WO2005049773A1 - Procede d'evaluation multidimensionnelle d'odeurs et de parfums favorisant l'activite nerveuse - Google Patents

Procede d'evaluation multidimensionnelle d'odeurs et de parfums favorisant l'activite nerveuse Download PDF

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Publication number
WO2005049773A1
WO2005049773A1 PCT/JP2004/017103 JP2004017103W WO2005049773A1 WO 2005049773 A1 WO2005049773 A1 WO 2005049773A1 JP 2004017103 W JP2004017103 W JP 2004017103W WO 2005049773 A1 WO2005049773 A1 WO 2005049773A1
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Prior art keywords
fragrance
index
belonging
methyl
nervous system
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PCT/JP2004/017103
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English (en)
Japanese (ja)
Inventor
Yoshiro Okazaki
Miyuki Takayanagi
Yoshiaki Numata
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Takasago International Corporation
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Priority to JP2005515632A priority Critical patent/JP4638353B2/ja
Publication of WO2005049773A1 publication Critical patent/WO2005049773A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B9/00—Essential oils; Perfumes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Definitions

  • the present invention relates to a method for evaluating a multi-dimensional function of a fragrance, a nerve activity promoting fragrance found by the method, and a fragrance composition containing the fragrance.
  • the present invention also relates to a fragrance composition having a sympathetic nerve activity promoting fragrance and a composition containing the fragrance.
  • the present invention provides a method for promoting sympathetic nerve activity comprising at least one compound selected from 2,2,6-trimethylcyclohexanecarboxylic acid esters and 2,2,6-trialkylcyclohexenecarboxylic acid esters.
  • fragrance is selected from 2,2,6-trimethylcyclohexanecarboxylic acid esters and 2,2,6-trialkylcyclohexenecarboxylic acid esters.
  • stress-reducing sympathetic nerve activity comprising at least one compound selected from 2,2,6-trialkylcyclohexanecarboxylates and 2,2,6-trialkylcyclohexenecarboxylates. Promoting perfume. Further, the present invention relates to a sympathetic nerve activity promoting fragrance composition containing these fragrances or a stress reducing sympathetic nerve activity promoting fragrance composition containing these fragrances.
  • the present invention also relates to a mood state improving flavor and a flavor composition containing the flavor. More specifically, the present invention relates to a mood-condition improving fragrance comprising at least one compound selected from macrocyclic musk compounds and camphorenyl-type sandals, and a mood-condition improving fragrance composition containing the fragrance.
  • the autonomic nervous system is roughly classified into two systems, a sympathetic nervous system and a parasympathetic nervous system, and it is known that the action of the sympathetic nervous system and the action of the parasympathetic nervous system act antagonistically. It is known that the action of the sympathetic nervous system promotes the state of activity of a person. For example, it has the function of dissipating energy, sweating, and increasing tension. In order to enhance the effect of the sympathetic nerve, it is necessary to take a drug that enhances the sympathetic nerve.If there is a fragrance that promotes the action of the sympathetic nerve nearby, it can be easily used and It is convenient because you can enjoy the scent of the water.
  • fragrances such as natural fragrances present in plants
  • the fragrances subtly act on the nervous system, etc., and give people a sense of comfort and satisfaction.
  • This is a therapy that gives and eliminates stress.
  • This method is human-friendly and can be said to be an excellent method.
  • fragrance used in the aromatherapy essential oils are often used.
  • Patent Document 5 a fragrance composition that suppresses secretion of stress substances has been reported. This report only discloses that a fragrance composition containing methyldihydrodiasmonate or the like promotes protease activity in the stratum corneum and normalizes metabolism of the stratum corneum.
  • the conventional physiological and psychological evaluation methods of the fragrance are such that the subject smells the scent of the fragrance and knows the increased amount of the compound in the urine, or the fragrance is brought into contact with the skin of the subject.
  • the odor of the fragrance is corresponded to one index, such as the method of knowing the increase of a specific compound in the stratum corneum of the skin or the method of contacting the fragrance directly with the surface of the subject's arm and knowing the heart rate fluctuation. Then, the fluctuation of the numerical value of the index is analyzed, the fragrance is evaluated, and the function of the fragrance is evaluated.
  • fragrances are so-called essential oils.
  • the raw materials are derived from natural products, and the quality and yield of the raw materials are affected by unpredictable conditions such as climate, so that the raw materials can be secured. Are pointed out as having problems.
  • Patent Document 1 Japanese Patent Application Laid-Open No. Hei 9 291038
  • Patent Document 2 JP 2002-193824 A
  • Patent Document 3 JP 2001-19992
  • Patent Document 4 JP 2001-49286 A
  • Patent Document 5 JP 2001-199832 A
  • Patent Document 6 JP-A-11 209294
  • the present inventors have been researching to find a fragrance having a function of promoting mental activity, for example, a fragrance effective for improving mood state. Focusing on the relationship, it was concluded that evaluating the function of the fragrance of a fragrance with a single index was an extremely one-sided evaluation method, and was not an appropriate evaluation method.
  • An object of the present invention is to develop a method for evaluating the functional evaluation of a fragrance by a more appropriate method. Also. The above method is also applied to many fragrances to find and provide fragrances having a function of promoting mental activity, for example, fragrances having a mood condition improving effect.
  • Another object of the present invention is to provide a sympathetic nervous activity promoting fragrance having little or no side effects in which the procurement of raw materials is less unstable. It is also an object of the present invention to provide a fragrance composition containing the fragrance. Further, it is an object of the present invention to provide a fragrance which promotes sympathetic nervous activity and a fragrance composition containing the fragrance, which exhibit a stress reducing property that makes the procurement of raw materials less unstable and which has no side effects.
