WO2005067934A1 - Verwendung von substituierten pyrimido[5,4-d]pyrimidinen zur behandlung von atemwegserkrankungen - Google Patents
Verwendung von substituierten pyrimido[5,4-d]pyrimidinen zur behandlung von atemwegserkrankungen Download PDFInfo
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- WO2005067934A1 WO2005067934A1 PCT/EP2005/000163 EP2005000163W WO2005067934A1 WO 2005067934 A1 WO2005067934 A1 WO 2005067934A1 EP 2005000163 W EP2005000163 W EP 2005000163W WO 2005067934 A1 WO2005067934 A1 WO 2005067934A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
Definitions
- the invention relates to the use of pyrimido [5,4-d] pyrimidines for the treatment of inflammatory and obstructive respiratory diseases, preferably asthma or COPD, and pharmaceutical compositions which contain these compounds.
- Inflammatory and obstructive respiratory diseases belong to the group of progressive respiratory diseases, which include characterized by breathing difficulties. These respiratory problems are usually associated with chronic inflammation of the airways, in which different cells play a role, especially macrophages, neutrophils and CD8 T lymphocytes.
- the object of the present invention is to provide a medicament for the treatment of inflammatory and obstructive respiratory diseases. Furthermore, it is an object of the present invention to provide medicaments for the treatment of inflammatory and obstructive respiratory diseases which are characterized by fewer side effects, in particular emesis and nausea.
- Pyrimido [5,4-dJ ⁇ yrimidines are known from the prior art as active substances with an antiproliferative effect.
- DE 1151806 describes pyrimido [5,4-d] pyrimidines as corona dilators.
- EP 23559 describes 2- (perhydro-1,4-diazino) pyrimido [5,4-d] pyrimidines as having an inhibitory effect on the aggregation of cancer cells washed into the bloodstream.
- EP 55444 describes trisubstituted pyrimido [5,4-d] pyrimidines as
- pyrimido [5,4-d] pyrimidines are suitable for the treatment of respiratory diseases, in particular inflammatory and obstructive respiratory diseases.
- Preferred is the use of substituted pyrimido [5,4-d] pyrimidines for the manufacture of a medicament for the treatment of inflammatory or obstructive respiratory diseases, particularly preferably COPD or asthma.
- substituted pyrimido [5,4-d] pyrimidines is particularly preferred. for the manufacture of a medicament for the treatment of inflammatory or obstructive respiratory diseases, particularly preferably COPD or asthma with simultaneous reduction of the side effects, in particular emesis or nausea.
- R 1 and R 2 is H or a residue selected from the group consisting of -C ⁇ -6 alkyl, -C 3-8 cycloalkyl and -C ⁇ . 6 -alkyl-O-C ⁇ . 6- alkyl, which may be one or can be substituted several times by one or more radicals selected from the group consisting of aryl, -CF 3 , -CN, -CONR 4 R 5 , -COOR 4 , -COR 6 , halogen, hetaryl, hetcycle, -NO 2 , - NR 4 COR 6 , -NR 4 R 5 , -NR 4 SO 2 R 4 , -OR 4 , -SO 2 NR 4 R 5 , -SO 2 R 4 , -SOR 4 and -SR 4 or
- R 1 and R 2 forms together with the nitrogen form a ring which optionally may be mono- or polysubstituted by one or more radicals selected from the group consisting of aryl, -C ⁇ -6 alkyl-OH ,, - CF 3, - CN, -CONR 4 R 5 , -COOR 4 , -COR 6 , halogen, hetaryl, hetcycle, -NO 2 , -NR 4 COR 6 , -NR 4 R 5 , -NR 4 SO 2 R 4 , -O-C ⁇ -6- alkyl, -OR 4 , -SO 2 NR 4 R 5 , -SO 2 R 4 , -SOR 4 and -SR 4 ;
- R 4 and R 5 independently of one another H, -C ⁇ . 6 alkyl
- R 6 H -C ⁇ . 6 -alkyl, -C 1-6 -alkyl-CO-C ⁇ -6 -alkyl, hetaryl, hetcycle, -NR 4 R 5 ;
- R 7 hetaryl, hetaryl fused with hetcyclus, hetcyclus or phenyl, which may optionally be mono- or polysubstituted with one or more substituents selected from the group consisting of -Ci-e-alkyl, -OC 1-6 -alkyl, halogen, -NO 2 and -CF 3 ;
- -NR 4 -, -S-, -O- means; as well as pharmacologically acceptable acid addition salts, tautomeric and isomeric forms or mixtures and individual geometric or optical isomers, in particular racemic or non-racemic mixtures of the isomers thereof.
