CN113230236A - Plaster for removing onychomycosis and preparation method thereof - Google Patents
Plaster for removing onychomycosis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a herbal plaster for removing onychomycosis, which belongs to the technical field of onychomycosis treatment, and comprises a base layer plaster body and a covering plaster body, and is characterized in that: the covering patch comprises a supporting carrier and calcium peroxide coated on one side of the supporting carrier, and the covering patch has the beneficial effects that: based on hydrogel, a plurality of materials and traditional Chinese medicine ointment are added into the formula, and the materials are added into excessive white vinegar, so that the problem that traditional Chinese medicine powder is not easily compatible with matrix materials in the basic formula of the existing hydrogel herbal patch is solved; the covering patch is added with calcium peroxide, the covering patch and the base patch act with excessive acetic acid to generate calcium acetate with antibacterial effect, the calcium acetate plays a role in fixing after being cured by matching with plaster of paris, and the traditional Chinese medicine ointment can fully exert the drug effect at the temperature of reaction release; in particular, the generated hydrogen peroxide is kept in the calcium acetate and gel system and is slowly released through the porous structure of the non-woven fabric, so that the durability of the drug effect is improved.
Description
The technical field is as follows:
the invention belongs to the technical field of onychomycosis treatment, and particularly relates to a herbal plaster for removing onychomycosis and a preparation method thereof.
Background art:
onychomycosis is a disease of nails caused by fungal infection, and the nails become thick, brittle, loose and empty after being infected; the surface is black, yellow, grey, white and the like, and areas with high air humidity adapt to the growth environment of fungi, so the incidence rate is higher. Onychomycosis also has infectivity, and affects the beauty and physical and mental health of patients.
The existing treatment methods of onychomycosis mainly comprise oral medicine systemic treatment and topical treatment of diseased nails by external medicines. Common oral therapeutic drugs include itraconazole, terbinafine hydrochloride and the like; the topical medicine comprises 10% iodine tincture, salicylic acid and benzoic acid solution, LIANGJIA, glacial acetic acid, etc.
Many patients always prefer to select external medicines for treatment because the oral medicines have great damage to the liver, and the external medicines and the method for treating the onychomycosis have no unified standard and medicines with specific curative effects at home and abroad.
The invention content is as follows:
in order to solve the problems and overcome the defects of the prior art, the invention provides the herbal plaster for removing the onychomycosis, the method is based on hydrogel, and by adding medicines with different efficacies, the composition can dissolve necrotic nails and promote the growth of new nails under the combined action of various raw materials, thereby effectively relieving the symptoms of the onychomycosis and treating the onychomycosis.
The specific technical scheme for solving the technical problems comprises the following steps: dispel onychomycosis herbal subsides, including basic unit's skin and cover skin, its characterized in that: the basic layer paster comprises a traditional Chinese medicine ointment, glycerol, ethylhexyl glycerol, sodium polyacrylate, 1, 2-pentanediol, butanediol, methyl hydroxybenzoate, phenoxyethanol, 1, 2-hexanediol, menthol and water, wherein the traditional Chinese medicine ointment comprises calcined gypsum, white vinegar, alcohol, pseudo-ginseng, alum, golden larch bark, golden cypress, radix sophorae flavescentis, garden balsam stem, rocket and single-clove garlic.
The covering paster body comprises a supporting carrier and calcium peroxide coated on one side of the supporting carrier.
The formula of the base layer patch comprises, by mass, 20-40 parts of a traditional Chinese medicine paste body, 10-20 parts of glycerol, 2-7 parts of ethylhexyl glycerol, 1-7 parts of sodium polyacrylate, 1-8 parts of 1, 2-pentanediol, 1-8 parts of butanediol, 2-6 parts of methylparaben, 1-6 parts of phenoxyethanol, 1-6 parts of 1, 2-hexanediol, 1-6 parts of menthol and 8-20 parts of water; the mass ratio of the traditional Chinese medicine ointment to the calcium peroxide is 4-8: 1.
