Classifications

• • A—HUMAN NECESSITIES
  • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
  • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
  • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
  • A24B15/18—Treatment of tobacco products or tobacco substitutes
  • A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
  • A24B15/241—Extraction of specific substances
  • A24B15/243—Nicotine
• • A—HUMAN NECESSITIES
  • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
  • A24D—CIGARS; CIGARETTES; TOBACCO SMOKE FILTERS; MOUTHPIECES FOR CIGARS OR CIGARETTES; MANUFACTURE OF TOBACCO SMOKE FILTERS OR MOUTHPIECES
  • A24D3/00—Tobacco smoke filters, e.g. filter-tips, filtering inserts; Filters specially adapted for simulated smoking devices; Mouthpieces for cigars or cigarettes
  • A24D3/06—Use of materials for tobacco smoke filters
  • A24D3/14—Use of materials for tobacco smoke filters of organic materials as additive
• • A—HUMAN NECESSITIES
  • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
  • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
  • A24F7/00—Mouthpieces for pipes; Mouthpieces for cigar or cigarette holders
  • A24F7/04—Mouthpieces for pipes; Mouthpieces for cigar or cigarette holders with smoke filters

Definitions

• the present invention relates to a -cotin reducing agent and a nicotine reducing smoking device used for reducing the amount of nicotine contained in mainstream smoke of tobacco.
• the present invention also relates to a method for reducing the amount of nicotine in the mainstream smoke of cigarettes and a method for reducing the amount of tar by using the nicotine-reducing agent or the nicotine-reducing smoking device.
• Tobacco smoke is said to contain about 4,000 types of chemical substances, and it is known that there are harmful substances and carcinogenic substances among them! Among them, nicotine, tar, and carbon monoxide are typical examples of harmful substances contained in tobacco smoke. Therefore, various methods for eliminating these harmful substances have been attempted in the tobacco smoke.
• a method of reducing the amount of nicotine contained in inhaled tobacco smoke (mainstream smoke) by impregnating the filter part of a smoking pipe with water and bringing the tobacco smoke into contact with water has been proposed (Patent Documents 1-3).
• This method is based on the fact that nicotine contained in cigarette smoke is soluble in water and has properties.
• a filter with a structure in which water is contained in a part of the filter of the smoking pipe can remove nicotine! /, although it can be expected to have an effect, but water containing harmful nicotine and tar content when smoking is consumed together with smoke. And may enter the body.
• Patent Document 4 a method of blending cyclodextrin or a water-absorbing polymer in a tobacco suction filter
• Patent Documents 5 and 6 a filter of a smoking pipe used by being attached to a tobacco suction portion
• the former method of incorporating a water-absorbing polymer into the mouthpiece filter of cigarettes increases the suction resistance during smoking because the mouthpiece absorbs a large amount of water under high humidity conditions, making smoking itself difficult.
• Patent Document 7 wooden and plastic smoking cessation pipes incorporating a filter impregnated with mucus are also known (Patent Document 7), but this method has the trouble of attaching accessories when smoking.
• Patent Document 8 a denicotinic-tar agent in which a thin gel-like substance is applied to a filter or a suction surface of a cigarette and then used as it is or inserted into a pipe for smoking.
• the gelled matter that does not infiltrate the filter and scatters on the filter into the mouth causes discomfort and makes suction difficult.
• Patent Document 1 JP-A-48-53871
• Patent Document 2 JP-A-50-130579
• Patent Document 3 JP-A-62-198378
• Patent Document 4 JP-A-51-32799
• Patent Document 5 JP-A-62-179376
• Patent Document 6 JP-A-47-30900
• Patent Document 7 JP-A-56-18583
• Patent Document 8 JP-A-61-177972
• An object of the present invention is to provide a nicotine-reducing agent and a nicotine-reducing smoking device used for reducing the amount of nicotine contained in mainstream smoke of tobacco. Further, an object of the present invention is to provide a nicotine reducing agent or a smoking device for reducing nicotine, whereby The mainstream smoke power of saws is also to provide a method to reduce the amount of nicotine and a method to reduce the amount of tar.
• the present inventors have conducted intensive studies to develop a method for reducing the amount of nicotine contained in the mainstream smoke of tobacco, and found that tamarind seed gum, xanthan gum, and mouth-to-mouth bean gum were used.
• An aqueous liquid composition containing a specific polysaccharide and adjusted to a viscosity of 500-3000 mPas has excellent ability to adsorb and remove nicotine, the mainstream smoke power of tobacco, which is used as a filter in tobacco and smoking equipment filters. It has been found that even if it is included, it has almost no effect on smoking.
• the present inventors by using these polysaccharides and, if necessary, by using these polysaccharides in combination with saccharides, can be used throughout seasons that are not easily affected by changes in temperature or long-term storage. It has been confirmed that an aqueous liquid composition having stable viscosity and properties can be obtained, and that a small aqueous liquid composition can be a suitable nicotine reducing agent for performing the above-mentioned nicotine reducing method.
• the present inventors have confirmed that increasing the amount of the aqueous liquid composition (the amount applied to the filter) increases the amount of nicotine that can be removed from mainstream smoke of tobacco.
• the smoker can easily control the amount of nicotine inhaled into the body by smoking by adjusting the use amount of the aqueous liquid composition. That is, according to the aqueous liquid composition, the amount used (the amount applied to the filter) is increased stepwise according to the nicotine dependence of the smoker, thereby gradually increasing the amount of nicotine inhaled into the body. In this way, it is possible to reduce the incidence of nicotine dependence, which is the biggest problem in smoking cessation, and eventually achieve smoking cessation.