- R 1 and R 2 together with the nitrogen form a ring which can optionally be substituted one or more times by one or more radicals selected from the group consisting of. 6- alkyl-OH, -CONR 4 R 5 , -COOR 4 , -COR 6 , -NR 4 COR 6 , -NR 4 R 5 , -NR 4 SO 2 R 4 , -OC 1-6 -alkyl, -OR 4 , -SO 2 NR 4 R 5 , -SO 2 R 4 , -SOR 4 and -SR 4 ;
- R 4 and R 5 are independently H, -C ⁇ -6 -alkyl
- R 6 H -de-alkyl, -C 1-6 -alkyl-CO-C 1 .
- 6 is alkyl, hetaryl, hetcycle, NR 4 R 5 ;
- R 3 H or a radical selected from the group consisting of -C 1-8 alkyl, -C 3-8 cycloalkyl, -C 1-6 alkyl R 7 and phenyl which may be annealed or substituted one or more times can be selected by one or more radicals from the group consisting of -CF 3 , -CN, -CONR 4 R 5 , -COOR 4 , -COR 4 , halogen, -NO 2 , -NR 4 COR 4 , -NR 4 R 5 , -NR 4 SO 2 R 4 , -OR 4 and -SR 4 ;
- R 7 hetaryl, hetaryl fused with hetcyclus, hetcyclus or phenyl, which may optionally be substituted one or more times with one or several substituents selected from the group consisting of -C 1-6 alkyl, -OC 1-6 alkyl, halogen, -NO and -CF 3 ;
- X is -S-, -S (O) -, -S (O 2 ) -;
- Y is -NR 4 -, -S-, -O-; as well as pharmacologically acceptable acid addition salts, tautomeric and isomeric forms or mixtures and individual geometric or optical isomers, in particular racemic or non-racemic mixtures of the isomers thereof.
- R 1 and R 2 H or a radical selected from the group consisting of -C ⁇ . 6 -a! Kyl, -C 3-8 -cycloalkyl and -C ⁇ -6 -alkyl-O-C ⁇ . 6- alkyl, which may be mono- or polysubstituted by one or more radicals selected from the group consisting of -OH, -NR 4 R 5 , morpholinyl and ⁇ pyridyl or
- R 1 and R 2 together with the nitrogen form a ring selected from the group consisting of morpholinyl, thiomorpholinonyl, piperidyl and piperazinyl which may be substituted one or more times by one or more radicals selected from the group consisting of -OH, -de -alkyl-OH, -OC 1-6 -alkyl, -COOR 4 , -NR 4 R 5 , -CO-NR 4 R 5 , -COR 6 and -NH-COR 6 ;
- R 4 and R 5 independently of one another H, -C ⁇ . 6 alkyl
- R 6 H -C 1-6 -alkyl, -NR 4 R 5 , -d- 6 -alkyl-CO-C ⁇ -6 -alkyl, furanyl, thiophenyi;
- R 7 furanyl, 2,3-dihydro-1H-inden-2-yl, naphthyl, 1, 3-benzodioxole or phenyl, which may optionally be substituted one or more times with one or more substituents selected from the group consisting of - d -6 -alkyl, -O-C ⁇ -6 -alkyl, halogen, -NO 2 and -CF 3 ;
- X is -S-, -S (O) -, -S (O 2 ) -;
- Y is -NR 4 -, -S-, -O-;
- R 1 Ci- ⁇ -alkyl, -C 3 . 8 -cycloalkyl or -C ⁇ -6 -alkyl-OC 1 . 6- alkyl, which may optionally be mono- or polysubstituted by one or more radicals selected from the group consisting of -OH, -NR 4 R 5 , morpholinyl and pyridyl or
- R 2 H or -C 1-6 alkyl
- R 4 and R 5 are independently H, -d -6 -alkyl
- -ds-alkyl -C 3 . 8 -cycloalkyl, -de-alkyl-R 7 or phenyl, which may optionally be annealed or substituted one or more times by one or more radicals selected from the group consisting of -CF 3 , -COOR 4 , halogen, -NO 2 , -NR 4 R 5 , -OR 4 and -SR 4 ;
