WO2005074885A1 - Procede de diffusion de molecules insolubles en milieu aqueux et composition mettant en oeuvre ce procede - Google Patents
Procede de diffusion de molecules insolubles en milieu aqueux et composition mettant en oeuvre ce procede Download PDFInfo
- Publication number
- WO2005074885A1 WO2005074885A1 PCT/FR2005/050062 FR2005050062W WO2005074885A1 WO 2005074885 A1 WO2005074885 A1 WO 2005074885A1 FR 2005050062 W FR2005050062 W FR 2005050062W WO 2005074885 A1 WO2005074885 A1 WO 2005074885A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lipophilic nature
- composition
- molecules
- composition according
- diffusion
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Definitions
- the inflammatory and painful affections of the bucco pharyngeal sphere are penalizing for the patients and it is necessary to note that the pharmacopoeia is poor to bring a fast, effective relief, of sufficient duration and limiting the side effects.
- bucco pharyngeal affections are of various origins and develop in the anterior part, on the mucous membranes of the floor and the walls of the mouth or on the posterior part, on the pharyngeal mucosa.
- the bucco pharyngeal sphere being a constant and privileged access route for all germs and irritant substances brought by the air and food routes.
- This mucous area is also a place of privileged development of bacterial populations, of more or less pathogenic viruses justifying a treatment of the inflammations which they generate.
- These inflammations can be more or less significant and debilitating ranging from the simple sensation of localized discomfort to the presence of macroscopically visible lesions of the type of those generated by aphtoses. Such inflammations are often devoid of major clinical signs such as fever or lymph node formations.
- One solution is to use powerful anti-inflammatory drugs that reduce pain while also treating associated inflammation.
- Such a galenical formulation has the advantage of giving the composition pharmaceutical stability over time for the active ingredients used.
- - ibuprofen lysinate 25 mg - magnesium stearate: 10 mg - talc: 50 mg - aspartame: 15 mg - metolose: 70 mg - flavor: 20 mg - sorbitol: 810 mg
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0506615-8A BRPI0506615A (pt) | 2004-02-03 | 2005-02-01 | composição de moléculas de estrutura lipofìlica, comprimido e utilização de uma composição |
US10/588,005 US8846083B2 (en) | 2004-02-03 | 2005-02-01 | Method for the diffusion of molecules which are insoluble in an aqueous medium and composition using said method |
EP05726342.8A EP1711162B1 (fr) | 2004-02-03 | 2005-02-01 | Composition pour l'utilisation dans le traitement local des affections bucco-pharyngées comprenant de l'ibuprofène ou du kétoprofène |
ES05726342.8T ES2657048T3 (es) | 2004-02-03 | 2005-02-01 | Composición para la utilización en el tratamiento local de afecciones bucofaríngeas que comprende ibuprofeno o ketoprofeno |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0450194A FR2865648B1 (fr) | 2004-02-03 | 2004-02-03 | Procede de diffusion de molecules insolubles en milieu aqueux et composition mettant en oeuvre ce procede |
FR0450194 | 2004-02-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2005074885A1 true WO2005074885A1 (fr) | 2005-08-18 |
Family
ID=34746529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2005/050062 WO2005074885A1 (fr) | 2004-02-03 | 2005-02-01 | Procede de diffusion de molecules insolubles en milieu aqueux et composition mettant en oeuvre ce procede |
Country Status (8)
Country | Link |
---|---|
US (1) | US8846083B2 (fr) |
EP (1) | EP1711162B1 (fr) |
BR (1) | BRPI0506615A (fr) |
ES (1) | ES2657048T3 (fr) |
FR (1) | FR2865648B1 (fr) |
PT (1) | PT1711162T (fr) |
RU (1) | RU2388468C2 (fr) |
WO (1) | WO2005074885A1 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2065038A1 (fr) * | 2007-11-30 | 2009-06-03 | Pharnext | Nouvelles approches thérapeutiques pour traiter la maladie de Charcot-Marie-Tooth |
EP2263665A1 (fr) | 2009-06-02 | 2010-12-22 | Pharnext | Nouvelles compositions pour traiter le CMT et troubles associés |
US9393241B2 (en) | 2009-06-02 | 2016-07-19 | Pharnext | Compositions for treating CMT and related disorders |