• the present invention has been completed based on such knowledge. That is, the present invention includes the following embodiments;
• Item 1 Select from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, cod gum, guar gum, pectin, pullulan, psyllium seed gum, methinoresenololose, canoleboximetinole cellulose, hydroxypropyl methylcellulose, and carrageenan
• a nicotine reducing agent comprising an aqueous liquid composition having a viscosity of 500 to 3000 mPa's, containing at least one polysaccharide to be used.
• Item 2 The nicotine reducing agent according to Item 1, wherein the polysaccharide is at least one selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, cod gum, guar gum, and pectin.
• Item 3 The nicotine reducing agent according to item 1, wherein the polysaccharide is at least one selected from the group consisting of tamarind seed gum, locust bean gum, and xanthan gum.
• Item 4 The nicotine reducing agent according to Item 1, further comprising a saccharide.
• Item 5 The nicotine according to Item 4, wherein the saccharide is at least one selected from the group consisting of trehalose, starch syrup, sucrose, glucose, fructose, maltose, sorbitol, maltitol, ratatitol, erythritol, xylitol, and dextrin. Reducing agent.
• Item 6 The nicotine reducing agent according to Item 4, wherein the saccharide is at least one selected from the group consisting of trehalose and starch syrup.
• Item 7 The nicotine reducing agent according to Item 1, which is used while being held by a filter of a smoking article.
• Item 8 A nicotine reducing agent in a container, wherein the container is filled with the nicotine reducing agent comprising the aqueous liquid composition according to Item 1.
• a dropping type container can be suitably used as the container.
• a smoking device for reducing nicotine comprising a part of a filter holding the nicotine reducing agent according to Item 1.
• the smoking article for reducing nicotine has a holder body provided with a suction port at one end and a cigarette insertion port at the other end, and a filter provided in the holder body.
• Item 10 A smoking device for reducing nicotine according to Item 9, wherein the smoking device retains the agent for reducing nicotine according to Item 1.
• a cigarette holder having a holder body provided with a suction port at one end and a cigarette insertion port at the other end, and a filter provided in the holder body.
• a smoking device for reducing nicotine comprising a detachable cap with a clip on the mouth side and a detachable lid on the tobacco insertion opening side of the holder body.
• Item 12 A smoking device for reducing nicotine according to Item 11, wherein the filter holds the nicotine-reducing agent according to Item 1.
• Item 13 The cigarette filter containing the nicotine-reducing agent described in Item 13.
• the aqueous liquid composition (nicotine reducing agent) of the present invention can be used to reduce the amount of nicotine contained in mainstream smoke of tobacco by using it, as shown in Experimental Example 4 described below. Can also be reduced. Therefore, the above “nicotine reducing agent” and “nicotine reducing smoking device” are “tar reducing agent” and “tar reducing smoking device”, respectively, “nicotine and tar reducing agent”, and “nicotine and tar It can be replaced with “reducing smoking gear”. Further, from the viewpoint of tar reduction, the present invention tends to provide the following method.
• Item 14 selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, cod gum, guar gum, pectin, pullulan, psyllium seed gum, methinoresenololose, canoleboxy methinolate cellulose, hydroxypropyl methylcellulose, and carrageenan Passing a mainstream cigarette smoke through a filter of a smoking article containing an aqueous liquid composition (tar reducing agent) containing at least one polysaccharide and having a viscosity of 500 to 3000 mPa's. A method to reduce the amount of tar in mainstream smoke of tobacco.
• aqueous liquid composition tar reducing agent
• the use of the nicotine reducing agent (aqueous liquid composition) of the present invention makes it possible to reduce the dependence of smokers on nicotine. Accordingly, the present invention also provides the following method from such a viewpoint.
• Item 15 For subjects with smoking habits, tamarind seed gum, locust bean gum, xanthan gum, cod gum, guar gum, pectin, punorelane, psyllium seed gum, methinoresenorelose, canoleboxy methinoresenolerose, hydroxy A group consisting of propinolemethinoresenolerose and carrageenan.
• a method of alleviating the subject's dependence on nicotine which comprises smoking using the provided smoking equipment.
• the present invention provides the following uses of the aqueous liquid composition of the present invention.
• Item 16 Tetramarind seed gum, locust bean gum, xanthan gum, cod gum, guar gum, pectin, pullulan, psyllium seed gum, methinoresenolerose, canoleboxy methinole
• Item 17 The use according to Item 16, wherein the aqueous liquid composition further contains a saccharide.
• Item 18 The above saccharide is at least one selected from the group consisting of trehalose, starch syrup, sucrose, glucose, fructose, maltose, sorbitol, maltitol, ratatitol, erythritol, xylitol, and dextrin. Use of.
• Item 19 selected from the group consisting of tamarind seed gum, locust bean gum, xanthan gum, cod gum, guar gum, pectin, pullulan, psyllium seed gum, methinoresenololose, canoleboxy methinolate cellulose, hydroxypropyl methylcellulose, and carrageenan Use of an aqueous liquid composition containing at least one polysaccharide and having a viscosity of 500 to 3000 mPa's to reduce nicotine or tar.
• Item 20 The use according to Item 19, wherein the aqueous liquid composition further contains a saccharide.
• the saccharide is at least one selected from the group consisting of trehalose, starch syrup, sucrose, glucose, fructose, maltose, sorbitol, maltitol, ratatitol, erythritol, xylitol, and dextrin.
• FIG. 1 is a plan view showing the appearance of a cigarette holder 1 which is one embodiment of a nicotine-reducing smoking device according to the present invention.
• FIG. 2 is a plan view showing the appearance of a cigarette holder ⁇ which is another embodiment of the nicotine reducing smoking device according to the present invention.
• FIG. 3 is a side view of the cigarette holder 11 of FIG.
• FIG. 4 is a sectional view taken along the line ⁇ - ⁇ of FIG. 2.
• FIG. 5 is a sectional view taken along the line IV-IV in FIG. 3.
