WO2006015675A1 - Preparation cosmetique pour la peau a base de lipides polyinsatures - Google Patents

Preparation cosmetique pour la peau a base de lipides polyinsatures Download PDF

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Publication number
WO2006015675A1
WO2006015675A1 PCT/EP2005/007415 EP2005007415W WO2006015675A1 WO 2006015675 A1 WO2006015675 A1 WO 2006015675A1 EP 2005007415 W EP2005007415 W EP 2005007415W WO 2006015675 A1 WO2006015675 A1 WO 2006015675A1
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Prior art keywords
skin
oil
preparation according
extract
preparation
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PCT/EP2005/007415
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German (de)
English (en)
Inventor
Wilfried Rähse
Original Assignee
Henkel Kommanditgesellschaft Auf Aktien
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Publication of WO2006015675A1 publication Critical patent/WO2006015675A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706—Algae
    • A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9741—Pteridophyta [ferns]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9755—Gymnosperms [Coniferophyta]
    • A61K8/9761—Cupressaceae [Cypress family], e.g. juniper or cypress
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9755—Gymnosperms [Coniferophyta]
    • A61K8/9767—Pinaceae [Pine family], e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/52—Stabilizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations

Definitions

  • the invention relates to a skin cosmetic preparation comprising at least eight active ingredients in four specific active complexes, as well as the use of this preparation. Furthermore, the invention relates to a product, a substrate and a shaped body, which each contain this Zu ⁇ preparation.
  • the human skin forms the interface of the human organism to the environment and therefore it has important protective functions, for example against the penetration of foreign substances, against mechanical stress or against adverse climatic influences.
  • the skin fulfills a variety of physiological functions, e.g. temperature regulation, regulation of water balance or vitamin D synthesis.
  • the skin is the seat of sensory cells for the perception of pressure, temperature, pain. A healthy skin is therefore of great importance for humans.
  • a very important component of the skin is, for example, the so-called hydrolipid layer.
  • This surface film on the skin is a layer consisting essentially of certain fats and fatty acids, amino acids, organic and inorganic salts and, above all, water, which has a pH of 5 to 6 and its components, at least in the Case of healthy skin, to be constantly replicated.
  • This hydrolipid layer together with the horny layer, forms an effective barrier against chemical, microbiological and mechanical effects and, moreover, also serves as an important barrier for the delivery of water to the body. In this way, the hydrolipid and horny layer contribute substantially to maintaining the functional capability of tissues and cells.
  • Skin care products are generally used in cosmetics and dermatology to help the skin maintain or return to its natural state of equilibrium. find and give her advantageously also an even better protection against external influences.
  • the skin condition should generally be improved.
  • the natural aging process of the skin should be counteracted. Damaged skin should be relieved and cared for, so that it can regenerate again.
  • This aspect is particularly important for people with a predisposition to atopic dermatitis, hives, psoriasis, ichthyosis, dyskeratosis or similar diseases of great importance, as well as those who have a particularly sensitive skin or a predisposition to skin irritation or - impurities , for this reason, skin care and treatment agents should also be prepared so that the skin is under no circumstances exposed to an additional burden during treatment with these agents, which results for example from certain ingredients of these agents and possibly leads to a new skin irritation which is induced by the agent application.
  • the object of the present invention was to provide a skin-cosmetic preparation which meets the aforementioned requirements, the use of which preserves and restores the barrier function of the skin, the preservation or improvement of the elasticity of the skin Providing the skin with moisture and fat, the protection of the skin from drying out and advantageously the retardation of skin aging is ensured, but in particular the improvement of the skin elasticity is achieved.
  • a skin-cosmetic preparation which comprises at least eight, preferably natural or nature-identical, active ingredients in a total amount of at least 20% by weight, advantageously at least 25% by weight, in particular at least 30% by weight.
  • % and at least the following four active complexes comprises: a) acid buffer consisting of at least one acid and a salt b) vitamin complex consisting of at least two vitamins, vitamin derivatives and / or vitamin precursors c) moisture regulators consisting of at least two non-ionic active ingredients d ) at least 3 wt .-%, preferably at least 5 wt .-% of natural fatty oils, the iodine numbers of more than 95 and preferably more than
  • the preparation according to the invention contributes very well to the maintenance and protection of the physiological skin balance. It has also been found that such a preparation of the skin helps particularly well to store moisture, so that the Feuch ⁇ activity content of the skin is improved and sustainable, d. H. is stabilized for a period of at least about 24 hours after application, advantageously also beyond. Skin moisture increases overall.
  • the fat content of the skin, surprisingly also of atopic skin increases markedly, but advantageously without the skin shining externally or appearing greasy, which is surprising.
  • the preparation also has skin-healing properties, which is particularly beneficial with regard to atopic skin. Skin healing and regeneration are accelerated.
  • the preparation protects the skin, especially sensitive skin from external influences.
  • the preparation is very easy to apply and very well distributed on the skin, absorbs very quickly and does not greasy. Elasticity and firmness of the skin are significantly increased by the preparation.
  • the skin feels tight, without creating a feeling of tension.
  • the general appearance of the skin is improved or beautified, the general skin condition is improved, the skin surface is noticeably strengthened and smoothed, skin roughness is reduced.
  • the skin appears silky, dull and fine pored.
  • the natural metabolism of the skin is activated and supported, which leads to a regeneration and (re) vitalization of the skin.
  • the skin is protected not only from harmful environmental influences, from skin irritation and redness, but also from visible traces of premature skin aging.
  • the skin aging is slowed down.
  • the formation of wrinkles is prevented and existing wrinkles are alleviated or reduced.
  • the skin feels smooth and supple as a result of using the preparation.
  • the reduction of fine lines, wrinkles or other unwanted textures of the skin surface takes place rapidly, preferably after a single application with an effective duration of advantageously at least 12 hours, in particular of at least 24 hours.
  • the effect thus does not occur only after application of the preparation over a relatively long period of time, for example 1-2 weeks, but preferably already after the first application, ie suddenly.
  • a sudden improvement of the skin surface and skin properties overall is achieved.
  • Skin hydration and skin elasticity improve even with a single application.
  • the resilience of the skin after deformation is increased after the first application, preferably with a duration of action of several hours.
  • the overall effect of the preparation is unexpected and appears to be due to the increasing interaction of the four active complexes.
  • a preparation according to the invention advantageously makes it possible to offer the skin a substantially comprehensive complete spectrum of its own constituents and thus to achieve maximum care success without burdening the skin.
  • complex in connection with the terms acid buffer, Vitamin ⁇ complex, moisture regulators, fatty oils, which each form such an active complex, that this each consists of at least 2 substances, preferably from at least 3 substances which interact.
  • the iodine counts of the fatty oils are above 105, preferably above 110, advantageously above 115, in a further advantageous manner above 120, even more advantageously above 125 and in particular above 130.
  • the preparation is present as an emulsion, preferably as an o / w emulsion, in particular as an o / w nanoemulsion, wherein the droplet size d 50 of the nanoemulsion is preferably not greater than 700 nm, more preferably not greater than 500 nm, advantageously not greater than 300 nm, more preferably not greater than 250 nm, even more advantageously not greater than 200 nm, in a highly advantageous manner is not greater than 150 nm, in particular does not exceed a value of 120 nm, and / or wherein the droplet size d 50 of the nanoemulsion is preferably not less than 10 nm, advantageously not less than 25 nm, more preferably not less than 40 nm is ins ⁇ particular a value of 60 nm not below.
  • the droplet size is preferably determined on the diluted preparation by laser diffraction, advantageously by means of laser diffraction according to Malvern, for example with a Maillvern Mastersizer 2000, wherein the dilution is advantageously carried out with water, preferably at a ratio of the preparation to water of 1: 500 in Vol .-%.
  • the nanoemulsion penetrates even faster into the skin and is able to transport the active ingredients contained even better into deeper layers of the skin, so that they can develop there an increased effect.
  • the described advantages of the present invention with respect to the skin i. the positive regulation of the skin condition, further enhanced if the preparations are present as an emulsion, preferably as an o / w emulsion, in particular as an o / w nanoemulsion.
  • the stability of the preparation and also its dispersibility on the skin are further improved, as well as the skin elasticity is further increased, as well as the rapidity of the onset of action is further improved.
  • this embodiment can store large amounts of moisture even in deeper layers of the skin over many hours, preferably up to 24 hours, in particular over 24 hours, so that the skin becomes elastic and soft for a very long time, even after a single application remains.
  • the emulsion may also be in the form of w / o (nano) emulsion, but preference is given to an o / w (nano) emulsion.
  • w / o emulsions fat contents generally remain directly on the skin, giving an occlusive effect (sealing the skin) and thus preventing it from drying out.
  • a fat film is left behind, which can be perceived as disturbing.
  • moisture is transported to the upper layers of the skin and held in the skin.
