WO2005007212A2 - Systeme de liberation de substance active a ajustage individuel - Google Patents

Systeme de liberation de substance active a ajustage individuel Download PDF

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Publication number
WO2005007212A2
WO2005007212A2 PCT/DE2004/001512 DE2004001512W WO2005007212A2 WO 2005007212 A2 WO2005007212 A2 WO 2005007212A2 DE 2004001512 W DE2004001512 W DE 2004001512W WO 2005007212 A2 WO2005007212 A2 WO 2005007212A2
Authority
WO
WIPO (PCT)
Prior art keywords
delivery system
drug delivery
individually adaptable
drug
carriers
Prior art date
Application number
PCT/DE2004/001512
Other languages
German (de)
English (en)
Other versions
WO2005007212A3 (fr
Inventor
Andreas Kokott
Martina Feldmann
Rainer Detsch
Matthias Schnabelrauch
Günter Ziegler
Sebastian Vogt
Original Assignee
Friedrich-Baur-Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Friedrich-Baur-Gmbh filed Critical Friedrich-Baur-Gmbh
Priority to EP04762372A priority Critical patent/EP1643920A2/fr
Publication of WO2005007212A2 publication Critical patent/WO2005007212A2/fr
Publication of WO2005007212A3 publication Critical patent/WO2005007212A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/72—Intramedullary pins, nails or other devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A61B17/8605—Heads, i.e. proximal ends projecting from bone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A61B17/864—Pins or screws or threaded wires; nuts therefor hollow, e.g. with socket or cannulated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/84—Fasteners therefor or fasteners being internal fixation devices
    • A61B17/86—Pins or screws or threaded wires; nuts therefor
    • A61B17/8685—Pins or screws or threaded wires; nuts therefor comprising multiple separate parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004—(bio)absorbable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A61F2002/2839—Bone plugs or bone graft dowels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • A61F2002/3068—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body the pharmaceutical product being in a reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A61L2300/608—Coatings having two or more layers
    • A61L2300/61—Coatings having two or more layers containing two or more active agents in different layers

