WO2007010598A1 - Procédé de production de stent et appareil de frittage de poudre - Google Patents

Procédé de production de stent et appareil de frittage de poudre Download PDF

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Publication number
WO2007010598A1
WO2007010598A1 PCT/JP2005/013266 JP2005013266W WO2007010598A1 WO 2007010598 A1 WO2007010598 A1 WO 2007010598A1 JP 2005013266 W JP2005013266 W JP 2005013266W WO 2007010598 A1 WO2007010598 A1 WO 2007010598A1
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WO
WIPO (PCT)
Prior art keywords
powder
stent
powder sintering
sintering
layer
Prior art date
Application number
PCT/JP2005/013266
Other languages
English (en)
Japanese (ja)
Inventor
Kenichi Shimodaira
Chiaki Abe
Akira Shinjo
Original Assignee
Homs Engineering Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Homs Engineering Inc. filed Critical Homs Engineering Inc.
Priority to PCT/JP2005/013266 priority Critical patent/WO2007010598A1/fr
Publication of WO2007010598A1 publication Critical patent/WO2007010598A1/fr

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10—Processes of additive manufacturing
    • B29C64/141—Processes of additive manufacturing using only solid materials
    • B29C64/153—Processes of additive manufacturing using only solid materials using layers of powder being selectively joined, e.g. by selective laser sintering or melting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/20—Direct sintering or melting
    • B22F10/28—Powder bed fusion, e.g. selective laser melting [SLM] or electron beam melting [EBM]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/60—Treatment of workpieces or articles after build-up
    • B22F10/64—Treatment of workpieces or articles after build-up by thermal means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/60—Treatment of workpieces or articles after build-up
    • B22F10/66—Treatment of workpieces or articles after build-up by mechanical means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F12/00—Apparatus or devices specially adapted for additive manufacturing; Auxiliary means for additive manufacturing; Combinations of additive manufacturing apparatus or devices with other processing apparatus or devices
    • B22F12/38—Housings, e.g. machine housings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F12/00—Apparatus or devices specially adapted for additive manufacturing; Auxiliary means for additive manufacturing; Combinations of additive manufacturing apparatus or devices with other processing apparatus or devices
    • B22F12/40—Radiation means
    • B22F12/41—Radiation means characterised by the type, e.g. laser or electron beam
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F12/00—Apparatus or devices specially adapted for additive manufacturing; Auxiliary means for additive manufacturing; Combinations of additive manufacturing apparatus or devices with other processing apparatus or devices
    • B22F12/70—Gas flow means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/25—Process efficiency

Definitions

  • the present invention relates to a method for manufacturing a stent and a powder sintering apparatus.
  • FIG. 22 is a view for explaining a conventional stent manufacturing method.
  • FIG. 22 (a) is a schematic view showing the main part of the laser device 900
  • FIG. 22 (b) is an external view of the manufactured stent 940.
  • FIG. 22 (a) is a schematic view showing the main part of the laser device 900
  • FIG. 22 (b) is an external view of the manufactured stent 940.
  • the laser irradiation apparatus 910 scans the surface of the metal tube 930 with the laser beam L, and processes the surface of the metal tube 930 into a mesh shape, thereby manufacturing the stent 940 (see, for example, Patent Documents 1 and 2). ) 0
  • a stent 940 having a predetermined mesh shape can be manufactured.
  • Patent Document 1 Japanese Patent Laid-Open No. 2005-095610
  • Patent Document 2 Japanese Patent Laid-Open No. 2001-219286
  • a stent having a relatively complicated shape at a treatment site using coronary artery interpension For example, when a stent is used for a blood vessel that has a shape that gradually decreases in the inner diameter along the axial direction, the shape in which the outer diameter gradually decreases in the axial direction (tapered). There is a need to use a stent having a shape. In addition, when a stent is used at a blood vessel bifurcation, there is a need to use a stent having a bifurcation.
  • the strut thickness is thicker at the axially central portion (see reference numeral 942 in FIG. 22 (b)), and at both axial end portions (see reference numeral 944 in FIG. 22 (b)).
  • a thinly constructed stent is conceivable.
  • the present invention has been made to solve the above-described problems, and provides a method for manufacturing a stent capable of easily manufacturing a stent having a relatively complicated shape. With the goal. Also, a powder sintered calorie device having a relatively complicated shape and suitable for producing a high-purity product such as a stent having such a relatively complicated shape is provided. With the goal.
  • an energy beam is selectively applied to the powder layer after the powder layer is formed on the powder sintered table using the powder layer forming apparatus.
  • the sintered layer is stacked by sequentially repeating a sintered layer forming step of forming a sintered layer by irradiation and a powder sintering processing table lowering step of lowering the powder sintering processing table by a predetermined amount. It includes a powder sintering process for forming a layered structure having a desired three-dimensional shape.
  • a structure having a desired three-dimensional shape by laminating a sintered layer formed by selectively irradiating a powder layer with an energy beam Therefore, it is possible to easily manufacture a stent having a relatively complicated shape.
  • the stent manufacturing method of the present invention it is possible to manufacture a stent having a desired composition by setting the composition of the powder contained in the powder layer to a desired composition. Become. In this case, a stent having a desired composition distribution can be manufactured by appropriately changing the composition of the powder contained in the powder layer.
  • the method of irradiation with the energy beam is changed, the heat treatment of the structure is performed unevenly after the structure is formed, or the composition of the powder contained in the powder layer is appropriately changed. This makes it possible to produce a stent having a desired density distribution.
  • the powder in the portion of the powder layer that has not been subjected to sintering can be reused after collection, so that the yield of the material can be increased. High manufacturing method.
