WO2007060448A2 - Chemical process for the preparation of an amido-phenoxybenzoic acid compound - Google Patents
Chemical process for the preparation of an amido-phenoxybenzoic acid compound Download PDFInfo
- Publication number
- WO2007060448A2 WO2007060448A2 PCT/GB2006/004399 GB2006004399W WO2007060448A2 WO 2007060448 A2 WO2007060448 A2 WO 2007060448A2 GB 2006004399 W GB2006004399 W GB 2006004399W WO 2007060448 A2 WO2007060448 A2 WO 2007060448A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formula
- compound
- azetidin
- ylcarbonyl
- reaction
- Prior art date
Links
- 0 CC(*)(/C=C/*1*)/C=C/C=C1/Oc1cc(OC(*)*)cc(C(NC2CCCCCCCCC2)=O)c1 Chemical compound CC(*)(/C=C/*1*)/C=C/C=C1/Oc1cc(OC(*)*)cc(C(NC2CCCCCCCCC2)=O)c1 0.000 description 4
- GYMPREHYURAWDZ-VIFPVBQESA-N C[C@@H](COC(C)(C)C)Oc1cc(C(O)=O)cc(Br)c1 Chemical compound C[C@@H](COC(C)(C)C)Oc1cc(C(O)=O)cc(Br)c1 GYMPREHYURAWDZ-VIFPVBQESA-N 0.000 description 1
- YKAGGLGYQNVKLO-VIFPVBQESA-N C[C@@H](COP)Oc1cc(C(O)=O)cc(C(C)=C)c1 Chemical compound C[C@@H](COP)Oc1cc(C(O)=O)cc(C(C)=C)c1 YKAGGLGYQNVKLO-VIFPVBQESA-N 0.000 description 1
- APYYLTZBCALLJB-UHFFFAOYSA-N Oc(cc1)ccc1C(N1CCC1)=O Chemical compound Oc(cc1)ccc1C(N1CCC1)=O APYYLTZBCALLJB-UHFFFAOYSA-N 0.000 description 1
- YXWIHFMCIKEWEZ-UHFFFAOYSA-N Oc(cc1)ccc1C(NI)=O Chemical compound Oc(cc1)ccc1C(NI)=O YXWIHFMCIKEWEZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Definitions
- R 1 is hydroxymethyl, methoxymethyl or methyl
- hydroxy protecting groups P 1 are t-butyl, benzyl, trityl (triphenylmethyl) and tetrahydropyran-2-yl; such that the preferred side chains on compounds of formula (I)-(III) are:
- P 1 is hydroxy or a hydroxy protecting group
- HET-I is an optionally substituted 5- or 6-membered, C-linked heteroaryl ring containing a nitrogen atom in the 2-position.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/095,101 US7973178B2 (en) | 2005-11-28 | 2006-11-27 | Chemical process for the preparation of an amido-phenoxybenzoic acid compound |
JP2008542822A JP2009517449A (en) | 2005-11-28 | 2006-11-27 | Chemical production method of amidophenoxybenzoic acid compound |
CA002629995A CA2629995A1 (en) | 2005-11-28 | 2006-11-27 | Chemical process for the preparation of an amido-phenoxybenzoic acid compound |
BRPI0619019-7A BRPI0619019A2 (en) | 2005-11-28 | 2006-11-27 | process for making a compound, and, compound |
EP06808668A EP1960354A2 (en) | 2005-11-28 | 2006-11-27 | Chemical process for the preparation of an amido-phenoxybenzoic acid compound |
AU2006318889A AU2006318889A1 (en) | 2005-11-28 | 2006-11-27 | Chemical process for the preparation of an amido-phenoxybenzoic acid compound |
NO20082116A NO20082116L (en) | 2005-11-28 | 2008-05-07 | Chemical process for preparing an amido-phenoxybenzoic acid compound |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74004205P | 2005-11-28 | 2005-11-28 | |
US60/740,042 | 2005-11-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007060448A2 true WO2007060448A2 (en) | 2007-05-31 |
WO2007060448A3 WO2007060448A3 (en) | 2008-04-10 |
Family
ID=38067585
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2006/004399 WO2007060448A2 (en) | 2005-11-28 | 2006-11-27 | Chemical process for the preparation of an amido-phenoxybenzoic acid compound |
Country Status (13)
Country | Link |
---|---|
US (1) | US7973178B2 (en) |
EP (1) | EP1960354A2 (en) |
JP (1) | JP2009517449A (en) |
KR (1) | KR20080072738A (en) |
CN (1) | CN101316815A (en) |
AR (1) | AR057937A1 (en) |
AU (1) | AU2006318889A1 (en) |
BR (1) | BRPI0619019A2 (en) |
CA (1) | CA2629995A1 (en) |
NO (1) | NO20082116L (en) |
TW (1) | TW200738621A (en) |
WO (1) | WO2007060448A2 (en) |
ZA (1) | ZA200804171B (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010092387A1 (en) * | 2009-02-13 | 2010-08-19 | Astrazeneca Ab | Process for preparation of bezoyl amino heterocyclyl compounds |
US7910747B2 (en) | 2006-07-06 | 2011-03-22 | Bristol-Myers Squibb Company | Phosphonate and phosphinate pyrazolylamide glucokinase activators |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2554310A1 (en) * | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Benzamide derivatives and their use as glucokinase activating agents |
TW200600086A (en) * | 2004-06-05 | 2006-01-01 | Astrazeneca Ab | Chemical compound |
TW200714597A (en) * | 2005-05-27 | 2007-04-16 | Astrazeneca Ab | Chemical compounds |
