WO2006054280A3 - Systeme et procede pour administrer un fluide a une barriere biologique souple - Google Patents

Systeme et procede pour administrer un fluide a une barriere biologique souple Download PDF

Info

Publication number
WO2006054280A3
WO2006054280A3 PCT/IL2005/000522 IL2005000522W WO2006054280A3 WO 2006054280 A3 WO2006054280 A3 WO 2006054280A3 IL 2005000522 W IL2005000522 W IL 2005000522W WO 2006054280 A3 WO2006054280 A3 WO 2006054280A3
Authority
WO
WIPO (PCT)
Prior art keywords
barrier
biological barrier
biological
delivering fluid
flexible
Prior art date
Application number
PCT/IL2005/000522
Other languages
English (en)
Other versions
WO2006054280A2 (fr
Inventor
Yehushua Yeshurun
Meir Hefetz
Yoel Sefi
Yotam Levin
Gilad Lavi
Original Assignee
Nanopass Technologies Ltd
Yehushua Yeshurun
Meir Hefetz
Yoel Sefi
Yotam Levin
Gilad Lavi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/IL2004/001065 external-priority patent/WO2005049107A2/fr
Application filed by Nanopass Technologies Ltd, Yehushua Yeshurun, Meir Hefetz, Yoel Sefi, Yotam Levin, Gilad Lavi filed Critical Nanopass Technologies Ltd
Priority to EP05741986.3A priority Critical patent/EP1819379B1/fr
Priority to CA2587216A priority patent/CA2587216C/fr
Priority to US11/719,541 priority patent/US8007466B2/en
Priority to JP2007542497A priority patent/JP5026980B2/ja
Publication of WO2006054280A2 publication Critical patent/WO2006054280A2/fr
Publication of WO2006054280A3 publication Critical patent/WO2006054280A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/34—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub
    • A61M2005/341—Constructions for connecting the needle, e.g. to syringe nozzle or needle hub angularly adjustable or angled away from the axis of the injector
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un système et un procédé pour administrer un fluide à une barrière biologique souple au moyen d'une structure à microaiguilles, une position finale de microaiguilles (12) insérées à travers la barrière biologique (14) s'étendant du système d'administration généralement latéralement, contrairement à un ensemble classique s'étendant vers le bas. Ces microaiguilles (12) s'étendent d'une surface de soulagement (16), distincte d'une zone de contact primaire (18, 26) avec la barrière biologique du système d'administration, et s'étendent généralement vers le haut en formant un angle avec la barrière biologique. Au cours de l'insertion, la zone de contact (18, 26) est mise en contact avec la barrière biologique (14) et déplacée parallèlement à la surface de cette barrière biologique souple, de façon à former une frontière (20) entre une partie tendue (22) et une partie détendue (24) de ladite barrière. Généralement, simultanément à ce mouvement, les microaiguilles (12) pénètrent dans la barrière biologique souple, de sorte qu'à la fin du mouvement, ces microaiguilles s'étendent à travers la barrière biologique souple de la zone frontière (20) en direction de la partie détendue (24). Un fluide est ensuite injecté à travers les orifices des microaiguilles creuses vers la partie détendue.
PCT/IL2005/000522 2004-11-18 2005-05-19 Systeme et procede pour administrer un fluide a une barriere biologique souple WO2006054280A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP05741986.3A EP1819379B1 (fr) 2004-11-18 2005-05-19 Systeme pour administrer un fluide a une barriere biologique souple
CA2587216A CA2587216C (fr) 2004-11-18 2005-05-19 Systeme et procede pour administrer un fluide a une barriere biologique souple
US11/719,541 US8007466B2 (en) 2004-11-18 2005-05-19 System and method for delivering fluid into flexible biological barrier
JP2007542497A JP5026980B2 (ja) 2004-11-18 2005-05-19 可撓性の生体障壁内へ流体を供給するための装置

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/IL2004/001065 WO2005049107A2 (fr) 2003-11-18 2004-11-18 Systeme de penetration ameliore et procede permettant de faire coulisser des micro-aiguilles
ILPCT/IL2004/001065 2004-11-18
US65186105P 2005-02-11 2005-02-11
US60/651,861 2005-02-11

Publications (2)

