WO2005037257A3 - Neue alanyl-aminopeptidasen-inhibitoren zur funktionellen beeinflussung unterschiedlicher zellen und zur behandlung immunologischer, entzündlicher, neuronaler und anderer erkrankungen - Google Patents

Neue alanyl-aminopeptidasen-inhibitoren zur funktionellen beeinflussung unterschiedlicher zellen und zur behandlung immunologischer, entzündlicher, neuronaler und anderer erkrankungen Download PDF

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WO2005037257A3
WO2005037257A3 PCT/EP2004/011643 EP2004011643W WO2005037257A3 WO 2005037257 A3 WO2005037257 A3 WO 2005037257A3 EP 2004011643 W EP2004011643 W EP 2004011643W WO 2005037257 A3 WO2005037257 A3 WO 2005037257A3
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Prior art keywords
diseases
neuronal
alanyl
inflammatory
novel
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PCT/EP2004/011643
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English (en)
French (fr)
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WO2005037257A2 (de
Inventor
Siegfried Ansorge
Ute Bank
Karsten Nordhoff
Michael Taeger
Frank Striggow
Original Assignee
Imtm Gmbh
Keyneurotek Ag
Siegfried Ansorge
Ute Bank
Karsten Nordhoff
Michael Taeger
Frank Striggow
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Application filed by Imtm Gmbh, Keyneurotek Ag, Siegfried Ansorge, Ute Bank, Karsten Nordhoff, Michael Taeger, Frank Striggow filed Critical Imtm Gmbh
Priority to AU2004281536A priority Critical patent/AU2004281536B9/en
Priority to CA002542723A priority patent/CA2542723A1/en
Priority to US10/575,882 priority patent/US20070037752A1/en
Priority to JP2006534706A priority patent/JP2007508349A/ja
Priority to EP04790485A priority patent/EP1673075A2/de
Publication of WO2005037257A2 publication Critical patent/WO2005037257A2/de
Publication of WO2005037257A3 publication Critical patent/WO2005037257A3/de

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Abstract

Die vorliegende Erfindung betrifft Substanzen, die Ala-p-Nitroanilid spaltende Peptidasen spezifisch inhibieren, für die Verwendung in der Medizin. Weiter betrifft die Erfindung die Verwendung mindestens einer derartigen Substanz oder mindestens einer mindestens eine derartige Substanz enthaltenden pharmazeutischen oder kosmetischen Zusammensetzung zur Prophylaxe und Therapie von Erkrankungen, insbesondere zur Prophylaxe und Therapie von Erkrankungen mit überschiessender Immunantwort (Autoimmunerkrankungen, Allergien und Transplantatrejektionen), von anderen chronisch-entzündlichen Erkrankungen, neuronalen Erkrankungen und zerebralen Schädigungen, Hauterkrankungen (u. a. Akne und Schuppenflechte), Tumorerkrankungen und speziellen Virusinfektionen (u. a. SARS).
PCT/EP2004/011643 2003-10-15 2004-10-15 Neue alanyl-aminopeptidasen-inhibitoren zur funktionellen beeinflussung unterschiedlicher zellen und zur behandlung immunologischer, entzündlicher, neuronaler und anderer erkrankungen WO2005037257A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2004281536A AU2004281536B9 (en) 2003-10-15 2004-10-15 Novel alanyl-amino peptidase inhibitors for functionally influencing different cells and treating immunological, inflammatory, neuronal, and other diseases
CA002542723A CA2542723A1 (en) 2003-10-15 2004-10-15 Novel alanyl-amino peptidase inhibitors for functionally influencing different cells and treating immunological, inflammatory, neuronal, and other diseases
US10/575,882 US20070037752A1 (en) 2003-10-15 2004-10-15 Novel alanyl-amino peptidase inhibitors for functionally influencing different cells and treating immunological, inflammatory, neuronal, and other diseases
JP2006534706A JP2007508349A (ja) 2003-10-15 2004-10-15 異なるタイプの細胞に機能的に影響を及ぼし、免疫性疾患、炎症性疾患、神経疾患、およびその他の疾患を治療するための新規なアラニルアミノペプチダーゼ阻害剤
EP04790485A EP1673075A2 (de) 2003-10-15 2004-10-15 Neue alanyl-aminopeptidasen-inhibitoren zur funktionellen beeinflussung unterschiedlicher zellen und zur behandlung immunologischer, entz ndlicher, neuronaler und anderer erkrankungen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10348023A DE10348023A1 (de) 2003-10-15 2003-10-15 Neue Alanyl-Aminopeptidasen-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen
DE10348023.4 2003-10-15

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WO2005037257A2 WO2005037257A2 (de) 2005-04-28
WO2005037257A3 true WO2005037257A3 (de) 2006-09-14

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PCT/EP2004/011643 WO2005037257A2 (de) 2003-10-15 2004-10-15 Neue alanyl-aminopeptidasen-inhibitoren zur funktionellen beeinflussung unterschiedlicher zellen und zur behandlung immunologischer, entzündlicher, neuronaler und anderer erkrankungen

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US (1) US20070037752A1 (de)
EP (1) EP1673075A2 (de)
JP (1) JP2007508349A (de)
CN (1) CN1897928A (de)
AU (1) AU2004281536B9 (de)
CA (1) CA2542723A1 (de)
DE (1) DE10348023A1 (de)
WO (1) WO2005037257A2 (de)

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US9217024B2 (en) 2007-12-18 2015-12-22 Acumen Pharmaceuticals, Inc. ADDL receptor polypeptides, polynucleotides and host cells for recombinant production
US9415043B2 (en) 2013-03-15 2016-08-16 Aerie Pharmaceuticals, Inc. Combination therapy
US9512101B2 (en) 2008-07-25 2016-12-06 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
US11590123B2 (en) 2016-08-31 2023-02-28 Aerie Pharmaceuticals, Inc. Ophthalmic compositions

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