WO2006049011A1 - ホスフェート-ホスホネート結合を有するリン化合物の製造方法 - Google Patents
ホスフェート-ホスホネート結合を有するリン化合物の製造方法 Download PDFInfo
- Publication number
- WO2006049011A1 WO2006049011A1 PCT/JP2005/019132 JP2005019132W WO2006049011A1 WO 2006049011 A1 WO2006049011 A1 WO 2006049011A1 JP 2005019132 W JP2005019132 W JP 2005019132W WO 2006049011 A1 WO2006049011 A1 WO 2006049011A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- group
- phosphonate
- phosphorus compound
- compound
- reaction
- Prior art date
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- -1 phosphorus compound Chemical class 0.000 title claims abstract description 91
- 229910052698 phosphorus Inorganic materials 0.000 title claims abstract description 55
- 239000011574 phosphorus Substances 0.000 title claims abstract description 43
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 23
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 claims abstract description 45
- 238000000034 method Methods 0.000 claims abstract description 28
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 12
- 230000001476 alcoholic effect Effects 0.000 claims abstract description 11
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical group CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 90
- 125000000217 alkyl group Chemical group 0.000 claims description 32
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 27
- 150000001875 compounds Chemical class 0.000 claims description 27
- 125000004122 cyclic group Chemical group 0.000 claims description 26
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 24
- 125000004432 carbon atom Chemical group C* 0.000 claims description 23
- 125000003118 aryl group Chemical group 0.000 claims description 22
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 18
- 239000000126 substance Substances 0.000 claims description 18
- 239000007795 chemical reaction product Substances 0.000 claims description 17
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 9
- 125000004437 phosphorous atom Chemical group 0.000 claims description 9
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 125000005843 halogen group Chemical group 0.000 claims description 7
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 7
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 125000005647 linker group Chemical group 0.000 claims description 4
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 4
- 238000005984 hydrogenation reaction Methods 0.000 claims description 3
- 229910014033 C-OH Inorganic materials 0.000 claims description 2
- 229910014570 C—OH Inorganic materials 0.000 claims description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 239000001301 oxygen Substances 0.000 claims description 2
- 239000002994 raw material Substances 0.000 abstract description 81
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 abstract description 39
- 239000003054 catalyst Substances 0.000 abstract description 20
- 229910001629 magnesium chloride Inorganic materials 0.000 abstract description 20
- 239000006227 byproduct Substances 0.000 abstract description 11
- 238000006243 chemical reaction Methods 0.000 description 61
- 230000015572 biosynthetic process Effects 0.000 description 32
- 239000004417 polycarbonate Substances 0.000 description 32
- 238000003786 synthesis reaction Methods 0.000 description 32
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 30
- 239000000047 product Substances 0.000 description 22
- 239000011541 reaction mixture Substances 0.000 description 22
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 21
- 239000000243 solution Substances 0.000 description 21
- 125000001424 substituent group Chemical group 0.000 description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 230000000052 comparative effect Effects 0.000 description 16
- 239000011259 mixed solution Substances 0.000 description 14
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 13
- 238000005481 NMR spectroscopy Methods 0.000 description 12
- MDBVZFGSKMWJFD-UHFFFAOYSA-N OP(O)=O.OP(O)(O)=O Chemical class OP(O)=O.OP(O)(O)=O MDBVZFGSKMWJFD-UHFFFAOYSA-N 0.000 description 11
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 10
- 239000007864 aqueous solution Substances 0.000 description 10
- 238000005406 washing Methods 0.000 description 10
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 238000009835 boiling Methods 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- 230000009257 reactivity Effects 0.000 description 9
- 229920005989 resin Polymers 0.000 description 9
- 239000011347 resin Substances 0.000 description 9
- 239000002904 solvent Substances 0.000 description 9
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 8
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical compound OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 8
- 238000010521 absorption reaction Methods 0.000 description 8
- 238000000921 elemental analysis Methods 0.000 description 8
- RAOZVFGTRXLBTA-UHFFFAOYSA-N 2-chloro-5,5-dimethyl-1,3,2-dioxaphosphinane Chemical compound CC1(C)COP(Cl)OC1 RAOZVFGTRXLBTA-UHFFFAOYSA-N 0.000 description 7
- 230000002378 acidificating effect Effects 0.000 description 7
- 125000002947 alkylene group Chemical group 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 230000002411 adverse Effects 0.000 description 6
- 230000007423 decrease Effects 0.000 description 6
- 238000004817 gas chromatography Methods 0.000 description 6
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 6
- 238000010992 reflux Methods 0.000 description 6
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 5
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 229910052739 hydrogen Inorganic materials 0.000 description 5
- 239000012535 impurity Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 229910052757 nitrogen Inorganic materials 0.000 description 5
- 238000003385 ring cleavage reaction Methods 0.000 description 5
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 4
- DYSKQFVISRUDLB-UHFFFAOYSA-N CC1(COP(=O)(OC1)OP(=O)(O)O)C Chemical compound CC1(COP(=O)(OC1)OP(=O)(O)O)C DYSKQFVISRUDLB-UHFFFAOYSA-N 0.000 description 4
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 4
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 4
- 229910019142 PO4 Inorganic materials 0.000 description 4
- 238000007259 addition reaction Methods 0.000 description 4
- 239000012298 atmosphere Substances 0.000 description 4
- 239000000460 chlorine Substances 0.000 description 4
- 229910052801 chlorine Inorganic materials 0.000 description 4
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 4
- BVXOPEOQUQWRHQ-UHFFFAOYSA-N dibutyl phosphite Chemical compound CCCCOP([O-])OCCCC BVXOPEOQUQWRHQ-UHFFFAOYSA-N 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000003063 flame retardant Substances 0.000 description 4
- 150000002576 ketones Chemical class 0.000 description 4