Publication Number Publication Date
WO2006054280A2 WO2006054280A2 (fr) 2006-05-26
WO2006054280A3 true WO2006054280A3 (fr) 2006-10-12

Family

ID=36407535

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2005/000522 WO2006054280A2 (fr) 2004-11-18 2005-05-19 Systeme et procede pour administrer un fluide a une barriere biologique souple

Country Status (4)

Country Link
US (1) US8007466B2 (fr)
EP (1) EP1819379B1 (fr)
CA (1) CA2587216C (fr)
WO (1) WO2006054280A2 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006054280A2 (fr) 2004-11-18 2006-05-26 Nanopass Technologies Ltd. Systeme et procede pour administrer un fluide a une barriere biologique souple
GB2436526B (en) * 2006-03-29 2010-01-27 Arash Bakhtyari-Nejad-Esfahani Syringe
GB0610553D0 (en) 2006-05-26 2006-07-05 Bakhtyari Nejad Esfahani Arash Dressing
CA2797205C (fr) 2010-04-28 2019-04-16 Kimberly-Clark Worldwide, Inc. Dispositifs medicaux pour l'administration d'arnsi
JP5868953B2 (ja) 2010-04-28 2016-02-24 キンバリー クラーク ワールドワイド インコーポレイテッド 射出成形型マイクロニードルアレイ及びその製造方法
JP5860032B2 (ja) 2010-04-28 2016-02-16 キンバリー クラーク ワールドワイド インコーポレイテッド 関節リウマチ薬の送達のためのデバイス
MX2012012567A (es) 2010-04-28 2012-11-21 Kimberly Clark Co Metodo para aumentar la permeabilidad de una barrera epitelial.
GB2487899A (en) 2011-02-01 2012-08-15 Olberon Ltd Needle holder with grip means
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
DE12722942T1 (de) 2011-03-31 2021-09-30 Modernatx, Inc. Freisetzung und formulierung von manipulierten nukleinsäuren
GB201112933D0 (en) 2011-07-27 2011-09-14 Olberon Ltd Improvements relating to needle insertion or cannulation
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
KR102145638B1 (ko) 2011-10-27 2020-08-18 소렌토 쎄라퓨틱스, 인코포레이티드 고점도 생체활성 제제의 경피 전달 방법
MX2014007233A (es) 2011-12-16 2015-02-04 Moderna Therapeutics Inc Composiciones de nucleosidos, nucleotidos y acidos nucleicos modificados.
WO2013136185A2 (fr) 2012-03-13 2013-09-19 Becton Dickinson France Procédé de fabrication d'un dispositif d'administration de médicament miniaturisé
CA2892529C (fr) 2012-11-26 2023-04-25 Moderna Therapeutics, Inc. Arn modifie a son extremite terminale
JP2016504050A (ja) 2013-01-17 2016-02-12 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 細胞表現型の改変のためのシグナルセンサーポリヌクレオチド
US20160024181A1 (en) 2013-03-13 2016-01-28 Moderna Therapeutics, Inc. Long-lived polynucleotide molecules
CN106061466A (zh) 2013-12-19 2016-10-26 诺华股份有限公司 瘦蛋白mRNA组合物和制剂
KR20160096206A (ko) 2013-12-23 2016-08-12 알크-아벨로 에이/에스 먼지 진드기 알레르기를 치료하기 위한 펩타이드 조합 및 그의 용도
WO2015131053A1 (fr) 2014-02-28 2015-09-03 Alk-Abelló A/S Polypeptides dérivés de phl p, procédés et utilisations de ces derniers pour moduler une réponse immunitaire
WO2015159525A1 (fr) * 2014-04-14 2015-10-22 凸版印刷株式会社 Dispositif d'injection
WO2016209959A2 (fr) 2015-06-22 2016-12-29 Alk-Abelló A/S Combinaisons de peptides et leur utilisation dans le traitement de l'allergie aux pollen de cèdre
US11013781B2 (en) 2015-07-01 2021-05-25 Alk-Abelló As Peptide combinations and uses thereof for treating grass allergy
WO2017179025A1 (fr) 2016-04-15 2017-10-19 Alk-Abelló A/S Polypeptides épitopiques d'allergènes de pollen d'ambroisie
US20180185623A1 (en) * 2017-01-03 2018-07-05 Nanopass Technologies Ltd. Clamp for use in assembly of a microprotrusion device and corresponding method
US11717660B2 (en) 2021-07-29 2023-08-08 Nanopass Technologies Ltd. Silicon microneedle structure and production method