  • An occlu- effect of the The care effect of an o / w-based preparation therefore depends very much on the effectiveness of the moisturizing complex, in particular on the overall formulation, ie the combined action of the active complexes used. Since the overall formulation in the case according to the invention leads to increased effectiveness as a result of the increasing interaction of the active complexes, the demands placed on an o / w emulsion are more than fulfilled and sealing of the skin is not necessary.
  • the acid buffer of the cosmetic preparation in a pH range of 4.0 to 6.0 puf ⁇ fert, wherein at least one acid (and / or salt thereof) is contained, which is preferably kept ⁇ selected from i) the group of barrier-stabilizing Acids, preferably from linoleic acid, linolenic acid, 12-hydroxystearic acid, stearic acid, isostearic acid, palmitic acid, 11-hydroxypalmitic acid, protein hydrolyzate condensates (eg palmitoylglutamic acid), hyaluronic acid and / or ii) from the group of ⁇ -hydroxycarboxylic acids, advantageously fruit acids, particular lactic acid, citric acid, malic acid and / or tartaric acid, and ß-hydroxycarboxylic acids, advantageously acids having additional preserving character such as formic acid, salicylic acid, acetic acid, and sulfonic acid and / or their derivatives or mixtures thereof, iii) from the group
  • Acid buffers of this embodiment enhance the advantages of the present invention with regard to the skin, in particular the regulation of the skin condition, advantageously even in atopic skin.
  • such an acid buffer acts synergistically with the natural buffer system of the skin, which is essentially composed of a lactic acid-lactate system, water-soluble compounds of the horny layer, tallow, numerous amino acids, and overall the result is an improved, very effective buffer system to maintain the pH of the skin.
  • the stability of the preparation is further improved, eben ⁇ so the skin elasticity is further increased.
  • results from the specific acid buffer in particular by combination with ⁇ -linolenic acid-containing oils improved, because faster skin-healing effect of Zuberei tion.
  • Even a slightly higher pH value, for example of 7, causes a disturbance of skin-healing processes and even damages the skin barrier, since, for example, the formation of skin-sealing lipids in the horny layer is disturbed at a pH of 7.
  • the acid buffer thus promotes skin healing in interaction with the other active complexes.
  • the acid buffer is formed by 1 to 4, in particular 2 to 4 acids and 2 to 3 salts.
  • the preparation according to the invention contains from 0.3 to 12% by weight, preferably from 0.7 to 7% by weight, in particular from 1 to 3% by weight, of acid buffer.
  • the vitamin complex of the preparation according to the invention contains vitamins and / or derivatives thereof and / or their precursors, which are preferably selected from vitamin A, vitamin A acid, vitamin A acetate, vitamin A palmitate, Vitamin C, vitamin C palmitate, vitamin C dipalmitate, vitamin E, vitamin E acetate, palmitate and linoleate, alfacalcidol, calcitriol, colecalciferol, ergocalciferol, transcalcifediol, calciprotriol, calcifediol, vitamin D 3 , carotene, panthenol , Pantothenic acid, tocopherols, biotin, vitamin B, niacinamide, nicotinic acid, nicotinyl alcohol, tocopherol nicotinate and / or their Deri ⁇ derivatives, salts or mixtures.
  • vitamins and / or derivatives thereof and / or their precursors which are preferably selected from vitamin A, vitamin A acid, vitamin
  • vitamins (derivatives) of this embodiment enhance the benefits of the present invention with respect to the skin, particularly the regulation of the condition of the skin, advantageously also the skin elasticity is further increased.
  • the preparation according to the invention contains panthenol.
  • panthenol as a component of the vitamin complex with the other active complexes leads to significantly improved healing of superficial skin changes. This advantageous combination calms irritated skin particularly well and the moisture binding in the hom layer is further improved, in particular also in atopic skin.
  • the preparation according to the invention contains 0.1 to 15 wt .-%, advantageously 1 to 12 wt .-%, preferably 2 to 9 wt .-%, in particular 4 to 8 wt .-% of vitamin complex, based on the entire preparation.
  • the preparation according to the invention also contains allantoin (5-ureidohydantoin). Its keratolytic, epithelizing and thus wound-healing effect is further enhanced by the four active complexes of the preparation according to the invention. It is particularly advantageous if panthenol and allantoin are used together in the preparation according to the invention, since in this way the wound-healing-promoting action is even greater, in particular also in atopic skin.
  • substances which are contained, which are selected from polyols, preferably glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, glycerol, inositol, sorbitol, mannitol, palatinit, maltodextrin, dextrin, cyclodextrin, glucose, fructose , Lactose, mannose, galactose and / or other saccharides, as well as from urea, amino acids and their salts, here preferably glutamic acid, glycine or glutamates, in particular arginine pyroglutamate, lactate, vitamin E, lecithin, gluconic acid, panthenol, allantoin , Ceramides, chondroitin sulfate, sodium acrylate-vinyl alcohol copolymers, oligopeptides, 2-pyrrolidone,
  • the substances of this embodiment that interact particularly well with the substances of the other three active complexes and, overall, lead to an increased active effect.
  • the stability of the preparation is also improved and the skin elasticity is further increased.
  • the moisture binding in the Hom Mrs and in deeper layers of the dermis even further improved, especially as far as atopic skin.
  • the preparation according to the invention contains 0.1 to 36 wt .-%, advantageously 3 to 30 wt .-%, preferably 5 to 25 wt .-%, in particular 10 to 20 wt .-% of moisture regulator.
  • the moisture regulators contain 2 to 12, preferably 3 to 10, in particular 4 to 7, of the moisture-regulating substances in the preparation, it being very advantageous if at least one amino acid and glycerol are present.
  • plant extracts of the Aloe Vera plant are contained in the preparation according to the invention. These have moisturizing properties. This was the thickened juice from the leaves of various aloe species (Liliaceae). The leaves of Aloe vera, Aloe barbadensis Miller, Aloe ferox or Aloe vulgaris are preferably used.
  • the aloe vera extract in combination with the active complexes of the preparation according to the invention, has a particularly advantageous effect on troubled and irritated skin conditions.
  • the skin is calmed and irritation of the skin are advantageously greatly alleviated by this combination, preferably after a single application.
  • the combination of aloe vera extract with the active complexes according to the invention leads to a further improved smoothing effect of the skin over several hours.
  • Skin roughness minor wrinkles and roughnesses
  • skin depth overall relief of the skin
  • the further improved skin surface structure provides even better protection against external influences, e.g.
  • skin compatibility is further improved by the combination with aloe vera extract, especially in atopic skin.
  • the natural fatty oils of the preparation according to the invention comprise oils which comprise a high content, preferably at least 7% by weight, of esterified polyunsaturated fatty acids, preferably selected from evening primrose oil, currant seed oil, borage oil , Echium oil, trichoderma oil, black cumin oil, rose hip oil, sea buckthorn oil, wheat germ oil, apricot oil, almond oil, hemp oil, linseed oil, sesame oil and / or sunflower oil.
  • oils, in particular the borage oil in combination with the three other active complexes in the preparations according to the invention lead to particularly good results, in particular surprisingly also with regard to skin elasticity.
  • the viscoelastic behavior of the skin is unexpectedly improved.
  • the skin after a provoked deformation, the skin returns more quickly to its original position; oils of this embodiment enhance the overall advantages of the present invention. It also results here advantageously very stable preparations.
  • the skin healing is further promoted.
  • the skin especially atopic skin, does not shine after application despite the oils contained therein and does not feel greasy but supple.
  • the preparation according to the invention contains at least 3% by weight, preferably at least 5% by weight, advantageously at least 7.5% by weight, more preferably at least 10% by weight, more preferably at least 15 %
  • natural fatty oils advantageously those having a C-chain distribution of the bound acids of at least 70% C-18 and, advantageously, iodine numbers of more than 95.
  • a maximum total content of the natural fat oils of 45 wt .-%, advantageously 35 wt .-%, in particular 30 wt .-% not exceeded.
  • the balance of the skin surface lipids is influenced even more favorably. Due to the features of this embodiment, the advantages of the present invention are generally enhanced, in particular with regard to the atopic skin.
  • the presence of these agents further enhances the previously described effect on the viscoelastic behavior of the skin. Actives of this embodiment generally enhance the benefits of the present invention.
  • green tea extract in the preparation is also advantageous because, in combination with the active complexes according to the invention, it leads to an intensification of the skin-soothing overall effect.
  • preparation according to the invention contains from 20 to 80% by weight, preferably from 30 to 70% by weight, in particular from 40 to 60% by weight, of water, a preferred embodiment is likewise present.
  • preparations with these water contents are particularly skin-compatible and anti-irritant, have a particularly good spreadability and stability. Overall, the water contents according to this embodiment enhance the advantages of the present invention.
  • this is a medicineoptima ⁇ ler range of values.
  • Another advantage of this pH range is that the preparation in this pH range has a very good stability, even with long storage, preferably supported by the acid buffer.
  • the preparation according to the invention is dye-free. If the preparation contains only natural aromas or is preferably free of fragrances, then there is also a preferred embodiment.
