WO2005002553A3 - Fluconazole capsules with improved release - Google Patents

Fluconazole capsules with improved release Download PDF

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Publication number
WO2005002553A3
WO2005002553A3 PCT/HU2004/000071 HU2004000071W WO2005002553A3 WO 2005002553 A3 WO2005002553 A3 WO 2005002553A3 HU 2004000071 W HU2004000071 W HU 2004000071W WO 2005002553 A3 WO2005002553 A3 WO 2005002553A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluconazole
active ingredient
capsules
release
improved release
Prior art date
Application number
PCT/HU2004/000071
Other languages
French (fr)
Other versions
WO2005002553A2 (en
Inventor
Pal Fekete
Judit Virgula
Eva Furdyga
Huszar Magdolna Leventiszne
Imre Klebovich
Nemes Katalin Baloghne
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Pal Fekete
Judit Virgula
Eva Furdyga
Huszar Magdolna Leventiszne
Imre Klebovich
Nemes Katalin Baloghne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egyt Gyogyszervegyeszeti Gyar, Pal Fekete, Judit Virgula, Eva Furdyga, Huszar Magdolna Leventiszne, Imre Klebovich, Nemes Katalin Baloghne filed Critical Egyt Gyogyszervegyeszeti Gyar
Priority to EA200600085A priority Critical patent/EA008585B1/en
Priority to SK5013-2006A priority patent/SK50132006A3/en
Priority to UAA200600919A priority patent/UA82532C2/en
Priority to EP04743730A priority patent/EP1648451A2/en
Publication of WO2005002553A2 publication Critical patent/WO2005002553A2/en
Publication of WO2005002553A3 publication Critical patent/WO2005002553A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The object of the invention is to provide fluconazole containing capsules with improved active ingredient release. The in vitro dissolution as well as in vivo absorption of the fluconazole capsules according to the invention is faster and more consistent than those of commercial compositions containing fluconazole. The invention is based on the fact that granulation of fluconazole particles with an agent capable to provide hydrophilic surface, e.g. lactose, to said particles results in fast an consistent release of the active ingredient. In this way, capsules according to the invention are suitable to provide enhanced absorption of said active ingredient.
PCT/HU2004/000071 2003-07-02 2004-06-30 Fluconazole capsules with improved release WO2005002553A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EA200600085A EA008585B1 (en) 2003-07-02 2004-06-30 Fluconazole capsules with improved release
SK5013-2006A SK50132006A3 (en) 2003-07-02 2004-06-30 Fluconazole capsules with improved release
UAA200600919A UA82532C2 (en) 2003-07-02 2004-06-30 Normal;heading 1;heading 2;FLUCONAZOLE CAPSULES WITH IMPROVED RELEASE
EP04743730A EP1648451A2 (en) 2003-07-02 2004-06-30 Fluconazole capsules with improved release

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HUP0302030 2003-07-02
HU0302030A HU227142B1 (en) 2003-07-02 2003-07-02 Capsule of improved release containing fluconazole

Publications (2)

Publication Number Publication Date
WO2005002553A2 WO2005002553A2 (en) 2005-01-13
WO2005002553A3 true WO2005002553A3 (en) 2005-03-24

Family

ID=89981480

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/HU2004/000071 WO2005002553A2 (en) 2003-07-02 2004-06-30 Fluconazole capsules with improved release

Country Status (10)