BRPI0613570B8 (en) * | 2005-07-09 | 2021-05-25 | Astrazeneca Ab | compound, pharmaceutical composition and use of a compound or a pharmaceutically acceptable salt thereof |
CL2007003061A1 (en) * | 2006-10-26 | 2008-08-01 | Astrazeneca Ab | COMPOUNDS DERIVED FROM 3,5-DIOXI-BENZAMIDA; PREPARATION PROCESS; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUNDS; AND ITS USE TO TREAT A MEDIUM DISEASE THROUGH GLK, SUCH AS TYPE 2 DIABETES. |
BRPI0917589A2 (en) | 2008-08-04 | 2015-11-17 | Astrazeneca Ab | compound, pharmaceutical composition, use of a compound, method for treating disease, process, pharmaceutical combination, and reaction of methyloxyran-2-carboxylate (ix) with a roh alcohol |
GB0902406D0 (en) | 2009-02-13 | 2009-04-01 | Astrazeneca Ab | Crystalline polymorphic form |
WO2010116176A1 (en) * | 2009-04-09 | 2010-10-14 | Astrazeneca Ab | Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity |
AR076220A1 (en) | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | DERIVATIVES OF PIRAZOL [4,5 - E] PYRIMIDINE |
Citations (3)
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WO2005054200A1 (en) * | 2003-11-29 | 2005-06-16 | Astrazeneca Ab | Benzoyl amino pyridyl carboxylic acid derivatives useful as glucokinase (glk) activators |
WO2005080359A1 (en) * | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Benzamide derivatives and their use as glucokinae activating agents |
WO2005121110A1 (en) * | 2004-06-05 | 2005-12-22 | Astrazeneca Ab | Hetroaryl benzamide derivatives for use as glk activators in the treatment of diabetes |
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-
2006
- 2006-11-20 TW TW095142890A patent/TW200738621A/en unknown
- 2006-11-24 AR ARP060105191A patent/AR057937A1/en not_active Application Discontinuation
- 2006-11-27 BR BRPI0619019-7A patent/BRPI0619019A2/en not_active IP Right Cessation
- 2006-11-27 US US12/095,101 patent/US7973178B2/en not_active Expired - Fee Related
- 2006-11-27 CA CA002629995A patent/CA2629995A1/en not_active Abandoned
- 2006-11-27 EP EP06808668A patent/EP1960354A2/en not_active Withdrawn
- 2006-11-27 CN CNA2006800442161A patent/CN101316815A/en active Pending
- 2006-11-27 JP JP2008542822A patent/JP2009517449A/en not_active Withdrawn
- 2006-11-27 KR KR1020087015241A patent/KR20080072738A/en not_active Application Discontinuation
- 2006-11-27 WO PCT/GB2006/004399 patent/WO2007060448A2/en active Application Filing
- 2006-11-27 AU AU2006318889A patent/AU2006318889A1/en not_active Abandoned
-
2008
- 2008-05-07 NO NO20082116A patent/NO20082116L/en not_active Application Discontinuation
- 2008-05-14 ZA ZA200804171A patent/ZA200804171B/en unknown
Patent Citations (3)
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WO2005054200A1 (en) * | 2003-11-29 | 2005-06-16 | Astrazeneca Ab | Benzoyl amino pyridyl carboxylic acid derivatives useful as glucokinase (glk) activators |
WO2005080359A1 (en) * | 2004-02-18 | 2005-09-01 | Astrazeneca Ab | Benzamide derivatives and their use as glucokinae activating agents |
WO2005121110A1 (en) * | 2004-06-05 | 2005-12-22 | Astrazeneca Ab | Hetroaryl benzamide derivatives for use as glk activators in the treatment of diabetes |
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US7910747B2 (en) | 2006-07-06 | 2011-03-22 | Bristol-Myers Squibb Company | Phosphonate and phosphinate pyrazolylamide glucokinase activators |
US8153677B2 (en) | 2006-07-06 | 2012-04-10 | Bristol-Myers Squibb Company | Substituted pyrazolylamide compounds useful as glucokinase activators |
US8614332B2 (en) | 2006-07-06 | 2013-12-24 | Bristol-Myers Squibb Company | Substituted pyrazolylamides useful as glucokinase activators |
WO2010092387A1 (en) * | 2009-02-13 | 2010-08-19 | Astrazeneca Ab | Process for preparation of bezoyl amino heterocyclyl compounds |
CN102395574A (en) * | 2009-02-13 | 2012-03-28 | 阿斯利康(瑞典)有限公司 | Process for preparation of bezoyl amino heterocyclyl compounds |
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US7973178B2 (en) | 2011-07-05 |
NO20082116L (en) | 2008-08-20 |
AU2006318889A1 (en) | 2007-05-31 |
CA2629995A1 (en) | 2007-05-31 |
KR20080072738A (en) | 2008-08-06 |
US20080300412A1 (en) | 2008-12-04 |
WO2007060448A3 (en) | 2008-04-10 |
EP1960354A2 (en) | 2008-08-27 |
AR057937A1 (en) | 2007-12-26 |
CN101316815A (en) | 2008-12-03 |
JP2009517449A (en) | 2009-04-30 |
ZA200804171B (en) | 2010-01-27 |
TW200738621A (en) | 2007-10-16 |
BRPI0619019A2 (en) | 2011-09-20 |
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