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6440096B1 (en) * 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US20030208167A1 (en) * 1999-06-04 2003-11-06 Prausnitz Mark R. Microneedle drug delivery device
US6689103B1 (en) * 1999-05-07 2004-02-10 Scimed Life System, Inc. Injection array apparatus and method
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2457464A (en) * 1946-11-08 1948-12-28 Joseph Grose Surgical instrument
US3324854A (en) * 1964-04-23 1967-06-13 Harry Swartz Apparatus for facilitating the insertion of a hypodermic syringe needle
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
DE4205036C1 (en) * 1992-02-19 1993-06-17 Henke-Sass, Wolf Gmbh, 7200 Tuttlingen, De Injection cylinder for subcutaneous vaccination - comprises first hollow cylindrical tube in which is fitted telescopically second tube with reduced dia.
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US5928207A (en) * 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
CA2330207C (fr) 1998-06-10 2005-08-30 Georgia Tech Research Corporation Dispositifs a microaiguilles et procedes de fabrication et d'utilisation correspondants
US6503231B1 (en) * 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
US7344499B1 (en) * 1998-06-10 2008-03-18 Georgia Tech Research Corporation Microneedle device for extraction and sensing of bodily fluids
GB9815820D0 (en) * 1998-07-22 1998-09-16 Secr Defence Improvements relating to micro-machining
US6312612B1 (en) * 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6256533B1 (en) * 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6379324B1 (en) * 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
US6569143B2 (en) * 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
US6569123B2 (en) * 1999-10-14 2003-05-27 Becton, Dickinson And Company Prefillable intradermal injector
US6843781B2 (en) * 1999-10-14 2005-01-18 Becton, Dickinson And Company Intradermal needle
US6494865B1 (en) * 1999-10-14 2002-12-17 Becton Dickinson And Company Intradermal delivery device including a needle assembly
US6776776B2 (en) * 1999-10-14 2004-08-17 Becton, Dickinson And Company Prefillable intradermal delivery device
US20020193740A1 (en) * 1999-10-14 2002-12-19 Alchas Paul G. Method of intradermally injecting substances
US6406638B1 (en) 2000-01-06 2002-06-18 The Regents Of The University Of California Method of forming vertical, hollow needles within a semiconductor substrate, and needles formed thereby
CA2424520C (fr) * 2000-08-21 2007-01-02 The Cleveland Clinic Foundation Reseau de microaiguilles et procede de fabrication
US6533949B1 (en) * 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
WO2002064193A2 (fr) * 2000-12-14 2002-08-22 Georgia Tech Research Corporation Appareils a microaiguilles et fabrication
US6767341B2 (en) * 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
SE0102736D0 (sv) 2001-08-14 2001-08-14 Patrick Griss Side opened out-of-plane microneedles for microfluidic transdermal interfacing and fabrication process of side opened out-of-plane microneedles
US7004928B2 (en) * 2002-02-08 2006-02-28 Rosedale Medical, Inc. Autonomous, ambulatory analyte monitor or drug delivery device
JP3836068B2 (ja) 2002-03-05 2006-10-18 三菱重工業株式会社 空気浮上式ウェブ走行支持装置及びそれを用いた塗工装置
JP2006521555A (ja) * 2003-03-24 2006-09-21 ローズデイル メディカル インコーポレイテッド 被分析物濃度検出の装置及び方法
US7273474B2 (en) * 2003-06-17 2007-09-25 Industrial Technology Research Institute Flexible substrate structure for microneedle arrays and its manufacturing method
US7560036B2 (en) * 2004-08-05 2009-07-14 Apogee Technology, Inc. System and method for drug delivery and microfluidic applications using microneedles
WO2006054280A2 (fr) 2004-11-18 2006-05-26 Nanopass Technologies Ltd. Systeme et procede pour administrer un fluide a une barriere biologique souple
JP4339319B2 (ja) * 2005-09-29 2009-10-07 シャープ株式会社 表示装置および電子機器
US7651946B2 (en) * 2005-12-12 2010-01-26 University College Cork - National University Of Ireland, Cork Wet etch processing
US8308960B2 (en) * 2005-12-14 2012-11-13 Silex Microsystems Ab Methods for making micro needles and applications thereof
DE102006028781A1 (de) * 2006-06-23 2007-12-27 Robert Bosch Gmbh Verfahren zur Herstellung von porösen Mikronadeln und ihre Verwendung
EP2036586B1 (fr) 2006-07-04 2015-09-09 Toppan Printing Co., Ltd. Procédé de fabrication d'une micro-aiguille
US8105499B2 (en) * 2008-07-14 2012-01-31 International Business Macines Corporation Transmission electron microscopy sample etching fixture