• FIG. 6 is a side view showing a state where a lid 77 is attached to a cap 66 with a clip of the cigarette holder 11 of FIG. 2.
• FIG. 7 is a longitudinal sectional view of FIG. 6.
• FIG. 4 is a diagram showing a rate (Experimental Example 4).
• a cigarette holder which is one embodiment of the smoking article for reducing nicotine of the present invention.
• Cigarette holder which is another embodiment of the smoking apparatus for reducing nicotine according to the present invention.
• Nicotine reducing agent [0016]
• the nicotine reducing agent of the present invention includes tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psyllium seed gum, methylcellulose, canoleboxymethinoresenorelose, hydroxypropinolemethinoresenorelose. And a group consisting of carrageenan.
• Tamarind seed gum is a water-soluble polysaccharide that can be obtained from the seeds of tamarind (Tamarindus erandifloraPERS.), A perennial dicotyledonous plant of the legume family.
• Locust bean gum is a polysaccharide that can be obtained from bran of legume carob (Ceratonia siliaua).
• Xantham gum is a fermented polysaccharide produced by the microorganism Xanthomonas campestris.
• Tara gum is a water-soluble polysaccharide that can be obtained from seeds of Actinidia callosa LINDL.
• Guar gum is a polysaccharide or guar gum that can also obtain the power of leguminous guar (Cvamopsis tetra ⁇ onolobas TAUB.). Lulase).
• Pectin is a polysaccharide mainly composed of methyli-dani polygalacturonic acid, which can be obtained by extracting water from citrus fruits, apples and the like.
• HM pectin (of which the ratio of methyli-dani galacturonic acid accounts for 50% or more of the total galacturonic acid) and LM pectin (of the total galacturonic acid) And those in which methylated galacturonic acid accounts for 50% or less).
• DE degree of esterification
• LM pectin of the total galacturonic acid
• any one of HM pectin and LM pectin can be used.
• Pullulan is a polysaccharide produced by black yeast (Aureobasidiumpullulans [DE Bary] ARN.). Psyllium seed gum is a polysaccharide that can also provide the seed power of Plantaeovata FORSK. Or a congener plant.
• Carrageenan (Carrageenan) is a species of the family Carrionaceae Irish moss (ChondruscrisDus LYNGB.), The carpenter (Gieartina tenella HARV.),
• Eucneumamuricatum WvBOSb Forma depaupaerata WvBOSSE), Ino-Funori-family ⁇ ⁇ Ivaranori (Hvpneaiaponica TANAKA) and other polysaccharides that can be obtained by extraction with leaf water. This can be divided into three categories: kappa ( ⁇ ), iota ( t ) and lambda ( ⁇ ). In the present invention, any one of ⁇ -carrageenan, carrageenan and ⁇ -carrageenan can be used, but ⁇ -force laginan can be used more preferably.
• polysaccharides are preferably tamarind seed gum, locust bean gum, xanthan gum, cod gum, guar gum, and pectin, and particularly preferred polysaccharides are tamarind seed gum, locust bean gum, and xanthan gum.
• the nicotine reducing agent of the present invention is characterized by comprising an aqueous liquid composition having a viscosity of 500 to 3000 mPa's.
• the viscosity is 20 ° C, using a B-type rotational viscometer (rotor No. 3 if the viscosity is less than 2000 mPa's, use rotor No.
• viscosity exceeds 2000 mPa's
• Preferred viscosities are from 500 to 2500 mPa ⁇ s, more preferably ⁇ 1000 to 2500 mPa ⁇ s.
• the method for adjusting the aqueous liquid composition to such a viscosity is not particularly limited. However, a solvent for dissolving each of the above polysaccharides is selected, the ratio of the polysaccharide used is adjusted, and other components are used. It can be performed by blending or the like.
• the solvent used for dissolving the above polysaccharide such as tamarind seed gum, xanthan gum or locust bean gum is not particularly limited as long as it can dissolve these components.
• water is also used for safety and convenience.
• water can be used in combination with ethanol, propylene glycol, glycerin or the like as long as the effects of the present invention are not impaired.
• the polysaccharides are one type.
• the nicotine reducing agent of the present invention can be used alone as an active ingredient, but two or more of them can be used in any combination as desired.
• Preferred combinations thereof include, but are not limited to, a combination of tamarind seed gum and locust bean gum, a combination of tamarind seed gum and xanthan gum, a combination of locust bean gum and methylcellulose, and a combination of tamarind seed gum and cod gum. Combinations and combinations of tamarind seed gum and guar gum can be exemplified.
• the above polysaccharides (tamarind seed gum, locust bean gum, xanthan gum, cod gum, guar gum, pectin, punorelane, silica seed gum, methinoresenololose, nicotine reducing agent (aqueous liquid composition),
• the proportion of carboxymethylcellulose, hydroxypropylmethylcellulose, or carrageenan is such that the viscosity of the resulting nicotine reducing agent (aqueous liquid composition) is in the range of 500 to 3000 mPa's, preferably 500 to 2500 mPa's, more preferably 500 to 2500 mPa's. It is not particularly limited as long as the ratio is 1000—2500 mPa's.
• the ratios shown in Table 1 can be exemplified.
• the ratio and the amount of the combination are determined based on the viscosity of the obtained nicotine reducing agent (aqueous liquid composition) based on the above-mentioned respective ratios.
• the range of 00-3000mPa's, preferred ⁇ 500-2,500mPa's, more preferred ⁇ 1000-2,500mPa's can be adjusted and determined as an index.
• the mixing ratio of each component is 0.1-10 parts by weight of locust bean gum to 1 part by weight of tamarind seed gum, preferably 0.2-5 parts by weight can be exemplified.
• the mixing ratio of each component may be, for example, 0.02-1 part by weight of xanthan gum, preferably 0.05-0.5 part by weight with respect to 1 part by weight of tamarind seed gum. it can.