  • the preparation contains at least one deodorizing agent, then there is also a preferred embodiment.
  • Particularly suitable in this regard are essential oils such as clove oil (eugenol), mint oil (menthol) and thyme oil (thymol) or comparable ethersische oils and farnesol.
  • these are preferably but added only in small doses, advantageously in amounts of less than 5 wt .-%, more preferably less than 3 wt .-%, in particular less than 1% by weight.
  • the preparation according to the invention by the combination of the active complexes contained has an enhanced effect, which is greater than would have been expected by mere counting together.
  • a preparation according to the invention contains a) from 0.3 to 12% by weight, preferably from 0.7 to 7% by weight, in particular from 1 to 0, to 3.0 acid buffer b) from 0.1 to 15 wt .-%, advantageously 1 to 12 wt .-%, preferably 2 to 9 wt .-%, in particular 4 to 8 wt .-% vitamin c) 0.1 to 35 wt .-%, advantageously 3 to 30 wt %, preferably 5 to 25% by weight, in particular 10 to 20% by weight of moisture regulator d) at least 3% by weight, advantageously at least 5% by weight, preferably at least 7.5% by weight, advantageously at least 10 wt .-%, more preferably at least 15 wt .-%, in particular at least 20 wt .-% natural fatty oils vor ⁇ preferably with a C-chain distribution of the bound acids of at least 70% C-18 and advantageously iodine numbers of over 95.
  • the preparations according to the invention contain tea tree oil, preferably in an amount of not more than 1% by weight, advantageously of not more than 0.7% by weight, more preferably of not more than 0.5% by weight. in particular of at most 0.3% by weight.
  • tea tree oil preferably in an amount of not more than 1% by weight, advantageously of not more than 0.7% by weight, more preferably of not more than 0.5% by weight. in particular of at most 0.3% by weight.
  • the preparations according to the invention contain ethanol, preferably in an amount of not more than 10% by weight, advantageously of not more than 6% by weight, more preferably not more than 4% by weight, in particular maximum 3% by weight.
  • the ethanol promotes the destruction of pathogenic microorganisms and is used for disinfection.
  • the preparation according to the invention advantageously also contains surfactants.
  • the preparation contains at least two surfactants, advantageously both a hydrophilic and a lipophilic surfactant, preferably in a total amount of at most 25% by weight, advantageously of at most 5% by weight, more advantageously of not more than 4% by weight, more preferably not more than 3% by weight, in particular not more than 2.5% by weight, the hydrophilic surfactant preferably being present in a quantity of at least 0.1% by weight. %, advantageously at least 0.5% by weight and the lipophilic surfactant is preferably present in an amount of at least 0.1% by weight, advantageously at least 0.3% by weight.
  • surfactants also includes emulsifiers.
  • a hydrophilic surfactant is substantially water-soluble, while a lipophilic surfactant is substantially oil-soluble.
  • One possibility for categorizing surfactants in water- or oil-soluble is also the HLB system.
  • HLB value is known to the person skilled in the art.
  • the HLB value is a measure of the water or oil solubility of predominantly nonionic surfactants introduced by Griffin (1950) and the stability of emulsions. Experimentally, the HLB value z. Example by the phenol titration method by adding the surfactant solution with 5% phenol solution to turbidity.
  • the HLB value can be determined (gas) chromatographically by determination of the dielectric constant or colorimetrically.
  • HLB values of commercial emulsifiers can be found in the relevant specialist literature or in reference works such. B. Kirk-Othmer Encyclopedia of Chemical Technology by John Wiley & Sons.
  • the HLB scale usually ranges from 1 to 20. Low HLB (3 to 8) substances are lipophilic and are generally considered to be good W / O emulsifiers, while higher HLB (8 to 18) substances are hydrophilic and act as O / W emulsifiers.
  • the surfactant constellation described in the last-mentioned embodiment is very advantageous for the stability of the preparations, in particular for the stability of nanoemulsions according to the invention.
  • the amount of surfactants to be used is kept low, since surfactants under unfavorable constellations also components of the hydrolipid and fat layer can optionally solve and thus possibly also lead to a partial loss of the natural barrier effect of the skin.
  • a hypothetical negative effect of the surfactants is by far overcompensated by the positive interaction of the four active complexes which ensure full supply of the skin and considerably support the natural barrier action of the skin.
  • the preparation according to the invention contains nonionic surfactants, preferably at least two nonionic surfactants, advantageously a hydrophilic and a lipophilic nonionic surfactant, in particular selected from the group of alkoxylated fatty alcohols, alkylphenol polyglycol ethers, fatty acid polyglycol esters, fatty amine polyglycol ethers, Alkyl polyglycosides, fatty amine ⁇ / oxides, long-chain alkyl sulfoxides, silicone-based nonionic surfactants and / or polymerization products of ethylene oxide and propylene oxide or propylene glycol.
  • nonionic surfactants preferably at least two nonionic surfactants, advantageously a hydrophilic and a lipophilic nonionic surfactant, in particular selected from the group of alkoxylated fatty alcohols, alkylphenol polyglycol ethers, fatty acid polyglycol esters, fatty amine polyglycol ethers,
  • Nonionic surfactants advantageously have the skin-friendliest properties in comparison to other surfactant types in combination with the 4 active complexes of the preparation according to the invention.
  • the presence advantageously of a hydrophilic and a lipophilic nonionic surfactant has a very positive effect on the stability of the preparations, in particular on the stability of the nanoemulsion according to the invention.
  • the spreadability of the preparation on the skin is further favored.
  • the surfactant constellation of the last-mentioned embodiment enhances the advantages of the present invention.
  • the lipophilic and hydrophilic surfactants present in the novel preparations are present in a weight ratio of from 0.05 to 10, advantageously from 0.1 to 5, in particular from 0.15 to 1.
  • the difference between the HLB values of the lipophilic and hydrophilic surfactants is advantageously at least 5, more preferably at least 6, and very advantageously at least 7, in particular at least 10.
  • the lipophilic surfactants preferably have an HLB value of from 1 to 7, in particular from 3 to about 5.
  • the hydrophilic surfactants preferably have HLB values above 13, in particular above 15.
  • Preferred nonionic surfactants are preferably used in each case those which additionally have a thickening effect, in a further advantageous manner have a molecular weight above 1000, in particular 5000.
  • all surfactants contained have molecular weights above 500, preferably above 1000 and in particular above 10000 g / mol.
  • silicone-containing nonionic lipophilic emulsifiers preferably highly lipophilic, such as ABIL® EM 90 (INCI: cetyl PEG / PPG-10/1 dimethicone), ABIL® WE 09 (INCI: polyglyceryl-4 isostearates, cetyl PEG / PPG -10/1 Dimethicone; Hexyl Lau ⁇ rate), ABIL®EM 97 (INCI: Bis-PEG / PPG-14/14 Dimethicone; Cyclopentasiloxane), all available from Degussa AG, Germany, or similar products.
  • ABIL® EM 90 INCI: cetyl PEG / PPG-10/1 dimethicone
  • ABIL® WE 09 INCI: polyglyceryl-4 isostearates, cetyl PEG / PPG -10/1 Dimethicone; Hexyl Lau ⁇ rate
  • ABIL®EM 97 INCI: Bis-PEG / PPG-14/14 Dime
  • PEG-free nonionic lipophilic emulsifiers preferably highly lipophilic, plant-based, such as, for example, Isolan® PDI (INCI: Diisostearoyl polyglyceryl-3 dimer dilinoleate), Isolan GI 34 (INCI: polyglyceryl-4 isostearate 5), Isolan® IS (INCI: Methyl Glucose Isostearate), all available from Degussa AG, Germany, or comparable products.
  • Isolan® PDI Diisostearoyl polyglyceryl-3 dimer dilinoleate
  • Isolan GI 34 INCI: polyglyceryl-4 isostearate 5
  • Isolan® IS Isolan® IS (INCI: Methyl Glucose Isostearate), all available from Degussa AG, Germany, or comparable products.
  • surfactant constellations just described lead advantageously to excellently stabilized preparations, with the nanoemulsions being distinguished by an extraordinary stability and exceptional rapidity of the onset of action.
  • very small amounts of surfactant are sufficient to stabilize the preparation very well. From a total amount of including 0.8 wt .-% surfactant resulting excellent stable preparations.
  • the described surfactant constellations according to the last-mentioned embodiments enable a very good spreadability of the preparation on the skin associated with a very good penetration into the skin and enhance the overall benefits of the present invention.
  • the preparation contains as surfactants only nonionic surfactants.
  • the presence of surfactants in conventional creams in the worst case can also have negative effects on the skin.
  • a theoretically conceivable disadvantageous surfactant effect is by far overcompensated by the interaction of the active complexes in the case according to the invention, it is still more advantageous to completely dispense with further surfactants than the nonionic surfactants in order to further relieve the skin.
  • a surfactant system according to the invention which preferably consists of small amounts of the nonionic surfactants described, can do without additional surfactants.