  • Examples of the powder include a powder made of austenitic stainless steel (for example, SUS316), a powder having Ni-Ti alloy power, a powder having Co-Cr alloy power, a powder having Au-Cu alloy power, Au —
  • a powder made of austenitic stainless steel for example, SUS316
  • Ni-Ti alloy power for example, Ni-Ti alloy power
  • Co-Cr alloy power for example, Ni-Ti alloy power
  • a powder having Au-Cu alloy power Au
  • Au a powder made of austenitic stainless steel
  • a powder having Ni-Ti alloy power for example, a powder having Ni-Ti alloy power, a powder having Co-Cr alloy power, a powder having Au-Cu alloy power, Au —
  • Various metal powders such as powders made of Pt—Pd alloy, and various ceramic powders such as powders made of aluminum oxide and powders made of silicon oxide can be used.
  • the powder a powder having an average particle diameter in the range of 0.05 / ⁇
  • the energy beam a laser beam, an electron beam, or an ion beam that can increase the energy density and can also increase the resolution can be preferably used.
  • a structure with a relatively short time and high shape accuracy for example, several m or less.
  • a structure with a relatively short time and high shape accuracy for example, several / zm or less.
  • Stents can be manufactured.
  • the energy beam it is preferable to use an energy beam having a beam diameter of 10 to 70 ⁇ m.
  • the powder sintering table one having a descending pitch in the range of 1 to 40 ⁇ m can be preferably used.
  • the structure is formed in an airtight chamber.
  • the stent is used in a harsh environment such as being placed in a blood vessel for a long period of time and exposed to pulsation or blood, it is preferable that the stent is a high-purity stent with very little contamination of impurities.
  • the stent manufacturing method of the present invention by using the method as described above, contamination of impurities such as moisture, oxygen, nitrogen, organic matter, and metal impurities from the outside is suppressed, and a high-purity stent is manufactured. It becomes possible.
  • the powder sintering process is performed in a state where the hermetic chamber is evacuated or an inert gas or a predetermined reducing gas is introduced into the hermetic chamber. It is preferable to do so.
  • the energy beam is an electron beam or an ion beam
  • the powder sintering process is preferably performed in a state where the hermetic chamber is evacuated.
  • the energy beam is a laser beam
  • the powder layer is formed from a laser beam irradiation device installed outside the hermetic chamber. It is preferable to irradiate with a laser beam.
  • a stent can be manufactured.
  • the powder is produced using a powder sintering processing table drive device installed outside the hermetic chamber. It is preferable to raise and lower the sintering table.
  • the powder layer forming apparatus driving device installed outside the hermetic chamber is used. It is preferable to drive the powder layer forming apparatus.
  • the powder layer forming apparatus is preferably driven using a magnet or a linear motor.
  • the structure is heated while being heated using a heating device installed outside the hermetic chamber. It is preferable to form
  • the temperature difference inside the structure during the formation of the structure can be reduced by forming the structure while heating, so that distortion in the structure can be reduced. Can do.
  • a heating device installed outside the hermetic chamber moisture, oxygen, nitrogen, organic matter, and metal Impurities such as pure substances are prevented from being mixed, and it becomes possible to manufacture a high-purity stent.
  • the heating device a heater, an infrared heating device, a high-frequency heating device, or the like can be preferably used.
  • the infrared heating apparatus which can heat the site
  • heating conditions it is preferable to heat the structure in a range of 60 to 300 ° C.
  • the sintered body is integrally formed by heat-treating the structure after the structure is formed. Because it becomes possible to alloy, stents of various compositions can be manufactured. For example, when the sintered layer is formed while gradually changing the components, a stent having a composition distribution in which the composition gradually changes (for example, a gradient alloy) is manufactured. It becomes possible.
  • a stent having a stepped composition distribution can be manufactured.
  • a stent which is hard at the center in the axial direction and has high flexibility at both ends in the axial direction that is, the stent can be supported with force after placement of the stent, which hardly damages the blood vessel when inserting the stent.
  • Possible stents can be manufactured.
  • the first method for increasing the sintered density of the structure after the powder sintering step It is preferable to further include a heat treatment step.
  • the sintered density of the structure can be increased, so that a stent having predetermined physical properties (for example, hardness, flexibility, density, porosity, etc.) is obtained. It can be manufactured.
  • predetermined physical properties for example, hardness, flexibility, density, porosity, etc.
  • the density ratio was 70-80% of the true metal density.
  • each sintering is performed by this heat treatment. Because the layers can be alloyed together, stents of various compositions can be manufactured.
  • a stent made of a Co—Cr alloy cover is produced from Co powder and Cr powder
  • a stent having Au—Pt—Pd alloy strength is manufactured from Au powder
  • Pt powder and Pd powder for example, heat treatment may be performed under the conditions of 880 to 1050 ° C. and 30 to 90 minutes. preferable.
  • metal powders with different metal component strengths instead of using metal powders with different metal component strengths as powder, alloy powders with different components can be used as powder, and alloy powder and single metal component strength can be used as powder. It is also possible to use a metal powder.
  • the second heat treatment for example, when manufacturing a stent having austenitic stainless steel (for example, SUS316) force, rapid cooling is performed after heat treatment at 950 to 1250 ° C for 30 to 90 minutes. It is preferable to perform a heat treatment such as performing. In addition, for example, when manufacturing a stent made of Co—Cr alloy, heat treatment such as rapid cooling after heat treatment at 1100 to 1300 ° C. for 30 to 90 minutes is performed. It is preferable. For example, when a stent having an Au-Pt-Pd alloy strength is manufactured, a heat treatment may be performed in which quenching is performed after heat treatment is performed at 1000 to 1050 ° C. for 30 to 90 minutes. preferable.
  • the method further includes a third heat treatment step for performing an age hardening treatment of the structure.
  • the structure is made of a metal material having age-hardening properties
  • the structure has a predetermined hardness' elasticity.