  • the mood improving fragrance refers to a fragrance that can improve the mood of a human when a human smells an odor that also emits fragrance power. It means that the mood state becomes a good mood state.
  • the mood state means the psychological and physiological state of the human
  • the good mood state means the mood state desired by the human.
  • the mood state improving flavor in the present invention include a parasympathetic nervous system activity promoting flavor, a stress reducing flavor, and a sedative flavor.
  • the psychological and physiological states of humans are complex, and the mood-condition improving fragrance of the present invention includes stress-reducing parasympathetic nervous system activity promoting fragrance, stress-reducing sedative fragrance, and parasympathetic nervous system activity promoting fragrance. Preference is given to sedative fragrances and, moreover, sedative fragrances which promote parasympathetic nervous system activity and have a stress reducing property.
  • the present inventors recorded a physiological response of the central nervous system and a physiological response of the autonomic nervous system in a polygraphic form.
  • the multi-dimensional function evaluation method of the scent was applied to other scents, the function of the scent was evaluated, and a scent having a mood state improving effect was found.
  • the present invention is as follows.
  • the invention of claim 1 combines at least two or three or more indexes selected from indexes belonging to the central nervous system index, indexes belonging to the autonomic nervous system index, indexes belonging to the psychological index, and indexes belonging to the behavioral index. Multidimensional functional evaluation of fragrances It is a valuation method.
  • the invention according to claim 2 is characterized in that the index belonging to the central nervous system index takes a positive value, and among the indexes belonging to the autonomic nervous system index, the index belonging to the sympathetic nervous system index indicates activation. It is a fragrance that promotes sympathetic activity.
  • the index belonging to the central nervous system index has a positive value, and among the indexes belonging to the autonomic nervous system index, the index belonging to the parasympathetic nervous system index indicates activation, and the psychological index.
  • the index belonging to the parasympathetic nervous system index indicates activation, and the psychological index.
  • the invention of claim 4 is a fragrance composition comprising the sympathetic nerve activity promoting fragrance of claim 2.
  • a fifth aspect of the invention is a fragrance composition comprising the parasympathetic nervous activity promoting fragrance of the third aspect.
  • the invention of claim 6 is the component (A): selected from 2,2,6-trialkylcyclohexanecarboxylic acid esters and 2,2,6 trialkylcyclohexenecarboxylic acid esters. 3.
  • the sympathetic nerve activity promoting fragrance according to claim 2, wherein the fragrance also has at least one compound power.
  • the invention according to claim 7 is characterized in that the compound of the component (A) is ethyl 2,2,6-trimethylcyclohexanecarboxylate, ethyl 2,2,6 trimethyl-4,6-cyclohexadienecarboxylate, 6-Trimethyl-4-methylcyclohexenecarboxylate, ⁇ -Methylcyclogelate, j8-Methylmethylperoxide, ⁇ -Methylcyclogelate, ⁇ -Ethyl cyclogelate, ⁇ -Ethylcyclogelate, Ethyl perethylcyclogelate, 7.
  • the invention according to claim 8 is characterized in that component ( ⁇ ): a macrocyclic musk compound and component (C): a force of one or more compounds selected from camphorenyl-type sandals, which are used for improving a mood state
  • component ( ⁇ ) a macrocyclic musk compound
  • component (C) a force of one or more compounds selected from camphorenyl-type sandals, which are used for improving a mood state
  • the parasympathetic nervous activity promoting fragrance according to claim 3 can be said to be a mood condition improving fragrance characterized by comprising the compound.
  • the invention according to claim 9 is characterized in that the compound belonging to the component ( ⁇ ) is 3-methylcyclopentadecanone 1, 3-methyl-4-cyclopentadecene 1 on, 9-cyclopentadecane 1 on, cyclopentadecanone, cyclohexadecenone, Hexadecanone, cyclopentadecanolide, Cyclopentadecene 1 lor 12 oride, cyclopentadecene 7 oride, cyclohexadecanolide, ethylene brassate, ethylene dodecadioate, 12-oxahexadenolide, 11-oxahexadecanolide, 10-oxahexanolide Item 8.
  • the present invention can be regarded as the mood condition improving fragrance according to claim 8, which is composed of the compound.
  • the invention according to claim 10 is characterized in that the compound belonging to the component (C) is 3-methyl-5- (2,2,3 trimethyl-3-cyclopentene-1-yl) -pentan-2ol, 2-ethyl-4- (2,2,2 3-trimethyl-3-cyclopentene-1-yl) -2-buten-1-ol, (E)-(R) -2-ethyl-4- (2,2,3-trimethyl-3-cyclopentene-1yl) -2- Butene 1 ol, 2-methyl 4- (2,2,3-trimethyl-3-cyclopentene 1-yl) -2-buten 1 ol, 2-methyl-41- (2,2,3-trimethyl-3-cyclopentene 1-yl) 1) butane 1ol, 3-methyl-5- (2,2,3-trimethyl-3-cyclopentene 1-yl) 4-pentene 2-wool, 3,3 dimethyl-5- (2,2,3-trimethyl-3-cyclopentene 1-yl) 4-penten-2-ol, 2-methyl-4-
  • the present invention is the mood-condition improving fragrance according to claim 8, which is the compound.
  • the invention of claim 11 is the fragrance composition according to claim 4, characterized by containing the fragrance for promoting sympathetic nerve activity according to claim 6.
  • the invention of claim 12 is the fragrance composition according to claim 5, comprising the parasympathetic nervous activity promoting fragrance according to claim 8, but also the mood state improving fragrance according to claim 8.
