydroxy-norephedrine et leur procede de fabrication WO2007077140A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06100135.0 2006-01-06
EP06100135 2006-01-06

Publications (1)

Publication Number Publication Date
WO2007077140A1 true WO2007077140A1 (fr) 2007-07-12

Family

ID=37885911

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/070058 WO2007077140A1 (fr) 2006-01-06 2006-12-21 Derives d’hydroxy-norephedrine et leur procede de fabrication

Country Status (1)

Country Link
WO (1) WO2007077140A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015063795A3 (fr) * 2013-10-31 2015-07-02 Laurus Labs Private Limited Nouveau procédé de préparation de noréphédrine optiquement pure et de ses dérivés
CN104805148A (zh) * 2015-04-30 2015-07-29 苏州汉酶生物技术有限公司 一种(1r,2s)-n-吡咯烷基去甲麻黄碱的生物制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003018531A1 (fr) * 2001-08-28 2003-03-06 Polychip Pharmaceuticals Pty Ltd Procedes de synthese d'amines, telles que l'ephedrine et des intermediaires
EP1340743A1 (fr) * 2000-11-09 2003-09-03 Mitsui Chemicals, Inc. Derive d'amine optiquement actif et methode de synthese
EP1512677A1 (fr) * 2002-06-11 2005-03-09 Kaneka Corporation Procede de production d'un $g(b)-aminoalcool optiquement actif
WO2005100299A1 (fr) * 2004-04-15 2005-10-27 Emmellen Biotech Pharmaceuticals Limited Procede pour preparer du 1-erythro-2-amino-1-phenyl-1-propanol actif de maniere optique

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1340743A1 (fr) * 2000-11-09 2003-09-03 Mitsui Chemicals, Inc. Derive d'amine optiquement actif et methode de synthese
WO2003018531A1 (fr) * 2001-08-28 2003-03-06 Polychip Pharmaceuticals Pty Ltd Procedes de synthese d'amines, telles que l'ephedrine et des intermediaires
EP1512677A1 (fr) * 2002-06-11 2005-03-09 Kaneka Corporation Procede de production d'un $g(b)-aminoalcool optiquement actif
WO2005100299A1 (fr) * 2004-04-15 2005-10-27 Emmellen Biotech Pharmaceuticals Limited Procede pour preparer du 1-erythro-2-amino-1-phenyl-1-propanol actif de maniere optique

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015063795A3 (fr) * 2013-10-31 2015-07-02 Laurus Labs Private Limited Nouveau procédé de préparation de noréphédrine optiquement pure et de ses dérivés
CN104805148A (zh) * 2015-04-30 2015-07-29 苏州汉酶生物技术有限公司 一种(1r,2s)-n-吡咯烷基去甲麻黄碱的生物制备方法
CN104805148B (zh) * 2015-04-30 2019-02-01 苏州汉酶生物技术有限公司 一种(1r,2s)-n-吡咯烷基去甲麻黄碱的生物制备方法

Similar Documents

Publication Publication Date Title
DE2853573A1 (de) Herstellung von n-substituierten derivaten des l-desoxynojirimycins
Jian-Xin et al. Reductive biotransformation of carbonyl compounds—application of fungus, Geotrichum sp. G38 in organic synthesis
EP1418170B1 (fr) Procédé de préparation d' aminoalcools optiquement actifs par résolution optique
CN104805142A (zh) 一种醇脱氢酶在不对称还原反应中的应用
EP1405917B1 (fr) Procédé de production de dérivés de l'acide 3-heteroaryl-3-hydroxy-propanoique par réduction énantiosélective microbienne
EP2245000B1 (fr) Préparation d'alpha aminocétals optiquement actifs
WO2007077140A1 (fr) Derives d’hydroxy-norephedrine et leur procede de fabrication
US5663360A (en) Process for preparing [R-(R*,R*)]-5-(3-chlorophenyl)-3-[2-(3,4-dimethoxylphenyl)-1-methyl-ethyl]-oxazolidin-2-one
EP1232279B1 (fr) Procede de preparation d'amines optiquement actives
DE60036758T2 (de) Verfahren zur Herstellung von optisch aktiver 3,3,3-Trifluor-2-hydroxy-2-methylpropionsäure und deren Salze
EP2096103A1 (fr) Procédé pour la production d'une bétaïne
CN105566242B (zh) 利奈唑胺及其中间体的制备方法
EP1688501B1 (fr) Procédé de préparation de manool et de manool cétone
DE60012802T2 (de) Verfahren zur Herstellung von optisch aktiven Cyanhydrinen
WO2014001075A1 (fr) Procédés de racémisation d'arylalkylamines optiquement actives
CN101481335B (zh) 卡巴拉汀中间体的制备方法
DE1543777B2 (de) Verfahren zur Herstellung von alpha niedrig Alkyl beta (4 hydroxy phenyl) alaninen
FR2468581A1 (fr) Preparation de b aminopropionamides
DE69905218T2 (de) Verfahren zur Herstellung von L-Allysin Acetal
WO2003093259A1 (fr) Beta-aminocetones optiquement actives, 1,3-aminoalcools optiquement actifs et procede de production de ces composes
CN109879775A (zh) 一种5-氨基乙酰丙酸盐酸盐中间体的环保制备方法
CN111393293B (zh) 一种酯氨解反应催化剂组合物及l-薄荷酰胺的制备方法
DE3890316C2 (fr)
CN112645824B (zh) 一种通过漆酶生物合成异丙胺盐酸盐的方法
WO2007077141A1 (fr) Procede de production de phenylacetylcarbinol substitue

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06841535

Country of ref document: EP

Kind code of ref document: A1