Definitions

  • the present invention relates to an active substance release system that is provided for local active substance release in human or animal hard and soft tissue and for the fulfillment of stabilizing, supporting and filling functions.
  • implants are used in the area of the hard tissue and also in the area of the soft tissue.
  • the majority of the implants are used in bone surgery and in orthopedics for the treatment of fractures, malpositions, tumor defects and inflammatory processes.
  • the focus here is on stabilizing fractures and restoring biofunctionality, as disclosed, for example, in the document DE 10129490 AI.
  • implant materials that contain an active pharmaceutical ingredient.
  • these systems each contain only one active ingredient, gentamicin in the form of gentamicin sulfate or gentamicin cobefate.
  • these implants are not load-bearing and do not have a permanent placeholder function.
  • Bone cements containing antibiotics, such as the Copal ® cement are an exception to this. These cements fulfill load-bearing functions and at the same time release antibiotics.
  • a combination of freely selectable active ingredients, depending on the indication available to the patient, is not possible with these systems.
  • Drug release systems known. Some systems are based on the microencapsulation of active substances in bioabsorbable polymers, for example disclosed in DE 0069215360 T2. Other systems are based on the simple physical inclusion of active pharmaceutical ingredients in degradable and non-degradable matrices (for example J. Jagur-Grodzinski: Biomedical application of functional polymers. eactive & Functional Polymers 39 (1999) 99-138).
  • the matrices can be used both in compact form as moldings and as coatings.
  • Osteosynthesis plates, screws, pins, bolts, cages and ceramic bone substitute materials consist in the fact that they can only perform mechanical tasks.
  • implant materials coated with active ingredients for example the MEDI-COAT ® system from STS Biopolymers, Inc., New York, which however have the decisive disadvantage that they contain only one active ingredient applied during manufacture. This means that it is not possible with these systems to perform local pharmacotherapy according to the individual indication of the patient.
  • the invention is based on the object of specifying a locally acting active substance release system which on the one hand permits a patient-specific combination of active substances and on the other hand can perform mechanical functions.
  • the medical user should be able to put together local pharmacotherapy for each patient according to the respective indication, whereby he should have several active ingredients available, which should differ with regard to the dose, the release rate and the indication.
  • this system should make it possible to release two or more active substances spatially separated at the implantation site at the same time or with a time delay, depending on the individual indication. This property is particularly important in order to be able to apply non-compatible active substances. Furthermore, it can be useful to achieve spatially separated therapeutic effects with different active ingredients.
  • the patient-specific drug combinations should be used in such a way that the drug combination can be compiled preoperatively or during the operation phase according to the indication.
  • an individually adaptable active ingredient release system is provided in a modular principle.
  • This modular system is characterized in that it consists of a) a dimensionally stable, load-bearing base body, which is made of a non-resorbable and / or resorbable material, b) at least two visually distinguishable active substance carriers, which are made of resorbable and / or non-resorbable material, of which each contains at least one other pharmaceutical active ingredient, the active ingredient carriers being attached spatially separated in externally accessible cavities and / or on the surface of the base body, that the active ingredient carriers are introduced reversibly and / or irreversibly into the base body and / or onto the base body and / or can be applied, c) application aids for introducing and / or applying the active substance carriers into and / or onto the base body, and d) application aids for implanting and also explanting the base bodies loaded with the active substance carriers.
  • the visual distinguishability of the active substance carriers is determined by differences in color and / or consistency and / or the geometry and / or the dimensions achieved.
  • the active substance carriers are marked with one or more colors, the colors being able to be mixed or arranged on or in the active substance carriers in a predetermined order.
  • the base body preferably consists of salts, ceramics, glass ceramics, metal, synthetic polymers, natural
  • the base body can be made of titanium, titanium alloys, cobalt-chrome steel, magnesium, magnesium alloys, aluminum oxide, zirconium oxide, hydroxyapatite, tricalcium phosphate, octacalcium phosphate, quartz glass, phosphate glass, glass ceramics, polyamides, cellulose esters, cellulose ethers, polyethylene, polypropylene, polyamide,
  • the base body can be designed as a sphere, as a hemisphere, as an oval body, as a tube, cylinder, as a triangle, as a cube, as a cuboid, as a plate, as a saddle-shaped plate, or as a polyhedron, which can contain one or more openings that do not are intended for the absorption of the active substance carriers.
  • the base body preferably has the shape of a pin, a filler body (FIG. 9), a bolt (FIGS. 4 and 11), a nail or a screw (FIGS. 1-4 and FIG. 12).
  • the nail and the screw preferably have a countersunk head and / or a polygonal head and / or a round head and / or a spherical head.
  • the base body contains a cross slot and / or a straight slot and / or an internal polygon and / or an internal screw thread.
  • the base body according to the invention can be hollow and have a reversibly insertable and / or screwable closure (designated B1, B2, B3, B4, B5 in the figures). It is according to the invention that the surface of the base body contains notches and / or threads and / or grooves.
  • the base body is non-porous and / or interconnectively porous and / or non-interconnectively porous.
  • the surface of the base body according to the invention can be smooth and / or rough.
  • the externally accessible cavities of the base body are designed as through openings and / or blind-hole-like openings, which are optionally connected to one another and / or closable.
  • the active substance carrier consists of a non-resorbable and / or resorbable matrix and at least one pharmaceutical active substance.
  • the matrix can crosslink from collagen, gelatin! Collagen, cross-linked gelatin, cross-linked casein, pullulan, hyaluronic acid, hyaluronic acid derivatives, dextran, dextran derivatives, polylactide, polyglycolide, lactic acid copolymers, triglycerides, waxes, tricalcium phosphate, calcium carbonate, calcium sulfate, highly disperse silicon dioxide, polyamide, ethylene glycol, methylene glycol acrylate, cellulose glycol methacrylate or mixtures thereof.
