WO2007023841A1 - Préparation d'agent pour la croissance des cheveux - Google Patents
Préparation d'agent pour la croissance des cheveux Download PDFInfo
- Publication number
- WO2007023841A1 WO2007023841A1 PCT/JP2006/316471 JP2006316471W WO2007023841A1 WO 2007023841 A1 WO2007023841 A1 WO 2007023841A1 JP 2006316471 W JP2006316471 W JP 2006316471W WO 2007023841 A1 WO2007023841 A1 WO 2007023841A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hair growth
- minoxidil
- preparation
- receptor agonist
- present
- Prior art date
Links
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Classifications
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the present invention relates to a hair growth preparation comprising minoxidil as an active ingredient.
- Minoxidil has a chemical name of 6- (1-piberidyl) -2,4-pyrimidinediamin-3-oxide, and has been reported for use as a hair restorer (see Patent Document 1), etc. There are many reports on hair growth, hair growth, and nourishing.
- Non-patent Document 1 an increase in the hair density (hair diameter) of beaked monkeys was observed by application of latanoprost.
- Patent Document 1 US Pat. No. 4,139,619
- Patent Document 2 JP 2001-2535
- Non-Patent Document 1 Acta Dermatol Venereol 82, 7-12 (2002)
- An object of the present invention is to further improve the excellent hair growth effect of minoxidil.
- the present invention provides
- a hair growth composition comprising minoxidil and an FP receptor agonist.
- the hair growth composition of the present invention has an excellent hair growth effect as compared to the case of the formulation component alone.
- the amount of minoxidil compounded in the present invention is 1 to 5 W / V% (hereinafter referred to as “W / V%”) of the whole preparation (in the case of an aerosol) in terms of hair growth effect. (It may be indicated by “%”). This is because if the amount is too small, the hair growth effect is insufficient, and if the amount is too large, preparation of the preparation becomes difficult because, for example, crystals of minoxidil precipitate.
- the blending amount of the FP receptor agonist blended in the present invention is preferably 0.00005 to 5% of the entire preparation from the viewpoint of hair growth promoting effect.
- the FP receptor agonist compounded in the present invention is preferably PGF2a, PGF2a alkyl ester or latanoprost.
- the alkyl ester is an alkyl ester having 1 to 6 carbon atoms, preferably a methyl ester.
- ethanol As the solvent for the hair growth composition of the present invention, ethanol, water or a mixture thereof is preferred.
- the blending amount in this case is preferably in the range of about 40 to 80% for ethanol and in the range of about 5 to 30% for water.
- blending with ethanol is preferable because it provides a good feeling of use due to ethanol volatilization immediately after application.
- the hair growth composition of the present invention preferably has a pH of 5.5 to 9.5 in terms of stability of the main ingredient, minoxidil, a feeling of use, a feeling of irritation to the skin during use, and a drug permeability.
- the range of 5.5 to 6.5 is more preferable.
- the pH can be adjusted by using commonly used acids and bases. Preferred examples include citrate, hydrochloric acid, lactic acid, phosphoric acid and salts thereof.
- Medicinal effect preferably added to and added to the hair growth composition of the present invention
- the components include menthol, vitamin E acetate, pantotulle ether, hinokitiol, glycyrrhetinic acid, diphenhydramine hydrochloride and the like.
- various active ingredients and auxiliary ingredients used in general external preparations such as excipients, vasodilators (carp chloride- Hum, benzyl nicotinate, assembly extract, ginseng extract, red pepper tincture, etc.), antihistamines (such as istipendil hydrochloride), anti-inflammatory agents (such as guaiazulene), keratolytic agents (such as urea and salicylic acid), fungicides (such as Chlorhexidine darconate, isopropyl methylphenol, quaternary ammonium salt, pyrotatone olamine, etc., moisturizer (sodium hyaluronate, chondroitin sulfate, etc.), various animals and plants (yichi, buttonpi, licorice, bonito, Dumplings, bean paste, power wormwood, comfrey, ashtap
- the hair growth composition of the present invention contains essential ingredients and, if necessary, other ingredients, and in the usual manner, lotions, aerosols, tonics, creams, ointments, gels It can be used as a suitable external preparation such as.
- the back body hair of C3H mice male, 7 weeks old was shaved.
- the hair growth state was scored with the scores shown in Table 1 on a daily basis from the administration start date of the test solution, and statistical analysis was performed using the scores on each observation day as an index.
- Table 2 shows the scores on the 19th and 22nd days after the start of administration.