- 239000003960 organic solvent Substances 0.000 description 4
- 235000021317 phosphate Nutrition 0.000 description 4
- 150000003018 phosphorus compounds Chemical class 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 3
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 description 3
- RNFJDJUURJAICM-UHFFFAOYSA-N 2,2,4,4,6,6-hexaphenoxy-1,3,5-triaza-2$l^{5},4$l^{5},6$l^{5}-triphosphacyclohexa-1,3,5-triene Chemical compound N=1P(OC=2C=CC=CC=2)(OC=2C=CC=CC=2)=NP(OC=2C=CC=CC=2)(OC=2C=CC=CC=2)=NP=1(OC=1C=CC=CC=1)OC1=CC=CC=C1 RNFJDJUURJAICM-UHFFFAOYSA-N 0.000 description 3
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- FSQPWLSBMZGPRY-UHFFFAOYSA-N 2-dibutoxyphosphorylpropan-2-ol Chemical compound CCCCOP(=O)(C(C)(C)O)OCCCC FSQPWLSBMZGPRY-UHFFFAOYSA-N 0.000 description 3
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 description 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- 150000001299 aldehydes Chemical class 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- 150000007514 bases Chemical class 0.000 description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 3
- 229910052794 bromium Inorganic materials 0.000 description 3
- 150000001721 carbon Chemical group 0.000 description 3
- 238000006704 dehydrohalogenation reaction Methods 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 125000001280 n-hexyl group Chemical group C(CCCCC)* 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- AQSJGOWTSHOLKH-UHFFFAOYSA-N phosphite(3-) Chemical class [O-]P([O-])[O-] AQSJGOWTSHOLKH-UHFFFAOYSA-N 0.000 description 3
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 3
- 238000001308 synthesis method Methods 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- QPFMBZIOSGYJDE-UHFFFAOYSA-N 1,1,2,2-tetrachloroethane Chemical compound ClC(Cl)C(Cl)Cl QPFMBZIOSGYJDE-UHFFFAOYSA-N 0.000 description 2
- OISVCGZHLKNMSJ-UHFFFAOYSA-N 2,6-dimethylpyridine Chemical compound CC1=CC=CC(C)=N1 OISVCGZHLKNMSJ-UHFFFAOYSA-N 0.000 description 2
- VZMUCIBBVMLEKC-UHFFFAOYSA-N 2-chloro-5,5-dimethyl-1,3,2$l^{5}-dioxaphosphinane 2-oxide Chemical compound CC1(C)COP(Cl)(=O)OC1 VZMUCIBBVMLEKC-UHFFFAOYSA-N 0.000 description 2
- BSKHPKMHTQYZBB-UHFFFAOYSA-N 2-methylpyridine Chemical compound CC1=CC=CC=N1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 description 2
- TUAMRELNJMMDMT-UHFFFAOYSA-N 3,5-xylenol Chemical compound CC1=CC(C)=CC(O)=C1 TUAMRELNJMMDMT-UHFFFAOYSA-N 0.000 description 2
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 2
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 2
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 2
- KWOLFJPFCHCOCG-UHFFFAOYSA-N Acetophenone Chemical compound CC(=O)C1=CC=CC=C1 KWOLFJPFCHCOCG-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- NBBJYMSMWIIQGU-UHFFFAOYSA-N Propionic aldehyde Chemical compound CCC=O NBBJYMSMWIIQGU-UHFFFAOYSA-N 0.000 description 2
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 150000004982 aromatic amines Chemical class 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
- WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 2
- DQTRYXANLKJLPK-UHFFFAOYSA-N chlorophosphonous acid Chemical class OP(O)Cl DQTRYXANLKJLPK-UHFFFAOYSA-N 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 2
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 2
- BGTOWKSIORTVQH-UHFFFAOYSA-N cyclopentanone Chemical compound O=C1CCCC1 BGTOWKSIORTVQH-UHFFFAOYSA-N 0.000 description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 238000004880 explosion Methods 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 238000005227 gel permeation chromatography Methods 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 125000003717 m-cresyl group Chemical group [H]C1=C([H])C(O*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 description 2
- 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 description 2
- 239000011777 magnesium Substances 0.000 description 2
- 229910052749 magnesium Inorganic materials 0.000 description 2
- 229910001507 metal halide Inorganic materials 0.000 description 2
- SLCVBVWXLSEKPL-UHFFFAOYSA-N neopentyl glycol Chemical compound OCC(C)(C)CO SLCVBVWXLSEKPL-UHFFFAOYSA-N 0.000 description 2
- 125000003261 o-tolyl group Chemical group [H]C1=C([H])C(*)=C(C([H])=C1[H])C([H])([H])[H] 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- IWDCLRJOBJJRNH-UHFFFAOYSA-N p-cresol Chemical group CC1=CC=C(O)C=C1 IWDCLRJOBJJRNH-UHFFFAOYSA-N 0.000 description 2
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 description 2
- FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 229920001955 polyphenylene ether Polymers 0.000 description 2
- 239000002516 radical scavenger Substances 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 229910000029 sodium carbonate Inorganic materials 0.000 description 2
- 150000003509 tertiary alcohols Chemical class 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- XTTGYFREQJCEML-UHFFFAOYSA-N tributyl phosphite Chemical compound CCCCOP(OCCCC)OCCCC XTTGYFREQJCEML-UHFFFAOYSA-N 0.000 description 2
- ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 2
- GETQZCLCWQTVFV-UHFFFAOYSA-N trimethylamine Chemical compound CN(C)C GETQZCLCWQTVFV-UHFFFAOYSA-N 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 1
- UOCLXMDMGBRAIB-UHFFFAOYSA-N 1,1,1-trichloroethane Chemical compound CC(Cl)(Cl)Cl UOCLXMDMGBRAIB-UHFFFAOYSA-N 0.000 description 1
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- OCJBOOLMMGQPQU-UHFFFAOYSA-N 1,4-dichlorobenzene Chemical compound ClC1=CC=C(Cl)C=C1 OCJBOOLMMGQPQU-UHFFFAOYSA-N 0.000 description 1
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
- FAJOHOSTGGEHAH-UHFFFAOYSA-N 1-dibutoxyphosphorylcyclohexan-1-ol Chemical compound CCCCOP(=O)(OCCCC)C1(O)CCCCC1 FAJOHOSTGGEHAH-UHFFFAOYSA-N 0.000 description 1
- JAPYIBBSTJFDAK-UHFFFAOYSA-N 2,4,6-tri(propan-2-yl)benzenesulfonyl chloride Chemical compound CC(C)C1=CC(C(C)C)=C(S(Cl)(=O)=O)C(C(C)C)=C1 JAPYIBBSTJFDAK-UHFFFAOYSA-N 0.000 description 1
- DSKYSDCYIODJPC-UHFFFAOYSA-N 2-butyl-2-ethylpropane-1,3-diol Chemical compound CCCCC(CC)(CO)CO DSKYSDCYIODJPC-UHFFFAOYSA-N 0.000 description 1
- RCMBNTZZKQOSGO-UHFFFAOYSA-N 2-hydroxy-5,5-dimethyl-1,3,2-dioxaphosphinane Chemical class CC1(C)COP(O)OC1 RCMBNTZZKQOSGO-UHFFFAOYSA-N 0.000 description 1
- VGVHNLRUAMRIEW-UHFFFAOYSA-N 4-methylcyclohexan-1-one Chemical compound CC1CCC(=O)CC1 VGVHNLRUAMRIEW-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 229910015900 BF3 Inorganic materials 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- 239000002841 Lewis acid Substances 0.000 description 1
- PHSPJQZRQAJPPF-UHFFFAOYSA-N N-alpha-Methylhistamine Chemical compound CNCCC1=CN=CN1 PHSPJQZRQAJPPF-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- WKZNAWCDMVRAFO-UHFFFAOYSA-N PCOP Chemical compound PCOP WKZNAWCDMVRAFO-UHFFFAOYSA-N 0.000 description 1