  • the active substance carrier according to the invention is formed from at least one active substance. This means that the active substance carrier does not contain a matrix and consists only of at least one active substance. The advantage of this is that large amounts of active ingredient can be immobilized.
  • the matrix is made of synthetic
  • Polymers natural polymers and derivatives of natural polymers, triglycerides, waxes, fatty acids, tricalcium phosphate,
  • Calcium hydrogen phosphate calcium carbonate, calcium sulfate, highly disperse silicon dioxide, ceramics, physiologically harmless dyes and their mixtures.
  • the active substance carriers have at least one active substance from the groups of growth factors, interleukins, prostaglandins, antiphlogistics, steroids, peptide hormones, anesthetics, antimicrobial chemotherapeutics, antirheumatics, antihistamines Containing cytostatics, enzymes and vitamins. It is also advantageous if the active substance carriers contain, in addition to the active substance, physiologically harmless dyes. For the purposes of the invention, the active ingredients are applied in a therapeutically effective amount for a treatment period.
  • the active substance carriers can be in the form of an elongated cylinder and / or thread and / or in the form of a spiral and / or in the form of a circularly curved cylinder and / or in the form of a disk and / or a funnel and / or a granulate and / or a gel be formed and have a solid and / or rubber-like and / or gel-like and / or plastically deformable consistency.
  • the combination of active substance carriers in the base body is patient-specific.
  • syringes and / or funnels and / or tweezers and / or mixers and / or pipettes find application aids for introducing and / or applying the active substance carriers into and / or onto the base body.
  • These devices are specially adapted to the body and active ingredient carrier, with screwdrivers and / or polygonal screwdrivers and / or pliers and / or socket wrenches and / or threaded rods and / or tweezers and / or thread cutters and / or drills and / or rasp application aids for implantation and also Explant the base bodies loaded with the active substance carriers.
  • These devices are specially adapted to the body and drug carrier.
  • an implantable modular system which consists of a dimensionally stable, load-bearing body and at least two drug carriers, each containing at least one different active ingredient.
  • Exemplary embodiment 1 A basic body in the form of a screw (height 15 mm, diameter 6 mm) with a cross head made of aluminum oxide is produced from a green body by mechanical processing and subsequent sintering, the two through bores (diameter 1.5 mm) perpendicular to Screw axis are arranged.
  • a cylindrical active ingredient carrier 1 (length 6 mm, diameter 1.5 mm) is produced from a mixture of 70 percent by weight poly-D, L-lactide (molecular weight 50,000 g / mol), 29 percent by weight dexamethasone phosphate, 1 percent by weight eosin acetate. The active ingredient carrier 1 is colored red.
  • a cylindrical active substance carrier 2 (length 6 mm, diameter 1.5 mm) is produced from a mixture of 70 percent by mass poly-D, L-lactide (molar mass 50,000 g / mol), 29 percent by mass erythromycin, 1 percent by mass.
  • the active ingredient carrier 2 is colorless.
  • the active substance carrier 1 is then introduced into one of the two bores in a form-fitting manner with an application aid.
  • the active ingredient carrier 2 is then introduced into the second hole.
  • the base body loaded with the active substance carriers is applied into an insulated cattle bone (thigh) after a threaded hole has been drilled using a Phillips screwdriver.
  • Example 2 Example 2:
  • a rubber-like, annular active substance carrier 1 (diameter 7 mm, ring thickness 2 mm) is produced from a mixture of 90 percent by weight of polymer (copolymer D, L-lactide and trimethylene carbonate), 9 percent by weight of vitamin D, 1 percent by weight of eosin acetate.
  • the active ingredient carrier 1 is colored red.
  • a rubber-like, annular active substance carrier 2 (diameter 7 mm, ring thickness 2 mm) is produced from a mixture of 90 percent by weight of polymer (copolymer D, L-lactide and trimethylene carbonate), 9 percent by weight of dexamethasone phosphate and 1 percent by weight of chlorophyll.
  • the active ingredient carrier 2 is colored green.
  • the active ingredient carrier 1 is then applied with an application aid in one of the two grooves. Then the drug carrier 2 is snapped into the second groove.
  • the base body loaded with the active substance carriers is applied to an insulated cattle bone (thigh) after using a conical opening with the aid of pliers.
  • a basic body in the form of a packing (height 15 mm, diameter 8 mm) is made from a green body by mechanical processing and subsequent sintering from zirconium oxide with a through hole (2 mm), which is screwed on one side by a screw-on cover ( 15) can be closed.
  • a gel-like active substance carrier 1 is produced from a mixture of 4 percent by weight sodium hyaluronic acid, 94 percent by weight water, 1 vitamin D, 1 percent by weight eosin. The active ingredient carrier 1 is colored red.
  • a gel-like active substance carrier 2 is produced from a mixture of 5% by mass sodium hyaluronic acid, 90% by mass water and 5% by mass taurolidine.
  • the active ingredient carrier 1 is then applied with an application aid in the form of a syringe into the bore from the closable side.
  • the hole is filled with the active ingredient carrier 2.
  • the hole is closed on one side with the cover provided.
  • the grand body loaded with the active ingredient carriers is applied into an isolated cattle bone (thigh) after opening an opening with the aid of pliers in the cancellous bone.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un système de libération de substance active. L'objectif de cette invention est de créer un système de libération de substance active à action topique qui permet une combinaison de substances actives spécifique à chaque patient et qui peut en outre remplir des fonctions mécaniques. A cet effet, un système à ajustage individuel est produit à partir d'un corps de base porteur qui présente une stabilité dimensionnelle et qui est constitué d'un matériau non résorbable et/ou résorbable. Au moins deux supports de substance active différenciables visuellement qui sont constitués d'un matériau résorbable et/ou non résorbable et qui contiennent respectivement au moins une substance pharmaceutique différente, sont montés de manière à être séparés spatialement, dans des espaces creux accessibles par l'extérieur et/ou sur les surfaces dudit corps de base, de façon à pouvoir être insérés de manière réversible et/ou irréversible dans le corps de base et/ou être disposés de manière réversible et/ou irréversible sur le corps de base. Le système de libération de substance active comprend en outre des auxiliaires d'application utilisés pour insérer le support de substance active dans le corps de base et/ou le disposer sur celui-ci, ainsi que des auxiliaires d'application pour implanter et explanter le corps de base comportant lesdits supports de substance active.
PCT/DE2004/001512 2003-07-10 2004-07-06 Systeme de liberation de substance active a ajustage individuel WO2005007212A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP04762372A EP1643920A2 (fr) 2003-07-10 2004-07-06 Systeme de liberation de substance active a ajustage individuel