  • the preparation according to the invention contains natural or nature-identical antioxidants, advantageously in amounts of from 0.03 to 8% by weight, preferably from 0.05 to 5% by weight, and in particular from 0.1 to 1% by weight. , in particular selected from terpene-containing antioxidants and / or vitamin E (derivatives), preferably in combination with vitamin C (derivatives).
  • the preparation is free of synthetic antioxidants.
  • the skin compatibility of the preparations according to the invention could be improved even further, particularly with regard to skin which is particularly prone to irritation.
  • the skin elasticity is further improved so that it reaches its initial position more quickly after deformation.
  • the stability of the preparations is further improved.
  • the natural or nature-identical antioxidants according to this embodiment enhance the advantages of the present invention as a whole, in particular, they further enhance the duration of action of the preparation.
  • the preparation according to the invention is characterized by the fact that at least one of the active substances contained is antiseptic or contains at least one antiseptic active ingredient.
  • the attribute of antiseptic efficacy means an effect that is beneficial to the self-regulating forces of human skin. This effectiveness is not in their expression with that of classical germicidal or germicidal agents such. As phenols or halogens with which z. B. skin u. Mucous membranes, wounds or even medical instruments treated to achieve asepsis (germ-free) compare.
  • the classical antiseptic comprises antimicrobial measures at the starting point or at the entry port of a possible infection or at the site of infection on the body surface.
  • the particular advantage of the antiseptic active substances which can be used according to the invention results from a synergistic interaction of these substances with the general functional mechanisms of human skin, since these substances have a mildly antiseptic action, eg. B. germs, including harmful germs reduce, but not perfect, so to sterility, destroy. So there are enough germs on the skin that are sufficient to train and strengthen the self-regulating powers of human skin.
  • the interaction of the self-regulating forces of the skin with the antiseptic capacity of the active ingredients contained in the preparation supports the general functional mechanisms of the skin. This is of great advantage in view of already irritated and / or otherwise damaged skin.
  • the preparation according to the invention supports and trains the natural skin flora of humans.
  • compositions of such an embodiment are particularly useful for their purpose when the antiseptic agent is an oil, preferably an ethereal oil.
  • This antiseptic oil is preferably an essential oil selected in particular from the group of Angelica fine - Angelica archangelica, Anis - Pimpinella anisum, Benzoin siam - Styrax tokinensis, Cabreuva - Myrocarpus fastigiatus, Cajeput - Melaleuca leucadendron, Cistus - Cistrus ladaniferus, Copaiba balm - Copaifera reticulata, Costus root - Saussurea discolor, Edeltann needle - Abies alba, Elemi - Canarium luzonicum, Fennel - Foeniculum dulce, Spruce needle - Picea abies, Geranium - Pelargonium graveolens, Ho leaves - Cinnamonum camphora , Immortelle Helichrysum ang., Ginger extra - Zingiber off., St.
  • Such preparations are even more compatible with the skin, and the overall effect of the preparation is further enhanced, in particular, by the above-mentioned essential oil, whereby a very good skin compatibility has advantageously been found even in very sensitive skin.
  • Another advantage of the aforementioned essential oils lies in their particular multifunctionality, which in addition to the described mild antiseptic activity from a variety give further desirable organoleptic properties, which are just attributable to these oils. In most cases, these oils are given an expectorant effect because they exert a mild, positive stimulus on the mucous membranes of the respiratory organs. Furthermore, a desirable feeling of warmth can be established. Deodorizing, pain-relieving, circulation-promoting, calming effects could be observed by the applicant in connection with the use according to the invention of these designated oils and be recognized as particularly advantageous.
  • the organoleptic properties of these oils are as a rule not influenced by the main components, but by the secondary or trace constituents, which often can go into the hundreds and sometimes interact synergistically. Another advantage associated with the oils mentioned is their harmonious fragrance and scent, which in many cases leads to positive feelings in humans.
  • the preparation according to the invention not only supports the natural Hautflo ⁇ ra of man, but helps the human body to additional benefits just described type.
  • the patchouli is of great advantage for the subject of the invention and leads to a further improvement of the skin compatibility.
  • the rosemary oil is particularly advantageous.
  • the composition according to the invention is free from conventional preservatives, in particular free from benzoic acid, benzyl alcohol, butyl paraben, chloroacetamide, chlorhexidine, diazolidinyl urea, dipropylene glycol, DMDM dantoin, ethyl paraben, formaldehyde, hexamidine diiso-dithionate, iodopropynyl butyl carbamate, isothiazolinone, methyl dibromoglutaronitrile , Methyl paraben, polyaminopropyl biguanide, propyl paraben, sodium benzoate, butylhydroxytoluene.
  • benzoic acid benzyl alcohol, butyl paraben, chloroacetamide, chlorhexidine, diazolidinyl urea, dipropylene glycol, DMDM dantoin, ethyl paraben, formaldehyde, hex
  • the preparations according to the invention may advantageously contain in general all other ingredients which are commonly used in cosmetic, preferably skin care, in particular facial cosmetic preparations.
  • Such ingredients as well as the relevant quantitative ranges in which these can be used are well known to the person skilled in the art or can be found in the relevant specialist literature, eg "Kosmetik, 2nd edition, W. Limbach, Wiley-VCH, 1995", or "Cosmetic Ingredients, Assessment Cosmetic Ingredients, Lehr, Reichelt, BoD GmbH Norderstedt, 2003 "or” The Cosmetic Preparations, Volume MII, Domsch, Andreas, Verlag für chemische Industrie H. Ziolkowsky GmbH, 1992-1994 ".
  • Possible ingredients include not only active ingredients but also the so-called adjuncts and additives. These may also be advantageously contained in the preparations. However, it is even more advantageous if the preparations according to the invention are largely free of auxiliaries and additives.
  • the water is basic material and no auxiliary or additive.
  • Auxiliary substances are surfactants, emulsifiers and thickeners whose amount should preferably be limited in terms of the number and weight fraction.
  • Active substances within the meaning of the invention are preferably all those substances which can be assigned to the abovementioned active complexes, in particular the substances listed by name in this context.
  • Active ingredients are preferably further those substances such as aloe vera extract, almond oil, green tea extract, carrot seed oil, mint oil, tea tree oil, essential oil such as patchouli, mimetic peptides, Antarcticine®, i. Such substances were pointed out for their positive effect in connection with the preparation according to the invention, the above examples being given only by way of illustration and not completely.
  • active ingredients in the context of the invention which are preferably selected from the named by name in this document agents used, such as.
  • agents used such as.
  • tea tree oil, ethanol or salicylic acid also have an additional conservative character.
  • the total proportion of the additives is preferably not higher than 10% by weight, advantageously not higher than 7% by weight.
  • the preparations according to the invention are largely free of auxiliaries and additives, preferably less than 10% by weight, advantageously less than 7% by weight, more preferably less than 5% by weight, in more preferably less than 3% by weight, more preferably less than 1% by weight, in particular no auxiliaries, the group of auxiliary agents and additives preferably comprising the following substances:
  • Acrylates in particular C 10-30 alkyl acrylate crosspolymer, alpha-dodecyl-omega-hydroxy-poly (oxyethylene) -2, aluminum, aluminum stearate, oatmeal, behenyl alcohol, benzoic acid, benzyl alcohol, butylhydroxytoluene, butyl paraben, C 12-15 alkyl alcohol benzoate, Carbomer, Cera alba, Cera microcristallina, ceresin, PEG-12 cetyl ether, ethoxylated cetyl stearyl ether, PEG-6 cetyl stearyl ether, cetylstearyl isononanoate, cetyl stearyl octanoate, PEG-20 cetyl ether, cetyl alcohol, dyes, cocamidopropyl betaine, dicyanecyl ester, dicaprylyl ether, diethylhexylbutamidotriazone , Dipentaerythr
  • the adjuvants merely constitute a ballast which pollutes the skin by its presence without really positively serving it, e.g. B. in that the skin is completely covered with fats (for example with paraffin, vaseline, waxes, etc.). According to the invention, such cover effects are dispensed with, instead of lipid supply of the skin via natural oils. In the worst case, the natural functions of the skin are even adversely affected by the excipients. In any case, the excipients must be broken down by the skin.
  • the preparation according to the invention therefore has an ⁇ -value of greater than 0.5, preferably greater than 0.6, advantageously greater than 0.7, very advantageously greater than 0.75, most preferably greater than 0.8 , even more advantageously greater than 0.85, more preferably greater than 0.87, wherein the ⁇ -value is given by formula (I)
  • ⁇ amount of active ingredient / (total amount of the preparation - amount of water), formula (I) wherein the amount is based on wt .-%.
  • the amount of active ingredient the mass of those ingredients to understand that are no auxiliaries, no additives and no water.
  • the preparations contain small pigment particles, in particular of zinc oxide, zirconium oxide and / or titanium oxide.
  • pigment particles serve to protect the skin, since they reflect in particular UV rays.
  • the zinc oxide also has a slightly disinfecting and skin-tightening effect.
