WO2005107707A1 - Retinoid-containing sustained release intraocular drug delivery systems and related methods of manufacturing - Google Patents

Retinoid-containing sustained release intraocular drug delivery systems and related methods of manufacturing Download PDF

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Publication number
WO2005107707A1
WO2005107707A1 PCT/US2005/015018 US2005015018W WO2005107707A1 WO 2005107707 A1 WO2005107707 A1 WO 2005107707A1 US 2005015018 W US2005015018 W US 2005015018W WO 2005107707 A1 WO2005107707 A1 WO 2005107707A1
Authority
WO
WIPO (PCT)
Prior art keywords
retinoid
tazarotene
drug delivery
eye
release
Prior art date
Application number
PCT/US2005/015018
Other languages
English (en)
French (fr)
Inventor
Patrick M. Hughes
Orest Olejnik
Glenn T. Huang
Joan-En Chang-Lin
Thierry Nivaggioli
Jane Guo Shiah
Michele Boix
Christian Sarrazin
Original Assignee
Allergan, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2005240078A priority Critical patent/AU2005240078A1/en
Application filed by Allergan, Inc. filed Critical Allergan, Inc.
Priority to JP2007511054A priority patent/JP2007535563A/ja
Priority to BRPI0509459-3A priority patent/BRPI0509459A/pt
Priority to EP05757761A priority patent/EP1765284A1/en
Priority to CA002565285A priority patent/CA2565285A1/en
Publication of WO2005107707A1 publication Critical patent/WO2005107707A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07Retinol compounds, e.g. vitamin A
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203Retinoic acids ; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts, ocular implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PCT/US2005/015018 2004-04-30 2005-04-29 Retinoid-containing sustained release intraocular drug delivery systems and related methods of manufacturing WO2005107707A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2005240078A AU2005240078A1 (en) 2004-04-30 2005-04-27 Retinoid-containing sustained release intraocular drug delivery systems and related methods of manufacturing
JP2007511054A JP2007535563A (ja) 2004-04-30 2005-04-29 レチノイド含有徐放性薬剤送達システム、ならびに関連する製造法
BRPI0509459-3A BRPI0509459A (pt) 2004-04-30 2005-04-29 sistemas de distribuição de droga intraocular com liberação sustentada contendo retinóide e métodos de fabricação relacionados
EP05757761A EP1765284A1 (en) 2004-04-30 2005-04-29 Retinoid-containing sustained release intraocular drug delivery systems and related methods of manufacturing
CA002565285A CA2565285A1 (en) 2004-04-30 2005-04-29 Retinoid-containing sustained release intraocular drug delivery systems and related methods of manufacturing

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US56733904P 2004-04-30 2004-04-30
US60/567,339 2004-04-30
US62992804P 2004-11-22 2004-11-22
US60/629,928 2004-11-22
US11/119,024 US20050271705A1 (en) 2004-04-30 2005-04-29 Retinoid-containing sustained release intraocular drug delivery system and related methods
US11/119,024 2005-04-29

Publications (1)

Publication Number Publication Date
WO2005107707A1 true WO2005107707A1 (en) 2005-11-17

Family

ID=34972221

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/015018 WO2005107707A1 (en) 2004-04-30 2005-04-29 Retinoid-containing sustained release intraocular drug delivery systems and related methods of manufacturing

Country Status (9)

Country Link
US (3) US20050271705A1 (US20110076318A1-20110331-C00009.png)
EP (1) EP1765284A1 (US20110076318A1-20110331-C00009.png)
JP (1) JP2007535563A (US20110076318A1-20110331-C00009.png)
AR (1) AR056254A1 (US20110076318A1-20110331-C00009.png)
AU (1) AU2005240078A1 (US20110076318A1-20110331-C00009.png)
BR (1) BRPI0509459A (US20110076318A1-20110331-C00009.png)
CA (1) CA2565285A1 (US20110076318A1-20110331-C00009.png)
TW (1) TW200538163A (US20110076318A1-20110331-C00009.png)
WO (1) WO2005107707A1 (US20110076318A1-20110331-C00009.png)

Cited By (8)