- 229920005830 Polyurethane Foam Polymers 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 240000006394 Sorghum bicolor Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- GJMMXPXHXFHBPK-UHFFFAOYSA-N [P].[Cl] Chemical group [P].[Cl] GJMMXPXHXFHBPK-UHFFFAOYSA-N 0.000 description 1
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 150000008365 aromatic ketones Chemical class 0.000 description 1
- DMLAVOWQYNRWNQ-UHFFFAOYSA-N azobenzene Chemical compound C1=CC=CC=C1N=NC1=CC=CC=C1 DMLAVOWQYNRWNQ-UHFFFAOYSA-N 0.000 description 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- ZTQSAGDEMFDKMZ-UHFFFAOYSA-N butyric aldehyde Natural products CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 description 1
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
- 229910001861 calcium hydroxide Inorganic materials 0.000 description 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
- 150000001728 carbonyl compounds Chemical class 0.000 description 1
- 239000012159 carrier gas Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- ITVPBBDAZKBMRP-UHFFFAOYSA-N chloro-dioxido-oxo-$l^{5}-phosphane;hydron Chemical compound OP(O)(Cl)=O ITVPBBDAZKBMRP-UHFFFAOYSA-N 0.000 description 1
- 150000003997 cyclic ketones Chemical class 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000005695 dehalogenation reaction Methods 0.000 description 1
- OSPSWZSRKYCQPF-UHFFFAOYSA-N dibutoxy(oxo)phosphanium Chemical compound CCCCO[P+](=O)OCCCC OSPSWZSRKYCQPF-UHFFFAOYSA-N 0.000 description 1
- WNLPQGMKIVUYEB-UHFFFAOYSA-N dibutoxyphosphorylmethanol Chemical compound CCCCOP(=O)(CO)OCCCC WNLPQGMKIVUYEB-UHFFFAOYSA-N 0.000 description 1
- 229940117389 dichlorobenzene Drugs 0.000 description 1
- HPYNZHMRTTWQTB-UHFFFAOYSA-N dimethylpyridine Natural products CC1=CC=CN=C1C HPYNZHMRTTWQTB-UHFFFAOYSA-N 0.000 description 1
- XMQYIPNJVLNWOE-UHFFFAOYSA-N dioctyl hydrogen phosphite Chemical compound CCCCCCCCOP(O)OCCCCCCCC XMQYIPNJVLNWOE-UHFFFAOYSA-N 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- 239000004210 ether based solvent Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 230000020169 heat generation Effects 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- 239000012433 hydrogen halide Substances 0.000 description 1
- 229910000039 hydrogen halide Inorganic materials 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 150000002440 hydroxy compounds Chemical class 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000012442 inert solvent Substances 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 150000007517 lewis acids Chemical class 0.000 description 1
- UNXVFOUTYUQFJD-UHFFFAOYSA-K magnesium;sodium;trichloride Chemical compound [Na+].[Cl-].Cl[Mg]Cl UNXVFOUTYUQFJD-UHFFFAOYSA-K 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000005309 metal halides Chemical class 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- CHJUOCDSZWMLRU-UHFFFAOYSA-N oxo(dipropoxy)phosphanium Chemical compound CCCO[P+](=O)OCCC CHJUOCDSZWMLRU-UHFFFAOYSA-N 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 239000005011 phenolic resin Substances 0.000 description 1
- ACVYVLVWPXVTIT-UHFFFAOYSA-M phosphinate Chemical compound [O-][PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-M 0.000 description 1
- 125000005538 phosphinite group Chemical group 0.000 description 1
- XRBCRPZXSCBRTK-UHFFFAOYSA-N phosphonous acid Chemical compound OPO XRBCRPZXSCBRTK-UHFFFAOYSA-N 0.000 description 1
- 150000008300 phosphoramidites Chemical class 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- UXCDUFKZSUBXGM-UHFFFAOYSA-N phosphoric tribromide Chemical compound BrP(Br)(Br)=O UXCDUFKZSUBXGM-UHFFFAOYSA-N 0.000 description 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 description 1
- 229920001707 polybutylene terephthalate Polymers 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 239000011496 polyurethane foam Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 150000003138 primary alcohols Chemical class 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- ODZPKZBBUMBTMG-UHFFFAOYSA-N sodium amide Chemical compound [NH2-].[Na+] ODZPKZBBUMBTMG-UHFFFAOYSA-N 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- MDDUHVRJJAFRAU-YZNNVMRBSA-N tert-butyl-[(1r,3s,5z)-3-[tert-butyl(dimethyl)silyl]oxy-5-(2-diphenylphosphorylethylidene)-4-methylidenecyclohexyl]oxy-dimethylsilane Chemical compound C1[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)C(=C)\C1=C/CP(=O)(C=1C=CC=CC=1)C1=CC=CC=C1 MDDUHVRJJAFRAU-YZNNVMRBSA-N 0.000 description 1
- 150000003512 tertiary amines Chemical class 0.000 description 1
- 229920005992 thermoplastic resin Polymers 0.000 description 1
- 229920001187 thermosetting polymer Polymers 0.000 description 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 1
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
- 125000002256 xylenyl group Chemical group C1(C(C=CC=C1)C)(C)* 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B61/00—Other general methods
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/6574—Esters of oxyacids of phosphorus
- C07F9/65746—Esters of oxyacids of phosphorus the molecule containing more than one cyclic phosphorus atom
Definitions
- the present invention is not limited to the kind of phosphonate having a phosphate phosphonate bond in one molecule, which is useful as a flame retardant for a resin material, to the type of phosphonate having an alcoholic hydroxy group as a raw material.
- the present invention relates to a novel production method that can be obtained with high purity and high yield by using only a nitrogen-containing basic compound without using a catalyst such as magnesium chloride.
- the “phosphate monophosphonate bond” means a structure in which a phosphorus atom has a substituent !, may be! /, And is bonded by a linking group of an alkylene group and an oxygen atom.
- Linyi compounds are generally used in various fields as multifunctional compounds, and various compounds have been developed.
- phosphorus compounds have an excellent function as a flame retardant and have been frequently used.
- the flame retardants are subject to a wide variety of resins, including thermoplastic resins such as polycarbonate, ABS resin, polyphenylene ether (PPE), and polyester (eg, polyethylene terephthalate and polybutylene terephthalate).
- thermosetting resins such as polyurethane, epoxy resin, and phenol resin.
- the forms of these resins are not limited to molded products, but are diverse.
- the flame retardancy of sorghum generally depends on the phosphorus content in the phosphorus compound, but when adding a phosphorus compound to the resin to give the desired flame retardancy, the amount added As a result, the physical properties of the resin itself, especially the mechanical properties, may be significantly reduced. Therefore, a phosphorus compound having a high phosphorus content is desired in order to impart sufficient flame retardancy to the resin with a smaller addition amount of the phosphorus compound.
