WO2006111160A1 - Dispositif d'irradiation sanguine au laser intraveineuse et procede de production d'un catheter a usage unique destine a un dispositif - Google Patents

Dispositif d'irradiation sanguine au laser intraveineuse et procede de production d'un catheter a usage unique destine a un dispositif Download PDF

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Publication number
WO2006111160A1
WO2006111160A1 PCT/DE2006/000723 DE2006000723W WO2006111160A1 WO 2006111160 A1 WO2006111160 A1 WO 2006111160A1 DE 2006000723 W DE2006000723 W DE 2006000723W WO 2006111160 A1 WO2006111160 A1 WO 2006111160A1
Authority
WO
WIPO (PCT)
Prior art keywords
coupling
optical fiber
disposable catheter
laser radiation
adapter
Prior art date
Application number
PCT/DE2006/000723
Other languages
German (de)
English (en)
Inventor
Michael Weber
Gerd Schnorrenberg
Original Assignee
Michael Weber
Gerd Schnorrenberg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Michael Weber, Gerd Schnorrenberg filed Critical Michael Weber
Publication of WO2006111160A1 publication Critical patent/WO2006111160A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/067—Radiation therapy using light using laser light
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/36—Mechanical coupling means
    • G02B6/38—Mechanical coupling means having fibre to fibre mating means
    • G02B6/3807—Dismountable connectors, i.e. comprising plugs
    • G02B6/381—Dismountable connectors, i.e. comprising plugs of the ferrule type, e.g. fibre ends embedded in ferrules, connecting a pair of fibres
    • G02B6/3825—Dismountable connectors, i.e. comprising plugs of the ferrule type, e.g. fibre ends embedded in ferrules, connecting a pair of fibres with an intermediate part, e.g. adapter, receptacle, linking two plugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/36—Mechanical coupling means
    • G02B6/38—Mechanical coupling means having fibre to fibre mating means
    • G02B6/3807—Dismountable connectors, i.e. comprising plugs
    • G02B6/389—Dismountable connectors, i.e. comprising plugs characterised by the method of fastening connecting plugs and sockets, e.g. screw- or nut-lock, snap-in, bayonet type
    • G02B6/3891—Bayonet type
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B6/00—Light guides; Structural details of arrangements comprising light guides and other optical elements, e.g. couplings
    • G02B6/24—Coupling light guides
    • G02B6/36—Mechanical coupling means
    • G02B6/38—Mechanical coupling means having fibre to fibre mating means
    • G02B6/3807—Dismountable connectors, i.e. comprising plugs
    • G02B6/389—Dismountable connectors, i.e. comprising plugs characterised by the method of fastening connecting plugs and sockets, e.g. screw- or nut-lock, snap-in, bayonet type
    • G02B6/3894—Screw-lock type