- the present invention can be used as a pharmaceutical, a quasi-drug, a cosmetic, and the like.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Bien qu’une préparation de minoxidil présente un excellent effet sur la croissance des cheveux, une préparation à effet encore meilleur est recherchée. Dans ce cadre, l'étude des divers moyens d'améliorer l'excellent effet sur la croissance des cheveux du minoxidil a mené à l'élaboration d'un agent de croissance des cheveux contenant un mélange de minoxidil et d'un agoniste de récepteur FP (PGF2α, ester alkylique de PGF2α ou latanoprost) qui présente un excellent effet sur la croissance des cheveux, non prévisible en ne considérant que les effets séparés de ses composants respectifs. Ainsi, la préparation selon l'invention peut être efficacement employée au titre de préparation à usage externe, telle qu'un produit pharmaceutique ou cosmétique.
Priority Applications (1)
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JP2007532144A JP5780690B2 (ja) | 2005-08-25 | 2006-08-23 | 発毛剤組成物 |
Applications Claiming Priority (2)
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JP2005243557 | 2005-08-25 | ||
JP2005-243557 | 2005-08-25 |
Publications (1)
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WO2007023841A1 true WO2007023841A1 (fr) | 2007-03-01 |
Family
ID=37771583
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/JP2006/316471 WO2007023841A1 (fr) | 2005-08-25 | 2006-08-23 | Préparation d'agent pour la croissance des cheveux |
Country Status (2)
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JP (1) | JP5780690B2 (fr) |
WO (1) | WO2007023841A1 (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013180229A1 (fr) * | 2012-05-30 | 2013-12-05 | 旭硝子株式会社 | Composition pour la croissance capillaire |
US8686035B2 (en) | 2003-08-12 | 2014-04-01 | R-Tech Ueno, Ltd. | Composition and method for promoting hair growth |
US11918579B2 (en) | 2019-08-07 | 2024-03-05 | Aneira Pharma, Inc. | Methods and compositions for the treatment of hair loss |
Citations (5)
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WO1998033497A1 (fr) * | 1997-02-04 | 1998-08-06 | Johnstone Murray A | Procede permettant de stimuler le developpement du systeme pileux et la pousse des cheveux |
WO2001074315A2 (fr) * | 2000-03-31 | 2001-10-11 | The Procter & Gamble Company | Compositions et methodes de traitement de la perte de cheveux au moyen de prostaglandines non naturelles |
WO2003009820A2 (fr) * | 2001-07-25 | 2003-02-06 | Alcon, Inc. | Analogues de prostaglandine destines a favoriser la croissance des cheveux |
JP2003155218A (ja) * | 2001-09-10 | 2003-05-27 | Lion Corp | 養育毛組成物 |
WO2003092617A2 (fr) * | 2002-05-03 | 2003-11-13 | Combinatorx, Incorporated | Combinaisons destinees au traitement de troubles cutanes inflammatoires |
Family Cites Families (2)
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US6284234B1 (en) * | 1998-08-04 | 2001-09-04 | Johnson & Johnson Consumer Companies, Inc. | Topical delivery systems for active agents |
EP1358868A3 (fr) * | 2002-04-23 | 2003-11-19 | L'oreal | Composition cosmétique pour favoriser la pousse et/ou empecher ou retarder la chute des cheveux |
-
2006
- 2006-08-23 WO PCT/JP2006/316471 patent/WO2007023841A1/fr active Application Filing
- 2006-08-23 JP JP2007532144A patent/JP5780690B2/ja active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998033497A1 (fr) * | 1997-02-04 | 1998-08-06 | Johnstone Murray A | Procede permettant de stimuler le developpement du systeme pileux et la pousse des cheveux |
WO2001074315A2 (fr) * | 2000-03-31 | 2001-10-11 | The Procter & Gamble Company | Compositions et methodes de traitement de la perte de cheveux au moyen de prostaglandines non naturelles |
WO2003009820A2 (fr) * | 2001-07-25 | 2003-02-06 | Alcon, Inc. | Analogues de prostaglandine destines a favoriser la croissance des cheveux |
JP2003155218A (ja) * | 2001-09-10 | 2003-05-27 | Lion Corp | 養育毛組成物 |
WO2003092617A2 (fr) * | 2002-05-03 | 2003-11-13 | Combinatorx, Incorporated | Combinaisons destinees au traitement de troubles cutanes inflammatoires |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8686035B2 (en) | 2003-08-12 | 2014-04-01 | R-Tech Ueno, Ltd. | Composition and method for promoting hair growth |
WO2013180229A1 (fr) * | 2012-05-30 | 2013-12-05 | 旭硝子株式会社 | Composition pour la croissance capillaire |
EP2857002A4 (fr) * | 2012-05-30 | 2015-12-09 | Asahi Glass Co Ltd | Composition pour la croissance capillaire |
JPWO2013180229A1 (ja) * | 2012-05-30 | 2016-01-21 | 参天製薬株式会社 | 育毛用組成物 |
US11918579B2 (en) | 2019-08-07 | 2024-03-05 | Aneira Pharma, Inc. | Methods and compositions for the treatment of hair loss |
Also Published As
Publication number | Publication date |
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JP5780690B2 (ja) | 2015-09-16 |
JPWO2007023841A1 (ja) | 2009-02-26 |
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