- R 7 furanyl, 2,3-dihydro-1H-inden-2-yl, naphthyl, 1, 3-benzodioxole or phenyl, which may optionally be substituted one or more times with one or more substituents selected from the group consisting of - d -6- alkyl, -OC 1-6 -alkyl, halogen, -NO 2 and -CF 3 ;
- X is -S-, -S (O) -, -S (O 2 ) -;
- Y is -S-
- R 2 H or -C ⁇ -6 -alkyl
- R 4 and R 5 are independently H, -C 1-6 alkyl
- X is -S-, -S (O) -, -S (O 2 ) -;
- Y is -S-
- R 7 furanyl, 2,3-dihydro-1H-inden-2-yl, naphthyl, 1, 3-benzodioxole or phenyl, which may optionally be substituted one or more times with one or more substituents selected from the group consisting of - C ⁇ . 6 -alkyl, -Od- 6 -alkyl, halogen, -NO 2 and -CF 3 ;
- X is -S-, -S (O) -, -S (O 2 ) -;
- Y is -S-
- R 7 furanyl, 2,3-dihydro-1H-inden-2-yl, naphthyl, 1, 3-benzodioxole or phenyl, which may optionally be substituted one or more times with one or more substituents selected from the group consisting of - C 1-6 alkyl, -OC 1-6 alkyl, halogen, -NO 2 and -CF 3 ;
- X is -S-, -S (O) -, -S (O 2 ) -;
- Y is -S-
- Another aspect of the invention form medicaments for the treatment of respiratory diseases, which contain one or more of the above-mentioned pyrimido [5,4-d] - pyrimidines of the general formula 1, which in combination with one or several additional active substances selected from the group of anticholinergics, steroids or ⁇ -agonists, together or in succession, can be used for simultaneous, sequential or separate administration.
- compositions are therefore preferably characterized by the content of one or more compounds of the formula 1 according to the preferred embodiments above.
- the present invention preferably relates to the use of compounds of general formula 1 for the manufacture of a medicament for the treatment of inflammatory or obstructive diseases of the upper and lower respiratory organs, including the lungs, such as, for example, allergic rhinitis, chronic rhinitis, bronchiectasis, cystic fibrosis, asthma, COPD, idiopathic pulmonary fibrosis and fibrosing alveolitis.
- inflammatory or obstructive diseases of the upper and lower respiratory organs, including the lungs such as, for example, allergic rhinitis, chronic rhinitis, bronchiectasis, cystic fibrosis, asthma, COPD, idiopathic pulmonary fibrosis and fibrosing alveolitis.
- the compounds of general formula 1 can be used alone or in combination with other compounds of general formula 1 according to the invention, optionally also in combination with other pharmacologically active substances.
- Anticholinergics ipratropium, oxitropium, tiotropium
- steroids or ⁇ 2 agonists albuterol, salmeterol, formoterol
- albuterol, salmeterol, formoterol may be mentioned as further pharmacologically active substances.
- Suitable forms of use are, for example, tablets, capsules, solutions, juices, emulsions or inhalation powder or aerosols.
