WO2005077902A3 - Methodes de synthese de pyridoxamine - Google Patents

Methodes de synthese de pyridoxamine Download PDF

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Publication number
WO2005077902A3
WO2005077902A3 PCT/US2005/003969 US2005003969W WO2005077902A3 WO 2005077902 A3 WO2005077902 A3 WO 2005077902A3 US 2005003969 W US2005003969 W US 2005003969W WO 2005077902 A3 WO2005077902 A3 WO 2005077902A3
Authority
WO
WIPO (PCT)
Prior art keywords
pyridoxamine
methods
synthesis
methylpyridine
aminomethyl
Prior art date
Application number
PCT/US2005/003969
Other languages
English (en)
Other versions
WO2005077902A2 (fr
Inventor
Raja Khalifah
Roland Keilitz
Christoph Koellner
Thorsten Degenhardt
Stephen Robert Brand
Original Assignee
Biostratum Inc
Raja Khalifah
Roland Keilitz
Christoph Koellner
Thorsten Degenhardt
Stephen Robert Brand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biostratum Inc, Raja Khalifah, Roland Keilitz, Christoph Koellner, Thorsten Degenhardt, Stephen Robert Brand filed Critical Biostratum Inc
Publication of WO2005077902A2 publication Critical patent/WO2005077902A2/fr
Publication of WO2005077902A3 publication Critical patent/WO2005077902A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • C07D213/67—2-Methyl-3-hydroxy-4,5-bis(hydroxy-methyl)pyridine, i.e. pyridoxine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

L'invention concerne des méthodes non oxydatives destinées à la fabricaiton à grande échelle de pyridoxamine (I) (4-aminométhyl-3-hydroxy-5-hydroxyméthyl-2-méthylpyridine) de formule (I), et des sels associés. Cette invention a aussi trait à des composés intermédiaires pour la synthèse de pyridoxamine, ainsi qu'à des compositions et à des méthodes de traitement et/ou de prévention de troubles liés à la formation de produits finaux de la glycation avancée post-Amadori.
PCT/US2005/003969 2004-02-09 2005-02-09 Methodes de synthese de pyridoxamine WO2005077902A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US54311504P 2004-02-09 2004-02-09
US60/543,115 2004-02-09

Publications (2)

Publication Number Publication Date
WO2005077902A2 WO2005077902A2 (fr) 2005-08-25
WO2005077902A3 true WO2005077902A3 (fr) 2006-01-12

Family

ID=34860378

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/003969 WO2005077902A2 (fr) 2004-02-09 2005-02-09 Methodes de synthese de pyridoxamine

Country Status (2)

Country Link
US (3) US7214799B2 (fr)
WO (1) WO2005077902A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005077902A2 (fr) * 2004-02-09 2005-08-25 Biostratum, Inc. Methodes de synthese de pyridoxamine
CN101227904A (zh) * 2005-05-24 2008-07-23 学校法人东海大学 腹膜保护剂
US20080032990A1 (en) * 2006-07-07 2008-02-07 Khalifah Raja G Inhibitors of advanced glycation end products
US20100261764A1 (en) * 2007-12-18 2010-10-14 Dmitri Valerievich Biryukov Substituted 3 -hydroxypyridines and pharmaceutical compositions thereof
US8252228B1 (en) * 2008-10-13 2012-08-28 Abbott Cardiovascular Systems Inc. Methods for sterilizing carriers for treatment of a kidney
US20170056381A1 (en) * 2014-02-20 2017-03-02 Nanometics Llc Pyridoxamine for the treatment of sickle cell disease, thalassemia and related blood diseases
WO2016031839A1 (fr) * 2014-08-29 2016-03-03 株式会社プロジェクトＰｍ Composition pharmaceutique formée par combinaison d'un composé de pyridoxamine et d'un composé de thiamine
JP6105111B1 (ja) 2016-03-02 2017-03-29 国立大学法人東北大学 自閉スペクトラム症改善用組成物
US20200149079A1 (en) 2017-05-12 2020-05-14 Mitsui Chemicals, Inc. Recombinant microorganism and method of producing pyridoxamine or salt thereof using recombinant microorganism
US20200123581A1 (en) 2017-05-12 2020-04-23 Mitsui Chemicals, Inc. Recombinant microorganism, method of producing pyridoxamine or salt thereof using recombinant microorganism, and method of producing pyridoxal or salt thereof using recombinant microorganism