  • a stent can be manufactured.
  • the first heat treatment step and the second heat treatment step can be used together, and the first heat treatment step, the second heat treatment step, and the third heat treatment step can be performed continuously.
  • the method for manufacturing a stent according to any one of (1) to (10) further includes a surface polishing step of polishing the surface of the structure.
  • a structure formed by powder sintering is generally formed in a form in which a large number of powders adhere to the surface.
  • the powder adhering to the surface can be removed, so that the surface of the stent can be made smooth.
  • the surface polishing step it is preferable to perform puff polishing, barrel polishing (wet or dry), electrolytic polishing or chemical polishing.
  • the stent manufacturing method according to any one of (1) to (11) preferably further includes a drug impregnation step of impregnating the structure with a drug.
  • DE S Drug-Eluting Stent
  • the characteristics as DES for example, chemical agent
  • Carrier characteristics, drug release characteristics, etc. can be made desired.
  • a growth inhibitor As the drug, a growth inhibitor, a growth inhibitory and immunosuppressant, an immunosuppressant, an extracellular matrix modifier, an endothelial repair promoter, or a drug appropriately combined with these can be preferably used.
  • a powder layer made of a metal powder coated with a resin is formed on a powder solidification table using a powder layer forming apparatus.
  • a powder solidified layer forming step for selectively irradiating the powder layer with an energy beam to melt the resin to form a powder solidified layer, and a powder for lowering the powder solidified table by a predetermined amount It is characterized by including a powder solidifying step of forming a structure having a desired three-dimensional shape by laminating the powder solidified layers by sequentially repeating a solidifying table lowering step.
  • a powder solidified layer formed by selectively irradiating a powder layer with an energy beam is laminated to have a desired three-dimensional shape. Since the structure is formed, a stent having a relatively complicated shape can be easily manufactured as in the case of the stent manufacturing method of the present invention.
  • the powder layer forming apparatus is used to form a powder layer made of a resin powder and a metal powder on a powder solidifying table.
  • a powder solidified layer formed by selectively irradiating a powder layer with an energy beam is laminated to obtain a desired three-dimensional shape.
  • a stent having a relatively complicated shape is easily manufactured. It becomes possible.
  • a stent having a relatively complicated shape, such as a thick stent formed at both ends in the axial direction, is also thin. It can be easily manufactured.
  • the porosity of the structure can be adjusted.
  • a powder sintering apparatus of the present invention includes an airtight chamber having a light-transmitting window, a powder sintering processing table disposed inside the airtight chamber and capable of moving up and down, and the air sintering chamber.
  • a powder layer forming device which is disposed inside a closed chamber and forms a powder layer on the powder sintering processing table; and a powder layer forming device which is disposed outside the hermetic chamber and passes through the translucent window.
  • a laser beam irradiation device for irradiating the layer with a laser beam.
  • a product having a relatively complicated shape can be manufactured by performing powder sintering, By performing the powder sintering process, it is possible to manufacture high-purity products with less contamination of impurities such as moisture, oxygen, nitrogen, organic matter, and metal impurities. Therefore, according to the powder sintering apparatus of the present invention, it is suitable for producing a high-purity product having a relatively complicated shape such as a stent having a relatively complicated shape.
  • the powder sintering apparatus of the present invention is not limited to a stent manufacturing method, but has a relatively complicated shape and requires high purity, for example, a custom-made artificial It can be suitably used in methods for producing joints, dental crowns and the like.
  • the laser beam irradiation device is preferably a UV laser beam irradiation device.
  • an Nd-YAG wavelength conversion (fourth harmonic) laser can be preferably used.
  • the translucent window Preferably has a curved surface portion.
  • the powder layer forming apparatus supplies the powder onto the powder sintering table. It is also preferable that the power of the powder supply device with the function of
  • the powder layer can be formed using the powder as it is, a special pretreatment for forming the powder layer (for example, production of a powder sheet, powder Etc.), and the manufacturing process can be simplified.
  • the powder in the powder layer that has not been sintered can be reused after collection.
  • the powder supply apparatus includes a plurality of powder supply apparatuses.
  • the sintered body is integrally alloyed by heat-treating the structure after the structure is formed. This makes it possible to produce products with various compositions.
  • the sintered layer is formed while gradually changing the components, it is possible to manufacture a product having a composition distribution in which the composition gradually changes (for example, made of a gradient alloy). It becomes possible.
  • the sintered layer is formed by changing the components stepwise during the process, a product having a stepwise composition distribution can be manufactured.
  • the powder sintering apparatus according to the above (19) or (20) further includes a vibration supply means for applying vibration to the powder on the powder sintering table. preferable.
  • the powder in the powder supply device or on the powder sintering processing table Therefore, it is possible to form a uniform powder layer with a high powder filling rate on the powder sintering table.
  • the vibration supply means an ultrasonic oscillator can be preferably used.
  • the powder layer forming apparatus uses a powder sheet on which powder is fixed as the powder. It is preferable that one or a plurality of powder sheet supply devices be supplied to the sintering table.
  • a powder sheet supply apparatus for supplying a powder sheet to a powder sintering processing table by feeding a roll-shaped powder sheet can be preferably used.
  • a new powder sheet is supplied onto the powder sintering process table, and then this powder sheet is cut and the powder sintering process table is cut.
  • a powder layer may be formed on the top, but before lowering the powder sintering table, a new powder sheet is supplied onto the powder sintering table and laser beam irradiation is performed as it is. After that, the powder sheet may be cut and the powder sintering table may be lowered.
  • the powder sheet may be cut with a dedicated cutting device or with a laser beam irradiation device for forming a sintered layer.
  • the powder sheet is fed into a powder sintering processing table by feeding out a sheet-like powder sheet that has been calendered according to the shape of the powder sintering processing table.