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6689103B1 (en) * 1999-05-07 2004-02-10 Scimed Life System, Inc. Injection array apparatus and method
US20030208167A1 (en) * 1999-06-04 2003-11-06 Prausnitz Mark R. Microneedle drug delivery device
US6743211B1 (en) * 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6440096B1 (en) * 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice

Also Published As

Publication number Publication date
WO2006054280A2 (fr) 2006-05-26
CA2587216C (fr) 2014-11-18
CA2587216A1 (fr) 2006-05-26
US8007466B2 (en) 2011-08-30
EP1819379A2 (fr) 2007-08-22
EP1819379B1 (fr) 2016-08-31
US20090069788A1 (en) 2009-03-12
EP1819379A4 (fr) 2010-10-06

Similar Documents

Publication Publication Date Title
WO2006054280A3 (fr) Systeme et procede pour administrer un fluide a une barriere biologique souple
EP1970084B8 (fr) Dispositif d'insertion pour une tête d'insertion, en particulier pour un ensemble d'infusion
WO2010011930A3 (fr) Dispositifs de type cathéter utilisables pour les injections dans le myocarde ou à d'autres effets
HK1125870A1 (en) System composed of an insertion head and an inserter
WO2004096854A3 (fr) Analogues de l'insuline ayant une action prolongee
WO2009014694A3 (fr) Procédé et appareil pour commander une corde
WO2006020255A3 (fr) Appareils et procedes de traitement de tissus a l'aide de systemes passifs d'injection
WO2007084726A3 (fr) Systeme et procede d'appareil transluminal
TW200514593A (en) Method and device for enhancing transdermal agent flux
WO2011039227A3 (fr) Procédé et ensemble pour dispositif d'administration de médicament
GB2446321B8 (en) High pressure pump controller.
EP1570783A4 (fr) Dispositif pour l'introduction d'aiguilles
HK1141319A1 (zh) 滾子泵
AU2003245646A1 (en) Catheter assembly with side wall exit lumen and method therefor
WO2007123997A3 (fr) Dispositif de renforcement péricardique
ATE498418T1 (de) Durch gasdruck betätigte mikronadel-anordnungen und damit zusammenhängende systeme und verfahren
WO2006083681A3 (fr) Microprojections recouvertes presentant une variabilite reduite et procede pour produire lesdites microprojections
WO2003074102A3 (fr) Dispositifs et procedes permettant le transport d'un fluide a travers une barriere biologique
EP2025356A3 (fr) Procédé d'utilisation d'un montage de seringue pour un injecteur de fluide médical
EP2289574A3 (fr) Articles médicaux de leur procédé de préparation
WO2008028087A3 (fr) Procédés et dispositifs comprenant un dispositif de pénétration de surface
WO2008039319A3 (fr) Injection de substance thérapeutique dans les zones poreuses d'un dispositif médical
WO2007047546A3 (fr) Prise de dispositifs electroniques
USD558337S1 (en) Anchor for holding an implantable medical lead or catheter
WO2005065754A3 (fr) Dispositif de guidage d'injection pour la toxine botulique

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KM KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NG NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2587216

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2007542497

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 200580039331.5

Country of ref document: CN

Ref document number: 11719541

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 1020077011336

Country of ref document: KR

NENP Non-entry into the national phase

Ref country code: DE

REEP Request for entry into the european phase

Ref document number: 2005741986

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2005741986

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2005741986

Country of ref document: EP