BR112012013503B8 (pt) | 2009-12-03 | 2021-05-25 | Alcon Res Llc | composição de suspensão oftálmica aquosa topicamente administrável, e método para manter sua viscosidade |
FR2997856B1 (fr) | 2012-11-14 | 2015-04-24 | Pf Medicament | Pastille medicamenteuse a base d'ibuprofene sodique dihydrate |
ES2691309T3 (es) | 2013-06-05 | 2018-11-26 | Pharnext | Soluciones orales estables para API combinados |
US10383870B2 (en) | 2016-06-10 | 2019-08-20 | Pharnext | Early treatment of CMT disease |
EP3508199A1 (fr) * | 2018-01-05 | 2019-07-10 | Dompé farmaceutici S.p.A. | Compositions pharmaceutiques à libération immédiate contenant un sel de lysine de kétoprofène |
WO2021105524A1 (fr) * | 2019-11-25 | 2021-06-03 | Mmc International Health Holding, S.L. | Composition pharmaceutique de sel d'ibuprofène avec de la lysine sous forme de solution orale |
Citations (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1103686A (en) * | 1965-12-08 | 1968-02-21 | Roussel Uclaf | Pharmaceutical compositions, and the active ingredients thereof |
EP0137668A2 (fr) * | 1983-08-31 | 1985-04-17 | The Upjohn Company | Ibuprofen, flurbiprofen et leur utilisation en thérapeutique |
EP0159604A2 (fr) * | 1984-04-09 | 1985-10-30 | Toyo Boseki Kabushiki Kaisha | Préparation à libération retardée applicable aux muqueuses de la cavité buccale |
WO1992000725A1 (fr) * | 1990-07-13 | 1992-01-23 | Farcon Ag | Compositions pharmaceutiques liquides de traitement oral presentant une activite anti-inflammatoire |
EP0523847A1 (fr) * | 1991-06-14 | 1993-01-20 | McNEIL-PPC, INC. | Enrobage masquant le mauvais goût pour la préparation de comprimés à mâcher pharmaceutiques |
WO1995008988A1 (fr) * | 1993-09-29 | 1995-04-06 | Werner Korsatko | Comprime contenant une masse de base contenant le cas echeant des principes actifs et des microparticules contenant des principes actifs |
WO1995015137A1 (fr) * | 1993-12-01 | 1995-06-08 | Rutgers, The State University Of New Jersey | Dispositif muco-adhesif pour l'apport a la cavite buccale d'associations medicamenteuses a action prolongee |
WO1997004808A1 (fr) * | 1995-07-28 | 1997-02-13 | The Procter & Gamble Company | Compositions contenant des analgesiques et des antihistaminiques et procedes de traitement d'affections respiratoires |
WO1997020572A1 (fr) * | 1995-12-06 | 1997-06-12 | Synthelabo | Compositions pharmaceutiques pour application buccale comprenant un nsaid et des ceramides |
WO1997026866A2 (fr) * | 1996-01-23 | 1997-07-31 | Basf Aktiengesellschaft | Preparations d'analgesiques non steroidiens |
WO1998052540A1 (fr) | 1997-05-22 | 1998-11-26 | The Boots Company Plc | Compositions pharmaceutiques |
WO1998052539A1 (fr) * | 1997-05-22 | 1998-11-26 | The Boots Company Plc | Procede de production de pastilles de flurbiprofene |
EP0935961A2 (fr) * | 1998-01-28 | 1999-08-18 | Dompé S.P.A. | Sels de l'acide (R)-2-(3-benzoylphenyl)propionique et préparations pharmaceutiques qui les contiennent |
WO2002067916A2 (fr) * | 2001-02-28 | 2002-09-06 | Grünenthal GmbH | Sels pharmaceutiques |
WO2002083119A1 (fr) * | 2001-04-10 | 2002-10-24 | The Boots Company Plc | Composition pharmaceutique contenant de l'ibuprofene et de la prochlorperazine |
WO2003043600A1 (fr) * | 2001-11-20 | 2003-05-30 | Apr Applied Pharma Research Sa | Compositions pharmaceutiques non effervescentes hydrosolubles contenant un anti-inflammatoire non steroidien |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4028906A1 (de) * | 1990-09-12 | 1992-03-19 | Paz Arzneimittelentwicklung | Arzneimittel sowie deren herstellung und deren verwendung bei der bekaempfung von schmerzen und/oder entzuendungen und/oder fieber an tieren und menschen |
CN1130354A (zh) * | 1993-09-07 | 1996-09-04 | 普罗克特和廿保尔公司 | 含有丙酸类非甾体消炎药氨基酸盐和减充血药、祛痰药、抗组胺药和镇咳药中至少一种的组合物 |
DE4428668C1 (de) * | 1994-08-12 | 1995-09-14 | Heinr Borgwaldt Gmbh | Verfahren und Vorrichtung zum Beschicken einer Rauchmaschine |
GB9523833D0 (en) * | 1995-11-22 | 1996-01-24 | Boots Co Plc | Medical treatment |
CA2243522C (fr) | 1996-01-23 | 2007-05-22 | Basf Aktiengesellschaft | Preparations d'analgesiques non steroidiens |
DE19733505A1 (de) * | 1997-08-01 | 1999-02-04 | Knoll Ag | Schnell wirksames Analgeticum |