- the resin is exposed to very high temperatures in the kneading and molding processes, it is desired that the phosphorus compound to be added has high stability even at high temperatures.
- the structure of phosphorus compounds is roughly classified into phosphate, phosphonate, phosphinate, phosphite, phosphonite, phosphinite, phosphine oxide, phosphine, and the like.
- Rin The compound has at least one of these structures in one molecule, and there are also phosphorus compounds having two or more different structures.
- Phosphate phosphonates are one example.For example, phosphate phosphonates containing halogen atoms such as chlorine and bromine in one molecule, phosphate phosphonates containing alcoholic hydroxyl group in one molecule, lower alkyl such as ethyl group. A phosphate phosphonate having a group is known.
- Patent Document 1 describes an alcoholic hydroxy compound in the presence of a Lewis acid such as salty magnesium as a catalyst and triethylamine as a salty hydrogen scavenger.
- a Lewis acid such as salty magnesium as a catalyst
- triethylamine as a salty hydrogen scavenger.
- a method is described in which a phosphate-phosphonate is synthesized by reacting a phosphonate having a group with phosphorus oxychloride or phosphorochloridate.
- Patent Document 2 describes trivalent phosphite compounds using trialkyl phosphates, carbonyl compounds such as ketones and aldehydes, and phosphorochloridites as raw materials. The synthesis method is described. The phosphate-phosphonate can be obtained by oxidizing the trivalent phosphite compound obtained by the above method.
- the synthesis method in the above specification is a synthesis under an acidic atmosphere in which a carbo compound is added and reacted in a phosphorochloridite without using a catalyst, and the product is decomposed, resulting in a decrease in yield. There is a problem of doing.
- Patent Document 1 US Patent No. 4697030
- Patent Document 2 British Patent No. 941706
- the present invention provides a catalyst such as magnesium chloride without limiting the phosphorus compound having a phosphate-phosphonate bond in one molecule to the kind of phosphonate having an alcoholic hydroxy group as a raw material. It is an object of the present invention to provide a novel production method that can be obtained in high purity and high yield with a small amount of by-products by using only nitrogen-containing basic compounds.
- the present inventors have an alcoholic hydroxy group by using a di-substituted phosphorohalidite having a high reaction activity as a raw material.
- a dehydrohalogenation reaction with phosphonates can be carried out, without being limited to the type of phosphonate, without the use of a catalyst such as magnesium chloride, by the use of nitrogen-containing basic compounds, and by-products
- the present inventors have found that a phosphate-phosphonate can be obtained with a high purity and a high yield with a small amount of azobenzene.
- R 1 and R 2 are the same or different from each other, and are a linear or branched alkyl group, a cycloalkyl group or an aryl group, or R 1 and R 2 are Together with the oxygen atom and phosphorus atom to form a cyclic structure
- R 3 and R 4 are the same or different from each other, and are a hydrogen atom, a linear or branched alkyl group or an aryl group. Or R 3 and R 4 together with the carbon atom to which they are attached form a cyclic structure
- R 5 and R 6 are the same or different from each other, and are a linear or branched alkyl group, a cycloalkyl group or an aryl group, or R 5 and R 6 are Combined with the oxygen and phosphorus atoms to form a ring structure, X is a halogen atom
- the phosphorus compound having a phosphate phosphonate bond in one molecule is not limited to the type of phosphonate having an alcoholic hydroxy group as a raw material.
- it can be produced with high purity and high yield with few by-products by using only a nitrogen-containing basic compound without using a catalyst such as magnesium chloride.
- the method for producing the phosphorus compound of the present invention comprises a phosphonate (II), a disubstituted phosphorone, a redite (III
- reaction product ( ⁇ ) Is subjected to a dehydrohalogenation reaction in the presence of a nitrogen-containing basic compound to obtain a reaction product ( ⁇ ), and then the reaction product ( ⁇ ) is oxidized to form a phosphate phosphonate bond.
- a phosphorus compound (I) having the following is obtained.
- the nitrogen-containing basic compound functions as a halogenated hydrogen scavenger.
- R 1 and R 2 in the phosphonate (II) are the same or different from each other, and are a linear or branched alkyl group, cycloalkyl group or aryl group, or R 1 and R 2 are A cyclic structure may be formed together with an oxygen atom and a phosphorus atom to which they are bonded.
- Examples of the linear or branched alkyl group of R 1 and R 2 include, for example, methyl, ethyl, n-propinole, iso-propinole, n-butinole, iso-butinore, sec-butinore, n-pentinole, n-hexyl, n-octyl, 2-ethylhexyl, etc., among which C to C
- a 2 8 kill group is particularly preferred.
- R 1 and R 2 are An alkyl group having 2 or more carbon atoms is preferred.
- alcohol having a large number of carbon atoms derived from the production of phosphonate (II) must remain in the final product. This is preferable because it can be difficult to remove!
- the cycloalkyl group of R 1 and R 2 for example, cyclopropyl, cyclobutyl, consequent opening Penchinore, Kishinore cyclohexane, Puchinore cyclohexane, Shikurookuchinore, Shikurono two Honoré, Shikurode sill can be mentioned, Celsius to Among them C-Cycloalkyl is preferred cyclohexyl
- the group is particularly preferred.
- the cycloalkyl Since the kill ring is likely to be unstable, a compound produced by ring cleavage may adversely affect the reaction system, which is preferable.
- the cycloalkyl group of R 1 and R 2 may have a substituent.
- substituents include C to C linear or branched alkyl groups. Among them, for example,
- ⁇ C alkyl groups such as methinole, ethinole, n-propinole, n-butinole, iso-butinole, sec-butinole and tert-butinole.
- Examples of the cycloalkyl group having a substituent include 3-methylcyclohexyl group and 4-methylcyclohexyl group. Phosphonate (II) having these groups is used for synthesizing phosphonate ( ⁇ ⁇ ⁇ ). It's easy to get raw materials at!
- Examples of the aryl group of R 1 and R 2 include phenol, 1-naphthyl, 2-naphthyl and the like.
- the aryl group of R 1 and R 2 may have a substituent.
- a C alkyl group is particularly preferred.
- Examples of the aryl group having a substituent include 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, 2,6-dimethylphenyl, 2,4-dimethylphenyl, 3,5- Examples include C to C aryl groups such as dimethylphenol and 2,6-di-tert-butyl-4-methylphenol.
- phosphonates (II) having a phenyl group, a 3-methylphenol group, and a 4-methylphenol group are readily available as raw materials for the synthesis of the phosphonate (II). !
- R 1 and R 2 may be combined with an oxygen atom and a phosphorus atom to which they are bonded to form a cyclic structure.
- Connecting Kiichi R 1 and R 2 is formed by bonding R 1 - ⁇ - as, R 1 and R sum of carbon atoms contained in 2 is preferably an alkylene group comprising 2 to 9 tool 2
- An alkylene group of ⁇ 6 is more preferred.