  • the particle size of the pigment particles is preferably in the range 100 to 300 nm, advantageously 150 to 250 nm, in particular 200 to 250 nm.
  • the refractive index of the pigment particles is preferably at least 2, in particular 2 to 3.
  • a hypothetical whitening on the Skin, caused by the pigment particles is advantageously no longer perceivable if the mentioned particle size criterion and / or the refractive index criterion be respected.
  • the compositions according to the invention about 0.05 to 6 wt .-%, preferably 0.1 to 3 wt .-%, in particular 0.5 to 2 wt .-% of the small pigment particles.
  • the small pigment particles further enhance the advantages of the present invention.
  • the stability of the preparation is improved.
  • the preparation when the preparation is present as a nanoemulsion, there is an excellent spreadability of the preparation and the pigment particles are deposited very evenly on the skin so that, even if the preparation contains absolutely only very few pigment particles, nevertheless ensuring optimum UV protection ,
  • the very uniform deposition of the pigment particles on the skin advantageously results in a very even skin appearance and fine lines and wrinkles are no longer visible.
  • Preferred formulations have an apparent viscosity of from about 3,000 to about 200,000 mPas.
  • preferred formulations have an apparent viscosity of from about 3,000 to about 15,000 mPas, preferably from about 6,000 to about 9,000 mPas.
  • the apparent viscosity can be determined by the usual methods. The viscosity of the preparation is measured after allowing the preparation to stabilize for at least 24 hours after preparation of the preparation under conditions of 25 ° C. ⁇ 10 ° C. and at ambient pressure. The apparent viscosity is measured at a temperature of the composition of 25 0 C ⁇ 1 ° C after 30 seconds spindle rotation.
  • the preparation according to the invention also contains thickening agents, preferably in the form of thickening surfactants, in particular fatty alcohols (derivatives). Less preferred but also suitable are fatty acids and silicone oil derivatives.
  • the preparations may also contain peptides.
  • Peptides consist of individual amino acids.
  • oligopeptides (2 to 10 amino acids) and polypeptides (10 to 100 amino acids).
  • Preferred peptides are mimetic peptides.
  • Mimetic peptides are skin-identical peptides or peptides that are found in the human body. In the organism, the oligopeptides and polypeptides fulfill important tasks, for example as hormones (peptide hormones) or as novel drugs. rotransmitter or neuromodulators (neuropeptides). Particularly preferred are mimetic hexapeptides (six amino acids).
  • An example of a particularly preferred mimetic hexapeptide is collaxyl, available from IMPAG GmbH, Offenbach, Germany.
  • the INCI name for the Collaxyl is: Water (and) Butylene Glycol (and) Hexapeptide-10.
  • the structure of the synthetic peptide collaxyl is congruent with a portion of the amino acid sequence found in human collagen IV and XVII. Collagen IV and XVII are important proteins of the basement membrane and therefore of great importance for the dermo-epidermal compound.
  • Collaxyl also shows significant effects on the collagen synthesis of the extracellular medium (ECM) and on the regeneration and differentiation of the epidermis. Firming and regeneration of the skin from the inside in turn leads to improved skin elasticity.
  • ECM extracellular medium
  • mimetic peptides can advantageously also be used, in particular the products commercially available with the INCI names Palmitoyl Oligopeptide, Palmitoyl Penapeptide-3, Palmitoyl Pentapeptide-2, Acetyl Hexapeptide-1, Acetyl Hexapeptide-3, Copper Tripeptides-1, hexapeptides -1, hexapeptides -2, MEA-hydrolyzed silks.
  • Derivatives of sericin and fibroin can also be used with advantage, typical examples of which are the following products available under the INCI names: Ethyl Ester of Hydrolyzed SiIk and Hydrolyzed SiIk PG-Propyl Methylsilanediol.
  • Argireline® Another example of a highly preferred mimetic peptide is Argireline® available from Lipotec S.A., Barcelona Spain.
  • the INCI name for Argireline is: acetyl hexapeptide-3.
  • Acetyl Hexapetide-3 is a non-toxic alternative to botulinum neurotoxins ("Botox”), which reduces excess catecholamine and influences the formation of the snare complex, which is important for neuro-transmission Significantly, the depth of such wrinkles, which arise as a result of frequent muscle tension especially on the forehead and around the eyes, is significant.
  • Botox botulinum neurotoxins
  • the amino acid sequence was mimicked at Argireline at the N-terminal end of SNAP-25. Argireline also inhibits Ca 2+ -dependent neurotransmitter release into the system. napsen. Argireline reduces muscle activity, while Botox paralyzes muscle activity.
  • the skin thereby obtains the possibility of regenerating particularly well by supplying the active complexes of the preparation according to the invention.
  • the pleat depth is thereby reduced by up to 50% and even further.
  • the advantage in connection with the preparation according to the invention is that wrinkles, as a result of the interaction with the active complexes, preferably first occur with considerable delay, and in particular do not arise at all. This is due to the interaction of acetyl hexapetide-3 with the active complexes of the preparation according to the invention.
  • the preparations contain at least one mimetic peptide.
  • the mimetic peptides are preferably present in total amounts of from 0.001 to 10% by weight, based on the total preparation. Total amounts of from 0.005 to 5% by weight, in particular from 0.01 to 3% by weight, are very particularly preferred.
  • the mimetic peptides further enhance the advantages of the preparation according to the invention, in particular the elasticity of the skin.
  • the preparations also contain Antarcticine®, INCI name: [Pseudoalteroma Ferment Extract], available from Lipotec S.A., Barcelona Spain.
  • This ingredient comes from an Antarctic bacterium.
  • the isolated glycoprotein reduces wrinkles by stimulating the regeneration of collagen I and IV, elastin, and the growth of fibroblasts. In addition, it promotes the cohesion of prickle and basal layers.
  • it provides through the interaction with the active complexes of the preparation according to the invention even further improved skin protection even in extremely dry and cold conditions. This is especially true when Pseudoalteromonas Ferment Extract is used together with acetyl Hexapetide-3 in the preparations of the invention.
  • Pseudoalteromonas Ferment Extract vorzugswei ⁇ se in amounts of 0.001 to 10 wt .-% based on the total preparation. Men ⁇ gene of 0.005 to 5, in particular 0.01 to 3 wt .-%, are very particularly preferred.
  • emulsions including nanoemulsions
  • the preparation of emulsions, including nanoemulsions is known to the person skilled in the art and he can make use of the relevant specialist literature; eg "The cosmetic preparations, volume I- III, Domsch, A., publishing house for chemical industry H. Ziolkowsky GmbH, 1992-1994 ".
  • the preparation according to the invention additionally contains an anti-aging complex which comprises at least 2, preferably at least 3, in particular at least 4, ingredients, which are advantageously selected from
  • the group of peptides preferably the mimetic peptides (skin-identical peptides), e.g. Acetyl hexapeptide-3, tripeptide-1, tetrapeptide-1, hexapeptide-2, acetyl-tetrapeptide-2, hexapeptide-9, pentadeca-peptide-1 or peptides already mentioned in the description
  • polyphenols e.g. green tea extract, rutoside, proanthocyanidins, in particular - phenolic acids ⁇ in this case (i) hydroxycinnamic acids (for example caffeic acid, ferulic acid), and (ii) hydroxybenzoic acids (for example gallic acid, ellagic acid, vanillic acid ⁇ ,
  • Flavonoids wherein (i) flavones, e.g. Apigenin, luteolin, (ii) isoflavonoids, e.g. Genistein, daidzein, (iii) flavonols, e.g. Quercetin, kaempferol, (iv) flavanones, e.g. Naringenin, hesperidin, (v) anthocyanins, e.g. Malvidin, Cyanidin, (vi) Proantho zayne, as e.g. Tannins, (vii) flavanols, e.g. Epigallocatechin gallate, catechin
  • plants (seed) extracts or powders preferably extracts of fruits, roots, barks and / or seeds, such as lychee (seed) extract, grape seed extracts, citrus fruit extract, preferably grapefruit (kem) extract, acerola extract, aronia ex Extract, broccoli powder, broccoli sprouts powder or extract, tomato extract, oil palm fruit extract, fenugreek extract, coffee bean extract, linseed extract, marsupial extract, maca root powder or extract, fig cactus (fruit or seed) extract, olive extract, olive leaf extract , Papaya Extract, textract, Chicory Extract, Artichoke Extract, Banana Extract, Plum Extract, Cherry Extract, Strawberry Extract, Centella Asiatica Extracts, Perilla (seed) Extract, Rice Seed Extract, Rosemary Extract, Rooibos Tea Extract, Soybean Seedling Extract, Grape Peel Extract, Grape Extract , Cinnamon bark extract, apple (seed) extract, field extract, amica extract, bearberry leaf extract,
  • Tauricus rose red (Rhodiola rosea) extract, Schisandra chinensis extract, Acanthopanax senticosus extract, frankincense extract, turmeric extract, pomegranate extract, nettle (leaf) extract, garlic extract, St.