  • the mood state improving fragrance composition characterized by containing
  • the method of multi-dimensionally evaluating fragrance is characterized by combining the central nervous system and the autonomic nervous system.
  • a feature is to combine at least two or more indices selected from indexes belonging to the central nervous system index, indexes belonging to the autonomic nervous system index, indexes belonging to the psychological index, and indexes belonging to the behavioral index.
  • Multi-dimensional scent This is a method for functional evaluation.
  • an index belonging to the autonomic nervous system index there is an index belonging to the sympathetic nervous system index or an index belonging to the parasympathetic nervous system index.
  • indices based on biochemical measurements of the endocrine system and the immune system may be added. Suitable biochemical indicators include cortisol levels, adrenocorticotropic hormone (ACTH) levels, catecholamine levels, immunoglobulin levels, and the like.
  • ACTH adrenocorticotropic hormone
  • CNS indices include measurement of the ratio of EEG ⁇ , ⁇ , and 0 waves, measurement of frequency fluctuation of EEG a-wave, measurement of scent awareness level using CNV, measurement of EEG P measurement, magnetoencephalography
  • Representative indices belonging to the central nervous system index include the consciousness level of aroma by CNV (awakening effect and sedation effect) and the frequency fluctuation of brain wave OC waves.
  • CNV scent consciousness level
  • This method of measuring the level of consciousness by CNV is a well-known method for evaluating the function of fragrance, and measures the arousal and sedative effects of fragrance by measuring the brain waves (CNV) of the frontal lobe after smelling the fragrance, It is a method to evaluate the function.
  • CNV is an acronym for Contingent Negative Variation, and is called contingency-negative fluctuation.It is one of the central nervous system reactions, one of the electroencephalogram nominations, and in a broad sense, event-related. It is a kind of what is called an electric potential.
  • Brain waves are mixed with waves of various frequencies ranging from about 0.1 Hertz below to about 40 Hertz above, and those with a frequency of 8 to 12 Hz are called alpha waves of brain waves.
  • the wave with the frequency of this ⁇ wave changes irregularly with time.
  • the a-wave of the electroencephalogram of the subject subjected to the stress load was measured, and the spectral force of the a-wave frequency fluctuation was measured.
  • the ⁇ -wave frequency fluctuation changes its fluctuation coefficient (gradient: slope) in the range of 0 to 1 according to the emotional state caused by the stress load. If the ⁇ -wave frequency fluctuation coefficient is close to 1, If the person's emotional state at that time is positive and the a-wave frequency fluctuation coefficient is close to 0, the person's current emotional state can be evaluated as negative.
  • an electroencephalogram can be measured only by mounting an electrode on the scalp.
  • an index belonging to the autonomic nervous system index will be described. Examples of the measurement of an index belonging to the autonomic nervous system index include measurement of pupil response, measurement of electrocardiogram, blood pressure and respiration, measurement of surface blood flow, measurement of fingertip pulse wave, and the like.
  • the autonomic nervous system is roughly divided into the sympathetic nervous system and the parasympathetic nervous system.
  • adrenaline, acetylcholine, and the like which also release nerve terminal power, exert an effect, and regulate the activities of the heart, blood vessels, pupils, gastrointestinal activities, sweat glands, and the like almost antagonistically. Therefore, as a method of measuring autonomic nervous activity, a method of directly measuring the amount of adrenaline and acetylcholine, and a method of measuring heart rate, blood flow, blood pressure, sweating, pupil reaction, and the like have been reported. In measuring the effect of the fragrance on the autonomic nervous system, the measuring method is not particularly limited as long as it is an appropriate method.
  • the skin temperature is adopted as a representative example of the index belonging to the sympathetic nervous system, but the present invention is not limited to this, and another index may be adopted.
  • the surface skin temperature of a human changes depending on the blood flow circulating in the skin tissue when the outside air temperature is constant, and the blood flow circulating in the skin tissue is regulated by contraction and expansion of vascular smooth muscle. I have. It is known that when vascular smooth muscle expands, local blood flow increases and skin temperature rises, and that vascular smooth muscle is mainly controlled by sympathetic vasoconstrictor fibers. From this, when sympathetic nerve activity is increased, vascular smooth muscle is reduced, and peripheral circulation is suppressed, so that blood flow and skin temperature are reduced.
  • the sympathetic nerve activity can be known.
  • an electrocardiogram waveform is also selected as an index as a response of the cardiovascular system under autonomic innervation.
  • a waveform of an electrocardiogram is selected as a response of the cardiovascular system subject to autonomic innervation, and the force is used as a representative example of an index belonging to the parasympathetic nervous system.
  • a peak called the R wave can be observed. It is known that the interval between the peak of this R wave and the next R wave (R-R interval) is not affected by the sympathetic nervous system!
  • R-R interval the interval between the peak of this R wave and the next R wave
  • a typical indicator is a transient stress subjective questionnaire. More specifically, the four factors of comfort, anger, anxiety, sway, and malaise, which are obtained from the subjective stress questionnaire, are used as indicators. In addition, the intensity of the scent and the degree of scent pleasure and discomfort were added as indicators.
  • Methods for measuring the effect of a scent on human psychological and emotional states from the behavior of a subject are already known. Examples of such methods include a flicker test, a Kraepelin test, a simulated VTR work, and a character erasure method.
  • the specific load content in the present invention is that the subject moves the frame so that the target (Target) that moves randomly on the display screen falls within the frame (Frame). As long as the target does not fit within the frame, it is set to sound loud!