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WO2008157614A2 (en) * 2007-06-21 2008-12-24 Yale University Sustained intraocular delivery of drugs from biodegradable polymeric microparticles
JP2009529538A (ja) * 2006-03-08 2009-08-20 アラーガン、インコーポレイテッド サーチュイン活性化剤を用いる眼処置
WO2009143288A1 (en) * 2008-05-20 2009-11-26 Yale University Biodegradable sustained-release polymeric microparticulates comprising a hydrophobic drug and determined for ophthalmic use
WO2012167018A1 (en) * 2011-06-03 2012-12-06 Allergan, Inc. Targeted delivery of retinoid compounds to the sebaceous glands
US8349005B2 (en) 2011-01-03 2013-01-08 Masatoshi Murata Method for burying implant to choroid
KR20150082326A (ko) * 2012-11-08 2015-07-15 고쿠리츠다이가쿠호우진 야마구치 다이가쿠 각결막 장해의 치료제
US9421175B2 (en) 2004-03-17 2016-08-23 Lars Michael Larsen Prevention of retinopathy by inhibition of the visual cycle
US10702502B2 (en) 2013-05-22 2020-07-07 Yamaguchi University Inhibitor for retinochoroidal disorders

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US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
US9498457B2 (en) 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
AU2005240078A1 (en) * 2004-04-30 2005-11-17 Allergan, Inc. Retinoid-containing sustained release intraocular drug delivery systems and related methods of manufacturing
US7993634B2 (en) 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US7998717B2 (en) * 2005-12-02 2011-08-16 Pacific Biosciences Of California, Inc. Mitigation of photodamage in analytical reactions
US20070260203A1 (en) * 2006-05-04 2007-11-08 Allergan, Inc. Vasoactive agent intraocular implant
US8969415B2 (en) * 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
US10064819B2 (en) 2008-05-12 2018-09-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
CN102026599A (zh) 2008-05-12 2011-04-20 犹他大学研究基金会 眼内药物递送装置及相关方法
US9095404B2 (en) 2008-05-12 2015-08-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US9877973B2 (en) 2008-05-12 2018-01-30 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US20110206773A1 (en) * 2008-05-20 2011-08-25 Yale University Sustained delivery of drugs from biodegradable polymeric microparticles
JP5890182B2 (ja) * 2009-02-12 2016-03-22 インセプト エルエルシー ヒドロゲルプラグによる薬物送達
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US8529492B2 (en) 2009-12-23 2013-09-10 Trascend Medical, Inc. Drug delivery devices and methods
US8834847B2 (en) 2010-08-12 2014-09-16 Pacific Biosciences Of California, Inc. Photodamage mitigation compounds and systems
EP2613776B1 (en) * 2010-09-01 2020-07-29 Thomas Jefferson University Composition and method for muscle repair and regeneration
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
WO2013082149A1 (en) * 2011-11-28 2013-06-06 Case Western Reserve University Polysaccharide therapeutic conjugates
EP2925314B1 (en) 2012-11-28 2020-04-01 Aphios Corporation Combination therapeutics and methods for the treatment of neurodegenerative and other diseases
US10123988B2 (en) 2013-03-15 2018-11-13 Allergan, Inc. Compositions including encapsulated isotretinoin and methods for use thereof
EP3099290A1 (en) 2014-01-28 2016-12-07 Allergan, Inc. Topical retinoid formulations and methods of use
JP6655610B2 (ja) 2014-05-29 2020-02-26 グローコス コーポレーション 制御された薬物送達機能を備えるインプラント及びそれを使用する方法
WO2015184453A1 (en) 2014-05-30 2015-12-03 Case Western Reserve University Retinylamine derivitives for treatment of ocular disorders
WO2015187840A2 (en) * 2014-06-03 2015-12-10 Duke University Methods and formulations for treatment of ocular disorders
US11129845B2 (en) 2014-06-18 2021-09-28 Case Western Reserve University Compositions and methods for the delivery of nucleic acids
US10925980B2 (en) 2014-08-04 2021-02-23 Case Western Reserve University Molecular probes and methods of use
US11407786B2 (en) 2015-06-18 2022-08-09 Case Western Reserve University Compositions and methods for the delivery of nucleic acids
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
US11564833B2 (en) 2015-09-25 2023-01-31 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
JP7003110B2 (ja) 2016-04-20 2022-01-20 ドーズ メディカル コーポレーション 生体吸収性眼球薬物送達デバイス
EP4249490A3 (en) 2016-06-08 2023-12-13 Clementia Pharmaceuticals Inc. Methods for treating heterotopic ossification
KR20190100187A (ko) 2016-11-16 2019-08-28 클레멘티아 파마슈티컬즈, 인크. 다중 골연골종(mo)을 치료하는 방법
CN111358766A (zh) * 2020-04-13 2020-07-03 青岛大学 一种包载他扎罗汀的plga纳米粒及其制备方法、用途

