WO2006003220A1 - Procedimiento para la obtención de 2-amino-6-alquil-amino-4,5,6,7-tetrahidrobenzotiazoles - Google Patents
Procedimiento para la obtención de 2-amino-6-alquil-amino-4,5,6,7-tetrahidrobenzotiazoles Download PDFInfo
- Publication number
- WO2006003220A1 WO2006003220A1 PCT/ES2005/000362 ES2005000362W WO2006003220A1 WO 2006003220 A1 WO2006003220 A1 WO 2006003220A1 ES 2005000362 W ES2005000362 W ES 2005000362W WO 2006003220 A1 WO2006003220 A1 WO 2006003220A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- formula
- compound
- asterisk
- amino
- solvent
- Prior art date
Links
- 0 CC1CC=C(*)CC1 Chemical compound CC1CC=C(*)CC1 0.000 description 2
- HMEKVIBWVMSQQU-UHFFFAOYSA-N CC(CCC1=O)CC1S Chemical compound CC(CCC1=O)CC1S HMEKVIBWVMSQQU-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
- C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/30—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007517312A JP2008503550A (ja) | 2004-06-25 | 2005-06-24 | 2‐アミノ‐6‐アルキルアミノ‐4,5,6,7‐テトラヒドロベンゾチアゾール類の製造方法 |
US11/571,270 US7638542B2 (en) | 2004-06-25 | 2005-06-24 | Method of obtaining 2-amino-6-alkyl-amino-4,5,6,7-tetrahydro-benzothiazoles |
EP05763015A EP1783120B1 (en) | 2004-06-25 | 2005-06-24 | Method of obtaining 2-amino-6-alkyl-amino-4,5,6,7-tetrahydrobenzothiazoles |
CA002569589A CA2569589A1 (en) | 2004-06-25 | 2005-06-24 | Method of obtaining 2-amino-6-alkyl-amino-4,5,6,7-tetrahydrobenzothiazoles |
DE602005014365T DE602005014365D1 (de) | 2004-06-25 | 2005-06-24 | Verfahren zur gewinnung von 2-amino-6-alkylamino-4,5,6,7-tetrahydrobenzothiazolen |
AT05763015T ATE430740T1 (de) | 2004-06-25 | 2005-06-24 | Verfahren zur gewinnung von 2-amino-6-alkylamino- 4,5,6,7-tetrahydrobenzothiazolen |
US12/619,651 US7875750B2 (en) | 2004-06-25 | 2009-11-16 | Method of obtaining 2-amino-6-alkyl-amino-4,5,6,7-tetrahydrobenzothiazoles |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ESP200401559 | 2004-06-25 | ||
ES200401559A ES2245604B1 (es) | 2004-06-25 | 2004-06-25 | Procedimiento para la obtencion de 2-amino-6-alquil-amino-4,5,6,7-tetrahidrobenzotiazoles. |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/571,270 A-371-Of-International US7638542B2 (en) | 2004-06-25 | 2005-06-24 | Method of obtaining 2-amino-6-alkyl-amino-4,5,6,7-tetrahydro-benzothiazoles |
US12/619,651 Division US7875750B2 (en) | 2004-06-25 | 2009-11-16 | Method of obtaining 2-amino-6-alkyl-amino-4,5,6,7-tetrahydrobenzothiazoles |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2006003220A1 true WO2006003220A1 (es) | 2006-01-12 |
Family
ID=35614431
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/ES2005/000362 WO2006003220A1 (es) | 2004-06-25 | 2005-06-24 | Procedimiento para la obtención de 2-amino-6-alquil-amino-4,5,6,7-tetrahidrobenzotiazoles |
Country Status (8)
Country | Link |
---|---|
US (2) | US7638542B2 (es) |
EP (1) | EP1783120B1 (es) |
JP (1) | JP2008503550A (es) |
AT (1) | ATE430740T1 (es) |
CA (1) | CA2569589A1 (es) |
DE (1) | DE602005014365D1 (es) |
ES (2) | ES2245604B1 (es) |
WO (1) | WO2006003220A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2245604B1 (es) * | 2004-06-25 | 2006-12-01 | Ragactives, S. L. | Procedimiento para la obtencion de 2-amino-6-alquil-amino-4,5,6,7-tetrahidrobenzotiazoles. |
ES2264378B1 (es) | 2005-05-09 | 2007-11-01 | Ragactives, S.L. | Procedimiento para la resolucion de 2-amino-6propilamino-4,5,6,7-tetrahidrobenzotiazol y compuestos intermedios. |
CN110117263B (zh) * | 2019-06-11 | 2020-12-25 | 湖南中医药大学 | 2-氨基-5-酰基噻唑衍生物及其合成方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3682945A (en) * | 1968-07-05 | 1972-08-08 | Exxon Research Engineering Co | Certain 2-acylamino-4,5,6,7-tetrahydrobenzothiazoles |
US5708187A (en) * | 1996-06-27 | 1998-01-13 | Eli Lilly And Company | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists |
WO2004026850A1 (en) * | 2002-09-17 | 2004-04-01 | Generics [Uk] Limited | Process for the preparation of 2-amino-4,5,6,7-tetrahydro-6-aminobenzothiaoles from cyclohexanes and cyclohexanones as intermediates |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA976170A (en) * | 1970-08-25 | 1975-10-14 | Esso Research And Engineering Company | Amino-thiazole and amino-oxazole derivatives and their use to control pests |
IL59334A (en) * | 1979-03-02 | 1984-01-31 | Velsicol Chemical Corp | Tetrahydrobenzothiazolylimidazolidinones and herbicidal compositions containing them |
CA1140227A (en) | 1979-10-19 | 1983-01-25 | Harry H. Kokken | Method of terminating shielded electrical cable and an assembly comprising an electrical connector terminating such cable |
ATE45735T1 (de) | 1984-12-22 | 1989-09-15 | Thomae Gmbh Dr K | Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arnzneimittel. |
DE3447075A1 (de) * | 1984-12-22 | 1986-07-03 | Dr. Karl Thomae Gmbh, 7950 Biberach | Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arzneimittel |
ZA864626B (en) | 1985-06-24 | 1988-02-24 | Lilly Co Eli | Dialkylaminotetrahydrobenzothiazoles and oxazoles |
ES2151993T3 (es) | 1995-06-23 | 2001-01-16 | Lilly Co Eli | 1,2,3,4-tetrahidro-9h-carbazoles 6-sustituidos y 10h-ciclohepta(7,6-b)indoles 7-sustituidos. |
FI108653B (fi) * | 2000-09-18 | 2002-02-28 | Metso Paper Inc | Menetelmä taipumakompensoidun teräpalkin taipuman ja/tai sijainnin säätämiseksi |
US7365086B2 (en) * | 2003-07-25 | 2008-04-29 | Synthon Ip Inc. | Pramipexole acid addition salts |
ES2245604B1 (es) * | 2004-06-25 | 2006-12-01 | Ragactives, S. L. | Procedimiento para la obtencion de 2-amino-6-alquil-amino-4,5,6,7-tetrahidrobenzotiazoles. |
ES2264378B1 (es) * | 2005-05-09 | 2007-11-01 | Ragactives, S.L. | Procedimiento para la resolucion de 2-amino-6propilamino-4,5,6,7-tetrahidrobenzotiazol y compuestos intermedios. |
-
2004
- 2004-06-25 ES ES200401559A patent/ES2245604B1/es not_active Expired - Fee Related
-
2005
- 2005-06-24 AT AT05763015T patent/ATE430740T1/de not_active IP Right Cessation
- 2005-06-24 EP EP05763015A patent/EP1783120B1/en not_active Not-in-force
- 2005-06-24 CA CA002569589A patent/CA2569589A1/en not_active Abandoned
- 2005-06-24 WO PCT/ES2005/000362 patent/WO2006003220A1/es active Application Filing
- 2005-06-24 US US11/571,270 patent/US7638542B2/en not_active Expired - Fee Related
- 2005-06-24 JP JP2007517312A patent/JP2008503550A/ja active Pending
- 2005-06-24 DE DE602005014365T patent/DE602005014365D1/de active Active
- 2005-06-24 ES ES05763015T patent/ES2327656T3/es active Active
-
2009
- 2009-11-16 US US12/619,651 patent/US7875750B2/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3682945A (en) * | 1968-07-05 | 1972-08-08 | Exxon Research Engineering Co | Certain 2-acylamino-4,5,6,7-tetrahydrobenzothiazoles |
US5708187A (en) * | 1996-06-27 | 1998-01-13 | Eli Lilly And Company | 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists |
WO2004026850A1 (en) * | 2002-09-17 | 2004-04-01 | Generics [Uk] Limited | Process for the preparation of 2-amino-4,5,6,7-tetrahydro-6-aminobenzothiaoles from cyclohexanes and cyclohexanones as intermediates |
Non-Patent Citations (2)
Title |
---|
GEWALD K. ET AL: "Reaction of enamines with sulfur and cyanamide", JOURNAL FUER PRAKTISCHE CHEMIE, vol. 312, no. 5, 1970, pages 776 - 779, XP003009242 * |
GEWALD K. ET AL: "Sulfur heterocyclics. XXX. Simple synthesis of 2-aminothiazoles", JOURNAL FUER PRAKTISCHE CHEMIE, vol. 23, no. 5-6, 1964, pages 298 - 300, XP003009241 * |
Also Published As
Publication number | Publication date |
---|---|
CA2569589A1 (en) | 2006-01-12 |
ATE430740T1 (de) | 2009-05-15 |
JP2008503550A (ja) | 2008-02-07 |
US7875750B2 (en) | 2011-01-25 |
US7638542B2 (en) | 2009-12-29 |
ES2327656T3 (es) | 2009-11-02 |
DE602005014365D1 (de) | 2009-06-18 |
US20100063324A1 (en) | 2010-03-11 |
EP1783120A1 (en) | 2007-05-09 |
US20070161798A1 (en) | 2007-07-12 |
EP1783120B1 (en) | 2009-05-06 |
ES2245604A1 (es) | 2006-01-01 |
ES2245604B1 (es) | 2006-12-01 |
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