- the ring in the cyclic structure is preferably a 5- to 7-membered ring, more preferably a 5-membered ring or a 6-membered ring, more preferably a 6-membered ring.
- this ring is an 8-membered ring or more or a 4-membered ring or less, the ring is likely to be unstable, resulting in ring cleavage. Therefore, the resulting acid component [P—OH] is not preferable because it may adversely affect the progress of the reaction.
- cyclic structure represented by the following general formula (VI):
- R 51 and R 52 are the same or different from each other, and are a hydrogen atom or a linear or branched alkyl group
- R 51 and R 52 preferably have a total number of carbon atoms contained in them of 0 to 6, specifically, a combination in which R 51 and R 52 are both methyl groups, or Examples include combinations in which R 51 and R 52 are an ethyl group and an n-butyl group, respectively.
- R 3 and R 4 in the phosphonate (II) are the same or different from each other, and are a hydrogen atom, a linear or branched alkyl group or an aryl group, or R 3 and R 4 are You may form a ring structure with the carbon atoms to be bonded.
- Examples of the linear or branched alkyl group represented by R 3 and R 4 include, for example, methyl, ethyl, n-propinole, iso-propinole, n-butinole, iso-butinole, sec-butinole, n-pentinore, Examples thereof include n-hexyl, and among them, a C to C alkyl group is particularly preferable.
- Examples of the aryl group of R 3 and R 4 include phenol, 1-naphthyl, 2-naphthyl and the like.
- the aryl group of R 3 and R 4 may have a substituent.
- substituents include C-C linear or branched alkyl groups such as methinole, ethinole, n-propinole, n-butinole, iso-butinole, sec-butinole, tert-butinole, and n-pentyl. Is mentioned.
- aryl group having a substituent examples include a phenyl group having a methyl group and a naphthyl group having a methyl group.
- R 3 and R 4 may be combined with the carbon atom to which they are bonded to form a cyclic structure represented by the following formula. [Chemical 6]
- R 3 and R 4 and connection is formed by combining Kiichi R 3 -R 4 -
- the sum of the number of carbon atoms contained in R 3 and R 4 are 4: alkylene groups consisting LO Is preferred.
- the ring in the cyclic structure is preferably a 5- to 7-membered ring, and more preferably a 6-membered ring having no substituent, more preferably a 6-membered ring. When this ring is an 8-membered ring or more or a 4-membered ring or less, the ring is likely to be unstable, and as a result, a compound produced by ring cleavage may adversely affect the progress of the reaction. What! /
- the alkylene group may have a substituent.
- substituents include C to C linear or branched alkyl groups such as methyl, ethinole, n-propinole, n-butinole, iso-butinole, sec-butinole, tert-butinole, and n-pentinole. Is mentioned.
- the sum of the number of carbon atoms contained in R 3 and R 4 is preferably 1-12.
- the number of carbon atoms contained in R 3 and R 4 of the phosphonate (II) is 1 or more and the sum of the number of carbon atoms contained in R 3 and R 4 is 2 to 12.
- R 3 and R 4 in the phosphonate (II) are a methyl group and a hydrogen atom, a methyl group and a methyl group, a methyl group and an ethyl group, a methyl group and an isobutyl group, a phenyl group and a hydrogen atom, a phenol And a methyl group, a combination of a phenyl group and a phenyl group, and a linking group in which R 3 and R 4 together with the carbon atom to which they are attached form a 6-membered ring. I like it.
- the phosphonate (II) has the formula (IV):
- Phosphonate (II) can be synthesized, for example, by addition reaction of aldehyde or ketone to phosphite (see, for example, JP-A-49-126623).
- Examples of the phosphite used in the above addition reaction include jetyl phosphite, di-n-propyl phosphite, di-n-butyl phosphite, di-n-octyl phosphite and bis (2-ethylhexyl).
- Examples thereof include dialkyl phosphites such as phosphites and cyclic phosphites such as neopentylene phosphites. Particularly preferred are dialkyl phosphites and cyclic phosphites substituted with the same alkyl groups as exemplified in view of availability as raw materials and price.
- aldehyde examples include formaldehyde, acetoaldehyde, propionaldehyde, and benzaldehyde.
- ketone examples include chain ketones such as acetone, methyl ethyl ketone, and methyl isobutyl ketone (MIBK), acetophenone, Examples include aromatic ketones such as benzophenone, and cyclic ketones such as cyclopentanone, cyclohexanone, and methylcyclohexanone.
- a catalyst is preferably used for the above addition reaction.
- examples of such catalysts include alkali metals such as sodium metal and potassium, alkali metal-containing bases such as sodium hydride, sodium alkoxide and sodium amide, aliphatic tertiary amines such as triethylamine and triptylamin, pyridine, and the like.
- basic catalysts such as aromatic amines such as lutidine and picoline, among which aliphatic tertiary amines are preferred. These can be used in combination of two or more.
- metal halides such as magnesium chloride, aluminum chloride, zinc chloride, titanium tetrachloride, and boron trifluoride ether complex can be used in combination. These can also be used as a mixture of two or more.
- the combination of the basic catalyst triethylamine and the metal halide magnesium chloride is preferred from the viewpoint of reactivity and handling.
- di-substituted phosphoramidite needles phosphoramidite (III) R 5 and R 6 in the same or different dates each other, a linear or branched alkyl group, a force or R 5 is a cycloalkyl group or Ariru group R 6 may be combined with the oxygen atom and phosphorus atom to which they are bonded to form a cyclic structure.
- X is a halogen atom.
- Examples of the linear or branched alkyl group of R 5 and R 6 include, for example, methyl, ethyl, n-propinole, iso-propinole, n-butinole, iso-butinole, sec-butinole, n-pentinore, n-hexyl, n-octyl, 2-ethylhexyl, etc., among which C to C
- a 2 8 kill group is particularly preferred.
- R 5 and R 6 Is preferably an alkyl group having a carbon number of S 2 or more.
- R 5 and R 6 has 9 or more carbon atoms, an alcohol having a large number of carbon atoms derived from the production of disubstituted phosphorohalidite (III) is finally produced. It is not preferable because it may remain in the product and may be difficult to remove.
- the cycloalkyl group of R 5 and R 6, for example, cyclopropyl, cyclobutyl, consequent opening Penchinore, Kishinore cyclohexane, Puchinore cyclohexane, Shikurookuchinore, Shikurono two Honoré, Shikurode sill can be mentioned, Celsius to Among them C-Cycloalkyl is preferred cyclohexyl
- the group is particularly preferred.
- the cycloalkyl ring is likely to be unstable. As a result, a compound generated by ring cleavage may adversely affect the reaction system, which is preferable.
- the cycloalkyl group of R 5 and R 6 may have a substituent.
- substituents include C to C linear or branched alkyl groups. Among them, for example,
- ⁇ C alkyl groups such as methinole, ethinole, n-propinole, n-butinole, iso-butinole, sec-butinole and tert-butinole.