- the proportion of the pharmaceutically active compound (s) should in each case be in the range from 0.1 to 90% by weight, preferably 0.5 to 50% by weight, of the total composition, i.e. in amounts sufficient to reach the dosage range given below.
- Oral administration can take the form of a tablet, a powder, a powder in a capsule (eg hard gelatin capsule), a solution or a suspension.
- the active ingredient combination can be in the form of a powder, an aqueous or aqueous-ethanolic solution or by means of a propellant gas formulation. It is preferred if the compounds of the general formula 1 are administered orally, it is particularly preferred if the administration is carried out once or twice a day.
- Corresponding tablets can be obtained, for example, by mixing the active ingredient (s) with known auxiliaries, for example inert diluents such as calcium carbonate, calcium phosphate or lactose, disintegrants such as corn starch or alginic acid, binders such as starch or gelatin, lubricants such as magnesium stearate or talc, and / or agents to achieve the depot effect, such as carboxymethyl cellulose, cellulose acetate phthalate, or polyvinyl acetate.
- auxiliaries for example inert diluents such as calcium carbonate, calcium phosphate or lactose, disintegrants such as corn starch or alginic acid, binders such as starch or gelatin, lubricants such as magnesium stearate or talc, and / or agents to achieve the depot effect, such as carboxymethyl cellulose, cellulose acetate phthalate, or polyvinyl acetate.
- auxiliaries for example inert d
- coated tablets can be produced by coating cores produced analogously to the tablets with agents conventionally used in tablet coatings, for example collidone or shellac, gum arabic, talc, titanium dioxide or sugar.
- the core can also consist of several layers to achieve a deposit effect or to avoid incompatibilities. The same can also
- Drage cover to achieve a depot effect consist of several layers, wherein the excipients mentioned above for the tablets can be used.
- Juices of the active substances or combinations of active substances according to the invention are Juices of the active substances or combinations of active substances according to the invention.
- a sweetener such as saccharin, cyclamate, glycerin or sugar as well as a taste-improving agent, e.g. Flavorings, such as vanillin or orange extract, contain. They can also contain suspending agents or thickening agents, such as sodium carboxymethyl cellulose, wetting agents, for example condensation products of fatty alcohols with ethylene oxide, or protective agents, such as p-hydroxybenzoates.
- the capsules containing one or more active ingredients or combinations of active ingredients can be produced, for example, by mixing the active ingredients with inert carriers, such as milk sugar or sorbitol, and encapsulating them in gelatin capsules.
- Suitable suppositories can be produced, for example, by mixing them with carriers, such as neutral fats or polyethylene glycol or its derivatives.
- auxiliaries are water, pharmaceutically acceptable organic solvents such as paraffins (for example petroleum fractions), oils of vegetable origin (for example peanut or sesame oil), monofunctional or polyfunctional alcohols (for example ethanol or glycerol), carriers such as natural rock meal (for example kaolins, Clays, talc, chalk) synthetic rock flour (e.g.
- silica and silicates highly disperse silica and silicates
- sugar e.g. cane, milk and dextrose
- emulsifiers e.g. lignin, sufite liquor, methyl cellulose, starch and polyvinylpyrrolidone
- lubricants e.g. magnesium stearate, talc, stearic acid and Sodium lauryl sulfate
- the tablets can of course also contain additives, such as e.g. Contain sodium citrate, calcium carbonate and dicalcium phosphate together with various additives such as starch, preferably potato starch, gelatin and the like.
- Lubricants such as magnesium stearate, sodium lauryl sulfate and talc can also be used for tableting.
- the active ingredients can be mixed with various flavor enhancers or colorants.
- the compounds of general formula 1 are inhaled. are administered, it is particularly preferred if the administration takes place once or twice a day.
- the compounds of general formula 1 must be provided in inhalable dosage forms.
- Inhalable dosage forms are inhalable powders, metered-dose aerosols containing propellant gas, or propellant-free inhalation solutions, which are optionally present in a mixture with customary physiologically tolerable auxiliaries.