  • a powder sheet supply device for supplying to the bull can be preferably used.
  • the powder layer forming apparatus supplies a liquid containing powder to the powder sintering processing table. It is also preferable that one or more powder feeders supply to the power.
  • a sintered layer by supplying a liquid containing powder to the powder sintering table and then removing the liquid component and then irradiating with a laser beam.
  • the gas sintering It is preferable to further include a powder sintering table driving device that is disposed outside the closed chamber and moves the powder sintering table up and down.
  • the powder is disposed outside the hermetic chamber and drives the powder layer forming apparatus. It is preferable to further include a body layer forming device driving device.
  • the heating device a heater, an infrared heating device, a high-frequency heating device, or the like can be preferably used.
  • the infrared heating apparatus which can heat the site
  • the powder sintering apparatus is disposed between the powder sintering process table and the translucent window, It is preferable to further include shielding means for shielding the spray of powder from the powder layer and the evaporated substance of the powder.
  • the shielding means is blown against the light-transmitting window and a gas supply device that blows gas onto the light-transmitting window. It is preferable to have a gas suction device for sucking gas.
  • the shielding means introduces a gas flow between the powder sintering process table and the translucent window. It is also preferable to have a gas flow supply device and a gas flow absorption device I that absorbs the gas flow from the gas flow supply device.
  • the shielding means is intermittently or continuously between the powder sintering table and the translucent window. It is also preferable to have a transparent film supply device that feeds the transparent film into.
  • FIG. 1 is a flowchart shown for explaining a stent manufacturing method according to Embodiment 1.
  • FIG. 2 is a flowchart shown for explaining the stent manufacturing method according to the first embodiment.
  • FIG. 3 is a view for explaining a powder sintering apparatus 100 according to Embodiment 1.
  • FIG. 4 is a view for explaining a powder sintering table 132 in the powder sintering apparatus 100.
  • FIG. 5 is a process diagram shown for explaining a powder sintering process (step S200).
  • FIG. 6 is a perspective view schematically showing the structure 10 during the sintering process.
  • FIG. 7 is a flowchart for explaining a post-processing step (step S300) in the stent manufacturing method according to the first embodiment.
  • FIG. 8 is a view for explaining a powder sintering apparatus 100a according to Modification 1.
  • FIG. 9 is a view for explaining a powder sintering apparatus 100b according to Modification 2.
  • FIG. 10 is a view for explaining a powder sintering apparatus 100c according to Modification 3.
  • FIG. 11 is a view for explaining a powder sintering apparatus lOOd according to modification example 4.
  • FIG. 12 is a view for explaining a powder sintering apparatus 100e according to Modification 5.
  • FIG. 13 is a view for explaining a powder sintering apparatus lOOf according to Modification 6.
  • FIG. 14 is a view shown for explaining a powder sintering apparatus 100g according to Modification 7.
  • FIG. 15 is a view for explaining a powder sintering apparatus 100 h according to Modification 8.
  • FIG. 16 is a view for explaining a powder sintering apparatus 100i according to Modification 9.
  • FIG. 17 is a view for explaining a powder sintering apparatus 100j according to Modification 10;
  • FIG. 18 is a flowchart shown for explaining a stent manufacturing method according to the second embodiment.
  • FIG. 19 is a flowchart shown for explaining the stent manufacturing method according to the third embodiment.
  • FIG. 20 is a flowchart for explaining the stent manufacturing method according to the fourth embodiment.
  • FIG. 21 is a view for explaining the structure of the stent 20 manufactured by the stent manufacturing method according to Embodiment 4.
  • FIG. 22 is a view for explaining a conventional stent manufacturing method.
  • FIG. 1 and FIG. 2 are flowcharts for explaining the stent manufacturing method according to the first embodiment.
  • the stent manufacturing method according to Embodiment 1 includes a powder preparation step (Step S100) for preparing powder used for powder sintering, and a third step by performing powder sintering.
  • the powder sintering process is a powder layer forming process in which a powder layer is formed on a powder sintering process table using a powder layer forming apparatus ( Step S212), a sintering layer forming step (Step S214) for selectively irradiating the powder layer with an energy beam to form a sintered layer, and a powder sintering for lowering the powder sintering processing table by a predetermined amount. Bonding process And a table lowering process (step S216). Then, by repeating these steps in sequence, a sintered body is laminated to form a structure having a desired three-dimensional shape.
  • step S200 The powder sintering process (step S200) is performed using a dedicated powder sintering apparatus.
  • FIG. 3 is a view for explaining the powder sintering apparatus 100 according to the first embodiment.
  • Fig. 3 (a) is a plan view of the hermetic chamber 110 in the powder sintering cabinet apparatus 100
  • Fig. 3 (b) is an A-A diagram in Fig. 3 (a) in the powder sintering cabinet apparatus 100. It is sectional drawing.
  • FIG. 4 is a view for explaining the powder sintering table 132 in the powder sintering apparatus 100.
  • the powder sintering apparatus 100 includes an airtight chamber 110 having a translucent window 112 and a powder sintering processing table 132 that is disposed inside the airtight chamber 110 and can be moved up and down.
  • the powder layer M is disposed inside the hermetic chamber 110 and placed on the powder sintering table 132 (see FIG. 5 (d)).
  • Powder supply devices 150a, 150b, 150c as powder layer forming devices, and a laser beam to the powder layer M through the light-transmitting window 112.
  • a laser beam irradiation device 170 for irradiation And a laser beam irradiation device 170 for irradiation.
  • the powder sintering apparatus 100 includes a vacuum pump 116 and an exhaust valve 114 for exhausting the hermetic chamber 110, an Ar gas cylinder 120 for storing a gas to be introduced into the hermetic chamber 110, and an H gas.
