WO2005102305A3 - Compositions de modificateurs d'hemoglobine allosteriques et leurs procedes de fabrication - Google Patents

Compositions de modificateurs d'hemoglobine allosteriques et leurs procedes de fabrication Download PDF

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Publication number
WO2005102305A3
WO2005102305A3 PCT/US2005/013876 US2005013876W WO2005102305A3 WO 2005102305 A3 WO2005102305 A3 WO 2005102305A3 US 2005013876 W US2005013876 W US 2005013876W WO 2005102305 A3 WO2005102305 A3 WO 2005102305A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
impurities
present
allosteric hemoglobin
compositions
Prior art date
Application number
PCT/US2005/013876
Other languages
English (en)
Other versions
WO2005102305A2 (fr
Inventor
Al Quick
Antonio M Santos
Alexandre J G G Carvalho
Douglas G Johnson
Jeffrey B Etter
Chris Murray
Original Assignee
Allos Therapeutics Inc
Al Quick
Antonio M Santos
Alexandre J G G Carvalho
Douglas G Johnson
Jeffrey B Etter
Chris Murray
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allos Therapeutics Inc, Al Quick, Antonio M Santos, Alexandre J G G Carvalho, Douglas G Johnson, Jeffrey B Etter, Chris Murray filed Critical Allos Therapeutics Inc
Priority to AU2005234796A priority Critical patent/AU2005234796A1/en
Priority to US10/598,874 priority patent/US20070293698A1/en
Priority to CA002563752A priority patent/CA2563752A1/fr
Priority to JP2007509685A priority patent/JP2007534691A/ja
Priority to EP05758713A priority patent/EP1745012A4/fr
Publication of WO2005102305A2 publication Critical patent/WO2005102305A2/fr
Publication of WO2005102305A3 publication Critical patent/WO2005102305A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group

Abstract

La présente invention porte sur de nouvelles compositions de modificateurs d'hémoglobine allostériques qui sont quasiment exempts d'impuretés, notamment d'impuretés polymères. Selon une forme de réalisation, les nouvelles compositions contiennent un composé du modificateur d'hémoglobine allostérique et moins de 100 ppm des impuretés polymères générées pendant la préparation de ce composé. L'invention porte également sur de nouveaux procédés de préparation des modificateurs d'hémoglobine allostériques qui sont quasiment exempts d'impuretés polymères, et sur des procédés améliorés de purification du produit obtenu selon cette invention. Les nouveaux procédés de purification consistent à extraire la composition brute avec un solvant immiscible ou partiellement immiscible dans l'eau tel que le méthylisobutyl cétone (MIBK) afin de réduire les quantités d'impuretés, notamment les impuretés polymères. L'invention porte également sur des procédés visant à réduire les impuretés par recristallisation du produit synthétisé brut, puis par filtration du produit recristallisé. L'invention porte notamment sur les produits obtenus par ces processus et sur des procédés d'analyse de compositions comprenant ces produits.
PCT/US2005/013876 2004-04-22 2005-04-22 Compositions de modificateurs d'hemoglobine allosteriques et leurs procedes de fabrication WO2005102305A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2005234796A AU2005234796A1 (en) 2004-04-22 2005-04-22 Compositions of allosteric hemoglobin modifiers and methods of making the same
US10/598,874 US20070293698A1 (en) 2004-04-22 2005-04-22 Compositions of Allosteric Hemoglobin Modifiers and Methods of Making the Same
CA002563752A CA2563752A1 (fr) 2004-04-22 2005-04-22 Compositions de modificateurs d'hemoglobine allosteriques et leurs procedes de fabrication
JP2007509685A JP2007534691A (ja) 2004-04-22 2005-04-22 アロステリックヘモグロビン修飾体の組成物および前記組成物の製造法
EP05758713A EP1745012A4 (fr) 2004-04-22 2005-04-22 Compositions de modificateurs d'hemoglobine allosteriques et leurs procedes de fabrication

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56472104P 2004-04-22 2004-04-22
US60/564,721 2004-04-22

Publications (2)

Publication Number Publication Date
WO2005102305A2 WO2005102305A2 (fr) 2005-11-03
WO2005102305A3 true WO2005102305A3 (fr) 2006-08-10

Family

ID=35197486

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/013876 WO2005102305A2 (fr) 2004-04-22 2005-04-22 Compositions de modificateurs d'hemoglobine allosteriques et leurs procedes de fabrication