- cycloalkyl group having a substituent include a 3-methylcyclohexyl group, a 4-methylcyclohexyl group, and the like. Disubstituted phosphorono having such a group and redidite (III) are obtained as raw materials. Easy, so preferred.
- Examples of the aryl group of R 5 and R 6 include phenol, 1-naphthyl, 2-naphthyl and the like.
- the aryl group of R 5 and R 6 may have a substituent.
- a C alkyl group is particularly preferred.
- aryl group having a substituent examples include 2-methylphenyl, 3_methylphenyl, 4-methylphenyl, 2,6-dimethylphenyl, 2,4-dimethylphenyl, and 3,5-dimethylphenol.
- C 6 -C aryl groups such as 2,6-di-tert-butyl-4-methylphenol.
- disubstituted phosphorono and redite (III) having a phenyl group, a 3-methylphenol group, and a 4-methylphenol group are preferable because they are easily available as raw materials.
- R 5 and R 6 may be combined with an oxygen atom and a phosphorus atom to which they are bonded to form a cyclic structure.
- As the linking group formed by combining R 5 and R 6 — R 5 —R 6 — an alkylene group in which the sum of carbon atoms contained in R 5 and R 6 is 2 to 9 is preferred. An alkylene group of 2 to 6 is more preferable.
- the ring in the cyclic structure is preferably a 5- to 7-membered ring, more preferably a 5-membered ring or a 6-membered ring, more preferably a 6-membered ring.
- this ring is an 8-membered ring or more or a 4-membered ring or less, the ring is likely to be unstable. As a result, the acid component [P—OH] generated by the ring cleavage adversely affects the progress of the reaction. It is not preferable because there is a risk of effects.
- the cyclic structure is a cyclic structure represented by the following general formula (VII):
- R 53 and R 54 are the same as or different from each other, and are a hydrogen atom or a linear or branched alkyl group
- R 53 and R 54 preferably have a total number of carbon atoms contained in them of 0 to 6, specifically, a combination in which R 53 and R 54 are both methyl groups, or R Examples include a combination in which 53 and R 54 are an ethyl group and an n-butyl group, respectively.
- halogen atom for X in the disubstituted phosphorohalidite (III) examples include fluorine, chlorine, bromine and iodine. Chlorine and bromine are preferred over chlorine because they are highly reactive.
- the disubstituted phosphorohalidite (III) has the formula (V):
- the one represented by is preferred.
- a di-substituted phosphorohalidite (III), for example, a cyclic alkylene phosphorohalidite can be synthesized by a reaction between a phosphorus, rogenated phosphorus and a diol compound (for example, JP-A-2-273688). See the official gazette).
- Examples of the phosphorus halide used in the above reaction include phosphorus trichloride, phosphorus tribromide and the like. Phosphorus trichloride is particularly preferred from the standpoint of availability as a raw material and price.
- the di-substituted phosphorohalidite (III) has a cyclic structure, the difference in the yield of the phosphorus compound (I) appears remarkably.
- the diol compound include 1,3-propanediol, 1,3-butanediol, 2,2-jetyl-1,3-propanediol, 2-ethyl-2-butyl-1,3- Examples thereof include propanediol, neopentyl glycol, and 2,2-dialyl-1,3-propanediol.
- 2-Ethyl-2-butyl-1,3-propanediol and neopentyldalycol are particularly preferred because of their availability and price as raw materials.
- phosphonate (II) and disubstituted phosphorohalidite (III) are subjected to dehalogenation hydrogenation reaction in the presence of a nitrogen-containing basic compound (step (1) )), And then the resulting reaction product ( ⁇ ) is acidified to obtain phosphorus compound (I) (step (2)).
- Examples of the nitrogen-containing basic compound used in step (1) include aliphatic tertiary amines such as triethylamine and triptylamin, and aromatic amines such as pyridine. Triethylamine, which is preferably a group III tertiary amine, is particularly preferred.
- the usage-amount of a nitrogen-containing basic compound is about 1.0-1.2 mol with respect to 1 mol of disubstituted phosphorohalidites (III).
- the amount of the di-substituted phosphorono and redite (III) used in the step (1) is preferably 1.0 to 1.5 monoreca, more preferably 1.01 to L 2 monoleca per 1 mol of the phosphonate (II). Better!/,.
- the amount of disubstituted phosphorohalidite (III) used is less than 1.0 mole per mole of phosphonate (11), the ratio of unreacted phosphonate (II) remaining in the reaction product As a result, it may be difficult to remove the phosphonate (II) from the final product, which is not preferable.
- the amount of di-substituted phosphorohalidite (III) used exceeds 1.5 mol per mol of phosphonate (II), and unreacted di-substituted phosphorohalidite (III) after completion of the reaction in step (1).
- the reaction temperature in the step (1) is preferably 10 to 100 ° C, more preferably 20 to 70 ° C.
- the reaction temperature is less than 10 ° C, the reactivity is lowered, which is not preferable.
- the reaction temperature exceeds 100 ° C, it is preferable because the nitrogen-containing basic compound may be scattered or the disubstituted phosphorone or redite (III) may cause a side reaction.
- the reaction time depends on conditions such as the reaction temperature, but usually 1 to 5 hours is sufficient.
- step (1) can be carried out in the presence of an organic solvent, if necessary.
- the organic solvent is not particularly limited as long as it is inert to this reaction.
- hydrocarbon solvents such as hexane, cyclohexane, heptane, octane, benzene, toluene, xylene and petroleum spirit;
- Halogen-containing hydrocarbon solvents such as mouth form, carbon tetrachloride, dichloromethane, dichloroethane, trichloroethane, tetrachloroethane, black mouth benzene and dichlorobenzene; diisopropyl ether, dibutyl ether, 1,4-dioxane and ethylene And ether solvents such as glycol jetyl ether.
- aromatic hydrocarbons such as toluene and black benzene are particularly preferable in terms of ease of handling.
- step (1) After completion of the reaction in step (1), it is preferable to remove the by-produced hydrogen halide salt of amine.
- the removal method include known methods such as filtration and washing with water.
- step (2) the reaction product ( ⁇ ) obtained in step (1) is acidified by a known method to obtain a phosphorus compound represented by the above general formula (I). Get the compound.
- the reaction product ( ⁇ ) and hydrogen peroxide are reacted under basic conditions (see, for example, JP-A-11-100391)
- step (2) when the reaction system is in an acidic condition, the reaction product (I ') is decomposed. Therefore, it is necessary to always keep the reaction system basic.
- a known basic compound can be used.
- Examples of such basic compounds include lithium hydroxide, sodium hydroxide, and hydroxide.
- Alkali metal hydroxides such as potassium hydroxide; carbonates typified by sodium carbonate; ammonia; dimethylamine, trimethylamine, triethylamine, tributylamine, amines such as ⁇ , ⁇ -dimethylaline And aromatic complex ring bases such as pyridine and picoline.