Country Link
EP (1) EP1648451A2 (en)
CN (1) CN1812783A (en)
BG (1) BG109430A (en)
CZ (1) CZ200657A3 (en)
EA (1) EA008585B1 (en)
HU (1) HU227142B1 (en)
PL (1) PL380995A1 (en)
SK (1) SK50132006A3 (en)
UA (1) UA82532C2 (en)
WO (1) WO2005002553A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005005446A1 (en) 2005-02-04 2006-08-10 Grünenthal GmbH Break-resistant dosage forms with sustained release
DE10361596A1 (en) 2003-12-24 2005-09-29 Grünenthal GmbH Process for producing an anti-abuse dosage form
DE102004032049A1 (en) 2004-07-01 2006-01-19 Grünenthal GmbH Anti-abuse, oral dosage form
GB0900786D0 (en) * 2009-01-19 2009-03-04 Natracine Uk Ltd Therapeutic compositions
MD3971C2 (en) * 2009-04-29 2010-06-30 Дмитрий СКУРТУ Chair-trainer
CN103857386A (en) 2011-07-29 2014-06-11 格吕伦塔尔有限公司 Tamper-resistant tablet providing immediate drug release
LT2736495T (en) 2011-07-29 2017-11-10 Grünenthal GmbH Tamper-resistant tablet providing immediate drug release
CN105682643B (en) 2013-07-12 2019-12-13 格吕伦塔尔有限公司 Tamper resistant dosage form containing ethylene-vinyl acetate polymer
CN105616378A (en) * 2014-10-31 2016-06-01 康普药业股份有限公司 Fluconazole capsule and preparation method therefor
EP3346991A1 (en) 2015-09-10 2018-07-18 Grünenthal GmbH Protecting oral overdose with abuse deterrent immediate release formulations
CN113230236A (en) * 2021-04-29 2021-08-10 山东优杰生物科技有限公司 Plaster for removing onychomycosis and preparation method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018757A1 (en) * 1992-03-17 1993-09-30 Pfizer Inc. Method of producing porous delivery devices
WO2000056726A1 (en) * 1999-03-24 2000-09-28 Fmc Corporation Improved aqueous solubility pharmaceutical formulations
US6214386B1 (en) * 1995-11-22 2001-04-10 Recordati, S.A. Prompt-release oral pharmaceutical compositions for extemporaneous suspensions
WO2001041765A1 (en) * 1999-12-08 2001-06-14 Dong A Pharm. Co., Ltd. Compositions containing itraconazole with improved bioavailability and narrow intra- and inter-individual variation of its absorption
RU2201230C1 (en) * 2001-12-24 2003-03-27 Закрытое акционерное общество "Брынцалов-А" Medicinal agent "flusol" eliciting antifungal effect

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018757A1 (en) * 1992-03-17 1993-09-30 Pfizer Inc. Method of producing porous delivery devices
US6214386B1 (en) * 1995-11-22 2001-04-10 Recordati, S.A. Prompt-release oral pharmaceutical compositions for extemporaneous suspensions
WO2000056726A1 (en) * 1999-03-24 2000-09-28 Fmc Corporation Improved aqueous solubility pharmaceutical formulations
WO2001041765A1 (en) * 1999-12-08 2001-06-14 Dong A Pharm. Co., Ltd. Compositions containing itraconazole with improved bioavailability and narrow intra- and inter-individual variation of its absorption
RU2201230C1 (en) * 2001-12-24 2003-03-27 Закрытое акционерное общество "Брынцалов-А" Medicinal agent "flusol" eliciting antifungal effect

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 200347, Derwent World Patents Index; Class B05, AN 2003-502496, XP002314064 *
EL-ASSASY A I ET AL: "Factorial design-based formulation of fluconazol capsules", EGYPTIAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 39, no. 4-6, 1998, pages 337 - 346, XP009042805, ISSN: 0301-5068 *
PORTA V ET AL: "Evaluation of the bioequivalence of capsules containing 150 mg of fluconazole", INTERNATIONAL JOURNAL OF PHARMACEUTICS, AMSTERDAM, NL, vol. 288, no. 1, 6 January 2005 (2005-01-06), pages 81 - 86, XP004682403, ISSN: 0378-5173 *

Also Published As

Publication number Publication date
EA008585B1 (en) 2007-06-29
EP1648451A2 (en) 2006-04-26
CN1812783A (en) 2006-08-02
PL380995A1 (en) 2007-04-16
UA82532C2 (en) 2008-04-25
EA200600085A1 (en) 2006-08-25
SK50132006A3 (en) 2006-05-04
HU227142B1 (en) 2010-08-30
WO2005002553A2 (en) 2005-01-13
HUP0302030A2 (en) 2005-03-29
HU0302030D0 (en) 2003-09-29
BG109430A (en) 2006-11-30
CZ200657A3 (en) 2006-04-12

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