• the mixing ratio of each component is, for example, 0.2 to 20 parts by weight of locust bean gum, preferably 0.5 to 10 parts by weight with respect to 1 part by weight of methylcellulose.
• examples of the mixing ratio of each component include 0.1 to 10 parts by weight, preferably 0.2 to 5 parts by weight of tara gum per 1 part by weight of tamarind seed gum.
• the mixing ratio of each component should be 0.1 to 10 parts by weight, preferably 0.2 to 5 parts by weight, based on 1 part by weight of tamarind seed gum. Can be.
• the nicotine-reducing agent of the present invention includes the above-mentioned tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, pectin, pullulan, psyllium seed gum, methyl cenorellose, canoleboxy methinoresenolerose, hydroxypropinole A group consisting of methinoresenolerose and carrageenan
• a saccharide can be blended within a range that does not impair the effects of the present invention. By combining a saccharide with the above polysaccharide, it is possible to improve the viscosity and viscosity stability and to improve the reduction rate of nicotine or tar.
• the saccharides preferably used in the present invention include monosaccharides such as glucose, fructose, galactose, mannose, xylose, and erythrose, or reducing sugars thereof (eg, sorbitole, xylitoleone, erythritole); trenoperulose, manoletose Disaccharides such as isomeranolose, -gelose, cellobiose, sucrose, ratatose, and their reducing sugars (eg, maltitol, ratatitol); beet oligosaccharides, maltooligosaccharides, isomaltoligosaccharides, fratatoligosaccharides, galatatooligosaccharides, xylooligosaccharides And saccharides derived from starch such as dextrin and starch syrup, and reducing sugars thereof (eg, reduced syrup).
• monosaccharides such as glucose, fructo
• monosaccharides such as glucose and fructose or reducing sugars thereof (sorbitol, xylitol, erythritol); disaccharides such as trehalose, maltose, sucrose or reducing sugars thereof (maltitol, ratatitol); dextrin, And syrup can be mentioned.
• glucose and its reducing sugar sorbitol
• maltose and its reducing sugar maltitol
• starch sugars such as trehalose, dextrin and starch syrup (starch is decomposed, enzymatically transferred and enzyme-bound by using enzymes or acids)
• the obtained monosaccharides, small sugars and their reduced products and particularly preferred are sorbitol, trehalose, and starch syrup.
• Preferred combinations include trehalose and syrup, sorbitol and syrup, and the like.
• the proportion of these saccharides blending nicotine-reducing agent (100 weight 0/0) of the present invention is not particularly restricted, the viscosity of the final nicotine-reducing agent is 500- 3000 mPa's, preferably in the range of 50 0 -2500 mPa's, more preferably 1000-2500 mPa's.
• the ratio of the saccharide is usually 5 to 60% by weight, preferably 10 to 50% by weight, more preferably 10 to 40% by weight.
• the ratio of the saccharide may be, for example, 5 to 50% by weight, preferably 10 to 40% by weight, and more preferably 10 to 30% by weight. it can.
• the nicotine reducing agent of the present invention may optionally contain a component having a viscosity increasing property as long as the effects of the present invention are not impaired.
• the powerful ingredients are cassia gum, dalcomannan, desilylated dielan gum, native dielane gum, natto bacteria gum, hydroxypropylcellulose (HPC), polybutylpyrrolidone (PVP), alginate, propylene glycol alginate, and gum arabic.
• gum thickeners such as tragacanth gum, gati gum, soy polysaccharide, macrohomopsis gum, ramzan gum, perlan gum, karaya gum, starch, processed starch, modified starch, fermented cellulose, agar and the like. These can be used alone or in any combination of two or more. These components are preferably water-soluble components.
• gum arabic, soybean polysaccharide, and karaya gum are used.
• ingredients include sweeteners (eg, high-intensity sweeteners such as sucralose, aspartame, acesulfame potassium, saccharin), natural or synthetic colorants, flavors, and acidulants (eg, taenoic acid, tartaric acid, ascorbic acid).
• sweeteners eg, high-intensity sweeteners such as sucralose, aspartame, acesulfame potassium, saccharin
• natural or synthetic colorants eg, taenoic acid, tartaric acid, ascorbic acid.
• Organic acids such as acids
• preservatives eg, sodium benzoate, potassium sorbate, etc.
• antioxidants eg, polyphenols such as tea catechins, anthocyanins, isoflavones, etc.
• various types of Extract chamomile, kidachi aloe, e Quinacea, hops, melissa, etc.
• amino acids minerals, vitamins, and the like.
• these components are also water-soluble components.
• the nicotine-reducing agent of the present invention comprises, as active ingredients, tamarind seed gum, locust bean gum, xanthan gum, cod gum, guar gum, pectin, punorelane, psyllium seed gum, methinoresenorelose, carboxymethylcellulose, and hydroxypropylmethylcellulose.
• the liquidity (pH) of the nicotine reducing agent of the present invention is not particularly limited, and can be set arbitrarily.
• the liquidity (pH) of pH 3-5, particularly pH 3.5-4.5, is weak. Acids can be mentioned.
• the nicotine reducing agent (aqueous liquid composition) of the present invention thus prepared is used while being held in a filter portion of a smoking article.
• the mode of holding is not particularly limited, and the nicotine reducing agent (aqueous liquid composition) of the present invention is provided to a part of the filter and held in a wet state (impregnation), and provided to a part of the filter and held in a dry state. Any of the embodiments may be adopted. Preferably, the wet state is maintained (impregnated) because of its high nicotine removing effect.
• the filter of the smoking article include a filter of a cigarette suction filter and a filter in a smoking pipe or a cigarette holder (used over the cigarette suction port). it can.