  • This parasympathetic nervous activity promoting fragrance is The index belonging to the transsystem index takes a positive value, and among the indexes belonging to the autonomic nervous system index, the index belonging to the parasympathetic nervous system indicates activation, or the index belonging to the sympathetic nervous system is suppressed. Or that the index belonging to the parasympathetic nervous system index indicates activity, the index belonging to the sympathetic nervous system index indicates suppression, and the index belonging to the psychological index indicates suppression of an unpleasant mental state. Parasympathetic activity promoting flavor and / or sympathetic activity suppressing flavor.
  • the index belonging to the central nervous system index takes a positive value means that the index belonging to the central nervous system index takes a value indicating a positive emotional state, or a value indicating an active state. Means that.
  • a fragrance usually used or a commonly used compounding agent may be added to these fragrances, and the fragrance may be added and blended with an object to be perfumed as a fragrance composition.
  • fragrances were found to be effective as sympathetic nervous activity promoting fragrances or stress-reducing stimulant sympathetic nervous activity promoting fragrances.
  • fragrances were found to be effective as sympathetic nerve activity promoting fragrances or stress-reducing stimulant sympathetic nerve activity promoting fragrances.
  • the alkyl group bonded to the cyclohexane ring or cyclohexene ring is a methyl group or an ethyl group
  • a compound in which an alkyl group derived from an alcohol component is a methyl group or an ethyl group is a typical compound.
  • Typical examples of these compounds include ethyl 2,2,6-trimethylcyclohexanecarboxylate (Tesalone: Takasago International Corporation), 2,2,6-trimethyl-4,6-cyclohexadiene carboxylic acid.
  • Ethyl acid ethylsuranate: Taest
  • methyl 2,2,6-trimethyl-4-cyclohexenecarboxylate methylsuranate: Taest
  • a-methyl methyl cyclogelate 13-methyl methyl cyclogelate, methyl dicyclogelate , ethyl ethyl cyclogelate , J8-ethyl ethyl cyclogelate, ⁇ -ethyl cycloethylate, and ethyl 2,2-dimethyl-6-ethyl-5-cyclohexenecarboxylate Dipescon: Givaudan
  • fragrances are already known, but it is not known at all that these fragrances have a sympathetic nervous activity promoting ability, and it is not known at all that these fragrances also have a stress reducing property.
  • the compound itself is effective as a sympathetic nerve activity promoting fragrance, but other compounding agents and the like may be added.
  • Other combinations include fragrances, sympathetic activity enhancers, bulking agents, antimicrobial agents, and the like.
  • Specific examples of combination agents include anti-obesity compounds such as capsaicin, spirantol, zingerone, and piperine, compounds having a slimming ability, xanthine derivatives such as caffeine, catechins such as catechin, Chinese tea, green tea extract, fennel, Herbal medicines such as ginger, pepper, ginger, Sennici holland, lavender, tamarind, inosit, dextran sulfate, and gymnema sylvester. These compounds may be used alone or in combination of two or more.
  • the preferred amount of the sympathetic activity promoting flavor in the blended flavor is about 10-80% (weight) based on the integrated flavor.
  • the amount of the sympathetic activity promoting fragrance is preferably about 10 to 50% by weight based on the fragrance composition.
  • Examples of the mood state improving fragrance in the present invention include macrocyclic musk compounds and camphorenyl-type sandals.
  • a macrocyclic musk compound is a cyclic compound consisting of 15 to 16 carbon atoms, and may further contain an oxygen atom.
  • Preferred macrocyclic musk compounds include 3-methylcyclopentadecanone 1 (muscon), 3-methyl-4-cyclopentadecene 1-one (dehydromuscone), 9-cyclopentadecane 1-on (divetone), cyclopentane Decano (Egisalton: Firmenich), cyclohexadecenone (Ambreton: Takasago International Corporation), cyclohexadecanone, cyclopentadecanolide, cyclopentadecene-11 orl2 oride, cyclopentadecene 7 oride, cyclohexadecanolide (cyclohexadecanolide) Hexadecanolide: IFF), ethylene brush rate (Musk T: Takasago International Corporation), ethylene dodecadioate (Musk
  • fragrances can be prepared by a known production method, or a commercially available product may be purchased.
  • the above fragrances are already known, but it is completely known that the fragrances are effective as a mood state improving fragrance. These fragrances have never been known to be effective as parasympathetic nervous system activity promoting fragrances or stress reducing fragrances.
  • Camphorenyl-type sandals can be said to be alicyclic alcohols having a 2,2,3-trimethylcyclopentyl group.
  • the alicyclic alcohol include 3-methyl-5- (2,2,3-trimethyl-3-cyclopentenyl) pentane-2ol (Sandaloa: dibodan), 2-ethyl-4- (2,2,2 3-trimethyl-3-cyclopentene 1-yl) -2-butene-1 ol (batadanol: IFF), (E)-(R) -2-ethyl- 4- (2,2,3-trimethyl-3-cyclopentene- 1-I le) - 2 - butene - 1 - ol (repo San Doll: Takasago International Co., Ltd.), 2-methyl-4- (2, 2, 3-trimethyl-3-cyclopenten 1 I) -2-butene —1 Ole (Sandal Mysorcoa: Kao Corporation), 2-Methyl-4- (2,2,3-trimethyl-3
  • fragrances can be prepared by a known production method, or a commercially available product may be purchased.
  • the above fragrances are already known, but it is completely known that the fragrances are effective as a mood state improving fragrance. None of them have been known to be effective as parasympathetic nervous system activity promoting fragrances, stress reducing fragrances, or sedative fragrances.
  • compounding agents include fragrances other than those described above, parasympathetic nervous activity promoters, bulking agents, antibacterial agents and the like.