WO1999052528A1 (fr) * | 1998-04-11 | 1999-10-21 | Errekappa Euroterapici S.P.A. | Preparations pharmaceutiques a base de sels de ketoprofene hydrosoluble et applications correspondantes |
DE19931708A1 (de) * | 1999-07-08 | 2001-01-18 | Bayer Ag | Verfahren zur Herstellung schnell zerfallender, fester pharmazeutischer Zubereitungen |
DE60128215T2 (de) * | 2000-04-20 | 2008-01-10 | Novartis Ag | Beschichtungszusammensetzung zur geschmacksmaskierung |
-
2004
- 2004-02-03 FR FR0450194A patent/FR2865648B1/fr not_active Expired - Fee Related
-
2005
- 2005-02-01 RU RU2006131601/15A patent/RU2388468C2/ru not_active IP Right Cessation
- 2005-02-01 EP EP05726342.8A patent/EP1711162B1/fr not_active Revoked
- 2005-02-01 US US10/588,005 patent/US8846083B2/en not_active Expired - Fee Related
- 2005-02-01 BR BRPI0506615-8A patent/BRPI0506615A/pt not_active Application Discontinuation
- 2005-02-01 PT PT57263428T patent/PT1711162T/pt unknown
- 2005-02-01 WO PCT/FR2005/050062 patent/WO2005074885A1/fr active Application Filing
- 2005-02-01 ES ES05726342.8T patent/ES2657048T3/es active Active
Patent Citations (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1103686A (en) * | 1965-12-08 | 1968-02-21 | Roussel Uclaf | Pharmaceutical compositions, and the active ingredients thereof |
EP0137668A2 (fr) * | 1983-08-31 | 1985-04-17 | The Upjohn Company | Ibuprofen, flurbiprofen et leur utilisation en thérapeutique |
EP0159604A2 (fr) * | 1984-04-09 | 1985-10-30 | Toyo Boseki Kabushiki Kaisha | Préparation à libération retardée applicable aux muqueuses de la cavité buccale |
WO1992000725A1 (fr) * | 1990-07-13 | 1992-01-23 | Farcon Ag | Compositions pharmaceutiques liquides de traitement oral presentant une activite anti-inflammatoire |
EP0523847A1 (fr) * | 1991-06-14 | 1993-01-20 | McNEIL-PPC, INC. | Enrobage masquant le mauvais goût pour la préparation de comprimés à mâcher pharmaceutiques |
WO1995008988A1 (fr) * | 1993-09-29 | 1995-04-06 | Werner Korsatko | Comprime contenant une masse de base contenant le cas echeant des principes actifs et des microparticules contenant des principes actifs |
WO1995015137A1 (fr) * | 1993-12-01 | 1995-06-08 | Rutgers, The State University Of New Jersey | Dispositif muco-adhesif pour l'apport a la cavite buccale d'associations medicamenteuses a action prolongee |
WO1997004808A1 (fr) * | 1995-07-28 | 1997-02-13 | The Procter & Gamble Company | Compositions contenant des analgesiques et des antihistaminiques et procedes de traitement d'affections respiratoires |
WO1997020572A1 (fr) * | 1995-12-06 | 1997-06-12 | Synthelabo | Compositions pharmaceutiques pour application buccale comprenant un nsaid et des ceramides |
WO1997026866A2 (fr) * | 1996-01-23 | 1997-07-31 | Basf Aktiengesellschaft | Preparations d'analgesiques non steroidiens |
WO1998052540A1 (fr) | 1997-05-22 | 1998-11-26 | The Boots Company Plc | Compositions pharmaceutiques |
WO1998052539A1 (fr) * | 1997-05-22 | 1998-11-26 | The Boots Company Plc | Procede de production de pastilles de flurbiprofene |
EP0935961A2 (fr) * | 1998-01-28 | 1999-08-18 | Dompé S.P.A. | Sels de l'acide (R)-2-(3-benzoylphenyl)propionique et préparations pharmaceutiques qui les contiennent |
WO2002067916A2 (fr) * | 2001-02-28 | 2002-09-06 | Grünenthal GmbH | Sels pharmaceutiques |
WO2002083119A1 (fr) * | 2001-04-10 | 2002-10-24 | The Boots Company Plc | Composition pharmaceutique contenant de l'ibuprofene et de la prochlorperazine |
WO2003043600A1 (fr) * | 2001-11-20 | 2003-05-30 | Apr Applied Pharma Research Sa | Compositions pharmaceutiques non effervescentes hydrosolubles contenant un anti-inflammatoire non steroidien |
Non-Patent Citations (1)
Title |
---|
See also references of EP1711162A1 |
Also Published As
Publication number | Publication date |
---|---|
PT1711162T (pt) | 2018-02-07 |
US20070110801A1 (en) | 2007-05-17 |
US8846083B2 (en) | 2014-09-30 |
ES2657048T3 (es) | 2018-03-01 |
EP1711162B1 (fr) | 2017-11-01 |
EP1711162A1 (fr) | 2006-10-18 |
FR2865648B1 (fr) | 2006-06-30 |
FR2865648A1 (fr) | 2005-08-05 |
RU2388468C2 (ru) | 2010-05-10 |
BRPI0506615A (pt) | 2007-05-02 |
RU2006131601A (ru) | 2008-03-10 |
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