• the method of retaining the nicotine reducing agent (aqueous liquid composition) on a part of the filter of the smoking article is not particularly limited.
• a method of directly immersing a part of a filter of a smoking article in a liquid of a nicotine reducing agent (aqueous liquid composition) or a method of applying a nicotine reducing agent to a part of a filter can be mentioned.
• a suitable method is to apply a drop of the nicotine reducing agent (aqueous liquid composition) to one part of the filter of the smoking device (about 50 mg) to several drops, preferably one to five drops. Can be.
• the nicotine-reducing agent (aqueous liquid composition) of the present invention is not limited. It is preferred that the sharpness is good.
• the nicotine reducing agent (aqueous liquid composition) of the present invention when applied to a part of the filter, quickly penetrates and impregnates the part of the filter, and preferably spreads over the whole.
• the nicotine reducing agent (aqueous liquid composition) of the present invention when contained in a part of the filter of a smoking article and inhaled, the suction pressure increases and the inhalation becomes inconvenient. It is preferable that any inconvenience does not occur when the water is scattered.
• the nicotine reducing agent (aqueous liquid composition) of the present invention comprises, as basic components, tamarind seed gum, locust bean gum, xanthan gum, cod gum, guar gum, pectin, pullulan, psyllium seed gum, methylcellulose, carboxymethylcellulose, hydroxy Group strength consisting of pill methylcellulose and carrageenan Using at least one selected polysaccharide and, if necessary, combining the above-mentioned saccharides, the viscosity is 500 to 300 mPa's, preferably ⁇
• the above characteristics can be provided by being prepared as an aqueous liquid composition in the range of 500 to 2500 mPa's, more preferably ⁇ 1000 to 2500 mPa's.
• the preferred nicotine reducing agent (aqueous liquid composition) of the present invention has a stable viscosity and properties throughout the year because the change in viscosity due to temperature and storage is suppressed. For this reason, it has an appropriate viscosity that does not cause inconvenience to dripping or permeation into a part of the filter, which does not significantly increase the viscosity even at a low temperature in winter, and smoking (suction).
• the nicotine reducing agent (aqueous liquid composition) of the present invention is usually supplied to a factory in a state filled in a container.
• the container for containing the nicotine reducing agent is not particularly limited, but as described above, the nicotine reducing agent of the present invention is preferably used in the form of dropping. (Including the formula) is preferably filled in a container.
• the dropping type container is not particularly limited as long as it has a portion capable of dropping a liquid content (aqueous liquid composition) drop by drop.
• the container itself is a dropper, and the contents (aqueous liquid composition) can be dropped directly from the mouth of the container.
• the lid (cap) of the container has a dropper function. And the like, in which the contents are sucked out of the container and dropped.
• the size (capacity) of the container containing the nicotine reducing agent is not particularly limited. However, from the viewpoint of the use of the present invention, the single use amount, and the convenience of carrying, the size is usually one to one. 1 It is desirable that the size (volume) is large enough to accommodate the contents (aqueous liquid composition) of OO mL volume, preferably 2 to 20 mL.
• the present invention provides a smoking device for reducing nicotine.
• the smoking article of the present invention includes smoking articles such as cigarettes with a filter (hereinafter simply referred to as “cigarettes” to distinguish them from the tools used for smoking below), as well as smoking pipes (including ), Cigarette holders (which are used by covering the mouth of a paper roll, etc., including disposables), and cigarettes (including cigarettes and chopped tobaccos), etc., which are used by mounting them in the cigarette holder And cigar smokers (hereinafter simply referred to as "pipes” to distinguish them from the cigarettes mentioned above).
• the pipe includes at least a tobacco storage portion or a tobacco insertion port, a mouthpiece, a passage (conduit portion) which guides the smoke to the tobacco storage portion or the tobacco insertion force, and the above-described nicotine reducing agent of the present invention. (Holding portion) for holding the (aqueous liquid composition).
• the smoking article of the present invention comprises the above-mentioned nicotine-reducing agent (aqueous liquid composition) of the present invention, which is held in a filter part of the above-mentioned filter-fitted tobacco or the pipe holding section.
• a smoking device for reducing nicotine which can reduce the amount of nicotine sucked into the body during smoking.
• the holding portion of the noive is provided in a portion through which the mainstream smoke of tobacco passes, and is formed so as to hold the nicotine reducing agent (aqueous liquid composition) of the present invention.
• the material does not matter. For example, it can be formed by mounting or filling a part that also has a porous force, such as paper, nonwoven fabric, fiber and sponge, into a part where mainstream smoke of tobacco passes.
• examples of the material include cellulose acetate, fatty acid polyester conjugate, cellulose ester, and the like without limitation.
• the pipe (smoking implement) of the present invention has an effect of removing nicotine by passing mainstream smoke of tobacco through the holding section holding the nicotine reducing agent (aqueous liquid composition). It has an effect.
• the holding part of the pipe can be defined as a part of the filter. In this sense, in this specification, the holding portion of the pipe is Together with the saw filter part, it may be collectively referred to as "smoker's filter part”.
• the capacity of the filter (part of the cigarette filter, holding portion of the pipe) of the smoking article according to the present invention is not particularly limited.
• the nicotine reducing agent (aqueous liquid composition) preferably has a capacity to hold as much as possible as stably as possible, but the nicotine reducing agent (aqueous liquid composition) preferably has a capacity of at least about 50 to 250 mg, and preferably 50 to 250 mg. — As long as the volume is about 150 mg and can be held, normal use is not affected!
• cigarette holders ⁇ as shown in FIG. 1 and cigarette holders 11 as shown in FIGS. 2 to 7 may be exemplified as one embodiment of the smoking apparatus for reducing nicotine of the present invention.
• the cigarette holder 1 is provided with a filter 2 corresponding to a holding portion in the holder body, so that the nicotine reducing agent of the present invention can be held.