Country Status (6)

Country Link
US (2) US7847120B2 (fr)
EP (1) EP1745012A4 (fr)
JP (1) JP2007534691A (fr)
AU (1) AU2005234796A1 (fr)
CA (1) CA2563752A1 (fr)
WO (1) WO2005102305A2 (fr)

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CN101134732B (zh) * 2007-09-21 2012-05-23 江苏先声药物研究有限公司 制备2-{4-[[(3,5-二甲基苯胺)羰基]甲基]苯氧基}-2-甲基丙酸钠的方法和它在水中的结晶
PT2797416T (pt) 2011-12-28 2017-10-23 Global Blood Therapeutics Inc Compostos de benzaldeído substituído e métodos para a sua utilização no aumento da oxigenação de tecidos
ES2790358T3 (es) 2011-12-28 2020-10-27 Global Blood Therapeutics Inc Compuestos de heteroaril aldehído sustituido y métodos para su uso en el aumento de la oxigenación tisular
AP2015008718A0 (en) 2013-03-15 2015-09-30 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
MY180206A (en) 2013-03-15 2020-11-25 Global Blood Therapeutics Inc Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en) 2013-03-15 2015-02-10 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en) 2013-03-15 2019-04-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9458139B2 (en) 2013-03-15 2016-10-04 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en) 2013-03-15 2017-03-28 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
CN105073728A (zh) 2013-03-15 2015-11-18 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
US10100043B2 (en) 2013-03-15 2018-10-16 Global Blood Therapeutics, Inc. Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation
US9802900B2 (en) 2013-03-15 2017-10-31 Global Blood Therapeutics, Inc. Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en) 2013-03-15 2016-08-23 Global Blood Therapeutics, Inc. Compounds and uses thereof for the modulation of hemoglobin
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
EP3092213B1 (fr) * 2013-12-27 2019-10-23 Virginia Commonwealth University Modificateurs allostériques de l'hémoglobine avec une partie libérant de l'oxyde nitrique
DK3102208T3 (da) 2014-02-07 2021-03-08 Global Blood Therapeutics Inc Krystallinsk polymorf af den frie base af 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyd
MA43373A (fr) 2015-12-04 2018-10-10 Global Blood Therapeutics Inc Régimes posologiques pour 2-hydroxy-6-((2- (1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)méthoxy)benzaldéhyde
CN107345944B (zh) * 2016-05-04 2019-05-07 中国石油天然气股份有限公司 一种测定液相混合物中乙醛含量的方法
AR108435A1 (es) 2016-05-12 2018-08-22 Global Blood Therapeutics Inc Proceso para sintetizar 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)-piridin-3-il)metoxi)benzaldehído
TWI778983B (zh) 2016-10-12 2022-10-01 美商全球血液治療公司 包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
JP7217913B2 (ja) * 2018-02-16 2023-02-06 株式会社日立ハイテクサイエンス プラスチック標準物質の製造方法
WO2020072377A1 (fr) 2018-10-01 2020-04-09 Global Blood Therapeutics, Inc. Modulateurs de l'hémoglobine pour le traitement de la drépanocytose
PT3880654T (pt) 2018-11-19 2022-04-08 Global Blood Therapeutics Inc Compostos de 2-formil-3-hidroxifeniloximetil capazes de modular hemoglobina

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WO2003086324A2 (fr) * 2002-04-10 2003-10-23 Allos Therapeutics, Inc. Elaboration et utilisation d'une formulation stable de composes aux effets allosteriques

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Title
GRELLA M.P. ET AL.: "Synthesis and Structure-Activity Relationships of Chiral Allosteric Modifiers of Hemoglobin", J. MED. CHEM., vol. 43, no. 25, 2000, pages 4726 - 4737, XP002275145 *
See also references of EP1745012A4 *

Also Published As

Publication number Publication date
US20070293698A1 (en) 2007-12-20
EP1745012A4 (fr) 2010-11-03
EP1745012A2 (fr) 2007-01-24
AU2005234796A1 (en) 2005-11-03
CA2563752A1 (fr) 2005-11-03
JP2007534691A (ja) 2007-11-29
US20050239893A1 (en) 2005-10-27
WO2005102305A2 (fr) 2005-11-03
US7847120B2 (en) 2010-12-07

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