  • compounding agents include catechins such as catechin, Chinese tea, green tea extract, crude drug, tamarind, dextran sulfate, and gymnema sylvester. These compounding agents may be used alone or in combination of two or more.
  • the amount of these components is appropriately changed depending on the relationship between the parasympathetic nervous activity promoting fragrance to be used, other fragrances to coexist, and other components, and may be added as long as the intended effect of the present invention is not impaired.
  • the preferred amount of the mood-improving flavor in the blended flavor is about 10-80% (by weight) based on the integrated flavor.
  • the preferable amount of the mood-condition improving fragrance is about 10 to 50% by weight based on the fragrance composition.
  • the sympathetic nerve activity promoting fragrance of the present invention or the composition containing the fragrance, and the mood-improving fragrance of the present invention, or the composition containing the fragrance can be used in various fields.
  • Frederance products basic cosmetics, finishing cosmetics, hair cosmetics, tanning cosmetics, medicated cosmetics, hair care products, stones, body cleaners, bath agents, detergents, softeners, cleaners, kitchen detergents, bleaching agents , Aerosols, deodorants, fragrances, incense, miscellaneous goods; foods and drinks, oral compositions, and pharmaceuticals.
  • the amount of the perfume composition for promoting sympathetic activity is not particularly limited, but is usually about 0.005 to 2% (weight).
  • the amount of the flavor improving composition is not particularly limited, but is usually about 0.005 to 2% (weight).
  • the above-mentioned Frederance products include perfume, eau de perfume, eau de toilette, eau de cologne, and the like.
  • facial cleansing cream nothing cream, cleansing cream, cold cream, massage cream, milky lotion, cosmetic Water, serum, knock, Make-up removers, etc., and finishes such as foundation, powdered powder, solid powder, talcum powder, lipstick, lip balm, lipstick, eyeliner, mascara, eyeshadow, eyebrow ink, eye pack, nail enamel, enamel
  • Hair cosmetics include pomade, brilantin, set lotion, hair tech, hair one solid, hair oil, hair treatment, hair cream, hair tonic, hair one liquid, hair spray, bandolin, hair restorer, Hair dyes and the like can be mentioned.
  • Tanning dani cosmetics include suntan products and sunscreen products, and medicated cosmetics include antiperspirants, after-shave lotions and jewels, permement wave agents, medicinal stones, medicated shampoos.
  • Hair care products include shampoos, rinses, rinse-in shampoos, conditioners, treatments, hair packs, and the like.
  • Stones include toilet stones, bath stones, and perfumes.
  • Stones, transparent stones, synthetic stones, etc., body washing agents include body soaps, body shampoos, hand soaps, etc.
  • bathing agents include bathing agents (bath salts, stab slats).
  • Bath liquid, etc. foam bath (bubble bath, etc.), bath oil (bath perfume, bath capsule, etc.)
  • Bath liquid, etc. foam bath
  • bath oil bath perfume, bath capsule, etc.
  • detergents include heavy detergents for clothing, light detergents for clothing, liquid detergents, laundry stones, compact detergents, powdered stones, etc.
  • Finishers include Softener, Fur-Chia Care, etc.
  • cleaners include cleansers, house cleaners, toilet cleaners, bathroom cleaners, glass cleaners, mold removers, drain cleaners, etc.
  • Kitchen detergents include kitchen stones, kitchen stones, dishwashing detergents, etc.
  • Bleaching agents include oxidizing bleaching agents (chlorine bleaching agents, oxygen bleaching agents, etc.).
  • bleaching agents such as reducing bleaching agents (sulfur bleaching agents, etc.), optical bleaching agents, etc., aerosoling agents include spray type and nozzle spraying, and deodorizing fragrances include solid bleaching agents.
  • Shape Ip, gel type, liquid type and the like are listed, and miscellaneous goods include tissue paper and toilet paper.
  • Foods and drinks include, for example, fruit drinks, fruit liquors, milk drinks, carbonated drinks, soft drinks, drinks such as drinks; ice creams, sorbets, ice candy, etc. Frozen sweets; Japanese confectionery, jams, candy, jellies, gums, pa Beverages such as coffee, coffee, cocoa, black tea, oolong tea, green tea; soups such as Japanese soup, Western soup, Chinese soup, flavor seasonings, various instant drinks and foods, and various snacks Foods and the like; oral compositions include, for example, toothpastes, mouthwashes, mouthwashes, troches, chewing gums, and the like; pharmaceuticals include external skin preparations such as haptics and ointments, and internal preparations. In the present invention, it is needless to say that the present invention is not limited to these.
  • a method for evaluating a multi-dimensional function of a scent can be provided, and a fragrance can be evaluated according to the evaluation method to provide a scent for promoting sympathetic nerve activity.
  • a sympathetic nerve activity promoting fragrance having a stress reducing property can be provided.
  • a sympathetic nerve activity promoting fragrance composition containing these fragrances and a sympathetic nerve activity promoting fragrance composition having a stress reducing property could be provided.
  • the above-mentioned fragrance or fragrance composition can be used in various fields, and can provide a sympathetic nerve activity promoting action and a stress reducing property.
  • Sarapiko is extremely practical because it has a slimming effect.
  • Fragrances can be evaluated according to the multi-dimensional fragrance function evaluation method of the present invention to provide a mood state improving fragrance.
  • a parasympathetic activity promoting fragrance e.g., a stress reducing fragrance, a sedative fragrance, and a fragrance having a plurality of actions thereof.
  • stress can be reduced, sedative effects can provide a more relaxed feeling of satisfaction, and a practical effect of improving mood can be achieved.
  • FIG. 1 is a diagram showing an experimental paradigm of a stress load experiment of the present invention.
  • the actual experimental paradigm is as follows.