• the holder main body 2 has a suction port 4 at one end and a cigarette insertion port at the other end.
• the holder 1 main body 3 has a flat shape in the vicinity of the mouth portion 4 and in the vicinity thereof, so that it can be easily held by the mouth.
• the cigarette holder 11 provided by the present invention as one embodiment of a nicotine reducing smoking device is a cigarette holder in which the nicotine reducing agent of the present invention is previously held in a part of its filter.
• the cigarette holder 11 is provided with the filter 2 corresponding to the holding portion in the holder main body so that the nicotine reducing agent of the present invention can be held.
• the cigarette holder ⁇ ⁇ provided by the present invention as a nicotine-reducing smoking device may have the filter 2 in which the nicotine-reducing agent of the present invention is held in advance, or the nicotine-reducing agent of the present invention may be used during use.
• the agent may be used by providing it to a part of the filter and holding it.
• the holder body has a mouthpiece 4 at one end and a cigarette insertion port at the other end.
• the holder body has a flat shape in the vicinity of the mouth part 4 and in the vicinity thereof, so that the mouth is easily held.
• the cigarette holder 11 can further include a cap with a detachable tap on one side of the holder main body and a detachable lid z on the other side of the holder main body.
• the cap with clip 6 is located on the suction port 4 side of the holder body. It is attached, and the lid z is attached to the holder body tobacco insertion port side.
• a cap with a clip and a projection for insertion into the suction opening 4 are provided.
• the cap with clip and the lid By attaching the cap with clip and the lid to the holder body, volatilization that occurs when the filter is impregnated with a nicotine reducing agent can be prevented.
• the clip of the cap with clip can be kept in a breast pocket or the like when not smoking. It is preferable that the cap with clip has a shape similar to the cap attached to a normal pen.
• the cap with clip and the lid are detachably configured.
• the lid ⁇ can be fitted and attached to the opening £ of the cap with clip.
• the lid Z has a flange 1 ⁇ , and the flange 1 ⁇ serves as a stopper when the lid Z is fitted to the cap with clip ⁇ .
• the lid ⁇ can be prevented from being lost by attaching the lid ⁇ to the cap with clip and fastening it to the chest pocket etc. with the clip.
• the present invention provides a method for reducing the amount of nicotine in mainstream smoke of tobacco.
• the aforementioned nicotine reducing agent aqueous liquid composition
• a filter of a smoking article for example, a tobacco suction filter, or a filter of a smoking pipe or cigarette holder
• the mainstream of cigarettes is smoked during smoking. This can be done by passing smoke through the filter.
• the amount can be significantly reduced.
• the amount of tar in mainstream smoke can be significantly reduced by adding nicotine to coconut. Accordingly, the present invention is at the same time providing a method for reducing the amount of tar in mainstream smoke of tobacco.
• the amount of the nicotine reducing agent (aqueous liquid yarn composition) contained in the filter by further increasing the amount of the nicotine reducing agent (aqueous liquid yarn composition) contained in the filter, the amount of nicotine in the mainstream smoke and The amount of tar can be further reduced.
• the volume of the nicotine reducer (aqueous liquid composition) retained in the filter is not particularly limited as long as the volume can be retained in the filter. However, it can be exemplified in the range of usually equivalent to every few drops (about 50 to several hundred mg), preferably equivalent to every 5 drops (about 50 to 250 mg).
• the main cause of smoking cessation is said to be physical and psychological dependence on nicotine, which is contained in mainstream cigarette smoke. Therefore, according to the method for reducing nicotine according to the present invention, it is possible to reduce the amount of nicotine inhaled into the body while smoking, even in subjects who smoke regularly, thereby gradually reducing nicotine dependence. Can be alleviated. Further, according to the nicotine reducing agent of the present invention, the amount of nicotine in the mainstream smoke to be inhaled can be controlled by the smoker himself adjusting the amount of use (the amount applied to the filter). For this reason, smokers can gradually reduce their nicotine intake according to their dependence on nicotine, and eventually eliminate nicotine dependence and achieve smoking cessation.
• Tamarind Seed Gum Screw Top * D-2033, San-Ei Gen F 'F' I Co., Ltd.
• Locust Bean Gum Screw Top * D-30, Saneigen F 'F' I Co., Ltd.
• Xanthan gum San Ace * C, Saneigen F 'F' I Co., Ltd.
• Guar gum Screw top * D-2029, Saneigen F 'F' I Co., Ltd.
• Pullulan Pullulan PF-20 (fine powder), Hayashibara Co., Ltd.
• HM ⁇ Kuchin Screw Top * D-2220, Saneigen F 'F' I Co., Ltd.
• Lambda Laginan Carrageenin CSL-1, Saneigen F 'F' I Co., Ltd.
• Trehalose Treha fine powder (trade name), Hayashibara Water syrup (acid saccharified syrup): Syrup low (trade name), Kogo Starch Co., Ltd.
• Soybean polysaccharide SM-920 (trade name), Saneigen F 'F' I Co., Ltd.
• Trisodium citrate Trisodium citrate F (trade name), Saneigen F 'F' I Co., Ltd.
• Glycine glycine P (trade name), Organic Synthetic Chemical Industry
• L-ascorbic acid Pischoline 80M (trade name), Daiichi Fine Chemical Co., Ltd.
• Tea catechin SD green tea extract powder NO.16714, San-Ei Gen F 'F' I Co., Ltd.
• Licorice powder Licotin P-1 (trade name), Ikeda Saccharification Co., Ltd.
• An aqueous liquid composition (Examples 11 to 15) was prepared according to the formulation shown in Table 2. Specifically, first, the polysaccharides listed in Table 1 (tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, punorelane, psyllium seed gum, HMectin, LMpectin, ⁇ -force laginan, carboxymethylcellulose) ) And trehalose were added to the ion-exchanged water, and dissolved by stirring with heating at 80 ° C for 10 minutes.