- propellant-free inhalation solutions also includes concentrates or sterile, ready-to-use inhalation solutions.
- the dosage forms which can be used in the context of the present invention are described in detail in the following part of the description.
- a mixture with physiologically acceptable auxiliaries can be used to represent the invention
- physiologically harmless adjuvants are used: monosaccharides (e.g. glucose or arabinose), disaccharides (e.g. lactose, sucrose, maltose), oligo- and polysaccharides (e.g. dextrans), polyalcohols (e.g. sorbitol, mannitol, xylitol), salts (e.g. Sodium chloride, calcium carbonate) or mixtures of these auxiliaries with one another.
- monosaccharides e.g. glucose or arabinose
- disaccharides e.g. lactose, sucrose, maltose
- oligo- and polysaccharides e.g. dextrans
- polyalcohols e.g. sorbitol, mannitol, xylitol
- salts e.g. Sodium chloride, calcium carbonate
- lactose or glucose being preferred, particularly but not exclusively in the form of their hydrates.
- Lactose most preferably lactose monohydrate, is used as an auxiliary as particularly preferred in the sense of the invention.
- Processes for producing the inhalable powders according to the invention by grinding and micronizing and by finally mixing the constituents are known from the prior art.
- the inhalable aerosols containing propellant gas which can be used in the context of the use according to the invention can contain 1 dissolved in the propellant gas or in dispersed form.
- the propellant gases which can be used to produce the inhalation aerosols are known from the prior art. Suitable propellants are selected from the group consisting of hydrocarbons such as n-propane, n-butane or isobutane and halogenated hydrocarbons such as preferably fluorinated derivatives of methane, ethane, propane, butane, cyclopropane or cyclobutane.
- the above-mentioned propellant gases can be used alone or in mixtures thereof.
- propellants are fluorinated alkane derivatives selected from TG134a (1, 1, 1, 2-tetrafluoroethane), TG227 (1, 1, 1, 2,3,3,3-heptafluoropropane) and mixtures thereof.
- the inhalable aerosols containing propellant gas which can be used in the context of the use according to the invention can furthermore contain further constituents, such as cosolvents, stabilizers, surfactants, antioxidants, lubricants and agents for adjusting the pH. All of these components are known in the art.
- Propellant-free inhalation solutions The use of compounds of the general formula 1 according to the invention is preferably used for the production of propellant-free inhalation solutions and inhalation suspensions.
- Suitable solvents for this purpose are aqueous or alcoholic, preferably ethanolic, solutions.
- the solvent can only be water or it is a mixture of water and ethanol.
- the solutions or suspensions are adjusted to a pH of 2 to 7, preferably 2 to 5, using suitable acids. Acids selected from inorganic or organic acids can be used to adjust this pH. Examples of particularly suitable inorganic acids are hydrochloric acid, hydrobromic acid, nitric acid, sulfuric acid and / or phosphoric acid.
- organic acids examples include: ascorbic acid, citric acid, malic acid, tartaric acid, maleic acid, succinic acid, fumaric acid, acetic acid, formic acid and / or propionic acid and others.
- Preferred inorganic acids are hydrochloric acid, sulfuric acid. It is also possible to use the acids which already form an acid addition salt with one of the active ingredients.
- organic acids are ascorbic acid, citric acid, malic acid, tartaric acid, maleic acid, succinic acid, fumaric acid, acetic acid, formic acid and / or propionic acid and others.
- Preferred inorganic acids are hydrochloric acid, sulfuric acid. It is also possible to use the acids which already form an acid addition salt with one of the active ingredients.
- organic acids are ascorbic acid,
- Fumaric acid and citric acid preferred. If necessary, mixtures of the acids mentioned can also be used, especially in cases of acids which, in addition to their acidifying properties, also have other properties, e.g. as flavors, antioxidants or complexing agents, such as citric acid or ascorbic acid. According to the invention, hydrochloric acid is particularly preferably used to adjust the pH.