  • the control condition that does not present the scent and the present-oil presentation condition are the same in the paradigm except for the presence or absence of the two odors.
  • EEG electrodes, electrocardiogram electrodes, and skin temperature sensors are attached to the subject, and then the EEG 'electrocardiogram' skin temperature is recorded for 6 minutes with the eyes closed, and the stress load is tracked for 12 minutes thereafter. Do the assignment.
  • brain waves are continued for 20 minutes with the eyes closed •
  • ECG Record skin temperature and end the experiment.
  • electroencephalogram, electrocardiogram, and skin temperature are continuously recorded from the start to the end of the experiment.
  • -oi is presented during this stress load period.
  • a questionnaire with psychological indicators is shown in this gray triangle at each phase boundary, that is, at the beginning of the rest period, at the boundary between the rest period and the stress period, at the boundary between the stress period and the recovery period, and at the recovery period.
  • the subject is given to the subject, and the subject writes the questionnaire on the questionnaire for psychological evaluation.
  • the subjective strength and the discomfort of the two-oi are evaluated at the same time as writing to the questionnaire for psychological evaluation.
  • FIG. 2 is an explanatory diagram of a stress task and work performance.
  • a tracking task was used as the stress task. This tracking task involves moving a fairly small target in a random trajectory on the display of the computer. A relatively large frame is also displayed on the screen, and this frame can be moved freely by the subject by operating the mouse at hand. The subject's task is to move and track the frame by manipulating the mouse at hand so that the randomly escaping target always stays within the frame. When the target is out of the frame, that is, when the condition is not met, the frame flashes and the computer power is set to full volume and a beeping alarm sounds. Subject was subject to a sloppy force and a fleeing target for 12 minutes in a row while being exposed to the beep Keep track. The result of this task was the number of errors, that is, the number of times the target was relieved S in 12 minutes, and the average recapture time, that is, the average time it took to recapture the missed target. To evaluate.
  • FIGS. 3A and 3B are diagrams showing potential fluctuations in the CNV measurement method.
  • CNV means a negative variable component between S1 and S2.
  • This CNV also has two component forces: an early component from 0.4 seconds to 1 second after the presentation of S1, and a late component close to S2, from 1 second after the presentation of S1 to just before the presentation of S2.
  • the early component changes according to the attention to the task and the level of alertness.
  • the change of the arousal level can be evaluated by the change of the early component.
  • the arousal level decreases (for a calming scent)
  • the area of this area decreases.
  • the level of arousal increases (in the case of an arousal scent)
  • the area of this part increases.
  • the parasympathetic nervous activity can be measured by analyzing the peak interval (R-R interval) called the R wave in each peak of the electrocardiogram waveform as an index of the autonomic nervous system. If this R—R interval is analyzed for variation using FFT spectrum analysis, the spectrum shown on the right is obtained. In this way, a bimodal spectrum having peaks on the low frequency side and the high frequency side is shown. Of these two peaks, the peak on the high frequency side called the HF component between 0.15 Hz and 0.5 Hz is shown. It is known that the area changes according to the parasympathetic activity.
  • FIG. 7 is a diagram in which words representing various emotional states of 15 items described in the transient stress subjective assessment questionnaire are described.
  • FIG. 8 shows the radar chart.
  • FIG. 8 is a radar chart when no two odors are presented.
  • radar charts can be displayed as an overall stress response pattern, observing and reviewing radar charts can facilitate understanding of perfume characteristics.
  • the indices measured and examined above have different units and different ranges of change.
  • the radar chart shows the result of the above conversion processing, the emotional state increases outward when the emotion state changes positively, and decreases inward when the emotional state changes negatively.
  • the emotional state is inferior, and the fluctuation coefficient is reduced, so that the state changes inward.
  • the scent with a wakeful effect increases outward and the scent with a sedative effect decreases inward.
  • the effect of the oil cannot be expressed, and therefore, it is set to 0 for convenience.
  • the parasympathetic nervous activity is increased, and when the HF component value is relatively increased, the parasympathetic nervous activity, which increases outward, is suppressed, and the HF component is suppressed. When the value decreases relatively, it decreases inward.
  • the stress load suppresses parasympathetic nervous activity and reduces the HF component.
  • the number of errors which is an index of the accuracy of the reaction
  • the recapture time which is an index of the speed of the reaction.
  • the behavioral index is evaluated based on the relative change based on the state of the control without odor, so the control alone cannot be evaluated. Therefore, similar to CNV, it was temporarily set to 0.
  • Psychological indices are factor 1, change in comfort, factor 2, anger, factor 3, anxiety and upset, factor 4, malaise, and The evaluation of the stress is described.
  • PSS Psychological indices
  • Each of these psychological indices is displayed so that the larger the score, the larger the outside, and the smaller the score, the smaller the inside. Therefore, when stress is applied, the psychological profile of a decrease in the positive factor of comfort, an increase in negative factors such as fatigue, as well as an increase in anger and anxiety, and an increase in stress.
  • Common transient stress response patterns in multidimensional evaluations include worsening mood status as a central response, promotion of the sympathetic nervous system and suppression of the parasympathetic nervous system, and psychologically positive factor scores. Decreased and negative factors scored increased calories and increased stress.
  • tesarone 2,2,6-trimethylcyclohexanecarboxylate
  • Formulation examples of the sympathetic nervous activity promoting fragrance composition containing the sympathetic nervous activity promoting scent defined by the present invention are shown below.
  • This fragrance composition is a fragrance composition having a fruity-like fragrance.