• Table 1 tamarind seed gum, locust bean gum, xanthan gum, tara gum, guar gum, punorelane, psyllium seed gum, HMectin, LMpectin, ⁇ -force laginan, carboxymethylcellulose
• methylcellulose Example 14
• hydroxypropylmethylcellulose Example 15
• trehalose ion-exchanged water
• aqueous solution of sodium benzoate an aqueous solution of sodium benzoate, an aqueous solution of citrate, an aqueous solution of trisodium citrate, and an aqueous solution of a coloring agent (Red No. 2, Red No. 40) previously dissolved in ion-exchanged water were added and mixed. The total amount was adjusted to 100% by weight with ion-exchanged water to prepare each aqueous liquid composition (Examples 11 to 15).
• Example 11 to 15 The evaluation of the penetration property and the resorption property of each aqueous liquid composition (Examples 11 to 15) were all performed by the same person according to the following criteria. In addition, the evaluation of respiration was performed by inhaling and injecting mainstream smoke three times.
• Table 2 shows the results of the measurement and evaluation in (2) and (3) above. Also, Based on the results obtained in (2) and (3) above, the results evaluated according to the following criteria are shown in Table 2 as a comprehensive evaluation.
• Viscosity stability * 3 ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ Overall evaluation * 4 ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇
• aqueous liquid composition (Examples 16 to 25) was prepared according to the formulation shown in Table 3. Specifically, tamarind seed gum and xanthan gum and each of the sugars listed in Table 3 (trehalose, sucrose, gnorecose, funolectose, manoletoose, sonorebitone, manoretitone, erythritol, xylitol, dextrin) are added to ion-exchanged water. Then, the mixture was stirred with heating at 80 ° C for 10 minutes to dissolve.
• sugars listed in Table 3 trehalose, sucrose, gnorecose, funolectose, manoletoose, sonorebitone, manoretitone, erythritol, xylitol, dextrin
• each aqueous liquid composition (Examples 16 to 25) (adjusted to 20 ° C) obtained above was dropped on the tip of a part of the tobacco filter.
• the penetration of the liquid into the inside was evaluated (penetration evaluation).
• the property of sucking back into the mouth when smoking was evaluated (absorption! ⁇ return evaluation).
• Table 3 shows the results of the measurement and evaluation in (2) and (3) above.
• Table 3 shows the results of evaluation based on the same criteria as in Experimental Example 1 based on the results obtained in (2) and (3) above as comprehensive evaluation.
• aqueous liquid composition (Examples 26 to 29) was prepared according to the formulation shown in Table 4 by the following procedure.
• the viscosity of each of the obtained aqueous liquid compositions was measured using a B-type rotational viscometer (Rotor No. 3) under the conditions of 20 ° C., 60 rpm, and 1 minute.
• locust bean gum was added little by little and heated. After reaching 90 ° C, the mixture was further stirred and dissolved at 90 ° C for 10 minutes. Then, trehalose was added and further stirred, methylcellulose was added little by little, and cooled to 20 ° C. There, cunic acid, daricin, L-ascorbic acid, tea catechin, trisodium citrate, and licorice powder were added, and a coloring agent was further added. Note that citrate, glycine, L-ascorbic acid, and tea catechin were all dissolved in a small amount of water in advance and used.
• Trisodium citrate and licorice powder were used by dissolving trisodium citrate in a small amount of water and adding licorice powder to this. After preparation, the total amount (100% by weight) was corrected with water, filled into a container, and sterilized by heating at 65 ° C for 10 minutes to obtain an aqueous liquid composition (Example 26).
• solution A While stirring water at 80 ° C, tamarind seed gum and xanthan gum were added little by little, and the mixture was stirred and dissolved at 80 ° C for 10 minutes (solution A). Separately, a powder mixture of soybean polysaccharide and trehalose was added little by little while stirring water at 80 ° C, and dissolved at 80 ° C. Dalicin, adipic acid, L-ascorbic acid, and tea catechin were added to the mixture, and a small amount of trisodium citrate dissolved in water with licorice powder added and dissolved was added, and a coloring agent was added. (Solution B).
• Solution A, solution B and starch syrup are mixed together with stirring, then the total amount (100% by weight) is corrected with water, filled into a container, and then sterilized by heating at 65 ° C for 10 minutes to obtain an aqueous liquid composition (actually).
• Example 27 was obtained.
• Example 28 An aqueous liquid composition (Example 28) was obtained in the same manner as in Example 27 except that xanthan gum was not used.
• Example 29 An aqueous liquid composition (Example 29) was obtained in the same manner as in Example 27, except that tamarind seed gum was not used.
• Example 26 Of the aqueous liquid compositions obtained above (Examples 26-29), for the aqueous liquid composition of Example 26, the temperature was changed from 10 ° C to 40 ° C to change the state of the liquid. Observed. As a result, the aqueous liquid composition of Example 26 maintained a smooth state regardless of a temperature change (10 ° C. ⁇ 40 ° C.).
• aqueous liquid compositions of Examples 27 to 29 were stored at 37 ° C. and the viscosity was measured over time (3 days, 7 days, 10 days, 14 days, and 21 days after storage). , And 28 days), the viscosity stability was evaluated.
• the viscosity measurement conditions are the same as above.
• Table 5 shows the results.
• the viscosity stability is represented by a residual viscosity rate (%) calculated according to the formula described in Experimental Example 1 (2). [0073] [Table 5]
• Each of the aqueous liquid compositions of Examples 26-29 uniformly penetrates in about 15 seconds when dropped on the tip of a tobacco filter, and also has a problem that the liquid scatters in the mouth during smoking and that it is difficult to inhale. Hana was powerful.
