WO2005003104A3 - Monohydrate de lamotrigine - Google Patents
Monohydrate de lamotrigine Download PDFInfo
- Publication number
- WO2005003104A3 WO2005003104A3 PCT/IN2004/000186 IN2004000186W WO2005003104A3 WO 2005003104 A3 WO2005003104 A3 WO 2005003104A3 IN 2004000186 W IN2004000186 W IN 2004000186W WO 2005003104 A3 WO2005003104 A3 WO 2005003104A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lamotrigine
- monohydrate
- anhydrous
- dichlorophenyl
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0315608.0 | 2003-07-03 | ||
GB0315608A GB2395483A (en) | 2003-07-03 | 2003-07-03 | Crystalline lamotrigine and its monohydrate |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005003104A2 WO2005003104A2 (fr) | 2005-01-13 |
WO2005003104A3 true WO2005003104A3 (fr) | 2005-09-22 |
Family
ID=27741536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2004/000186 WO2005003104A2 (fr) | 2003-07-03 | 2004-06-28 | Monohydrate de lamotrigine |
Country Status (2)
Country | Link |
---|---|
GB (1) | GB2395483A (fr) |
WO (1) | WO2005003104A2 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005027149A1 (de) * | 2005-06-11 | 2006-12-14 | Lanxess Deutschland Gmbh | Verfahren zur Herstellung von substituierten Benzoylcyaniden |
US20120142919A1 (en) * | 2006-08-02 | 2012-06-07 | Medichem, S.A. | Method for synthesizing lamotrigine |
CN103570637A (zh) * | 2013-09-13 | 2014-02-12 | 盐城凯利药业有限公司 | 一种拉莫三嗪的制备方法 |
CN106083753B (zh) * | 2016-06-07 | 2019-04-02 | 浙江奇彩环境科技股份有限公司 | 一种改进的拉莫三嗪合成工艺 |
CN114948868B (zh) * | 2021-04-16 | 2023-04-14 | 上海奥科达医药科技股份有限公司 | 一种拉莫三嗪水合物的晶体形式、其制备方法及包含其的组合物 |
CN115068422B (zh) * | 2022-08-19 | 2022-11-29 | 上海奥科达生物医药科技有限公司 | 一种拉莫三嗪湿混悬剂及其制备方法和应用 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0247892A1 (fr) * | 1986-05-30 | 1987-12-02 | The Wellcome Foundation Limited | Sels de triazine |
EP0963980A2 (fr) * | 1998-06-10 | 1999-12-15 | The Wellcome Foundation Limited | Dérivé de 1,2,4-triazine, la preparation et l'utilisation comme marqueur de référence pour verifié la pureté et la stabilité de "lamotrigine" |
WO2000035888A1 (fr) * | 1998-12-14 | 2000-06-22 | Sharad Kumar Vyas | Procede et appareil ameliore de preparation de 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine |
EP1127873A2 (fr) * | 2000-02-25 | 2001-08-29 | Chemagis Ltd. | Procédé pour la préparation de benzoylcyanide amidinohydrazones |
WO2002068398A1 (fr) * | 2001-02-27 | 2002-09-06 | Teva Pharmaceutical Industries Ltd. | Nouvelles formes cristallines de lamotrigine et leurs procedes de preparation |
WO2003078407A1 (fr) * | 2001-12-24 | 2003-09-25 | Apotex Pharmachem Inc. | Nouveau procede efficace pour preparer de la lamotrigine et des 3,5-diamino-6-substitutees-1,2,4-triazines associees |
WO2004083191A1 (fr) * | 2003-03-17 | 2004-09-30 | Hetero Drugs Limited | Nouvelles formes cristallines de lamotrigine |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS234018B2 (en) * | 1979-06-01 | 1985-03-14 | Wellcome Found | Method of 3,5-diammino-6-1,2,4-triazine derivatives making |
-
2003
- 2003-07-03 GB GB0315608A patent/GB2395483A/en not_active Withdrawn
-
2004
- 2004-06-28 WO PCT/IN2004/000186 patent/WO2005003104A2/fr active Application Filing
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0247892A1 (fr) * | 1986-05-30 | 1987-12-02 | The Wellcome Foundation Limited | Sels de triazine |
EP0963980A2 (fr) * | 1998-06-10 | 1999-12-15 | The Wellcome Foundation Limited | Dérivé de 1,2,4-triazine, la preparation et l'utilisation comme marqueur de référence pour verifié la pureté et la stabilité de "lamotrigine" |
WO2000035888A1 (fr) * | 1998-12-14 | 2000-06-22 | Sharad Kumar Vyas | Procede et appareil ameliore de preparation de 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine |
EP1127873A2 (fr) * | 2000-02-25 | 2001-08-29 | Chemagis Ltd. | Procédé pour la préparation de benzoylcyanide amidinohydrazones |
WO2002068398A1 (fr) * | 2001-02-27 | 2002-09-06 | Teva Pharmaceutical Industries Ltd. | Nouvelles formes cristallines de lamotrigine et leurs procedes de preparation |
WO2003078407A1 (fr) * | 2001-12-24 | 2003-09-25 | Apotex Pharmachem Inc. | Nouveau procede efficace pour preparer de la lamotrigine et des 3,5-diamino-6-substitutees-1,2,4-triazines associees |
WO2004083191A1 (fr) * | 2003-03-17 | 2004-09-30 | Hetero Drugs Limited | Nouvelles formes cristallines de lamotrigine |
Non-Patent Citations (1)
Title |
---|
KUBICKI, M. ET AL: "Hydrogen bonding patterns in 3,5-diamino-6-aryl triazines", JOURNAL OF MOLECULAR STRUCTURE , 570(1-3), 53-60 CODEN: JMOSB4; ISSN: 0022-2860, 2001, XP002308632 * |
Also Published As
Publication number | Publication date |
---|---|
GB0315608D0 (en) | 2003-08-13 |
WO2005003104A2 (fr) | 2005-01-13 |
GB2395483A (en) | 2004-05-26 |
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