The traditional Chinese medicine ointment is prepared from 2-4 parts of plaster of paris, 15-30 parts of white vinegar, 6-8 parts of alcohol, 2-6 parts of pseudo-ginseng, 2-6 parts of alum, 2-6 parts of golden larch bark, 2-6 parts of golden cypress, 2-6 parts of radix sophorae flavescentis, 2-6 parts of garden balsam stem, 2-6 parts of herba solidaginis and 2-6 parts of single-clove garlic in parts by weight.
The preparation method of the herbal plaster for removing onychomycosis comprises the following steps: preparing a base layer skin and preparing a covering skin,
the preparation of the basic layer skin comprises the following steps:
weighing according to a process formula;
adding glycerol, ethylhexyl glycerol, sodium polyacrylate, 1, 2-pentanediol, butanediol, methyl hydroxybenzoate, phenoxyethanol, 1, 2-hexanediol and menthol into a water bath kettle, refluxing in water bath to form a uniform solution, collecting, and cooling to room temperature;
mixing Gypsum Fibrosum Preparatum, white vinegar, alcohol, Notoginseng radix, Alumen, cortex pseudolaricis, cortex Phellodendri, radix Sophorae Flavescentis, herba Speranskiae Tuberculatae, herba Achilleae and Bulbus Allii according to formula, and stirring slowly to obtain uniform Chinese medicinal paste; adding the obtained traditional Chinese medicine paste and water into the solution obtained in the step (II), fully dissolving and slowly stirring;
fourthly, stirring the mixed solution obtained in the third step until the mixed solution is uniformly mixed under the condition that the vacuum degree is not lower than-0.06 MPa, and avoiding the generation of bubbles; pouring the mixed solution into a forming mold, and cooling to form the hydrogel herbal plaster;
preparing a covering skin body: adding calcium peroxide into absolute ethyl alcohol according to the weight ratio of 1:1-3 according to the weight of the formula to prepare a suspension, and coating the suspension on one side of a support carrier.
The support carrier is non-woven fabric.
In the step (II), the water bath temperature is 70-85 ℃, and the water bath time is 1-1.5 h.
In the step (IV), the stirring speed is 65-75rpm, and the stirring time is 5-15 min.
The invention has the beneficial effects that:
the hydrogel is creatively used as the basis, a plurality of materials and the traditional Chinese medicine ointment are added into the formula, and the materials are added into the excessive white vinegar, so that the problem that the traditional Chinese medicine powder is not easily compatible with the matrix material in the basic formula of the existing hydrogel herbal plaster is solved while the medicine effect is fully exerted;
the invention creatively designs the base layer paster body and the covering paster body, calcium peroxide is added into the covering paster body, the covering paster body and the base layer paster body are excessively added with acetic acid to act, calcium acetate with bacteriostasis effect is generated, the calcium acetate plays a role in fixing after being matched with plaster of paris after solidification,
meanwhile, the temperature released by reaction can fully exert the drug effect of the traditional Chinese medicine ointment;
in particular, the generated hydrogen peroxide is kept in the calcium acetate and gel system and is slowly released through the porous structure of the non-woven fabric, so that the durability of the drug effect is improved.
The specific implementation mode is as follows:
in the description of the invention, specific details are given only to enable a full understanding of the embodiments of the invention, but it should be understood by those skilled in the art that the invention is not limited to these details for the implementation. In other instances, well-known structures and functions have not been described or shown in detail to avoid obscuring the points of the embodiments of the invention. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
The specific implementation mode of the invention is as follows:
dispel onychomycosis herbal subsides, including basic unit's skin and cover skin, its characterized in that: the basic layer paster comprises a traditional Chinese medicine ointment, glycerol, ethylhexyl glycerol, sodium polyacrylate, 1, 2-pentanediol, butanediol, methyl hydroxybenzoate, phenoxyethanol, 1, 2-hexanediol, menthol and water, wherein the traditional Chinese medicine ointment comprises calcined gypsum, white vinegar, alcohol, pseudo-ginseng, alum, golden larch bark, golden cypress, radix sophorae flavescentis, garden balsam stem, rocket and single-clove garlic.
