JPS62158252A - 4-aminopyridinebenzamide derivative - Google Patents

4-aminopyridinebenzamide derivative

Info

Publication number
JPS62158252A
JPS62158252A JP29940985A JP29940985A JPS62158252A JP S62158252 A JPS62158252 A JP S62158252A JP 29940985 A JP29940985 A JP 29940985A JP 29940985 A JP29940985 A JP 29940985A JP S62158252 A JPS62158252 A JP S62158252A
Authority
JP
Japan
Prior art keywords
formula
aminopyridine
compound
lower alkyl
aminopyridinebenzamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP29940985A
Inventor
Tateshi Osawa
Kazumasa Sakakibara
Nobuyasu Yoneshima
Original Assignee
Kirin Brewery Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Brewery Co Ltd filed Critical Kirin Brewery Co Ltd
Priority to JP29940985A priority Critical patent/JPS62158252A/en
Publication of JPS62158252A publication Critical patent/JPS62158252A/en
Application status is Pending legal-status Critical

Links

Abstract

NEW MATERIAL:The compound of formula I [R is H, halogen, lower alkoxy, lower alkyl, nitro, cyano or di(lower alkyl)amino; n is 1W3; the position of R is 2', 3', 4', 5' or 6' or an arbitrary combination thereof].
EXAMPLE: N-benzoyl-4-aminopyridine.
USE: It has activity to promote myocardial contraction and is useful as a remedy for congestive cardiac insufficiency and a cardiotonic agent.
PREPARATION: The compound of formula I can be produced by reacting an acid halide of formula II (X is Cl or Br) with 4-aminopyridine in a solvent such as chloroform in the presence of a base (e.g. triethylamine) at about room temperature.
COPYRIGHT: (C)1987,JPO&Japio
JP29940985A 1985-12-28 1985-12-28 4-aminopyridinebenzamide derivative Pending JPS62158252A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP29940985A JPS62158252A (en) 1985-12-28 1985-12-28 4-aminopyridinebenzamide derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP29940985A JPS62158252A (en) 1985-12-28 1985-12-28 4-aminopyridinebenzamide derivative

Publications (1)

Publication Number Publication Date
JPS62158252A true JPS62158252A (en) 1987-07-14

Family

ID=17872185

Family Applications (1)

Application Number Title Priority Date Filing Date
JP29940985A Pending JPS62158252A (en) 1985-12-28 1985-12-28 4-aminopyridinebenzamide derivative

Country Status (1)

Country Link
JP (1) JPS62158252A (en)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0669311A1 (en) * 1991-01-28 1995-08-30 Rhone Poulenc Rorer Limited Benzamides
EP0757038A1 (en) * 1994-04-18 1997-02-05 Yoshitomi Pharmaceutical Industries, Ltd. Benzamide compound and medicinal use thereof
US5679696A (en) * 1992-07-28 1997-10-21 Rhone-Poulenc Rorer Limited Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group
US5840724A (en) * 1993-06-01 1998-11-24 Rhone-Poulenc Rorer Limited Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or
US6255326B1 (en) 1991-01-28 2001-07-03 Aventis Pharma Limited Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group
US7390908B2 (en) * 2001-08-17 2008-06-24 Astrazeneca Ab Compounds effecting glucokinase
US7642263B2 (en) 2005-07-09 2010-01-05 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
US7696191B2 (en) 2006-12-21 2010-04-13 Astrazeneca Ab Crystalline compound
US7700640B2 (en) 2004-10-16 2010-04-20 Astrazeneca Ab Process for making phenoxy benzamide compounds
US7709505B2 (en) 2002-11-19 2010-05-04 Astrazeneca Ab Benzofuran derivatives, process for their preparation and intermediates thereof
WO2010142752A1 (en) * 2009-06-11 2010-12-16 F. Hoffmann-La Roche Ag Janus kinase inhibitor compounds and methods
US7902200B2 (en) 2006-10-23 2011-03-08 Astrazeneca Ab Chemical compounds
JP2011509280A (en) * 2008-01-10 2011-03-24 アンスティテュート キュリー Chemical molecules that inhibit the slicing mechanism to treat diseases resulting from splicing abnormalities
US7973178B2 (en) 2005-11-28 2011-07-05 Astrazeneca Ab Chemical process for the preparation of an amido-phenoxybenzoic acid compound
US8071608B2 (en) 2009-04-09 2011-12-06 Astrazeneca Ab Therapeutic agents
US9890112B2 (en) 2011-04-01 2018-02-13 Abivax Compounds for use as therapeutic agents affecting p53 expression and/or activity
US10538485B2 (en) 2011-04-01 2020-01-21 Abivax Compounds for use as therapeutic agents affecting P53 expression and/or activity

