DE602005014365D1 - Verfahren zur gewinnung von 2-amino-6-alkylamino-4,5,6,7-tetrahydrobenzothiazolen - Google Patents

Verfahren zur gewinnung von 2-amino-6-alkylamino-4,5,6,7-tetrahydrobenzothiazolen

Info

Publication number
DE602005014365D1
DE602005014365D1 DE602005014365T DE602005014365T DE602005014365D1 DE 602005014365 D1 DE602005014365 D1 DE 602005014365D1 DE 602005014365 T DE602005014365 T DE 602005014365T DE 602005014365 T DE602005014365 T DE 602005014365T DE 602005014365 D1 DE602005014365 D1 DE 602005014365D1
Authority
DE
Germany
Prior art keywords
amino
compound
reacting
solvent
tetrahydrobenzothiazolene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005014365T
Other languages
English (en)
Inventor
Coca Gustavo Pascual
Juarez Jorge Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Curia Spain SA
Original Assignee
Ragactives SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ragactives SL filed Critical Ragactives SL
Publication of DE602005014365D1 publication Critical patent/DE602005014365D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/33—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C211/39—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton
    • C07C211/40—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of an unsaturated carbon skeleton containing only non-condensed rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/30—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE602005014365T 2004-06-25 2005-06-24 Verfahren zur gewinnung von 2-amino-6-alkylamino-4,5,6,7-tetrahydrobenzothiazolen Active DE602005014365D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200401559A ES2245604B1 (es) 2004-06-25 2004-06-25 Procedimiento para la obtencion de 2-amino-6-alquil-amino-4,5,6,7-tetrahidrobenzotiazoles.
PCT/ES2005/000362 WO2006003220A1 (es) 2004-06-25 2005-06-24 Procedimiento para la obtención de 2-amino-6-alquil-amino-4,5,6,7-tetrahidrobenzotiazoles

Publications (1)

Publication Number Publication Date
DE602005014365D1 true DE602005014365D1 (de) 2009-06-18

Family

ID=35614431

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005014365T Active DE602005014365D1 (de) 2004-06-25 2005-06-24 Verfahren zur gewinnung von 2-amino-6-alkylamino-4,5,6,7-tetrahydrobenzothiazolen

Country Status (8)

Country Link
US (2) US7638542B2 (de)
EP (1) EP1783120B1 (de)
JP (1) JP2008503550A (de)
AT (1) ATE430740T1 (de)
CA (1) CA2569589A1 (de)
DE (1) DE602005014365D1 (de)
ES (2) ES2245604B1 (de)
WO (1) WO2006003220A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2245604B1 (es) * 2004-06-25 2006-12-01 Ragactives, S. L. Procedimiento para la obtencion de 2-amino-6-alquil-amino-4,5,6,7-tetrahidrobenzotiazoles.
ES2264378B1 (es) 2005-05-09 2007-11-01 Ragactives, S.L. Procedimiento para la resolucion de 2-amino-6propilamino-4,5,6,7-tetrahidrobenzotiazol y compuestos intermedios.
CN110117263B (zh) * 2019-06-11 2020-12-25 湖南中医药大学 2-氨基-5-酰基噻唑衍生物及其合成方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3682945A (en) * 1968-07-05 1972-08-08 Exxon Research Engineering Co Certain 2-acylamino-4,5,6,7-tetrahydrobenzothiazoles
CA976170A (en) * 1970-08-25 1975-10-14 Esso Research And Engineering Company Amino-thiazole and amino-oxazole derivatives and their use to control pests
IL59334A (en) * 1979-03-02 1984-01-31 Velsicol Chemical Corp Tetrahydrobenzothiazolylimidazolidinones and herbicidal compositions containing them
CA1140227A (en) 1979-10-19 1983-01-25 Harry H. Kokken Method of terminating shielded electrical cable and an assembly comprising an electrical connector terminating such cable
DE3447075A1 (de) * 1984-12-22 1986-07-03 Dr. Karl Thomae Gmbh, 7950 Biberach Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arzneimittel
ATE45735T1 (de) 1984-12-22 1989-09-15 Thomae Gmbh Dr K Tetrahydro-benzthiazole, deren herstellung und deren verwendung als zwischenprodukte oder als arnzneimittel.
ZA864626B (en) 1985-06-24 1988-02-24 Lilly Co Eli Dialkylaminotetrahydrobenzothiazoles and oxazoles
EP0749962B1 (de) 1995-06-23 2000-11-02 Eli Lilly And Company 6-Subsitituierte-1,2,3,4-tetrahydro-9H-Carbazole und 7-substituierte-1OH-Cyclohepta(7,6-B)-Indole
US5708187A (en) * 1996-06-27 1998-01-13 Eli Lilly And Company 6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
FI108653B (fi) * 2000-09-18 2002-02-28 Metso Paper Inc Menetelmä taipumakompensoidun teräpalkin taipuman ja/tai sijainnin säätämiseksi
GB0221513D0 (en) * 2002-09-17 2002-10-23 Generics Uk Ltd Novel compounds and processes
US7365086B2 (en) * 2003-07-25 2008-04-29 Synthon Ip Inc. Pramipexole acid addition salts
ES2245604B1 (es) * 2004-06-25 2006-12-01 Ragactives, S. L. Procedimiento para la obtencion de 2-amino-6-alquil-amino-4,5,6,7-tetrahidrobenzotiazoles.
ES2264378B1 (es) * 2005-05-09 2007-11-01 Ragactives, S.L. Procedimiento para la resolucion de 2-amino-6propilamino-4,5,6,7-tetrahidrobenzotiazol y compuestos intermedios.