- Co-solvents and / or other auxiliaries can be added to the propellant-free inhalation solutions which can be used in the context of the use according to the invention.
- Preferred co-solvents are those which contain hydroxyl groups or other polar groups, for example alcohols - in particular isopropyl alcohol, glycols - in particular propylene glycol, polyethylene glycol, polypropylene glycol, glycol ether, glycerol, polyoxyethylene alcohols and polyoxyethylene fatty acid esters.
- auxiliaries and additives are understood to mean any pharmacologically acceptable substance that is not an active ingredient, but together with the (the)
- Active ingredient (s) can be formulated in the pharmacologically suitable solvent in order to improve the qualitative properties of the active ingredient formulation. These substances preferably have no or no significant or at least no undesirable pharmacological effect in the context of the desired therapy.
- the auxiliaries and additives include, for example, surface-active substances, such as, for example, soy lecithin, oleic acid, sorbitan esters, such as polysorbates, polyvinylpyrrolidone, other stabilizers, complexing agents, antioxidants and / or preservatives which guarantee or extend the useful life of the finished pharmaceutical formulation, flavors, vitamins and / or other known in the art Additives.
- the additives also include pharmacologically acceptable salts such as sodium chloride as isotonic agents.
- the preferred auxiliary substances include antioxidants, such as, for example, ascorbic acid, unless already used for adjusting the pH, vitamin A, vitamin E, tocopherols and similar vitamins or provitamins occurring in the human organism.
- antioxidants such as, for example, ascorbic acid, unless already used for adjusting the pH, vitamin A, vitamin E, tocopherols and similar vitamins or provitamins occurring in the human organism.
- Preservatives can be used to protect the formulation from contamination with germs. Suitable preservatives are those known from the prior art, in particular cetylpyridinium chloride, benzalkonium chloride or benzoic acid or benzoates such as sodium benzoate in the concentration known from the prior art.
- Another aspect of the invention is a method for treating respiratory diseases using pyrimido [5,4-d] pyrimidines, in particular in which side effects such as emesis or nausea are reduced.
- ready-to-use pack of a medicament for the treatment of respiratory diseases including an enclosed description containing the words selected from the group respiratory disease, COPD or asthma, a pyrimido [5,4-d] pyrimidine and one or more combination partners selected from the group of anticholinergics , Steroids or ß-agonists.
- Pharmacologically compatible acid addition salts are understood to mean, for example, those salts which are selected from the group consisting of hydrochloride, hydrobromide, hydroiodide, hydrosulfate, hydrophosphate, hydromethanesulfonate, hydronitrate, hydromaleate, hydroacetate, hydrocitrate, hydrofumarate, hydrotartrate, hydrouccinate, hydrooxalate Hydrobenzoate and hydro-p-toluenesulfonate, preferably hydrochloride, hydrobromide, hydrosulfate, hydrophosphate, hydrofumarate and hydromethanesulfonate.
- -d- 6 -alkyl denotes branched and unbranched alkyl groups having 1 to 6 carbon atoms. Examples include: methyl, ethyl, propyl or butyl.
- the abbreviations Me, Et, Pr or Bu may also be used to denote the groups methyl, ethyl, propyl or butyl.
- the definitions propyl and butyl encompass all conceivable isomeric forms of the respective radicals.
- propyl includes n-propyl and / so-propyl
- butyl includes / so-butyl, sec-butyl and terf-butyl etc.
- Preferred are methyl, ethyl, ⁇ -propyl, / so-propyl, / so-butyl, seo -Butyl and tert-butyl.
- -C 3 . 8 -cycloalkyl with 3-8 carbon atoms are, for example, cyclopropyl
- Cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl or cyclooctyl are preferred. Cyclopropyl and cyclohexyl are preferred.
- Halogen in the context of the present invention is fluorine, chlorine, bromine or iodine. Unless stated otherwise, fluorine, chlorine and bromine are preferred halogens.
- aryl stands for an aromatic ring system with 6 to 10 carbon atoms.