  • a cylinder 120a, other (for example, ammonia decomposition gas) gas cylinder 120b, an introduction valve 118, and a heater 180 as a heating device for heating the structure are further provided.
  • the three powder supply devices 150a, 150b, and 150c are powder supply devices having a function of supplying the powder M onto the powder sintering table 132 as shown in FIG. 3 (a). , Respectively, shafts 152a, 152b, 152c, arms 154a, 1 54b, 154c rotatable around the shafts 152a, 152b, 152c, and powder inner yarns provided at the ends of the arms 154a, 154b, 154c. 156a, 156b, 156c and magnet parts 158a, 158b, 158c.
  • the force that the powder M is supplied only to the powder supply device 150a is supplied to the other powder supply devices 150b and 150c.
  • Body M is supplied.
  • the lower surface of the hermetic chamber 110 is made of permalloy, which is a magnetically permeable material.
  • the powder sintering apparatus 100 vibrates the powder in the powder storage units 156a, 156b, and 156c and the powder on the sintering apparatus powder sintering table 132.
  • An ultrasonic oscillator (not shown) as a vibration supply device is further provided.
  • the laser beam irradiation device 170 is a UV laser beam irradiation device.
  • the laser beam irradiation power is an Nd-YAG wavelength conversion (fourth harmonic) laser power that emits a UV laser beam.
  • the oscillator 172, a two-dimensional scanning mirror 174 that reflects the UV laser beam, a condenser lens 176 that condenses the UV laser beam, and a control unit 178 that controls these operations are included.
  • the powder sintering cache table 132 has a shaft portion 134 extending downward, and is freely rotatable in a lower portion of the powder sintering processing table storage portion 130. It is supported by the arranged powder sintering table support part 136. A magnet portion 138 is disposed below the powder sintering processing table support portion 136.
  • the powder sintering processing table driving device 140 has a rotating body 142 having a magnet portion 142 disposed on the upper surface and configured to be rotatable by the rotation of the motor 146, and the powder sintering process is performed by the rotation of the rotating body 142.
  • the rotation of the caulking table support 136 is controlled.
  • the powder sintering table storage section 130 has a permalloy force that is a magnetically permeable material.
  • the powder sintering apparatus 100 is further provided with a heater 160 as a heating device that is disposed outside the hermetic chamber 110 and heats the structure.
  • FIG. 5 is a process diagram shown for explaining the powder sintering cache process (step S 200).
  • FIG. 6 is a perspective view schematically showing the structure during the sintering process. In FIG. 6, the illustration of the powder M existing around the structure 10 is omitted.
  • the powder sintering table 132 at a predetermined position is lowered by a predetermined amount as shown in FIG. 5 (b). .
  • the powder supply device 150a is rotated in a state where the powder M is in the powder storage unit 156a, and the powder sintering processing table is turned on. Powder layer M on top of 132
  • the powder layer M is transferred from the laser beam irradiation device 170.
  • a laser beam is irradiated to form the sintered layer M.
  • the powder sintering table 132 is lowered by a predetermined amount as shown in FIG. 5 (g), and the powder supply device 150a is moved as shown in FIGS. 5 (h) to 5 (i).
  • the powder layer M is formed on the powder sintering processing table 132 by rotating again.
  • the powder layer forming process, the sintered layer forming process, and the powder sintering process table lowering process are sequentially repeated to perform sintering.
  • the layers are stacked to form a structure having the desired three-dimensional shape.
  • a structure 10 having a three-dimensional structure as shown in FIG. 6 can be formed.
  • the stent manufacturing method according to Embodiment 1 is performed by performing the powder sintering process using the powder sintering apparatus 100.
  • the laser beam is applied to the powder layer M.
  • Sintered layers M formed by selectively irradiating the film are laminated to form a structure having a desired three-dimensional shape, so that a stent having a relatively complicated shape can be easily manufactured.
  • composition of the powder M contained in the powder layer M is appropriately changed.
  • a stent having a desired density can be manufactured.
  • the energy beam irradiation method is changed, the heat treatment of the structure is unevenly performed after the structure is formed, or the powder M contained in the powder layer M is
  • Examples of the powder include powder made of austenitic stainless steel (for example, SUS316), powder having Ni-Ti alloy power, powder having Co-Cr alloy power, powder having Au-Cu alloy power, Au — Pt— Pd alloy power Various metal powders including various powders and various ceramic powders can be used. In this case, when ceramic powder is used as the powder, it is possible to use the ceramic powder alone, but it is preferable to use the ceramic powder together with the metal powder.
  • the shape accuracy is relatively short (for example, number: zm or less). It is possible to form a structure, and as a result, it is possible to manufacture a stent in a relatively short period of time and with high shape accuracy (for example, several / zm or less).
  • the structure is formed in the airtight chamber 110, moisture, oxygen, nitrogen, organic matter, metal impurities, etc. from the outside are used. It is possible to manufacture a high-purity stent. In this case, it is preferable to perform the powder sintering process in a state where the hermetic chamber 110 is evacuated or an inert gas or a predetermined reducing gas is introduced into the hermetic chamber 110.
  • the laser beam irradiation device 170 installed outside the hermetic chamber 110 is placed on the powder layer M.
  • impurities such as moisture, oxygen, nitrogen, organic matter, and metal impurities are prevented from entering the hermetic chamber 110 due to the laser beam irradiation, and a high-purity stent Can be manufactured.
  • the powder sintering table 132 is moved up and down using the powder sintering table driving device 140 installed outside the hermetic chamber 110.
  • impurities such as moisture, oxygen, nitrogen, organic matter, and metal impurities from entering the hermetic chamber 110 due to the raising and lowering of the powder sintering cabinet table 132, and to manufacture high-purity stents. It becomes possible to do.