Cited By (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6255326B1 (en) 1991-01-28 2001-07-03 Aventis Pharma Limited Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group
AU664694B2 (en) * 1991-01-28 1995-11-30 Rhone-Poulenc Rorer Limited Benzamides
EP0497564B1 (en) * 1991-01-28 1995-12-27 Rhone-Poulenc Rorer Limited Benzamides
EP0669311A1 (en) * 1991-01-28 1995-08-30 Rhone Poulenc Rorer Limited Benzamides
US5679696A (en) * 1992-07-28 1997-10-21 Rhone-Poulenc Rorer Limited Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic-or heteroatom-containing linking group
US5840724A (en) * 1993-06-01 1998-11-24 Rhone-Poulenc Rorer Limited Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or
EP0757038A4 (en) * 1994-04-18 1997-08-06 Yoshitomi Pharmaceutical Benzamide compound and medicinal use thereof
EP0757038A1 (en) * 1994-04-18 1997-02-05 Yoshitomi Pharmaceutical Industries, Ltd. Benzamide compound and medicinal use thereof
EP1195372A1 (en) * 1994-04-18 2002-04-10 Mitsubishi Pharma Corporation N-heterocyclic substituted benzamide derivatives with antihypertensive activity
EP1391454A1 (en) 1994-04-18 2004-02-25 Mitsubishi Pharma Corporation Substituted benzamide compounds with antihypertensive activity
US7390908B2 (en) * 2001-08-17 2008-06-24 Astrazeneca Ab Compounds effecting glucokinase
US7524957B2 (en) 2001-08-17 2009-04-28 Astrazeneca Ab Compounds effecting glucokinase
KR100920439B1 (en) 2001-08-17 2009-10-08 아스트라제네카 아베 Compounds effecting glucokinase
US7951830B2 (en) 2001-08-17 2011-05-31 Astrazeneca Ab Compounds effecting glucokinase
US7709505B2 (en) 2002-11-19 2010-05-04 Astrazeneca Ab Benzofuran derivatives, process for their preparation and intermediates thereof
US7700640B2 (en) 2004-10-16 2010-04-20 Astrazeneca Ab Process for making phenoxy benzamide compounds
US7642259B2 (en) 2005-07-09 2010-01-05 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
US7977328B2 (en) 2005-07-09 2011-07-12 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
US7642263B2 (en) 2005-07-09 2010-01-05 Astrazeneca Ab Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes
US7973178B2 (en) 2005-11-28 2011-07-05 Astrazeneca Ab Chemical process for the preparation of an amido-phenoxybenzoic acid compound
US7902200B2 (en) 2006-10-23 2011-03-08 Astrazeneca Ab Chemical compounds
US7696191B2 (en) 2006-12-21 2010-04-13 Astrazeneca Ab Crystalline compound
US9233931B2 (en) 2008-01-10 2016-01-12 Centre Nationale De Recherche Scientifique Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies
JP2011509280A (en) * 2008-01-10 2011-03-24 アンスティテュート キュリー Chemical molecules that inhibit the slicing mechanism to treat diseases resulting from splicing abnormalities
EP3536691A1 (en) * 2008-01-10 2019-09-11 Centre National De La Recherche Scientifique - Cnrs Chemical molecules that inhibit the splicing mechanism for treating diseases resulting from splicing anomalies
US10130595B2 (en) 2008-01-10 2018-11-20 Centre Nationale De Recherche Scientifique Chemical molecules that inhibit the slicing mechanism for treating diseases resulting from splicing anomalies
US8071608B2 (en) 2009-04-09 2011-12-06 Astrazeneca Ab Therapeutic agents
JP2012529470A (en) * 2009-06-11 2012-11-22 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Janus kinase inhibitor compounds and methods
US8486950B2 (en) * 2009-06-11 2013-07-16 F. Hoffmann-La Roche Ag Janus kinase inhibitor compounds and methods
CN102459187A (en) * 2009-06-11 2012-05-16 弗·哈夫曼-拉罗切有限公司 Janus kinase inhibitor compounds and methods
AU2010258597B2 (en) * 2009-06-11 2016-02-25 F. Hoffmann-La Roche Ag Janus kinase inhibitor compounds and methods
US20100317643A1 (en) * 2009-06-11 2010-12-16 Genentech, Inc. Janus kinase inhibitor compounds and methods
WO2010142752A1 (en) * 2009-06-11 2010-12-16 F. Hoffmann-La Roche Ag Janus kinase inhibitor compounds and methods
US9890112B2 (en) 2011-04-01 2018-02-13 Abivax Compounds for use as therapeutic agents affecting p53 expression and/or activity
US10538485B2 (en) 2011-04-01 2020-01-21 Abivax Compounds for use as therapeutic agents affecting P53 expression and/or activity

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