  • John's wort extract Blueberry Extract, Gooseberry Extract, Blueberry Extract, Raspberry Extract, Blackberry Extract, Blackcurrant Extract, Cranberry Extract, Beetroot Extract, Lettuce Plant Extract, Uncaria Tomentoza (Cat's Claw) Extract, Rhubarb Extract, Lilac Extract, Elderberry Extract, Oak Bark Extract, Hamamelis Leaves and Bark Extract, Waternel Extract, Comfrey Extract, as well as Extracts or Powders of Coniferous Woods, Spruce Needles, Mountain Pine, Bald Cypress, Yews, Seed Ferns, Arrowhead, Dragon Tree, Chestnuts, yellows, tulips, saffron, pineapples, sugar cane, rye, corn, duckweed, nutmeg, bold leaves, bay leaves, pepper, celandine, mulberry, red fennel, ragwort, goosefoot Newleaf, spinach, beetroot, knotweed, birch, gooseberry, saxifrage, sundew, horticultural, meadowsweet, blood
  • proteins of plant origin such as, preferably, soya, almonds, peas, cocoa, algae, potato and wheat proteins, but especially soya proteins such as e.g. Vegeseryl® HGP (soya protein concentrate, INCI: Glycine soybean (soybean) protein)
  • animal proteins such as elastin, collagen, keratin, silk and milk protein.
  • amino acids e.g. Arginine, alanine, histidine, tyrosine, phenylalanine, DOPA (dihydroxyphenylalanine), ornithine, lysine, taurine and tryptophan, proline, aspartic acid, carnetine, cysteine, glutamine, glycine, isoleucine, leucine, methionine, serine, threonine, tryp tophan, valine , Asparagine, glutamic acid, in particular glutathione, cysteine and / or tau rin.
  • amino acids e.g. Arginine, alanine, histidine, tyrosine, phenylalanine, DOPA (dihydroxyphenylalanine), ornithine, lysine, taurine and tryptophan, proline, aspartic acid, carnetine, cysteine, glutamine, glycine, isoleucine, leucine, methionine
  • proteins also encompasses derivatives of the proteins, protein hydrolysates, derivatives of the protein hydrolysates, for example their fatty acid condensation products or cationic derivatives.
  • Protein hydrolysates are product mixtures obtained by acid, alkaline or enzymatically catalyzed degradation of proteins (proteins).
  • Vegeseryl® HGP is a natural botanical protein which is a combination of natural albumins and globulins. The molecular weight is about 50,000 daltons. It is available from Cognis France or Laboratoires Serobiogistics S.A.
  • L-arginine is preferably included in the formulation.
  • L-arginine is a proteinogenic amino acid found in almost all proteins. Arginine must be available for the formation of collagenous connective tissue.
  • L-lysine is preferably included in the preparation.
  • L-lysine is an essential amino acid and a component of the collagenous connective tissue, which means that it has a substantial share of its stability and its mechanical strength.
  • L-methionine is preferably included in the preparation. L-methionine is an essen- essential proteinogenic amino acid, which is indispensable for a functional connective tissue. It also strengthens the antioxidant capacity of the organism.
  • the green tea extract is a preferred component of the anti-aging complex.
  • the polyphenols contained in green tea, especially the catechins, have many positive qualities. They have an antioxidant effect.
  • White tea extract is also preferred.
  • Peptides are a preferred component of the anti-aging complex, in particular tyrosine- and / or tryptophan-containing peptides are preferably contained as extremely effective antioxidants.
  • the antioxidant peptides contain aromatic ring systems with the ability to form stable radicals, in particular tyrosine or tryptophan residues. The oxidation of dissolved or fibrillar proteins, lipoprotein particles and membrane lipids is prevented by the peptides.
  • Litchi extract (Litchi chinensis) is a preferred component of the anti-aging complex. It can inhibit the breakdown of collagen and support the buildup of new collagen. It contains flavanoids, is therefore antioxidant and can neutralize free radicals. Litchi extract inhibits collagenase. The enzyme collagenase breaks down the collagen. The consequences are wrinkling and loss of skin elasticity with age. In addition, Lit ⁇ schi extract can cause an increase in collagen production, which is known to decrease from the age of 20 years. Lychee Extrakat inhibits elastase. Elastase is an enzyme that breaks down elastin. Elastin is a structural protein related to collagen, which constitutes the main constituent of the elastic fibers of the connective tissue.
  • the skin owes its tension essentially to a balanced amount of collagen, elastin and hyaluronic acid.
  • Lychee Extrakat also inhibits hyaluronidase.
  • Hyaluronic acid is an important component of the extracellular matrix in skin and cartilage tissues. It is degraded by hyaluronidase.
  • Litchi Extrakat also inhibits tyrosinase. Tyrosinase, using molecular oxygen, forms quinones, highly reactive molecules that tend to spontaneously polymerize and form brown pigments. Age spots and various lesions of the skin, including tumors, are associated with these pigmentations.
  • Litchi extract also improves the moisture content of the skin and improves the pH of the skin.
  • lychee extract has a high antioxidative effect.
  • Perilla seed extract inhibits lipoxygenase and thus inflammatory processes (of the skin).
  • Perilla seed extract develops anti-allergic activity, which can benefit the skin.
  • Perilla seed extract has a high content of Poyphenol.
  • the anti-aging complex is preferably present in amounts of from 0.1 to 35% by weight in the preparation, based on the entire preparation.
  • the lower limit in preferred embodiments, may also be values such as 0.5, 1, 0, 1, 5, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5 or 5 , 0 wt .-% are.
  • the upper limit may be preferred embodiments also at values such as 30, 25, 20, 15 or 10 wt .-%.
  • Such a preparation with an anti-aging complex can even better contribute to maintaining, protecting and positively influencing a healthy skin condition, in particular to preserve as long as possible a youthful appearance of the skin.
  • Such a preparation with anti-aging complex can contribute even better to that. a reduction in wrinkle depth is achieved and new wrinkling is prevented. In particular, a mitigation of wrinkles, crow's feet, fine lines can be promoted even better and also their new formation can be delayed even better.
  • the preparation can lead to an improvement of the skin tightening, so that the skin, for example, appears even smoother and firmer. In particular, tighter skin around the eyes can be better promoted be ⁇ .
  • Such a preparation with anti-aging complex is very well tolerated.
  • the preparation can be used even in the case of very sensitive and problematic skin, since it preferably does not cause any allergic or irritative intolerance reactions.
  • the decline of redness and feelings of tension can be further promoted.
  • the prevention of skin irritation can be further promoted.
  • Such a preparation with anti-aging complex is especially effective in the cosmetic treatment of dry, sensitive and mature skin. Even a further improvement in impure skin and pimples can be achieved.
  • Such a preparation with anti-aging complex can especially better contribute to the fact that the skin moisture increases. It can even better contribute to a more elastic skin. It can further improve the subjectively perceived skin feel, so that the skin can feel noticeably smoother and finer. It can have an invigorating effect on the skin. It can do even better to strengthen the skin cell structure.
  • the Kol ⁇ layer structure can be supported even better. Even after the first application, an improvement in the feel of the skin can be noticed.
  • the stimulation of the regeneration of skin cells and skin-own lipids can be supported even better.
  • the quality of the skin's lipids can be better supported.
  • the skin roughness can be reduced even more clearly by such a preparation with anti-aging complex.
  • a tactile improvement even on very rough skin areas such as upper arms and elbows can be further promoted.
  • the care of dry, cracked and rough skin, even keratinized skin can be further favored, so that, for example, existing cracks can be regressed.
  • the smoothing of chapped skin can be further promoted.
  • a soft to very soft skin feeling can be further promoted. Existing itching can be further reduced.
  • the upper skin layer needs significantly more time for renewal.
  • the elastic fibers in the skin begin to lose elasticity.
  • the number of sebaceous glands is reduced considerably.
  • the skin becomes noticeably drier.
  • the skin circulation is reduced.
  • Upper lip wrinkles develop and forehead transverse folds and nasolabial folds (nasal lip folds) increase.
  • the reducing estrogen production makes the skin drier, thinner and more sensitive.
  • the number of elastin fibers decreases greatly and accelerates the formation of sacks and sagging skin. UV light and free radicals continuously damage the collagen fibers and cause wrinkles and wrinkles over time.
  • the preparation according to the invention preferably with anti-aging complex, can help to counteract these developments and to slow down the aging process of the skin.
  • the problem of aging skin does not affect the elderly, but the skin begins to age as early as the middle of the 20th century.
  • the cell production decreases, the connective tissue can store less moisture, and at the same time the skin loses its resistance to damaging environmental influences.
  • the preparation according to the invention preferably with anti-aging complex, can also already help in this stage to counteract these developments and to slow down the aging process of the skin.
  • the changes related to normal aging processes of the skin which lead to a dilution of all layers of the skin and to a decrease in the function of the skin glands, can be counteracted with the preparation according to the invention, preferably with anti-aging complex.