- sodium hydroxide and triethylamine are particularly preferable.
- These basic compounds can also be used as a mixture of two or more.
- the amount of hydrogen peroxide used in step (2) is preferably 1.0 to 1.5 monoreca, more preferably 1.01 to L 2 monoleca per 1 mol of the reaction product ( ⁇ ). ! / ⁇ .
- the amount of hydrogen peroxide used is less than 1.0 mole relative to 1 mole of the reaction product ( ⁇ ), the oxidation reaction will not be completed and the unreacted reaction product ( ⁇ ) will be This is not preferable because the ratio remaining in the mixture becomes high and, as a result, the yield of the phosphorus compound (I) may be reduced.
- the larger the amount of hydrogen peroxide solution used the more the oxidation reaction proceeds and the yield of the phosphorous compound (I) increases.
- unreacted hydrogen peroxide with the risk of explosion remains. This is not preferable in terms of safety.
- the upper limit of the amount of hydrogen peroxide used is about 1.5 moles per mole of reaction product ( ⁇ ). Appropriate, up to about 1.2 moles is practical.
- the reaction temperature in step (2) is preferably 0 to 80 ° C, more preferably 10 to 70 ° C.
- the reaction temperature is less than 0 ° C, hydrogen peroxide having a risk of explosion accumulates in the reaction system and there is a risk of causing a rapid reaction, which is not preferable.
- the reaction temperature exceeds 80 ° C, decomposition of hydrogen peroxide itself is accelerated, which is not preferable.
- the reaction time is usually about 1 to 5 hours, although it depends on the reaction temperature and other conditions.
- step (2) can be carried out in the presence of an organic solvent, if necessary.
- the organic solvent is not particularly limited as long as it is an inert solvent for this reaction, and examples thereof include those exemplified in the step (1). It is preferable to use the same solvent in step (1) and step (2) because the solvent recovery step can be simplified at a time.
- the target compound, phosphorus compound (I) can be obtained by removing the solvent and low-boiling components under reduced pressure.
- the nitrogen-containing basic compound in the reaction mixture can be removed.
- the obtained reaction mixture may be washed with acidic water such as hydrochloric acid, sulfuric acid, oxalic acid, nitric acid, phosphoric acid and citrate.
- reaction mixture acidic components and unreacted hydrogen peroxide in the reaction mixture can be removed by neutralization.
- the obtained reaction mixture may be washed with an alkaline aqueous solution such as sodium hydroxide, potassium hydroxide, calcium hydroxide, sodium carbonate or the like.
- dibutylphosphite 213.4 g (l. 1 mol), triethylamine 5.6 g (0.06 mol) and 1.9 g (0.020 mol) of sodium chloride magnesium was charged. While stirring this mixed solution at 40 ° C., 70.2 g (l. 2 mol) of acetone was added over 1 hour. Further, the reaction was completed by stirring at the same temperature (40 ° C.) for 1 hour.
- reaction solution was washed successively with a 1% dilute hydrochloric acid aqueous solution and a saturated sodium carbonate aqueous solution, and further washed twice with water to remove triethylamine and magnesium chloride.
- water was recovered under a reduced pressure of about 2.7 kPa while heating the reaction mixture to 80 ° C.
- nitrogen topping was performed under the same conditions to remove low boiling point, and 254.6 g of dibutyl (1-hydroxy-1-methylethyl) phosphonate (raw material 2) was obtained.
- a 2 liter four-necked flask equipped with a stirrer, thermometer, dropping device and reflux tube was charged with 213.4 g (l.1 mol) of dibutyl phosphite, 5.6 g (0.06 mol) of triethylamine and 1.05 g (0.011) of magnesium chloride. Mole). While stirring this mixed solution at 25 ° C., methyl isobutyl ketone (MIBK) 120. Og (l.2 mol) was added over 1 hour. Further, the reaction was completed by stirring at the same temperature (25 ° C) for 1 hour.
- MIBK methyl isobutyl ketone
- the temperature of the reaction mixture was raised to 60 ° C, 222.3 g of water (30% by weight with respect to the reaction mixture) was added to the reaction mixture, and the mixture was stirred at the same temperature (60 ° C) for 30 minutes and then allowed to stand to separate. It was made to match. The aqueous phase was recovered and triethylamine hydrochloride formed as a by-product was removed.
- the structure of the resulting product was determined by IR, NMR, elemental analysis and P% by absorption.
- Example 2 After completion of the above reaction, the reaction was carried out in the same manner as in Example 1 except that the raw material 4 was used instead of the raw material 2 to obtain 432.8 g of a colorless and transparent liquid.
- the structure of the resulting product was determined by IR, NMR, elemental analysis and P% by absorption.
- Example 1 Further, the product obtained in Example 1 was used for identification.
- a reaction was carried out in the same manner as in Example 1 except that the raw material 5 was used instead of the raw material 2, and 381.8 g of a colorless transparent liquid was obtained.
- the structure of the resulting product was determined by IR, NMR, elemental analysis and P% by absorption.
- Example 1 Further, the product obtained in Example 1 was used for identification.
- a tertiary alcohol having low reactivity (Example 1) or a tertiary alcohol (Examples 2 and 3) which is sterically hindered and expected to be low in reactivity is used as a raw material. Even if their reactivity is good, phosphate monophosphonate in high purity and high yield It can be seen that it can be synthesized.
- phosphate phosphonate can be synthesized with high purity and high yield even when raw material is used in the reaction of step (1) (Examples 4 and 5). Furthermore, even when a primary alcohol such as dibutyl (hydroxymethyl) phosphonate is used as a raw material, the same effects as described above can be obtained.
- neopentylene pyrophosphate represented by the following formula cannot be removed from the target compound by steam topping or nitrogen topping, but only by hydrolysis using alkali. Can be removed. However, this hydrolysis causes some degradation of the target compound, resulting in a decrease in yield.
- Comparative Example 4 the reaction atmosphere is strongly acidic, and even if the target compound is produced, it is assumed that it will decompose immediately. For this reason, in Comparative Example 5, an attempt was made to prevent decomposition of the target compound by using triethylamine under a basic reaction atmosphere. However, as in Comparative Example 4, the target compound was obtained only by obtaining an unknown component. I could't get it.
- the present invention relates to a Japanese patent application No. 2004-319529 filed on November 2, 2004, and claims the priority thereof, the contents of which are hereby incorporated by reference.