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WO2007123978A3 (fr) * 2006-04-21 2008-03-06 Davol Inc Procédé et appareil de fixation chirurgicale
EP1981417A2 (fr) * 2006-01-13 2008-10-22 BioDynamics LLC Attaches chirurgicales et dispositifs de greffes associes a composants bioabsorbables
EP2341852A1 (fr) * 2008-08-29 2011-07-13 Smed-Ta/Td, Llc Implant orthopédique
US9265539B2 (en) 2008-07-01 2016-02-23 Biedermann Technologies Gmbh & Co. Kg Bone anchor with plug member and tool for inserting the plug member into the bone anchor
US9271725B2 (en) 2006-07-18 2016-03-01 Davol, Inc. Method and apparatus for surgical fastening
WO2017017648A1 (fr) * 2015-07-30 2017-02-02 Tecres S.P.A. Dispositif prothétique comprenant des antibiotiques
RU187285U1 (ru) * 2019-01-17 2019-02-28 Общество с ограниченной ответственностью "Демико-про" Металлоконструкция для интрамедуллярного остеосинтеза трубчатых костей
US12023252B2 (en) 2015-07-30 2024-07-02 Tecres S.P.A. Prosthetic device with antibiotics

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DE102007039871A1 (de) 2007-08-21 2009-02-26 Friedrich-Baur-Gmbh Weichgewebe-Implantat mit antibakterieller Wirkung

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US5660225A (en) * 1993-08-30 1997-08-26 Saffran; Bruce Nathan Method of fracture treatment by restraining macromolecules or macromolecular aggregates adjacent to damaged tissues
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US5984926A (en) * 1998-02-24 1999-11-16 Jones; A. Alexander M. Bone screw shimming and bone graft containment system and method
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EP1981417A2 (fr) * 2006-01-13 2008-10-22 BioDynamics LLC Attaches chirurgicales et dispositifs de greffes associes a composants bioabsorbables
EP1981417A4 (fr) * 2006-01-13 2009-11-18 Biodynamics L L C Attaches chirurgicales et dispositifs de greffes associes a composants bioabsorbables
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US7862573B2 (en) 2006-04-21 2011-01-04 Darois Roger E Method and apparatus for surgical fastening
WO2007123978A3 (fr) * 2006-04-21 2008-03-06 Davol Inc Procédé et appareil de fixation chirurgicale
EP2361559A1 (fr) * 2006-04-21 2011-08-31 Davol, Inc. Appareil de fixation chirurgicale
US9271725B2 (en) 2006-07-18 2016-03-01 Davol, Inc. Method and apparatus for surgical fastening
US9730745B2 (en) 2008-07-01 2017-08-15 Biedermann Technologies Gmbh & Co. Kg Bone anchor with plug member and tool for inserting the plug member into the bone anchor
US9265539B2 (en) 2008-07-01 2016-02-23 Biedermann Technologies Gmbh & Co. Kg Bone anchor with plug member and tool for inserting the plug member into the bone anchor
EP2140824B1 (fr) * 2008-07-01 2016-06-08 Biedermann Technologies GmbH & Co. KG Ancrage canulé d'os avec élément de prise et outil d'insertion de l'élément de prise dans l'ancrage d'os
EP2341852A4 (fr) * 2008-08-29 2014-06-04 Smed Ta Td Llc Implant orthopédique
EP2341852A1 (fr) * 2008-08-29 2011-07-13 Smed-Ta/Td, Llc Implant orthopédique
WO2017017648A1 (fr) * 2015-07-30 2017-02-02 Tecres S.P.A. Dispositif prothétique comprenant des antibiotiques
US11051945B2 (en) 2015-07-30 2021-07-06 Tecres S.P.A. Prosthetic device with antibiotics
US12023252B2 (en) 2015-07-30 2024-07-02 Tecres S.P.A. Prosthetic device with antibiotics
RU187285U1 (ru) * 2019-01-17 2019-02-28 Общество с ограниченной ответственностью "Демико-про" Металлоконструкция для интрамедуллярного остеосинтеза трубчатых костей

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DE10332072A1 (de) 2005-03-24
EP1643920A2 (fr) 2006-04-12
WO2005007212A3 (fr) 2005-03-31

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