Definitions

  • the present invention relates to a device for intravascular laser blood irradiation according to the preamble of claim 1 and a method for producing a disposable catheter for such a device.
  • Intravascular laser blood irradiation leads to an immunological activation of the irradiated cells and to an uptake of the supplied light quanta.
  • This absorbed energy is distributed by the blood cells in the systemic circulation and released to energy-weakened and diseased cells, which thus undergo an energetic regeneration, activate their metabolism and stabilize their cell membrane potential.
  • laser radiation from the low-power laser range (soft laser) is supplied, which unfolds in this energy range no physical effects such as tissue destruction, but only biostimulatory effects.
  • FIG. 1 shows a prior art apparatus developed in Russia for intravascular blood irradiation with laser light.
  • the device has a sterile disposable catheter a made of an optical fiber b, which is embedded in a plastic handling and connecting piece c. and extended beyond this.
  • This extension b ' is in turn involved in a coupling approach d, wherein the end of the optical fiber b exposed at the end of the coupling approach d for coupling to a laser radiation source.
  • the laser radiation source used is a laser module which, as usual, has a laser diode and a driver chip.
  • the latter For the optical coupling of the disposable catheter a with the laser module e, the latter has an insertion lug g made of plastic, which has an insertion opening i, which is bounded by a peripheral edge h.
  • the edge h springs outward, so that the coupling lug d can pass until finally the peripheral edge h engages in a groove j of the coupling lug.
  • disposable catheter a Prior to making this connection between the disposable catheter a and the laser module e, disposable catheter a is inserted into a disposable steel cannula k, which is then placed in a body vein.
  • the disposable catheter a To integrate the disposable catheter a into the single-use steel cannula k, the latter and the handling and connecting piece c of the disposable catheter a are equipped with corresponding conical adapters I and m, respectively.
  • the disadvantage of using a steel disposable cannula k is that it can injure the venous walls for as little as 30 minutes and more, even with small movements.
  • the disposable catheter a once it has been taken out of the cannula, can not be reinserted due to the small opening.
  • Object of the present invention is therefore to provide a device of the generic type, which is much better meet the practical and hygienic requirements in the daily flow in a doctor's office, and a cost-effective method for producing a disposable catheter for such a device ready put.
  • the disposable catheter is no longer connected directly to a laser module but to a coupling adapter having a coupling channel. From the one side, a standardized SMA plug is inserted into this coupling channel, while from the other side the coupling approach of the disposable catheter is inserted.
  • the coupling channel itself and additionally at least one radially biased in this latching element, which acts on a coupling projection provided in the recess, for a sufficiently precise axial and radial guidance of the optical fiber of disposable catheter in the coupling adapter, on the other side of the laser radiation source optical fiber is optically precisely integrated via an SMA plug connection, so that the light emitted by the laser beam source laser light is coupled in an effective manner in the optical fiber of the disposable catheter.
  • the at least one latching element also secures the plug connection between the coupling adapter and the coupling attachment of the disposable catheter so that it only releases when there is a lot of tension that does not occur during treatment under normal conditions.
  • the coupling adapter is relatively small in comparison to a laser module, so that there are no problems for its fixation on the body of a patient. In addition, it is de-energized, which is also advantageous over the prior art, since the attachment of a current-carrying component (laser module) is not required. Furthermore, the coupling adapter is a separate component, which can be cleaned separately after releasing the connection with the disposable catheter and with the SMA connector. If the coupling adapter, as provided in an advantageous embodiment of the invention, is made of metal or another suitable material, it can also be easily sterilized.
  • the wavelength of the laser light is to be changed during a blood irradiation, then only the SMA plug of the respectively currently connected laser module is to be loosened and connected to a corresponding, different laser module. Handling the patient is not necessary.
  • a dwell brown reduces the risk of injury because it is made of plastic.
  • Another advantage is the fact that you can stop them after a treatment with a stylet and use over the next few days again, without having to sting again and again.
  • the disposable catheter can be easily reintroduced into the Braunüle.
  • a disposable catheter for the device for intravascular laser blood irradiation can be produced particularly cost.
  • the optical fiber is produced by scratching and breaking, whereby a complex polishing of the fiber end is eliminated.
  • Equally inexpensive is the production of the adhesive bond between the optical fiber and the coupling approach of disposable catheter, the central recess ensures that the splice is shifted back and so does not pollute the so important for the coupling of the laser light fiber end.
  • FIG. 2 shows a schematic overall view of a device according to the invention
  • FIG. 5 shows a perspective view of a protective sleeve for the single-use catheter of the device
  • Fig. 6 is a side view of the coupling adapter of the device.