  • This fragrance composition can be blended with various cosmetics, and can provide cosmetics having a sympathetic nerve activity promoting action or a stress reducing action. It is advantageous to make the perfume or the like having a sympathetic nervous activity promoting action by dissolving it.
  • the multidimensional function evaluation method of the present invention was applied to discrimination of the fragrance of umbreton.
  • Figure 10 shows the measurement results.
  • the ⁇ -wave frequency fluctuation changed in a positive direction, which was large, that is, close to 1 Zf.
  • this umbreton was found to have a sedative effect by CNV measurement.
  • the autonomic nervous reaction it was found that sympathetic nervous activity was suppressed and parasympathetic nervous activity was promoted.
  • the behavioral index does not show any particular changes to these physiological responses, as you can see, but the psychological index increases the positive factor, comfort score, and the negative factors, anger and anxiety '' Upset and fatigue scores decreased, as did subjective stress.
  • Typical stress responses are physiologically whitening of alpha wave fluctuation, promotion of sympathetic nervous system and suppression of parasympathetic nervous system.
  • a decrease in the score of the positive factor an increase in the score of the negative factor, and the presentation of umbrella, such as the power of umbrella, suppressed these stress response patterns.
  • the multidimensional function evaluation method of the present invention was applied to discriminating the flavor of musk.
  • Fig. 11 shows the measurement results.
  • the multidimensional function evaluation method of the present invention was applied to discrimination of fragrance of reposandole.
  • Figure 12 shows the measurement results.
  • the formulation of the mood-improving fragrance composition containing the mood-improving fragrance specified by the present invention is not limited to T self.
  • This fragrance composition is a fragrance composition having a musk-like fragrance.
  • This fragrance composition can be blended with various kinds of cosmetics and can provide cosmetics having an effect of improving a mood state. Particularly, when the composition is diluted with a solvent, it is applied to a perfume having an effect of improving a mood state. it can.
  • the formulation of the mood-improving fragrance composition containing the mood-improving fragrance specified by the present invention is not limited to T self.
  • This fragrance composition is a fragrance composition having a woody floral fragrance.
  • This fragrance composition can be blended with various cosmetics and can provide a cosmetic having a mood state improving effect.
  • a perfume or the like having a mood state improving effect by being diluted with a solvent can be provided. It is advantageous to do so.
  • the invention can also be described as follows.
  • the index belonging to the autonomic nervous system index comprises an index belonging to a sympathetic nervous system index or an index belonging to a parasympathetic nervous system index.
  • Item 1 The method for evaluating a multidimensional function of a scent according to Item 1.
  • a fragrance composition for promoting stress-reducing sympathetic nerve activity which comprises the fragrance for promoting stress-reducing sympathetic nerve activity according to (4).
  • Component ( ⁇ ) An operation comprising at least one compound selected from 2,2,6-trialkylcyclohexanecarboxylic acid esters and 2,2,6-trialkylcyclohexenecarboxylic acid esters.
  • a fragrance that promotes performance and enhances sympathetic nervous activity.
  • a fragrance composition that promotes work performance and enhances sympathetic nerve activity which comprises the fragrance according to (6).
  • a fragrance composition comprising a fragrance as described in (7) above, which has a stress-reducing property and improves work performance and enhances sympathetic nerve activity.
  • the compound of component ( ⁇ ) is ethyl 2,2,6-trimethylcyclohexanecarboxylate, 2,2,6-trimethyl-4,6-cycloethylhexenecarboxylate, 2,2,6-trimethyl- Methyl 4-cyclohexenecarboxylate, ⁇ -methyl methyl cyclogelate, j8-methyl methyl cyclogelate, methyl ⁇ -cyclogelate, ethyl ethyl ⁇ -cyclogelate, ethyl ethyl j8-cyclogelate
  • Component ( ⁇ ) a macrocyclic musk compound and component ( ⁇ ): A stress-reducing fragrance comprising at least one compound selected from camphorenyl-type sandals.
  • Component (C) a macrocyclic musk compound and component (B): a stress-reducing sedative fragrance comprising at least one compound selected from camphorenyl-type sandals.
  • Component (C) macrocyclic musk compound and component (B): a stress-reducing parasympathetic nervous system activity-stimulating sedative fragrance comprising at least one compound selected from camphorenyl-type sandals.
  • the compound belonging to component (C) is 3-methylcyclopentadecanone 1, 3-methyl-4-cyclopentadecene 1 on, 9-cyclopentadecane 1 on, cyclopentadecanone, cyclohexadecenone, and cyclohexane Oxadecanone, Cyclopentadecanolide, Cyclopentadecene 1 lor 12 Olide, Cyclopentadecene 7 Oride, Cyclohexadecanolide, Ethylene Brassate, Ethylene Dodecadioate, 12-Oxahexadecanolide, 11-Oxahexadecanolide, 10-Oxa The fragrance according to the above (11)-(18), which is hexadecanolide.
  • the compound belonging to the component (B) is 3-methyl-5- (2,2,3-trimethyl-3-cyclopenten-l-yl) -pentane-2ol, 2-ethyl 2- (2,2,3-) Trimethyl-3-cyclopentene 1-yl) -2-butene 1-ol, (E) — (R) —2-ethyl 4 -— (2,2,3-trimethyl-3-cyclopentene 1-yl) —2-butene 1-ol, 2-methyl-4,2,3-trimethyl-3-cyclopentene 1-yl) -2-butene-1 ol, 2-methyl-4-1 (2,2
  • FIG. 1 is a diagram showing an experimental paradigm of a stress load experiment of the present invention.
  • FIG. 2 is an explanatory diagram of a stress task and work performance.
  • FIG. 3 is a diagram showing potential fluctuations in a CNV measurement method.