  • the powder supply devices 150a, 150b, and 150c are used by using the powder supply device driving devices 160a, 160b, and 160c installed outside the hermetic chamber 110. Therefore, it is possible to prevent impurities such as moisture, oxygen, nitrogen, organic matter, and metal impurities from entering the hermetic chamber 110 due to the driving of the powder supply devices 150a, 150b, and 150c. It becomes possible to produce a high-purity stent.
  • the temperature difference inside the structure 10 during the structure formation can be reduced. Distortion in the structure 10 can be reduced.
  • the heater 180 installed outside the hermetic chamber 110 moisture, oxygen, nitrogen, organic matter, metal impurities, etc. in the hermetic chamber 110 due to the heating of the structure 10. It is possible to manufacture a high-purity stent.
  • FIG. 7 is a flowchart for explaining the post-processing step (step S300) in the stent manufacturing method according to the first embodiment.
  • the post-processing step (step S300) in the stent manufacturing method according to Embodiment 1 includes the first heat treatment step (step S312) for increasing the sintered density of the structure, and the melt of the structure.
  • a second heat treatment step (step S314) for performing a heat treatment for performing a heat treatment
  • the stent manufacturing method according to Embodiment 1 further includes a first heat treatment step for increasing the sintered density of the structure after the powder sintering step.
  • a first heat treatment step for increasing the sintered density of the body, it becomes possible to produce a stent having predetermined physical properties (for example, hardness, flexibility, density, porosity, etc.).
  • the density ratio of 70 to 80% of the true metal density before the first heat treatment step is set to 97 to the LOO% density ratio of the true metal density after the first heat treatment step. be able to.
  • each sintering is performed by the first heat treatment step. Since the tie layers can be alloyed together, stents of various compositions can be manufactured.
  • a stent made of a Co—Cr alloy cover is produced from Co powder and Cr powder
  • a stent having Au—Pt—Pd alloy strength is manufactured from Au powder
  • Pt powder and Pd powder for example, heat treatment may be performed under the conditions of 880 to 1050 ° C. and 30 to 90 minutes. preferable.
  • metal powders with different metal component strengths instead of using metal powders with different metal component strengths as powder, alloy powders with different components can be used as powder, and alloy powder and single metal component strength can be used as powder. It is also possible to use a metal powder.
  • the stent manufacturing method according to Embodiment 1 further includes a second heat treatment step of performing a melt treatment of the structure after the first heat treatment step, and the structure is made of age-hardened metal.
  • the structure since the structure further includes a third heat treatment step for performing age hardening treatment of the structure, it becomes possible to manufacture a stent having a predetermined hardness and elasticity.
  • the second heat treatment for example, in the case of manufacturing a stent having austenitic stainless steel (for example, SUS316) strength, rapid cooling is performed after heat treatment at 950 to 1250 ° C for 30 to 90 minutes. It is preferable to perform a heat treatment such as performing.
  • heat treatment such as rapid cooling after heat treatment at 1100 to 1300 ° C. for 30 to 90 minutes is performed. It is preferable.
  • a heat treatment may be performed in which quenching is performed after heat treatment is performed at 1000 to 1050 ° C. for 30 to 90 minutes. preferable.
  • the third heat treatment for example, when manufacturing a stent having Co—Cr alloy strength, it is preferable to perform the heat treatment under conditions of 700 to 850 ° C. for 30 to 180 minutes.
  • the heat treatment under conditions of 800 to 960 ° C. and 30 to 180 minutes.
  • first heat treatment step and the second heat treatment step can be used together, and the first heat treatment step, the second heat treatment step, and the third heat treatment step can be performed continuously.
  • the stent manufacturing method according to Embodiment 1 further includes a surface polishing step of polishing the surface of the structure. For this reason, since the powder adhering to the surface of the structure can be removed, the surface of the stent can be made smooth. In this surface polishing process, it is preferable to perform puff polishing, barrel polishing (wet or dry), electrolytic polishing or chemical polishing.
  • FIG. 8 is a view for explaining the powder sintering apparatus 100a according to the first modification.
  • FIG. 9 is a view for explaining the powder sintering apparatus 100b according to the second modification.
  • FIG. 10 is a diagram for explaining a powder sintering apparatus 100c according to Modification 3. In FIGS. 8 to 10, the illustration of the laser beam irradiation device 170 is omitted.
  • the powder sintering apparatus 100a, 100b, 100c according to the modified examples 1 to 3 basically has the same configuration as the powder sintering apparatus 100 according to the first embodiment. However, the powder sintering apparatus 100a, 100b, 100c according to the modified examples 1 to 3 is used for the powder droplets from the powder layer M and the powder particles.
  • the powder sintering apparatus 100 further includes a shielding means for shielding the evaporated material! [0131]
  • a shielding means for shielding the evaporated material!
  • a gas supply apparatus 190a that constantly blows fresh gas to the translucent window 112.
  • a gas suction device 190b for sucking the gas blown to the translucent window 112.
  • a fresh gas is always provided between the powder sintering table 132 and the translucent window 112 as a shielding means.
  • a gas flow supply device 192a for introducing a flow and a gas flow suction device 192b for sucking a gas flow from the gas flow supply device 192a are provided.
  • the shielding means is intermittently or continuously between the powder sintering table 132 and the translucent window 112.
  • a transparent film supply device 194 for feeding the transparent film is provided.
  • the powder droplets from the powder layer M and the evaporated powder adhere to the translucent window 112 and are translucent.
  • Deterioration of the light transmittance of the window 112 can be suppressed. For this reason, it is possible to always irradiate the laser beam under a certain condition during the formation of the structure, and the quality of the stent can be further improved.
  • FIG. 11 is a view for explaining a powder sintering apparatus 100d according to Modification 4.
  • FIG. 11 (a) is a sectional view of the powder sintering apparatus 100d
  • FIG. 11 (b) is a plan view of the powder sintering apparatus 100d.