  • FIG. 7 shows a section AA according to FIG. 6.
  • the apparatus shown schematically in the overall construction in FIG. 2 consists of a disposable catheter 1, a coupling adapter 2 and an optical fiber 3, each of which is equipped with an SMA plug 4 at its ends and guided in an envelope 3.1.
  • the disposable catheter 1 comprises an optical fiber 5 made of quartz or plastic, which is made by scratching and breaking off a running fiber strand.
  • an optical fiber 5 made of quartz or plastic, which is made by scratching and breaking off a running fiber strand.
  • the coupling approach 6 has a through hole with a slightly larger diameter than the diameter of the optical fiber 5.
  • the optical fiber 5 is inserted so far through the coupling approach 6, that they from the coupling adapter. 2 montage side facing end protrudes slightly. This projecting area is then provided with a glue point at some distance from the end and pulled back slightly into the coupling projection 6, so that the optical fiber 5 can bond to the wall of the through-hole.
  • the coupling attachment 6 has a short central
  • Protective cover 9 is provided, which has a hose piece 10 made of plastic, which is glued into a likewise made of plastic connecting lug 11.
  • the connecting lug 11 has an external thread 12, which can be screwed into an internal thread 13, which is formed on a sleeve-like union 6.1 of the coupling attachment 6.
  • This thread pairing 12-13 is to be found in the manner of a frequently encountered in medical technology.
  • Luer-lock screwing executed.
  • the length of the optical fiber 5 and the hose piece 10 are selected so that the optical fiber 5 does not protrude from the hose piece 10 at the front after production of the screw connection.
  • This unit of disposable catheter 1 and protective sheath 9 is sterilized and packaged in a sterile wrapper for use.
  • two diametrically opposed wings 14 are provided on the connecting lug 11 and on the coupling lug 6, respectively.
  • the coupling adapter 2 is designed as a metal cylinder with beveled edges 2.1. It has an axially continuous coupling channel 15 which continues through a lug 16, this lug 16 being provided integrally with the coupling adapter 2 and as an SMA socket for connection to one of the SMA connectors 4 of the optical fiber 3.
  • the projection 16 is equipped with an external thread 17, which can be screwed to an internal thread 18 of the SMA plug 4.
  • the coupling channel 15 has a portion 15.1, which merges in a paragraph in a section 15.2 of larger diameter.
  • the section 15.2 is assigned to the disposable catheter 1 on the assembly side, wherein the section 15.1 is selected slightly larger in diameter than the diameter of the terminal extensions 6.2 and 4.1 of the coupling attachment 6 and the SMA connector 4 to these two extensions 6.2 and 4.1 with small radial clearance in this section 15.1 of the coupling channel 15 to introduce.
  • a means piece 6.3 larger diameter, wherein the transition between the extension 6.2 and the middle 6.3 is formed by a conical surface 6.4.
  • a circumferential groove 19 is provided, which cooperates in a manner to be described with a latching mechanism of the coupling adapter 2.
  • the spring means ensure that the balls can be prestressed in the direction of the coupling channel and at the same time can spring into the threaded bores when radial pressure is exerted on them from the coupling channel 15.
  • the spring force of the spring means is adjustable by a more or less wide screwing in the grub screws in the threaded holes 20.
  • the coupling adapter 2 is connected to a laser module, not shown, by one of the SMA connector 4 is connected to the laser module and the other SMA connector 4 to the coupling adapter 2.
  • the insertion depth of the end extension 4.1 of the SMA connector 4 in the Section 15.1 of the coupling channel 15 results from the screw connection between the SMA plug 4 and the projection 16 of the coupling adapter 2.
  • the disposable catheter 1, which is still provided with the protective cover 9, is removed from the sterile packaging and with it Coupling approach 6 introduced into the coupling channel 15 of the coupling adapter 2.
  • Coupling adapter 2 set and secured the connector against excessive train, on the other hand, this locking connection in conjunction with the coupling channel 15 for a radially and axially exact alignment of the optical fiber 5, so that the end is arranged substantially exactly in front of the end of the optical fiber 3.
  • an effective coupling of the laser module coming from the laser light is ensured in the optical fiber 5 of the disposable catheter 1, wherein the interface 21 between the non-sterile coming from the laser module optical fiber 3 and the sterile optical fiber 5 of disposable catheter 1 in the coupling adapter 2 is located.
  • the protective cover 9 is unscrewed and the optical fiber 5 is inserted into a Braunüle already placed in a body vein.
  • This Braunüle has the same external thread as the protective cover 9, so that the disposable catheter 1 can be screwed to the Braunüle.
  • the rotation of the disposable catheter 1 relative to the coupling adapter 2 is harmless, since the coupling attachment 6 is rotatably mounted in the coupling adapter 2.
  • it is also possible to reverse the procedure namely first to unscrew the disposable catheter 1 on the Braunüle and then produce the connector with the coupling adapter 2.
  • the blood of a patient is treated intravascularly for about 30 minutes with powers of one to three mW. Different wavelengths such as red, infrared, green or blue of the laser light can be used. The following effects can be observed:
  • Analgesia improvement of microcirculation - antiallergic, antiarrhythmic, antibacterial, spasmolytic and antiinflammatory action
  • Mitochondria A particularly effective therapy is expected in the following diseases:

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Physics & Mathematics (AREA)
  • Laser Surgery Devices (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

La présente invention concerne un dispositif d'irradiation sanguine au laser intraveineuse doté d'un cathéter à usage unique stérile constitué d'une fibre optique qui est introduite dans une canule placée dans une veine de l'organisme et présente, à une extrémité, un embout de couplage dans lequel une extrémité de la fibre optique est libre pour le couplage optique à une source de rayonnement laser. L'invention vise à créer un tel dispositif qui soit mieux adapté aux exigences liées à l'aspect pratique et à l'hygiène dans le déroulement quotidien d'un cabinet médical, ainsi qu'un procédé économique destiné à la production d'un cathéter à usage unique d'un tel dispositif. A cet effet, un adaptateur de couplage (2) qui est placé entre la fibre optique (3) de la source de rayonnement laser et la fibre optique (5) du cathéter à usage unique (1), garantit une injection efficace de la lumière laser dans la fibre optique (5) du cathéter à usage unique (1).
PCT/DE2006/000723 2005-04-22 2006-04-20 Dispositif d'irradiation sanguine au laser intraveineuse et procede de production d'un catheter a usage unique destine a un dispositif WO2006111160A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005019006A DE102005019006A1 (de) 2005-04-22 2005-04-22 Vorrichtung zur intravasalen Laserblutbestrahlung und Verfahren zur Herstellung eines Einmal-Katheters für eine solche Vorrichtung
DE102005019006.5 2005-04-22

Publications (1)

Publication Number Publication Date
WO2006111160A1 true WO2006111160A1 (fr) 2006-10-26

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ID=36928390

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2006/000723 WO2006111160A1 (fr) 2005-04-22 2006-04-20 Dispositif d'irradiation sanguine au laser intraveineuse et procede de production d'un catheter a usage unique destine a un dispositif

Country Status (2)

Country Link
DE (2) DE202005021421U1 (fr)
WO (1) WO2006111160A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3016606A1 (fr) * 2013-07-03 2016-05-11 UVLRX Therapeutics Inc. Dispositif d'accès vasculaire ayant un guide lumineux intégré
WO2020043302A1 (fr) * 2018-08-31 2020-03-05 Synergia Medical Connecteur de fibres optiques pour dispositif médical implantable actif (aimd) optoélectronique

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567650A (en) * 1984-04-09 1986-02-04 Automation Industries, Inc. Fiber optic crimping tool
US4707072A (en) * 1984-12-18 1987-11-17 U.S. Philips Corp. Auto-aligning optical fiber connector
US4807957A (en) * 1987-10-15 1989-02-28 Siecor Corporation Connector for optical fibers
EP0877267A2 (fr) * 1997-05-09 1998-11-11 Point Source Limited Connecteur pour fibres optiques

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7033347B2 (en) * 2002-12-11 2006-04-25 Angiodynamics, Inc. Endovascular laser treatment device

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567650A (en) * 1984-04-09 1986-02-04 Automation Industries, Inc. Fiber optic crimping tool
US4707072A (en) * 1984-12-18 1987-11-17 U.S. Philips Corp. Auto-aligning optical fiber connector
US4807957A (en) * 1987-10-15 1989-02-28 Siecor Corporation Connector for optical fibers
EP0877267A2 (fr) * 1997-05-09 1998-11-11 Point Source Limited Connecteur pour fibres optiques

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3016606A1 (fr) * 2013-07-03 2016-05-11 UVLRX Therapeutics Inc. Dispositif d'accès vasculaire ayant un guide lumineux intégré
EP3016606A4 (fr) * 2013-07-03 2017-04-05 UVLRX Therapeutics Inc. Dispositif d'accès vasculaire ayant un guide lumineux intégré
WO2020043302A1 (fr) * 2018-08-31 2020-03-05 Synergia Medical Connecteur de fibres optiques pour dispositif médical implantable actif (aimd) optoélectronique
US11372182B2 (en) 2018-08-31 2022-06-28 Synergia Medical Optical fibres connector for optoelectronic active implantable medical device (AIMD)

Also Published As

Publication number Publication date
DE102005019006A1 (de) 2006-11-09
DE202005021421U1 (de) 2008-01-31

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