- Preferred aryl radicals are phenyl or naphthyl, where the cycle can be substituted as indicated in the definitions.
- heteroaryl rings are understood to mean aromatic ring systems which contain one, two or three heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur and, as defined above, can optionally be substituted.
- heteroaryl rings also abbreviated to hetaryl
- aromatic ring systems which contain one, two or three heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur and, as defined above, can optionally be substituted.
- furan, thiophene, pyrrole, pyrazole, imidazole, pyridine, pyrimidine, triazine, oxazole, isoxazole, thiazole, isothiazole, oxadiazole and pyrazolidine are mentioned, where the heterocycle can be substituted as indicated in the definitions.
- Furan, tetrahydrofuran, 2-methyltetrahydrofuran, for example, are used as 5- or 6-membered saturated or unsaturated heterocyclic rings (also abbreviated as heterocyclic), which can contain one, two or three heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur as heteroatoms , 2-hydroxymethylfuran, tetrahydrofuranone, ⁇ -butylrolactone, ⁇ -pyran, ⁇ -pyran, dioxolane, tetrahydropyran, dioxane, Thiophene, dihydrothiophene, thiolan, dithiolan, pyrrole, pyrroline, pyrrolidine, pyrazole, pyrazoline, imidazole, imidazoline, imidazolidine, triazole, tetrazole, pyridine, piperidine, pyridazine, pyrimidine, pyrazine, piperazine, triazine,
- Examples of 5-, 6- or 7-membered, saturated or unsaturated, heterocyclic rings which can be formed together with the nitrogen through the radicals R 1 and R 2 are: pyrrole, pyrroline, pyrrolidine, 2-ethylpyrrolidine, 3 -Methylpyrrolidine, piperidine, piperazine, ⁇ / -Methylpiperazine, ⁇ / -ethylpiperazine, ⁇ / - (n-propyl) -piperazine, N-benzylpiperazine, morpholine, thiomorpholine, imidazole, imidazoline, imidazolidine, pyrazole, pyrazoline, pyrazoline, preferably pyrazoline , ⁇ / -benzylpiperazine, piperazine, and piperidine, where the heterocycles mentioned can be substituted as indicated in the definitions.
- pyrrole piperidine, piperazine, ⁇ / -methylpiperazine, ⁇ / -benzylpiperazine, morpholine, imidazole, imidazoline, imidazolidine, pyrazole, pyrazoline, pyrazolidine, preferably morpholine, N-benzylpiperazine, piperazine, and Piperidine, where the heterocycles mentioned can be substituted as indicated in the definitions.
- respiratory diseases are understood to mean disorders which cause breathing difficulties, shortness of breath or pain in the respiratory tract in a patient, in particular inflammatory or obstructive respiratory diseases are mentioned here.
- Inflammatory or obstructive diseases of the upper and lower respiratory organs, including the lungs such as, for example, allergic rhinitis, chronic rhinitis, bronchiectasis, cystic fibrosis, asthma, COPD, idiopathic pulmonary fibrosis and fibrosing alveolitis are preferred.
- Asthma, chronic bronchitis or COPD are particularly preferred.