  • the illustration of the laser beam irradiation device 170 is omitted.
  • the powder sintering apparatus 100d according to Modification 4 basically has a configuration similar to that of the powder sintering apparatus 100 according to Embodiment 1, but Embodiment 1
  • the structure of the powder layer forming apparatus is different from the powder sintering apparatus 100 according to FIG.
  • the powder layer forming apparatus performs powder sintering processing on the powder sheet M on which the powder M is fixed.
  • the powder sheet supply device 200 to be supplied to the And a cutting device 202 for cutting.
  • the powder sheet M on which the powder M is fixed can be supplied to the powder sintered casing table 132.
  • powder sintered casing table 132 powder
  • FIG. 12 is a view for explaining a powder sintering apparatus 100e according to Modification 5.
  • the illustration of the laser beam irradiation device 170 is omitted.
  • the powder sintering apparatus 100e according to Modification 5 basically has a configuration similar to that of the powder sintering apparatus lOOd according to Modification 4, but the modification The means for cutting the powder sheet M is different from the powder sintering apparatus lOOd according to 4.
  • the used portion of the powder sheet M is replaced with a laser beam irradiation apparatus 170 (not shown).
  • powder sheet M M
  • the means for cutting the powder sheet M2 is different from the powder sintering apparatus lOOd according to the modification 4.
  • the powder sheet M on which the powder M is fixed can be supplied to the powder sintering carriage table 132.
  • FIG. 13 is a view for explaining a powder sintering apparatus 100f according to Modification 6.
  • FIG. 13 (a) is a plan view of the powder sintering apparatus 100f
  • FIG. 13 (b) is a cross-sectional view taken along line AA in FIG. 13 (a) of the powder sintering apparatus 100f. is there.
  • the powder sintering apparatus 100f according to Modification 6 basically has a configuration similar to that of the powder sintering apparatus lOOd according to Modification 4, Powder sintering machine 1 The structure of the powder layer forming device is different from OOd.
  • the powder layer forming apparatus has a powder sheet having a shape corresponding to the shape of the powder sintering processing table.
  • the powder sintering apparatus 100f according to the modified example 6 differs from the powder sintering apparatus lOOd according to the modified example 4 in the configuration of the powder layer forming apparatus, but the powder M is Since it is possible to supply the fixed powder sheet M to the powder sintering carriage table 132, the modification 4
  • FIG. 14 is a view for explaining a powder sintering apparatus 100g according to Modification 7.
  • FIG. 14 (a) is a plan view of the powder sintering apparatus lOOd
  • FIGS. 14 (b) and 14 (c) are cross-sectional views of the powder sintering apparatus lOOd.
  • 14B is a cross-sectional view when the powder supply device 230 is on the powder sintering table 132
  • FIG. FIG. 12 is a cross-sectional view when on the carpentry table 132.
  • the illustration of the laser beam irradiation device 170 is omitted.
  • the powder sintering apparatus 100g according to Modification 7 basically has a configuration similar to that of the powder sintering apparatus 100 according to Embodiment 1, but Embodiment 1
  • the structure of the powder layer forming apparatus is different from the powder sintering apparatus 100 according to FIG.
  • the powder layer forming apparatus supplies the liquid M containing powder to the powder sintering processing table 132.
  • It consists of a powder supply device 230 and a flattening device 250 for flattening liquid M containing powder.
  • the powder supply apparatus 230 includes a shaft 232, an arm 234 rotatable around the shaft 232, a powder storage portion 236 provided at the tip of the arm 234, and a magnet portion 238.
  • the flattening device 250 includes a shaft 252, an arm 254 that is rotatable about the shaft 252, a flattening processing unit 256 that is provided at the tip of the arm 254 and can move up and down, and a magnet unit 258. . And flat By moving the carrier processing unit 256 up and down, the liquid M containing the powder supplied to the powder sintering table 132 is flattened.
  • the powder supply device 230 and the flattening device 250 are driven by a powder supply device driving device 240 and a flat plate device driving device 260 installed outside the hermetic chamber 110.
  • the powder sintering apparatus lOOg according to the modified example 7 differs from the powder sintering apparatus 100 according to the first embodiment in the configuration of the powder layer forming apparatus, but in the first embodiment.
  • FIG. 15 is a view for explaining a powder sintering apparatus 100h according to Modification 8.
  • FIG. 15 (a) is a sectional view of the powder sintering apparatus 100h
  • FIG. 15 (b) is a plan view of the powder sintering apparatus 100h.
  • the powder sintering apparatus 100h according to Modification 8 basically has a configuration similar to that of the powder sintering apparatus 100 according to Embodiment 1, but Embodiment 1
  • the structure of the heating apparatus is different from the powder sintering apparatus 100 according to the above.
  • the part where the structure is disposed is efficiently and locally heated.
  • Two infrared heating devices 182 are provided.
  • the powder sintering apparatus 100h according to the modified example 8 has a different structure of the heating device.
  • the structure is being heated.
  • an infrared heating device 182 installed outside the hermetic chamber 110, moisture, oxygen, nitrogen, organic matter, and metal impurities are added to the hermetic chamber 110 due to the heating of the structure. It is possible to manufacture a high-purity stent.
  • FIG. 16 is a view for explaining the powder sintering apparatus lOOi according to the ninth modification.
  • the powder sintering apparatus 100i (not shown) according to Modification 9 basically has a configuration that is very similar to the powder sintering apparatus 100h according to Modification 8.
  • the powder sintering process table drive device for controlling the lifting and lowering of the powder sintering process table uses a drive device using a linear motor, and therefore the powder according to Modification 8 is used. It differs from the case of body sintering machine 100h.
  • the powder sintering table 270 is provided with a magnet portion 272, and around the powder sintering processing table storage portion 130, there is an electromagnet portion supporting portion.