  • an acceleration of cell renewal, improvement of Gewebestruk ⁇ tur reduce the depth of wrinkles and improve skin metabolism can be achieved.
  • the preparation according to the invention preferably with anti-aging complex, can contribute to the fact that the affected (skin) cells live longer and retain a better ability to divide.
  • the preparation according to the invention makes it possible to keep youthful appearance longer .
  • the visual symptoms of aging of the skin eg, fine lines and wrinkles, brown spots, and uneven skin tone
  • the symptoms of skin aging can be considered to be significantly reduced, both in the case of self-assessment by the applicator or in the case of external evaluation by a third party.
  • the preparation according to the invention preferably with an anti-aging complex, can have an antioxi dative action and intercept free radicals which stabilize and protect the highly sensitive cell membrane.
  • the skin-lipid barrier which is decisive for the protection of the skin can be better stabilized with the aid of the preparation according to the invention, preferably with an anti-aging complex, and its regeneration is promoted.
  • the preparation according to the invention preferably with aging protection complex, can protect the skin's own cell and energy metabolism, it can protect and regenerate skin's own antioxidants, it can protect and regenerate the skin's own repair and enzyme systems.
  • the preparation of the invention preferably with anti-aging complex, therefore, help that the tissue is rebuilt between the skin cells, that the ability of the skin to retain moisture is restored, that the thickness of the skin is increased, that the elasticity of the skin is improved.
  • the preparation according to the invention preferably with anti-aging complex, has good bioavailability, so that active substance applied to the surface of the skin is absorbed very well in the living skin layers and can interact positively with the skin's own systems.
  • the mechanisms of skin aging at the cellular level can be positively influenced.
  • the preparation according to the invention may also contain silicone oil (s). These can be very well tolerated by the skin since they are just as breathable on the skin as the natural plant oils; they do not form an opaque film, even at higher concentrations than mineral oils.
  • the agent according to the invention can therefore have a content of cyclic and / or linear silicone oils.
  • cyclomethicone octamethylcyclotetrasiloxane
  • other silicone oils are also advantageous for the purposes of the present invention, for example hexamethylcyclotrisiloxane, polydimethylsiloxane, poly (methylphenylsiloxane).
  • cyclomethicone and isotridecyl isononanoate are particularly advantageous.
  • cyclomethicone and isotridecyl isononanoate are particularly advantageous.
  • cationically modified silicone oils can be used with advantage.
  • phenyltrimethicone can also be selected as silicone oil.
  • Other silicone oils for example dimethicone, phenyldimethicone, cetyl dimethicone, behenoxydimethicone, are also advantageously to be used in the context of the present invention.
  • Silicone oil (s) are preferably contained in the preparation in amounts of from 0.1 to 35% by weight, based on the total preparation.
  • the lower limit may also be advantageously in embodiments such as 0.5, 1, 0, 1, 5, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5 or 5.0 wt .-% are.
  • the upper limit in preferred embodiments can advantageously also be values such as 30, 25, 20, 15 or 10 wt .-%.
  • Another object of the present invention is a process for preparing a preparation according to the invention, wherein in such a method, the starting mixture comprising at least water and the 4 active complexes prior to emulsification preferably with a thickening agent, in particular fatty alcohol and / or nonionic silicone surfactant ver ⁇ sets and is pre-emulsified with a stirrer.
  • the fine emulsification is preferably carried out in a second step, including this mixture a high-pressure homogenizer at least 400th bar, in particular at least 600 bar and at a temperature of below 50 0 C, preferably below 46 ° C is supplied.
  • nanoemulsions in particular nanoemulsions
  • the nanoemulsions thus prepared are not only excellent in stability, but also have an excellent spreadability on the skin, as well as an excellent penetration ability into the skin.
  • Another object of the invention is a product consisting of a Ap ratessvor ⁇ direction, preferably a spray applicator and a preparation according to the invention.
  • Another subject of the invention is a substrate impregnated with a preparation according to the invention.
  • Another object of the invention is the use of the invention Zube ⁇ preparations to improve the skin elimination.
  • the preparation according to the invention contains natural ⁇ -linolenic acid sources, preferably hemp oil, borage oil, evening primrose oil, the blackcurrant seed oil, Echium oil, trichodesma oil and / or black seed oil as ⁇ -linolenic acid source.
  • natural ⁇ -linolenic acid sources preferably hemp oil, borage oil, evening primrose oil, the blackcurrant seed oil, Echium oil, trichodesma oil and / or black seed oil.
  • the seed oils of other species from the families of Boraginaceous, Scrophulariaceae, Onagraceae and / or Saxifragaceae are also preferably used as ⁇ -linolenic acid sources.
  • the most beneficial in terms of skin elasticity is the borage oil.
  • the natural ⁇ -linolenic acid in the form of the above-mentioned oils for example borage and night candle oil, actively intervenes in the metabolism and especially in prostaglandin synthesis and thus positively influences the condition of the skin.
  • it becomes positive Influence and strengthen the natural ⁇ -linolenic acid in the form of the above oils, the effect of other active complexes.
  • the capillary bleeding is improved, the natural ability to hydrate increased, the skin fat is stimulated and promote skin healing, especially the healing of fine cracks on the skin surface.
  • Another object of the invention are moldings which contain a preparation according to the invention, preferably for peroral application.
  • shaped bodies are understood in particular to be tablets, dragees and capsules, which are particularly suitable for peroral application.
  • Tablets are prepared by pressing powder mixtures or granules containing the erfin ⁇ inventive preparation at least partially under (high) pressure in a mold.
  • Dragees are tablet cores which are provided with a coating, preferably of digestible plastic materials.
  • the preparation of tablets, capsules and dragees is familiar to the person skilled in the art or he can use the relevant specialist literature or reference works such as Kirk-Othmer Encyclopedia of Chemical Technology by John Wiley & Sons.
  • soft gelatin capsules are preferred, in particular in the form of round or egg-shaped uniform hollow bodies. These contain the preparation according to the invention.
  • the capsules are manually (slightly) open, so that their contents can also be applied to the skin.
  • the preparation according to the invention is also suitable in flowable form (drops and juices) for peroral application.
  • the following preparation according to the invention was prepared in a high-pressure homogenizer. It is a nanoemulsion.
  • the droplet size d 50 is 180 nm.
  • - Tocomix L70 mixture of alpha-, beta-, gamma-, delta- tocopherol in sunflower oil (tocopherol content 70% by weight) ex Jan Dekker Nederland B: V.
  • This comparison product was "5% urea face cream" of the brand Eucerin® from Beiersdorf.
  • 5% Urea Face Cream is also an O / W emulsion intended for the care of dry skin, which, according to the manufacturer, quickly and permanently increases the moisture binding capacity of the skin, reduces the feeling of tightness and absorbs very quickly and does not contain fragrances and fragrances Dyes.
  • "5% urea face cream” is according to manufacturer's information especially for preventive use in constitutional, um- or occupationally conditioned forms of dry skin and is also the therapy-accompanying care in all dermatoses such as ichthyosis, psoriasis, eczema, atopic dermatitis suitable.
  • Acid Buffer Lactic Acid
  • Moisture regulator urea, glycerin, biosaccharides Gum-1, sodium lactate (note: sodium lactate is also a weak buffer)
  • Methylparaben, Benzyl Alcohol Emulsifiers PEG-40 Stearates, Glyceryl Stearates,
  • Bodying agent Cetyl Alcohol
  • the difference to the preparation according to the invention thus lies in the active complexes:
  • the vitamin complex according to the invention consisting of at least two vitamins, vitamin derivatives and / or vitamin precursors is completely absent. Furthermore, the lipid supply is different.
  • the measurement was carried out with the Sebumeter SM 810 (COURAGE + KHAZAKA ELECTRONIC GMBH, Cologne, Germany).
  • the measuring time (pressure time) on the skin was 30 seconds with a uniform pressure of 3 N at the take-off point on the skin.
  • the effect of the application on the fat content of the skin was examined on the forearm of 6 subjects, with all subjects having atopic skin.
  • Sebumeter values were determined before the first application and after 4 weeks of application. The preparation was applied daily for 4 weeks in the morning in a defined amount on the forearm on 1 test area.
  • the fat content of the skin which is important for the natural protection, increased more markedly when using the preparation according to the invention over the 4 weeks in all subjects than when using "5% urea face cream", as shown in the following tables
  • the skin shone despite the good supply of fat, it did not feel smooth, but not greasy
  • the participants, who all had atopic skin also reported excellent compatibility of the preparation according to the invention.
  • the subject's forearm was perpendicular to the upper arm during the measurement, the palms facing up.
  • the measuring point was flat, without hair. With a marked band, which was attached with a ring on the middle finger of the subject, the measuring point could be determined exactly at each measurement time.
  • the quotient Ur / Ue is used as a measure of skin elasticity and describes the elastic function (References: EEMCO Guidance to the in vivo Assessment of Tensile Functional Properties of the skin.) Luis Rodrigues, EEMCO Group, Skin Pharmacol Appl Skin Physiol 2001; 14: 52-67). Ue is the initial skin extensibility / deformation (Immediate Skin Extensibility) and Ur is the initial skin recovery / recovery (Immediate Skin Recovery). In an improvement of the elasticity of the skin Ur / Ue should be greater.