- reduced side effects are understood to mean that a dose of a pharmaceutical composition can be administered without
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Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002552539A CA2552539A1 (en) | 2004-01-17 | 2005-01-11 | Use of substituted pyrimido[5,4-d]pyrimidines for the treatment of respiratory diseases |
EP05700801A EP1708714A1 (de) | 2004-01-17 | 2005-01-11 | Verwendung von substituierten pyrimido 5,4-d¨pyrimidinen zur behandlung von atemwegserkrankungen |
JP2006548242A JP2007517827A (ja) | 2004-01-17 | 2005-01-11 | 呼吸器疾患の治療のための置換ピリミド[5,4−d]ピリミジンの使用 |
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DE102004002557A DE102004002557A1 (de) | 2004-01-17 | 2004-01-17 | Verwendung von substituierten Pyrimido(5,4-d)pyrimidinen zur Behandlung von Atemwegserkrankungen |
DEDE102004002557.6 | 2004-01-17 |
Publications (1)
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WO2005067934A1 true WO2005067934A1 (de) | 2005-07-28 |
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PCT/EP2005/000163 WO2005067934A1 (de) | 2004-01-17 | 2005-01-11 | Verwendung von substituierten pyrimido[5,4-d]pyrimidinen zur behandlung von atemwegserkrankungen |
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US (1) | US20050159414A1 (de) |
EP (1) | EP1708714A1 (de) |
JP (1) | JP2007517827A (de) |
CA (1) | CA2552539A1 (de) |
DE (1) | DE102004002557A1 (de) |
WO (1) | WO2005067934A1 (de) |
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US6861422B2 (en) * | 2003-02-26 | 2005-03-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
DE102004029784A1 (de) * | 2004-06-21 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 2-Benzylaminodihydropteridinone, Verfahren zur deren Herstellung und deren Verwendung als Arzneimittel |
DE102004033670A1 (de) * | 2004-07-09 | 2006-02-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Pyridodihydropyrazinone, Verfahren zu Ihrer Herstellung und Ihre Verwendung als Arzneimittel |
US20060074088A1 (en) * | 2004-08-14 | 2006-04-06 | Boehringer Ingelheim International Gmbh | Dihydropteridinones for the treatment of cancer diseases |
US20060058311A1 (en) * | 2004-08-14 | 2006-03-16 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation |
US7759485B2 (en) * | 2004-08-14 | 2010-07-20 | Boehringer Ingelheim International Gmbh | Process for the manufacture of dihydropteridinones |
US20060035903A1 (en) * | 2004-08-14 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Storage stable perfusion solution for dihydropteridinones |
US7728134B2 (en) * | 2004-08-14 | 2010-06-01 | Boehringer Ingelheim International Gmbh | Hydrates and polymorphs of 4[[(7R)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl)-benzamide, process for their manufacture and their use as medicament |
EP1632493A1 (de) * | 2004-08-25 | 2006-03-08 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
EP1630163A1 (de) * | 2004-08-25 | 2006-03-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinonderivative, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
DE102004058337A1 (de) * | 2004-12-02 | 2006-06-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten |
US7439358B2 (en) * | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
EP2185559A1 (de) * | 2007-08-03 | 2010-05-19 | Boehringer Ingelheim International GmbH | Kristalline form eines dihydropteridionderivats |
AR073501A1 (es) * | 2008-09-08 | 2010-11-10 | Boehringer Ingelheim Int | Derivados de pirimido[5,4-d]pirimidina inhibidores de la tirosinoquinasa |
US8546566B2 (en) | 2010-10-12 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Process for manufacturing dihydropteridinones and intermediates thereof |
US9358233B2 (en) | 2010-11-29 | 2016-06-07 | Boehringer Ingelheim International Gmbh | Method for treating acute myeloid leukemia |
US9370535B2 (en) | 2011-05-17 | 2016-06-21 | Boehringer Ingelheim International Gmbh | Method for treatment of advanced solid tumors |
KR20150143498A (ko) * | 2013-03-15 | 2015-12-23 | 갈레온 파마슈티칼스, 인코포레이티드 | 신규 호흡 조절 제어 화합물 및 그의 사용방법 |
EP3024464A1 (de) | 2013-07-26 | 2016-06-01 | Boehringer Ingelheim International GmbH | Behandlung des myelodysplastischen syndroms |
US9867831B2 (en) | 2014-10-01 | 2018-01-16 | Boehringer Ingelheim International Gmbh | Combination treatment of acute myeloid leukemia and myelodysplastic syndrome |
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Also Published As
Publication number | Publication date |
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JP2007517827A (ja) | 2007-07-05 |
US20050159414A1 (en) | 2005-07-21 |
EP1708714A1 (de) | 2006-10-11 |
CA2552539A1 (en) | 2005-07-28 |
DE102004002557A1 (de) | 2005-08-04 |
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