The covering paster body comprises a supporting carrier and calcium peroxide coated on one side of the supporting carrier.
The formula of the base layer patch comprises, by mass, 20-40 parts of a traditional Chinese medicine paste body, 10-20 parts of glycerol, 2-7 parts of ethylhexyl glycerol, 1-7 parts of sodium polyacrylate, 1-8 parts of 1, 2-pentanediol, 1-8 parts of butanediol, 2-6 parts of methylparaben, 1-6 parts of phenoxyethanol, 1-6 parts of 1, 2-hexanediol, 1-6 parts of menthol and 8-20 parts of water; the mass ratio of the traditional Chinese medicine ointment to the calcium peroxide is 4-8: 1.
The traditional Chinese medicine ointment is prepared from 2-4 parts of plaster of paris, 15-30 parts of white vinegar, 6-8 parts of alcohol, 2-6 parts of pseudo-ginseng, 2-6 parts of alum, 2-6 parts of golden larch bark, 2-6 parts of golden cypress, 2-6 parts of radix sophorae flavescentis, 2-6 parts of garden balsam stem, 2-6 parts of herba solidaginis and 2-6 parts of single-clove garlic in parts by weight; .
The preparation method of the herbal plaster for removing onychomycosis comprises the following steps: preparing a base layer skin and preparing a covering skin,
the preparation of the basic layer skin comprises the following steps:
weighing according to a process formula;
adding glycerol, ethylhexyl glycerol, sodium polyacrylate, 1, 2-pentanediol, butanediol, methyl hydroxybenzoate, phenoxyethanol, 1, 2-hexanediol and menthol into a water bath kettle, refluxing in water bath to form a uniform solution, collecting, and cooling to room temperature;
mixing Gypsum Fibrosum Preparatum, white vinegar, alcohol, Notoginseng radix, Alumen, cortex pseudolaricis, cortex Phellodendri, radix Sophorae Flavescentis, herba Speranskiae Tuberculatae, herba Achilleae and Bulbus Allii according to formula, and stirring slowly to obtain uniform Chinese medicinal paste; adding the obtained traditional Chinese medicine paste and water into the solution obtained in the step (II), fully dissolving and slowly stirring;
fourthly, stirring the mixed solution obtained in the third step until the mixed solution is uniformly mixed under the condition that the vacuum degree is not lower than-0.06 MPa, and avoiding the generation of bubbles; pouring the mixed solution into a forming mold, and cooling to form the hydrogel herbal plaster;
preparing a covering skin body: adding calcium peroxide into absolute ethyl alcohol according to the weight ratio of 1:1-3 according to the weight of the formula to prepare a suspension, and coating the suspension on one side of a support carrier.