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US20050009910A1 (en) * 2003-07-10 2005-01-13 Allergan, Inc. Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug
AU2005240078A1 (en) * 2004-04-30 2005-11-17 Allergan, Inc. Retinoid-containing sustained release intraocular drug delivery systems and related methods of manufacturing

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Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9421175B2 (en) 2004-03-17 2016-08-23 Lars Michael Larsen Prevention of retinopathy by inhibition of the visual cycle
JP2014028822A (ja) * 2006-03-08 2014-02-13 Allergan Inc サーチュイン活性化剤を用いる眼処置
JP2009529538A (ja) * 2006-03-08 2009-08-20 アラーガン、インコーポレイテッド サーチュイン活性化剤を用いる眼処置
WO2008157614A3 (en) * 2007-06-21 2009-02-05 Univ Yale Sustained intraocular delivery of drugs from biodegradable polymeric microparticles
WO2008157614A2 (en) * 2007-06-21 2008-12-24 Yale University Sustained intraocular delivery of drugs from biodegradable polymeric microparticles
US8492334B2 (en) 2007-06-21 2013-07-23 Yale University Sustained intraocular delivery of drugs from biodegradable polymeric microparticles
WO2009143288A1 (en) * 2008-05-20 2009-11-26 Yale University Biodegradable sustained-release polymeric microparticulates comprising a hydrophobic drug and determined for ophthalmic use
US8349005B2 (en) 2011-01-03 2013-01-08 Masatoshi Murata Method for burying implant to choroid
CN103732218A (zh) * 2011-06-03 2014-04-16 阿勒根公司 类维生素a化合物至皮脂腺的靶向递送
WO2012167018A1 (en) * 2011-06-03 2012-12-06 Allergan, Inc. Targeted delivery of retinoid compounds to the sebaceous glands
KR20150082326A (ko) * 2012-11-08 2015-07-15 고쿠리츠다이가쿠호우진 야마구치 다이가쿠 각결막 장해의 치료제
US9492431B2 (en) 2012-11-08 2016-11-15 Yamaguchi University Therapeutic agent for keratoconjunctive disorders
US9750721B2 (en) 2012-11-08 2017-09-05 Yamaguchi University Therapeutic agent for keratoconjunctive disorders
US10016395B2 (en) 2012-11-08 2018-07-10 Yamaguchi University Therapeutic agent for keratoconjunctive disorders
CN109589324A (zh) * 2012-11-08 2019-04-09 国立大学法人山口大学 角结膜病症的治疗剂
US10537556B2 (en) 2012-11-08 2020-01-21 Yamaguchi University Therapeutic agent for keratoconjunctive disorders
KR102173932B1 (ko) 2012-11-08 2020-11-04 고쿠리츠다이가쿠호우진 야마구치 다이가쿠 각결막 장해의 치료제
US11471440B2 (en) 2012-11-08 2022-10-18 Yamaguchi University Therapeutic agent for keratoconjunctive disorders
US10702502B2 (en) 2013-05-22 2020-07-07 Yamaguchi University Inhibitor for retinochoroidal disorders
US11730718B2 (en) 2013-05-22 2023-08-22 Yamaguchi University Inhibitor for retinochoroidal disorders

Also Published As

Publication number Publication date
BRPI0509459A (pt) 2007-09-04
US20050271705A1 (en) 2005-12-08
EP1765284A1 (en) 2007-03-28
CA2565285A1 (en) 2005-11-17
TW200538163A (en) 2005-12-01
US20090163550A1 (en) 2009-06-25
JP2007535563A (ja) 2007-12-06
AR056254A1 (es) 2007-10-03
US20110076318A1 (en) 2011-03-31
AU2005240078A1 (en) 2005-11-17

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