Citations (3)

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Publication number Priority date Publication date Assignee Title
US2522407A (en) * 1950-09-12 Cxchzoh
GB1101369A (en) * 1965-12-15 1968-01-31 Tanabe Seiyaku Co Derivatives of vitamin b and a process for preparing the same
US6489345B1 (en) * 1999-07-13 2002-12-03 Medicure, Inc. Treatment of diabetes and related pathologies

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US6740668B1 (en) * 1995-08-28 2004-05-25 Kansas University Medical Center Methods for inhibiting diabetic complications
US6716858B1 (en) 1995-08-28 2004-04-06 Kansas University Medical Center Methods for inhibiting diabetic complications
US6228858B1 (en) * 1995-09-12 2001-05-08 University Of Kansas Medical Center Advanced glycation end-product intermediaries and post-amadori inhibition
US6750209B1 (en) * 1995-09-12 2004-06-15 Kansas University Medical Center Advanced glycation end-product intermediaries and post-amadori inhibition
US6436969B1 (en) * 1995-09-12 2002-08-20 Kansas University Medical Center Research Institute Inc. Dialysis solutions and methods
US6730686B1 (en) * 1995-09-12 2004-05-04 Kansas University Medical Center Methods for inhibiting oxidative modification of proteins
US5744451A (en) * 1995-09-12 1998-04-28 Warner-Lambert Company N-substituted glutamic acid derivatives with interleukin-1 β converting enzyme inhibitory activity
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US7030146B2 (en) * 1996-09-10 2006-04-18 University Of South Carolina Methods for treating diabetic neuropathy
WO2000051987A2 (fr) * 1999-03-05 2000-09-08 Kansas University Medical Center Nouveaux inhibiteurs post-amadori de reactions de glycation avancee
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ATE333868T1 (de) * 2000-11-02 2006-08-15 Univ South Carolina Verwendung von pyridoxamin für die behandlung und unterdrückung von komplikationen im zusammenhang mit adipositas
WO2002039994A2 (fr) * 2000-11-20 2002-05-23 University Of Kansas Medical Center Methodes de traitement et de prevention des calculs urinaires
JP2006501247A (ja) * 2002-08-30 2006-01-12 バイオストラタム，インコーポレイティド ポストａｍａｄｒｉの後生的糖化最終産物の阻害物質
ES2374399T3 (es) * 2003-06-20 2012-02-16 Nephrogenex, Inc. Piridoxamina para uso en el tratamiento de nefropatía diabética en diabetes tipo ii.
WO2005077902A2 (fr) * 2004-02-09 2005-08-25 Biostratum, Inc. Methodes de synthese de pyridoxamine

Patent Citations (4)

* Cited by examiner, † Cited by third party
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US2522407A (en) * 1950-09-12 Cxchzoh
GB1101369A (en) * 1965-12-15 1968-01-31 Tanabe Seiyaku Co Derivatives of vitamin b and a process for preparing the same
US6489345B1 (en) * 1999-07-13 2002-12-03 Medicure, Inc. Treatment of diabetes and related pathologies
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Non-Patent Citations (8)

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DING-YAH YANG ET. AL.: "Chemical Synthesis of Stereospecifically Labelled Pyridoxamine 5'-Phosphate.", JOURNAL OF ORGANIC CHEMISTRY, vol. 56, no. 8, 1991, pages 2940 - 2946, XP002334157 *
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K. J. FRANKLIN ET. AL.: "Reactions of metal Ions with Vitamins. 2. Crystal strucutre of Copper complexes with Anionic and with Neutral Pyridoxamine.", INORGANIC CHEMISTRY, vol. 19, 1980, pages 2107 - 2113, XP002334154 *
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Also Published As

Publication number Publication date
US20070161678A1 (en) 2007-07-12
US8431712B2 (en) 2013-04-30
WO2005077902A2 (fr) 2005-08-25
US20100305162A1 (en) 2010-12-02
US7214799B2 (en) 2007-05-08
US20050272781A1 (en) 2005-12-08

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