The support carrier is non-woven fabric. In the step (II), the water bath temperature is 70-85 ℃, and the water bath time is 1-1.5 h. In the step (IV), the stirring speed is 65-75rpm, and the stirring time is 5-15 min;
the pharmacology involved therein includes: plaster of paris (promoting granulation, stopping bleeding), pseudo-ginseng (promoting blood circulation, removing obstruction in channels), alum (relieving itching, stopping bleeding), alcohol (sterilizing and disinfecting), cortex pseudolaricis (removing blood stasis, removing obstruction in channels, resisting bacteria, stopping itching), phellodendron (clearing heat, detoxifying), sophora flavescens (clearing heat, dispelling wind, killing parasites), lopseed (relaxing tendons and activating collaterals), herba solidaginis (promoting blood circulation, removing blood stasis, relieving swelling and pain), garlic (sterilizing), white vinegar (killing parasites and stopping bleeding) are added into the formula, the invention creatively takes hydrogel as the basis, and various materials and the traditional Chinese medicine ointment are added into the formula, so that the problem that the traditional Chinese medicine powder is not easily compatible with the matrix material in the existing hydrogel plaster basic formula is solved while the medicine effect is fully exerted;
in order to more intuitively show the process advantages of the invention, the method of the invention adopting the base layer veneer and the covering veneer with calcium peroxide is compared with the method of the same process adopting equivalent replacement,
comparative example one:
the preparation method is the same as the embodiment except that: in the preparation process of the comparative example, no calcium peroxide was added to the covering patch;
comparative example two:
the preparation method is the same as the embodiment except that: in the preparation process of the comparative example, no white vinegar was added to the base layer skin;
comparative example three:
the preparation method is the same as the embodiment except that: in the preparation process of the comparative example, the amount of the white vinegar added to the base layer skin is reduced from 15-30 parts to 5 parts;
the above examples and comparative examples were used according to the method of use of the present invention, and the temperature, pH and the effect of forming the hydrogel during use were measured, and the results of the measurements are shown in Table 1:
table 1: performance index of herbal plaster under different conditions
| Self-heating | Action pH | Molding rate | |
| Examples | Is provided with | Acidity | 98％ |
| Comparative example 1 | Is free of | Acidity | 96％ |
| Comparative example No. two | Is free of | Alkalescence | 85％ |
| Comparative example No. three | Is provided with | Neutral property | 90％ |
Testing basis: the patients with onychomycosis were selected and aged at random, and the severity of onychomycosis was randomized, and the patients were covered with herbal patches on the nail covers after washing their feet before sleeping for 3 months in 20 groups of individuals who had received the compositions prepared in the examples and comparative examples, respectively.
Table 2: drug effect index of herbal plaster under different conditions
According to the data analysis of the table 1 and the table 2, the following results can be obtained:
for the first proportion, the material has no self-heating property, high forming and poor effect,
the reason is probably that calcium peroxide is not added, so that although an acidic environment is provided, a higher forming rate is ensured, the calcium acetate cannot be converted, heat and hydrogen peroxide are released at the same time, and the herbal patch does not have a self-heating function and cannot ensure the efficient release of traditional Chinese medicine substances;
for the second proportion, the material does not have the self-heating characteristic, the molding is poor, the effect is poor,
the reason for this is probably that acetic acid is not added, the medicine acts in a weakly alkaline environment, the matrix materials in the basic formula of the hydrogel herbal plaster are not easy to be compatible under alkaline conditions, the forming rate is poor, the hydrogel herbal plaster cannot be converted into calcium acetate and release heat and hydrogen peroxide at the same time, the herbal plaster does not have a self-heating function, and the high-efficiency release of traditional Chinese medicine substances cannot be guaranteed;
for the third ratio, the material has certain self-heating property, is general in forming and general in action,
because the acetic acid and the calcium peroxide are converted into the calcium acetate to a certain degree and release heat and hydrogen peroxide at the same time, the calcium acetate has the bacteriostasis effect and plays a fixing effect after being matched with the plaster of paris for solidification,
the heat release ensures that the traditional Chinese medicine ointment fully exerts the drug effect, and the drug effect is improved to a certain extent from 65% to 85%; the generated hydrogen peroxide is kept in the calcium acetate and gel system and is slowly released through the porous structure of the non-woven fabric, so that the durability of the drug effect is improved;
however, although acetic acid is added, the acetic acid can only meet the action with calcium peroxide, the action of the medicine is in a neutral environment, and the matrix materials in the basic formula of the herbal plaster are still incompatible to a certain extent, so that the forming rate is influenced.