  • An electromagnet portion 274 supported by 276 is provided. Then, by controlling the voltage applied to the electromagnet unit 274, the lifting / lowering operation of the powder sintering table 270 is controlled.
  • the modification example is that the driving apparatus using the linear motor is used as the powder sintering process table drive apparatus.
  • the force different from the case of the powder sintering apparatus 100h according to 8 is modified.
  • the external force can also raise and lower the powder sintering table 270. It is possible to suppress the entry of moisture, oxygen, nitrogen, organic matter, metal impurities and other impurities into the hermetic chamber 110 due to the lifting and lowering of the powder sintering table 270 and high purity. Can be manufactured.
  • FIG. 17 is a view for explaining a powder sintering apparatus 100j according to Modification 10.
  • the illustration of the laser beam irradiation apparatus 170 is omitted.
  • the powder sintering apparatus 100j according to Modification 10 basically has a configuration similar to that of the powder sintering apparatus 100 according to Embodiment 1, but Embodiment 1
  • the structure of the heating apparatus is different from the powder sintering apparatus 100 according to the above.
  • the powder sintering apparatus 100j according to the modified example 10 includes a high-frequency heating device 184 as a heating device, as shown in FIG.
  • the powder sintering apparatus 100j according to the modified example 10 includes the high-frequency heating apparatus 184 instead of the heater 180 as a heating apparatus, and thus the powder sintering apparatus 1 according to the first embodiment.
  • FIG. 18 is a flow chart shown for explaining the manufacturing method of the stent according to the second embodiment.
  • the manufacturing method of the stent according to Embodiment 2 is performed after the surface polishing step.
  • the method further includes a drug impregnation step of impregnating the structure with the drug.
  • DES Drug—Eluting Stent (drug-eluting stent) in which a necessary drug is impregnated in the pores of the structure body
  • the characteristics as DES for example, drug carrying characteristics, drug Release characteristics etc.
  • DES drug carrying characteristics, drug Release characteristics etc.
  • a growth inhibitor a growth inhibitory and immunosuppressant, an immunosuppressant, an extracellular matrix modifier, an endothelial repair promoter, or a drug appropriately combined with these can be preferably used.
  • FIG. 19 is a flowchart for explaining the stent manufacturing method according to the third embodiment.
  • the stent manufacturing method according to Embodiment 3 is a stent manufacturing method in which the sintered layer is formed while changing the composition for each layer in the powder sintering process.
  • the component is changed by selecting a desired powder (either power of powder A or powder B) in the powder selection step (step S222) in FIG.
  • FIG. 20 is a flow chart for explaining the stent manufacturing method according to the fourth embodiment.
  • FIG. 21 is a view for explaining the structure of the stent manufactured by the stent manufacturing method according to the fourth embodiment.
  • the stent manufacturing method according to Embodiment 4 is a stent manufacturing method in which the sintered layers are formed by changing the components during the powder sintering process. is there.
  • the component is changed by selecting a desired powder (any one of powder A, powder B, and powder C) in the powder selection step (step S232) in FIG.
  • the sintered layer is formed by gradually changing the components during the process, it is possible to manufacture a stent having a thread and component fabric that changes smoothly.
  • a sintered layer is formed by changing the components in a stepped manner during the process, a stent having a stepped composition distribution can be manufactured.
  • the force using a UV laser beam irradiation apparatus as the energy beam irradiation apparatus is not limited to this.
  • a laser beam irradiation device in the visible region or the infrared region can be used, and an electron beam irradiation device or an ion beam irradiation device can also be used.
  • the force using a flat quartz glass substrate as the translucent window is not limited to this.
  • a curved quartz glass substrate or other substrate can be used as the translucent window.
  • the force for forming the structure along the axial direction of the stent is not limited to this.
  • a structure can be formed along the diameter direction of the stent.
  • the structure is formed using metal powder, but the present invention is not limited to this.
  • the structure may be formed using metal powder coated with resin! However, it is also possible to form a structure using both powdered resin powder and metal powder.
  • the force for forming the structure using the metal powder is not limited to this.
  • a structure may be formed using a ceramic powder. In this case, it is possible to use ceramic powder alone. It is preferable to use ceramic powder together with metal powder.
  • Powder storage unit 158a, 158b, 158c, 218a, 218b, 218c, 238 ... Magnet unit, 160a, 22 Oa, 240 ... Powder feeder drive unit, 162a, 222a, 242, 262 ⁇ axis, 164a, 224a, 244, 264 ⁇ arm, 166a, 226a, 246, 266 ⁇ motor, 168a, 228a, 248, 268 ... magnet part, 170 ... laser beam irradiation device, 172 ... Laser oscillator, 174 ... Two-dimensional scanning mirror, 176 ... Condensing lens, 178 ... Control 180 Heater 182 Infrared heating device 1 84 High frequency heating device 190a ...

Abstract

La présente invention concerne un procédé pour produire un stent, caractérisé en ce qu'il comprend une étape de frittage de poudre qui consiste à répéter de manière séquentielle l'étape de formation de poudre de couche frittée pour fournir une couche de poudre sur une table de frittage de poudre en utilisant une unité de formation de couche de poudre ; il passe ensuite par la réalisation d'une irradiation sélective de la couche de poudre avec des faisceaux d'énergie pour former ainsi une couche frittée, puis par l'étape de descente de la table de frittage de poudre consistant à descendre la table d'une ampleur donnée de manière à superposer les couches frittées, ce qui produit une structure de morphologie souhaitée en trois dimensions. Ce procédé de production de stent permet de simplifier la production d'un stent avec une morphologie relativement complexe.
PCT/JP2005/013266 2005-07-19 2005-07-19 Procédé de production de stent et appareil de frittage de poudre WO2007010598A1 (fr)

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