  • FIG. 4 is a diagram showing a measured brain wave and a brain wave obtained by extracting a certain frequency from the measured brain wave.
  • FIG. 5 is a diagram showing a spottle obtained by performing FFT spectrum analysis of a time-series fluctuation of the frequency of an ex wave.
  • Fig. 6 is a view showing a part of an electrocardiogram waveform and R-R intervals.
  • FIG. 7 is a diagram in which words representing various emotional states of 15 items described in a transient stress subjective assessment questionnaire are shown.
  • FIG. 8 is a radar chart showing measurement results when the multidimensional function evaluation method of the present invention was applied without showing -oi.
  • FIG. 9 is a radar chart showing measurement results when the multidimensional function evaluation method of the present invention was applied to Tesalone.
  • FIG. 10 is a radar chart showing measurement results when the multidimensional function evaluation method of the present invention is applied to umbreton.
  • FIG. 11 is a radar chart showing measurement results when the multidimensional function evaluation method of the present invention was applied to Musk T.
  • FIG. 12 is a radar chart showing measurement results when the multidimensional function evaluation method of the present invention was applied to reposandole.

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Abstract

L'invention concerne un procédé permettant d'évaluer de manière plus appropriée la fonction odorante d'un parfum et de produire un parfum destiné à rafraîchir les humeurs ou un promoteur d'activité nerveuse sympathique. Une odeur est évaluée de manière multidimensionnelle par combinaison d'au moins deux indices choisis parmi ceux entrant dans les catégories des indices du système nerveux central, du système nerveux autonome, du système psychologique et du système du comportement. L'application de ce procédé révèle qu'au moins un composé choisi parmi les esters d'acide 2,2,6-trialkyl-cyclohexanecarboxylique et les esters d'acide 2,2,6-trialkyl-cyclohexénecarboxylique est efficace en tant que parfum favorisant l'activité nerveuse sympathique, et qu'au moins un composé choisi dans les composés appartenant aux composés de musc macrocycliques et composés appartenant aux santals de camphorényle est efficace comme parfum destiné à rafraîchir les humeurs.
PCT/JP2004/017103 2003-11-18 2004-11-17 Procede d'evaluation multidimensionnelle d'odeurs et de parfums favorisant l'activite nerveuse WO2005049773A1 (fr)

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JP2008304445A (ja) * 2007-05-09 2008-12-18 T Hasegawa Co Ltd 香料の評価方法
JP2011098898A (ja) * 2009-11-05 2011-05-19 Nippon Menaade Keshohin Kk オキシトシン産生促進剤
WO2011158965A1 (fr) * 2010-06-17 2011-12-22 日本電気株式会社 Système d'évaluation de la sensibilité, procédé d'évaluation de la sensibilité, et programme
WO2012165406A1 (fr) 2011-05-31 2012-12-06 高砂香料工業株式会社 Agent et composition pour une exaltation mentale
JP2015077124A (ja) * 2013-09-13 2015-04-23 大正製薬株式会社 飲料
JP2017072524A (ja) * 2015-10-08 2017-04-13 小林製薬株式会社 乗り物酔い止め用香料の評価方法
JP2018179603A (ja) * 2017-04-06 2018-11-15 高砂香料工業株式会社 心理、神経、内分泌、免疫指標を用いた香りの生理心理効果の評価方法
WO2020004182A1 (fr) * 2018-06-25 2020-01-02 高砂香料工業株式会社 Agent améliorateur de sommeil
WO2023282160A1 (fr) * 2021-07-07 2023-01-12 高砂香料工業株式会社 Composition de parfum
WO2023247604A1 (fr) * 2022-06-22 2023-12-28 Firmenich Sa Procédés pour améliorer les performances mentales et compositions destinées à être mises en oeuvre dans ces procédés

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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008304445A (ja) * 2007-05-09 2008-12-18 T Hasegawa Co Ltd 香料の評価方法
JP2011098898A (ja) * 2009-11-05 2011-05-19 Nippon Menaade Keshohin Kk オキシトシン産生促進剤
JP5958825B2 (ja) * 2010-06-17 2016-08-02 日本電気株式会社 感性評価システム、感性評価方法、およびプログラム
WO2011158965A1 (fr) * 2010-06-17 2011-12-22 日本電気株式会社 Système d'évaluation de la sensibilité, procédé d'évaluation de la sensibilité, et programme
JPWO2011158965A1 (ja) * 2010-06-17 2013-08-19 日本電気株式会社 感性評価システム、感性評価方法、およびプログラム
WO2012165406A1 (fr) 2011-05-31 2012-12-06 高砂香料工業株式会社 Agent et composition pour une exaltation mentale
JP2015077124A (ja) * 2013-09-13 2015-04-23 大正製薬株式会社 飲料
JP2017072524A (ja) * 2015-10-08 2017-04-13 小林製薬株式会社 乗り物酔い止め用香料の評価方法
JP2018179603A (ja) * 2017-04-06 2018-11-15 高砂香料工業株式会社 心理、神経、内分泌、免疫指標を用いた香りの生理心理効果の評価方法
WO2020004182A1 (fr) * 2018-06-25 2020-01-02 高砂香料工業株式会社 Agent améliorateur de sommeil
JPWO2020004182A1 (ja) * 2018-06-25 2021-08-19 高砂香料工業株式会社 睡眠改善剤
WO2023282160A1 (fr) * 2021-07-07 2023-01-12 高砂香料工業株式会社 Composition de parfum
WO2023247604A1 (fr) * 2022-06-22 2023-12-28 Firmenich Sa Procédés pour améliorer les performances mentales et compositions destinées à être mises en oeuvre dans ces procédés

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