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Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
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EP05795790.4A EP1808437B1 (en) | 2004-11-02 | 2005-10-18 | Method for producing phosphorus compounds having phosphate-phosphonate bond |
US11/718,296 US7728162B2 (en) | 2004-11-02 | 2005-10-18 | Process for preparing phosphorus compounds having phosphate-phosphonate bond |
JP2006543011A JP4320344B2 (ja) | 2004-11-02 | 2005-10-18 | ホスフェート−ホスホネート結合を有するリン化合物の製造方法 |
KR1020077011894A KR101345181B1 (ko) | 2004-11-02 | 2007-05-25 | 포스페이트-포스포네이트 결합을 가지는 인 화합물의제조방법 |
Applications Claiming Priority (2)
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JP2004319529 | 2004-11-02 | ||
JP2004-319529 | 2004-11-02 |
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WO2006049011A1 true WO2006049011A1 (ja) | 2006-05-11 |
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PCT/JP2005/019132 WO2006049011A1 (ja) | 2004-11-02 | 2005-10-18 | ホスフェート-ホスホネート結合を有するリン化合物の製造方法 |
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US (1) | US7728162B2 (ja) |
EP (1) | EP1808437B1 (ja) |
JP (1) | JP4320344B2 (ja) |
KR (1) | KR101345181B1 (ja) |
CN (1) | CN100577670C (ja) |
MY (1) | MY143324A (ja) |
TW (1) | TWI355387B (ja) |
WO (1) | WO2006049011A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1810975A1 (en) * | 2004-11-02 | 2007-07-25 | Daihachi Chemical Industry Co., Ltd. | Method for producing phosphonate having alcoholic hydroxy group |
WO2011040287A1 (ja) | 2009-10-01 | 2011-04-07 | 大八化学工業株式会社 | 環状アルキレンホスホロハリダイトおよび環状リン酸エステルの製造方法 |
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US6737302B2 (en) | 2001-10-31 | 2004-05-18 | Semiconductor Energy Laboratory Co., Ltd. | Manufacturing method for field-effect transistor |
JP2012501335A (ja) * | 2008-08-28 | 2012-01-19 | ダウ グローバル テクノロジーズ エルエルシー | リン含有化合物およびそれを含むポリマー組成物 |
CN103739626A (zh) * | 2013-10-18 | 2014-04-23 | 内蒙古大学 | 无催化、一锅法合成含羟基的反应型膦酸酯阻燃剂的方法 |
CN109053806A (zh) * | 2018-08-22 | 2018-12-21 | 浙江万盛股份有限公司 | 一种磷酸酯膦酸酯的制备方法 |
KR102377102B1 (ko) | 2018-09-13 | 2022-03-21 | 재단법인 대구경북첨단의료산업진흥재단 | TGase 2 억제제로서의 퀴놀린-5,8-디온 유도체의 제조 방법 |
KR20230060027A (ko) * | 2021-10-27 | 2023-05-04 | 솔브레인 주식회사 | 비대칭형 포스페이트계 화합물의 제조방법 |
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FR1244625A (fr) | 1958-12-15 | 1960-09-19 | Monsanto Chemicals | Esters du phosphore trivalent d'hydroxy-phosphonates, leur préparation et leurs applications, notamment comme additifs contre l'auto-allumage dans les carburants |
JPS516128B2 (ja) | 1973-04-11 | 1976-02-25 | ||
JPS5636512A (en) * | 1979-08-31 | 1981-04-09 | Daihachi Kagaku Kogyosho:Kk | Flame retardant for polyurethane foam |
US4697030A (en) | 1985-05-23 | 1987-09-29 | Stauffer Chemical Company | Phosphate-containing and phosphonate-containing phosphate esters |
JPH02273688A (ja) | 1989-04-14 | 1990-11-08 | Sanyo Kagaku Kenkyusho:Kk | 環状亜リン酸エステル誘導体 |
JP3383198B2 (ja) | 1996-11-21 | 2003-03-04 | 大八化学工業株式会社 | 有機リン化合物の製造方法 |
KR100897225B1 (ko) * | 2003-06-09 | 2009-05-14 | 다이하치 카가쿠 고교 가부시키가이샤 | 포스페이트-포스포네이트 결합을 지닌 유기인 화합물 및각각 이를 포함한 난연성 폴리에스테르 섬유 및 난연성폴리우레탄 수지 조성물 |
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- 2005-10-18 CN CN200580037224A patent/CN100577670C/zh active Active
- 2005-10-18 WO PCT/JP2005/019132 patent/WO2006049011A1/ja active Application Filing
- 2005-10-18 JP JP2006543011A patent/JP4320344B2/ja active Active
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- 2005-10-25 MY MYPI20055011A patent/MY143324A/en unknown
- 2005-10-26 TW TW094137462A patent/TWI355387B/zh active
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2007
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Non-Patent Citations (4)
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KONOVALOVA I.V. ET AL: "Effect of acid impurities on the thermal stability of alpha-phosphorylated trialkyl phosphites", ZHURNAL OBSHCHEI KHIMII, vol. 49, no. 6, 1979, pages 1424 - 1425, XP002994787 * |
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ROCH-NEIREY C. ET AL: "Rhodium-catalyzed hydroformylation of styrene at low temperature using potentially hemilabile phosphite-phosphonate ligands", TETRAHEDRON LETTERS, vol. 42, no. 4, 22 January 2001 (2001-01-22), pages 643 - 645, XP004314754 * |
See also references of EP1808437A4 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1810975A1 (en) * | 2004-11-02 | 2007-07-25 | Daihachi Chemical Industry Co., Ltd. | Method for producing phosphonate having alcoholic hydroxy group |
EP1810975A4 (en) * | 2004-11-02 | 2010-03-10 | Daihachi Chem Ind | PROCESS FOR PREPARING PHOSPHONATE WITH ALCOHOLIC HYDROXY GROUP |
WO2011040287A1 (ja) | 2009-10-01 | 2011-04-07 | 大八化学工業株式会社 | 環状アルキレンホスホロハリダイトおよび環状リン酸エステルの製造方法 |
US8674130B2 (en) | 2009-10-01 | 2014-03-18 | Daihachi Chemical Industry Co., Ltd. | Processes for production of cyclic alkylene phosphorohalidite and cyclic phosphoric acid ester |
JP5762297B2 (ja) * | 2009-10-01 | 2015-08-12 | 大八化学工業株式会社 | 環状アルキレンホスホロハリダイトおよび環状リン酸エステルの製造方法 |
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CN101048420A (zh) | 2007-10-03 |
JPWO2006049011A1 (ja) | 2008-05-29 |
JP4320344B2 (ja) | 2009-08-26 |
TWI355387B (en) | 2012-01-01 |
TW200626606A (en) | 2006-08-01 |
EP1808437A1 (en) | 2007-07-18 |
KR20070084573A (ko) | 2007-08-24 |
CN100577670C (zh) | 2010-01-06 |
EP1808437B1 (en) | 2013-09-11 |
EP1808437A4 (en) | 2010-03-10 |
US7728162B2 (en) | 2010-06-01 |
US20090062554A1 (en) | 2009-03-05 |
MY143324A (en) | 2011-04-29 |
KR101345181B1 (ko) | 2013-12-27 |
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