  • the skin elasticity of the skin treated with the composition of the invention improved more than that treated with the urea 5% face cream.
  • the values give the average resulting from measurements on 10 people, with each measurement being repeated 4 times on each person.
  • composition according to the invention essentially provides the skin with its 4 active complexes with a complete spectrum of its own natural constituents and thereby enables the best possible full supply of the skin from the outside.
  • the interaction of the 4 specific active complexes makes it possible to obtain a maximum of care up to the support of skin healing, as has been found in individual examples with regard to dandruff, atopic dermatitis, sunburn and scars.

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Abstract

L'invention concerne des préparations cosmétiques pour la peau dont les complexes actifs spécifiques sont bénéfiques pour la peau de diverses manières, en particulier, ils améliorent l'hydratation et l'élasticité de la peu, et assurent un meilleur apport lipidique. Les complexes actifs correspondent sensiblement au spectre complet des composants naturels d'une peau saine et permettent, lorsqu'ils sont associés les uns aux autres, de réaliser un soin intégral optimal de la peau. La présente invention se rapporte également à un produit, à un substrat, et à un corps moulé renfermant lesdites préparations.
PCT/EP2005/007415 2004-08-04 2005-07-08 Preparation cosmetique pour la peau a base de lipides polyinsatures WO2006015675A1 (fr)

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DE102004037753A DE102004037753A1 (de) 2004-08-04 2004-08-04 Hautkosmetische Zubereitung
DE102004037753.7 2004-08-04

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Cited By (10)

* Cited by examiner, † Cited by third party
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EP1911358A1 (fr) * 2006-10-13 2008-04-16 Compagnie Gervais Danone Nouvelle composition pour améliorer la qualité de la peau et son procédé de préparation
WO2008068656A2 (fr) * 2006-12-05 2008-06-12 Orhan Vaizoglu Compositions dermatologiques
EP1952797A1 (fr) * 2007-01-24 2008-08-06 Dr. August Wolff GmbH & Co. KG Arzneimittel Utilisation d'une composition cosmétique comprenant d'agonistes du récepteur NMDA pour le traitement cosmétique de la peau
WO2009046116A1 (fr) * 2007-10-01 2009-04-09 Dennis Gross Produits de soin pour la peau contenant de multiples améliorateurs
EP2100593A1 (fr) * 2008-03-14 2009-09-16 Symrise GmbH & Co. KG Mélanges ternaires dotés d'un effet croissant de synthèse du collagène
WO2011011808A1 (fr) * 2009-07-30 2011-02-03 Roman Buga Composition cosmétique comprenant du chlorure de sodium en combinaison avec et/ou au moins une protéine, un collagène, une gélatine, un acide aminé
ITMI20131053A1 (it) * 2013-06-25 2014-12-26 Maria Oliva Salviati Composizione che comprende ortica
WO2016133824A1 (fr) * 2015-02-16 2016-08-25 Axim Biotechnologies, Inc. Compositions cosmétiques et topiques comprenant du cannabigérol
DE102016101175A1 (de) * 2016-01-22 2017-07-27 Werner Beck Warzenmittel
WO2023085959A1 (fr) * 2021-11-12 2023-05-19 Aflofarm Farmacja Polska Sp Z Oo Composition cosmétique pour l'exfoliation enzymatique trichologique du cuir chevelu et son procédé d'obtention

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ES2336995B1 (es) * 2008-10-13 2011-02-09 Lipotec, S.A. Composicion cosmetica o dermofarmaceutica para el cuidado de la piel,cuero cabelludo y uñas.
US20230108443A1 (en) * 2021-09-30 2023-04-06 L'oreal Cosmetic skin conditioning composition with high urea content

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EP0875156A2 (fr) * 1997-04-16 1998-11-04 Pharmaberatung für Ernährung & Pflege Renate Helling Produits pour soutenir le traitement de dermatite atopique
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WO2004108107A1 (fr) * 2003-06-10 2004-12-16 Henkel Kommanditgesellschaft Auf Aktien Preparation pour la peau
EP1520577A1 (fr) * 2003-09-30 2005-04-06 Kneipp-Werke Kneipp-Mittel-Zentrale GmbH & CO. KG Composition cosmétique ou dermatologique comprenant l'huile d'onagre

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US4702913A (en) * 1983-12-28 1987-10-27 Roussel Uclaf Novel cosmetic compositions
DE4021082A1 (de) * 1990-07-03 1992-01-23 Hans Dr Lautenschlaeger Hautbehandlungsmittel mit hohen lipidgehalten unter verwendung eines bilayer enthaltenden systems, salzen organischer saeuren, alkohol und stabilisator
DE4232140A1 (de) * 1992-09-25 1994-03-31 Medi Concept Unternehmensberat Verfahren und Pflegeset zur Behandlung der Haut bei Neurodermitis
DE4310015A1 (de) * 1993-03-27 1994-09-29 Boerlind Ges Fuer Kosmetische Mittel zur Pflege der menschlichen Haut
FR2704390A1 (fr) * 1993-04-29 1994-11-04 Boiron Complément nutritionnel absorbable per-os destiné à améliorer la peau.
US20020044977A1 (en) * 1997-01-28 2002-04-18 Graeme A. Close Centipeda plant extract
EP0875156A2 (fr) * 1997-04-16 1998-11-04 Pharmaberatung für Ernährung & Pflege Renate Helling Produits pour soutenir le traitement de dermatite atopique
US6423363B1 (en) * 1997-08-22 2002-07-23 Lipton, Division Of Conopco, Inc. Aqueous dispersion
US6261603B1 (en) * 1999-05-11 2001-07-17 Mcelwain Elizena A. Skin cream
WO2004060393A2 (fr) * 2002-12-30 2004-07-22 Thorel Jean-Noel Activateur cutane associant de l’atp avec d’autres bio-molecules a effet metabolique.
WO2004108107A1 (fr) * 2003-06-10 2004-12-16 Henkel Kommanditgesellschaft Auf Aktien Preparation pour la peau
EP1520577A1 (fr) * 2003-09-30 2005-04-06 Kneipp-Werke Kneipp-Mittel-Zentrale GmbH & CO. KG Composition cosmétique ou dermatologique comprenant l'huile d'onagre

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008043856A1 (fr) * 2006-10-13 2008-04-17 Compagnie Gervais Danone Nouvelle composition servant à améliorer la qualité de la peau et procédé servant à préparer celle-ci
EP1911358A1 (fr) * 2006-10-13 2008-04-16 Compagnie Gervais Danone Nouvelle composition pour améliorer la qualité de la peau et son procédé de préparation
WO2008068656A2 (fr) * 2006-12-05 2008-06-12 Orhan Vaizoglu Compositions dermatologiques
WO2008068656A3 (fr) * 2006-12-05 2009-01-15 Orhan Vaizoglu Compositions dermatologiques
EP1952797A1 (fr) * 2007-01-24 2008-08-06 Dr. August Wolff GmbH & Co. KG Arzneimittel Utilisation d'une composition cosmétique comprenant d'agonistes du récepteur NMDA pour le traitement cosmétique de la peau
US8980344B2 (en) 2007-10-01 2015-03-17 Dennis F. Gross Skin care products containing multiple enhancers
WO2009046116A1 (fr) * 2007-10-01 2009-04-09 Dennis Gross Produits de soin pour la peau contenant de multiples améliorateurs
EP2100593A1 (fr) * 2008-03-14 2009-09-16 Symrise GmbH & Co. KG Mélanges ternaires dotés d'un effet croissant de synthèse du collagène
EP2100594A1 (fr) * 2008-03-14 2009-09-16 Symrise GmbH & Co. KG Mélanges ternaires dotés d'un effet croissant de synthèse du collagène
WO2011011808A1 (fr) * 2009-07-30 2011-02-03 Roman Buga Composition cosmétique comprenant du chlorure de sodium en combinaison avec et/ou au moins une protéine, un collagène, une gélatine, un acide aminé
ITMI20131053A1 (it) * 2013-06-25 2014-12-26 Maria Oliva Salviati Composizione che comprende ortica
WO2014207584A1 (fr) * 2013-06-25 2014-12-31 Salviati Maria Olivia Composition comprenant de l'ortie
WO2016133824A1 (fr) * 2015-02-16 2016-08-25 Axim Biotechnologies, Inc. Compositions cosmétiques et topiques comprenant du cannabigérol
DE102016101175A1 (de) * 2016-01-22 2017-07-27 Werner Beck Warzenmittel
WO2023085959A1 (fr) * 2021-11-12 2023-05-19 Aflofarm Farmacja Polska Sp Z Oo Composition cosmétique pour l'exfoliation enzymatique trichologique du cuir chevelu et son procédé d'obtention

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