WO2007034282A3 - Composes de biphenylimidazole utilises comme antagonistes du recepteur du c3a - Google Patents

Composes de biphenylimidazole utilises comme antagonistes du recepteur du c3a Download PDF

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Publication number
WO2007034282A3
WO2007034282A3 PCT/IB2006/002568 IB2006002568W WO2007034282A3 WO 2007034282 A3 WO2007034282 A3 WO 2007034282A3 IB 2006002568 W IB2006002568 W IB 2006002568W WO 2007034282 A3 WO2007034282 A3 WO 2007034282A3
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Prior art keywords
diaryl
heterocycle
receptor antagonists
imidazole compounds
compounds condensed
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PCT/IB2006/002568
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English (en)
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WO2007034282A2 (fr
Inventor
Michelle Marie Claffey
Steven Wayne Goldstein
Stanley Jung
Arthur Nagel
Volker Shulze
Original Assignee
Pfizer Prod Inc
Michelle Marie Claffey
Steven Wayne Goldstein
Stanley Jung
Arthur Nagel
Volker Shulze
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Application filed by Pfizer Prod Inc, Michelle Marie Claffey, Steven Wayne Goldstein, Stanley Jung, Arthur Nagel, Volker Shulze filed Critical Pfizer Prod Inc
Publication of WO2007034282A2 publication Critical patent/WO2007034282A2/fr
Publication of WO2007034282A3 publication Critical patent/WO2007034282A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention porte sur des composés aryles substitués imidazo[4,5-c] pyridine. Ces composés sont utiles dans des compositions pharmaceutiques comme antagonistes du C3a pour traiter différents états médicaux associés à la cascade du complément. L'invention porte également sur des méthodes de traitement desdits états.
PCT/IB2006/002568 2005-09-19 2006-09-18 Composes de biphenylimidazole utilises comme antagonistes du recepteur du c3a WO2007034282A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71851705P 2005-09-19 2005-09-19
US60/718,517 2005-09-19

Publications (2)

Publication Number Publication Date
WO2007034282A2 WO2007034282A2 (fr) 2007-03-29
WO2007034282A3 true WO2007034282A3 (fr) 2007-05-18

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Family Applications (1)

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PCT/IB2006/002568 WO2007034282A2 (fr) 2005-09-19 2006-09-18 Composes de biphenylimidazole utilises comme antagonistes du recepteur du c3a

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WO (1) WO2007034282A2 (fr)

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US11566026B2 (en) 2016-12-22 2023-01-31 Incyte Corporation Heterocyclic compounds as immunomodulators

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CA2820262A1 (fr) 2010-12-08 2012-06-14 Vanderbilt University Utilisation de composes bicycliques de pyrazole en tant que modulateurs allosteriques des recepteurs mglur5
WO2012125732A1 (fr) * 2011-03-15 2012-09-20 Vanderbilt University Imadazapyrinidin-5(6h)-ones substituées en tant que modulateurs allostériques des récepteurs mglur5
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TWI644899B (zh) 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
US9079866B2 (en) 2013-02-04 2015-07-14 Janssen Pharmaceutica Nv Flap modulators
BR112015025140A2 (pt) * 2013-05-23 2017-07-18 Hoffmann La Roche 2-fenilimidazo[1,2-a]pirimidinas como agentes de imagem
AU2016269839B2 (en) 2015-06-03 2021-07-08 The University Of Queensland Mobilizing agents and uses therefor
MA52119A (fr) 2015-10-19 2018-08-29 Ncyte Corp Composés hétérocycliques utilisés comme immunomodulateurs
SG11201804152RA (en) 2015-11-19 2018-06-28 Incyte Corp Heterocyclic compounds as immunomodulators
CN105439965B (zh) * 2015-11-20 2018-05-22 江苏恒安化工有限公司 喹喔啉杂环及其衍生物的合成方法
ES2844374T3 (es) 2015-12-22 2021-07-22 Incyte Corp Compuestos heterocíclicos como inmunomoduladores
EP3452476B1 (fr) 2016-05-06 2021-12-15 Incyte Corporation Composés hétérocycliques utilisés comme immunomodulateurs
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11566026B2 (en) 2016-12-22 2023-01-31 Incyte Corporation Heterocyclic compounds as immunomodulators

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