Also Published As

Publication number Publication date
ES2245604B1 (es) 2006-12-01
JP2008503550A (ja) 2008-02-07
EP1783120B1 (de) 2009-05-06
ATE430740T1 (de) 2009-05-15
WO2006003220A1 (es) 2006-01-12
ES2327656T3 (es) 2009-11-02
US20100063324A1 (en) 2010-03-11
US7875750B2 (en) 2011-01-25
EP1783120A1 (de) 2007-05-09
ES2245604A1 (es) 2006-01-01
CA2569589A1 (en) 2006-01-12
US7638542B2 (en) 2009-12-29
US20070161798A1 (en) 2007-07-12

Similar Documents

Publication Publication Date Title
DE602005025251D1 (de) Verfahren zur herstellung eines 2-ethylaminopyridinderivats
PE20100093A1 (es) Derivados de acetileno
CY1108104T1 (el) (4-μεθοξυ-7-μορφολιν-4-υλο-βενζοθειαζολ-2-υλο) αμιδιο του 4-υδροξυ-4-μεθυλο-πιπεριδινο-1-καρβοξυλικου οξεος
PE20050147A1 (es) Derivados de pirimidina, piridina y tiazol como inhibidores de fosfatidilinositol 3-quinasa
ATE533775T1 (de) Verfahren zur herstellung von 17-vinyl-triflaten als intermediate
RS52704B (en) PROCEDURES FOR OBTAINING 4-AMINO-2- (2,6-DIOXOPIPERIDIN-3-IL) ISOINDOLINE-1,3-DIONIC COMPOUNDS
JP2008523069A5 (de)
PE20121500A1 (es) 2-amino-5,5-difluor-5,6-dihidro-4h-oxazinas como inhibidores de bace 1 y/o bace 2
DE602005007021D1 (de) Cyanopyrrolhaltige cyclische carbamat- und thiocarbamatbiaryle und verfahren zu deren herstellung
AR067896A1 (es) Procedimiento para sintetizar compuestos utiles para tratar hepatitis c
DE602006008962D1 (de) Verfahren zur herstellung von valsartan
JP2013538198A5 (de)
DE502006002659D1 (de) Verfahren zur herstellung von 5-(4-ä4-(5-cyano-3-indolyl)-butylü-1-piperazinyl)-benzofuran-2-carboxamid
PE20050079A1 (es) Derivados de pirrolidona como inhibidores de maob
ATE449082T1 (de) (3,4-dihydro-chinazolin-2-yl)-(2-aryloxy-ethyl) amine mit aktivität am 5-ht-rezeptor
DE60315664D1 (de) Verfahren zur herstellung von 5-(1,3-oxazol-2-yl)benzoesäurederivaten
SI3133073T1 (en) IAP Inhibitors
DE602005014365D1 (de) Verfahren zur gewinnung von 2-amino-6-alkylamino-4,5,6,7-tetrahydrobenzothiazolen
ATE447567T1 (de) Verfahren zur herstellung von tryptase- inhibitoren
ATE513801T1 (de) Verfahren zur synthese von propargylatierten aminoindanderivativen
WO2007070865A3 (en) Piperazine compounds as agonists of trpv4 channel receptors
DE602006015458D1 (de) Verfahren zur herstellung eines carbonsäureamidderivats
DE602007012725D1 (de) Verfahren zur Herstellung von N-(Diphenylmethyl)piperazinen
ATE496907T1 (de) Verfahren zur herstellung von cilostazol
DE60208682D1 (de) Verfahren zur herstellung eines thiazol-ppar-liganden sowie dessen polymorphe

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
R082 Change of representative

Ref document number: 1783120

Country of ref document: EP

Representative=s name: LEMCKE, BROMMER & PARTNER, PATENTANWAELTE, DE

R081 Change of applicant/patentee

Ref document number: 1783120

Country of ref document: EP

Owner name: CRYSTAL PHARMA, S.A.U., ES

Free format text: FORMER OWNER: RAGACTIVES, S.L., BOECILLO, ES

Effective date: 20121126

R082 Change of representative

Ref document number: 1783120

Country of ref document: EP

Representative=s name: LEMCKE, BROMMER & PARTNER, PATENTANWAELTE, DE

Effective date: 20121126