• all of the filters after smoking have turned black, indicating that more nicotine and tar have been trapped in the tobacco filters than when the aqueous liquid composition was not impregnated. all right.
• one drop (approximately 50 mg) of the aqueous liquid composition of Example 27 was applied to the filter tip of tobacco (mild seven 'light, Japan Tobacco Inc .: nicotine content 0.7 mg, tar content 8 mg). ), 2 drops (about 100 mg), or 3 drops (about 150 mg), and immediately measured the amount of nicotine and tar contained in tobacco smoke.
• the amount of nicotine and the amount of tar contained in cigarette smoke were measured in the same manner as above, except that water (one, two, or three drops) was used instead of the aqueous liquid composition.
• the amount of nicotine and the amount of tar contained in the untreated tobacco smoke, which does not use the aqueous liquid composition and water, are set to 100%, respectively.
• the nicotine reduction rate (%) and tar reduction rate (%) were calculated from the contained nicotine amount and tar amount, respectively.
• the tobacco used for the measurement should be stored at 22 ⁇ 1 ° C and 60 ⁇ 2% humidity for at least 2 days and at least 7 days to prepare the conditions.
• Smoke collector Use a cigarette holder equipped with a glass fiber filter.
• the filter should be 44mm in diameter and 12mm in thickness and capable of collecting 99.9% or more of all octyl phthalate particles with a diameter of 0.3m or more at a speed of 140mmZ seconds.
• the filter pressure drop at this speed is less than 93 mmH 0 (900 Pa). Note that
• Carrier gas helium
• Chromosolve W washed with acid and distilled water coated with polyethylene glycol 20W (10% by weight) and potassium hydroxide (2% by weight), or equivalent or better performance
• Carrier gas helium or nitrogen
• Smoking waveform A bell type with a maximum value between 0.8 and 1.2 seconds from the start of smoking, with a maximum flow rate of 25-30 mlZ seconds.
• Crude tar amount [weight of smoke collector after smoking (mg)-weight of smoke collector before smoking (mg)] Z Number of smokers
• Inject 1 ⁇ l of the sample solution into the gas chromatograph calculate the ratio of the peak area of water to the peak area of ethanol, and (6) (Using the calibration curve created by the method of 0, calculate the amount of water in the sample solution (mg / This is measured to two decimal places (rounded down to three digits), and the average daily moisture content of the filter is subtracted from this value to obtain the moisture content in the crude tar, which is measured twice for each sample solution. And calculate the average value.
• the amount of tar ( mg / piece) is calculated to the second decimal place by subtracting the amount of water and nicotine in the crude tar from the amount of crude tar.
• FIG. 8 shows the results.
• the nicotine reducing agent (aqueous liquid composition) of the present invention by applying the nicotine reducing agent (aqueous liquid composition) of the present invention to a tobacco filter, both the amount of nicotine and the amount of tar contained in mainstream smoke of tobacco are reduced. % Or more. Further, as can be seen from the figure, the nicotine and tar reduction effect of the nicotine reducing agent (aqueous liquid composition) of the present invention is about 2 to 5 times that of the effect when only water is used. There is. Furthermore, as can be seen from the figure, the effect of reducing -cotin and tar increases as the amount of the nicotine reducing agent (aqueous liquid composition) provided to the tobacco filter is increased. Thus, by controlling the amount of the nicotine reducing agent (aqueous liquid composition) of the present invention (the amount applied to the filter), the amount of nicotine and tar contained in the mainstream smoke of tobacco can be appropriately controlled. You can see that you can do it.
• the nicotine reducing agent according to the present invention is contained in a part of the filter of the smoking device and smoked, so that the nicotine reducing agent in the nicotine power filter contained in the mainstream smoke of tobacco can be efficiently used. Captured and removed.
• the more preferable nicotine reducing agent according to the present invention can be dripped well on a part of the filter based on the fact that it has a specific polysaccharide and has an appropriate viscosity, and that after the dripping, the part of the filter becomes It spreads quickly and evenly between the fibers and stays in a part of the filter.
• the preferred nicotine reducing agent according to the present invention suppresses the change in viscosity due to temperature, so that even under low temperatures in winter, the nicotine reducing agent does not undesirably thicken under normal use conditions. And maintain an appropriate viscosity. As a result, even if it is outdoors in winter, it has the same viscosity as indoors, so that it is difficult to cause a problem that it is difficult to drip on a part of the filter.
• nicotine and tar components contained in mainstream smoke of tobacco are efficiently removed, and a part of the filter of the smoking device has a larger amount than in normal smoking. Nicotine and tar components will adhere.
• the nicotine-reducing agent of the present invention can be used for a filter in a smoking pipe or a cigarette holder.
• nicotine in mainstream smoke can be reduced by directly using the filter in a cigarette itself. In this case, the economic efficiency is improved compared to using a smoking pipe or cigarette holder, which can be discarded after smoking.
• the nicotine reducing agent according to the present invention also increases the amount of nicotine trapped in a part of the octopus filter as the amount of caroten in the smoking article increases. Therefore, by increasing the amount of the nicotine-reducing agent according to the present invention, the nicotine intake can be gradually reduced, so that the onset of nicotine dependence under smoking-free smoking is gradually alleviated and smoking cessation is achieved. It becomes possible.

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• 2005
  • 2005-02-18 MX MXPA06009506A patent/MXPA06009506A/es unknown
  • 2005-02-18 EP EP05719318A patent/EP1723860A4/en not_active Withdrawn
  • 2005-02-18 WO PCT/JP2005/002649 patent/WO2005079609A1/ja active Application Filing
  • 2005-02-18 RU RU2006133378/12A patent/RU2363361C2/ru active
  • 2005-02-18 JP JP2006519353A patent/JP3882125B2/ja not_active Expired - Fee Related
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