In summary, the following steps: the hydrogel is creatively used as the basis, a plurality of materials and the traditional Chinese medicine ointment are added into the formula, and the materials are added into the excessive white vinegar, so that the problem that the traditional Chinese medicine powder is not easily compatible with the matrix material in the basic formula of the existing hydrogel herbal plaster is solved under the acidic condition while the medicine effect is fully exerted;
the base layer patch and the covering patch are creatively designed, calcium peroxide is added into the covering patch, the covering patch and the base layer patch are excessively added with acetic acid to act, calcium acetate with an antibacterial effect is generated, the calcium acetate is matched with plaster of paris to play a fixing effect after being solidified, and meanwhile, the temperature of reaction release can fully exert the drug effect of the traditional Chinese medicine ointment; in particular, the generated hydrogen peroxide is kept in the calcium acetate and gel system and is slowly released through the porous structure of the non-woven fabric, so that the durability of the drug effect is improved.
Claims (8)
1. Dispel onychomycosis herbal subsides, including basic unit's skin and cover skin, its characterized in that: the basic layer paster comprises a traditional Chinese medicine ointment, glycerol, ethylhexyl glycerol, sodium polyacrylate, 1, 2-pentanediol, butanediol, methyl hydroxybenzoate, phenoxyethanol, 1, 2-hexanediol, menthol and water, wherein the traditional Chinese medicine ointment comprises calcined gypsum, white vinegar, alcohol, pseudo-ginseng, alum, golden larch bark, golden cypress, radix sophorae flavescentis, garden balsam stem, rocket and single-clove garlic.
2. The herbal patch for removing onychomycosis of claim 1, wherein the covering patch comprises a support carrier and calcium peroxide coated on one side of the support carrier.
3. The herbal patch for removing onychomycosis according to claim 1, wherein the formulation of the basic patch comprises, by mass, 20-40 parts of a traditional Chinese medicine paste, 10-20 parts of glycerin, 2-7 parts of ethylhexyl glycerin, 1-7 parts of sodium polyacrylate, 1-8 parts of 1, 2-pentanediol, 1-8 parts of butanediol, 2-6 parts of methyl hydroxybenzoate, 1-6 parts of phenoxyethanol, 1-6 parts of 1, 2-hexanediol, 1-6 parts of menthol and 8-20 parts of water; the mass ratio of the traditional Chinese medicine ointment to the calcium peroxide is 4-8: 1.
4. The herbal plaster for removing onychomycosis according to claim 1, wherein the traditional Chinese medicine ointment comprises, by mass, 2-4 parts of plaster of paris, 15-30 parts of white vinegar, 6-8 parts of alcohol, 2-6 parts of pseudo-ginseng, 2-6 parts of alum, 2-6 parts of golden larch bark, 2-6 parts of golden cypress, 2-6 parts of radix sophorae flavescentis, 2-6 parts of garden balsam stem, 2-6 parts of rhizoma typhonii and 2-6 parts of single clove garlic.
5. The preparation method of the herbal plaster for removing onychomycosis, which is used for preparing the herbal plaster for removing onychomycosis of any one of claims 1-4, is characterized in that: the method comprises the following specific steps: preparing a base layer skin and preparing a covering skin,
II, preparing a basic layer skin body, comprising the following steps:
weighing according to a process formula;
adding glycerol, ethylhexyl glycerol, sodium polyacrylate, 1, 2-pentanediol, butanediol, methyl hydroxybenzoate, phenoxyethanol, 1, 2-hexanediol and menthol into a water bath kettle, refluxing in water bath to form a uniform solution, collecting, and cooling to room temperature;
mixing Gypsum Fibrosum Preparatum, white vinegar, alcohol, Notoginseng radix, Alumen, cortex pseudolaricis, cortex Phellodendri, radix Sophorae Flavescentis, herba Speranskiae Tuberculatae, herba Achilleae and Bulbus Allii according to formula, and stirring slowly to obtain uniform Chinese medicinal paste; adding the obtained traditional Chinese medicine paste and water into the solution obtained in the step (II), fully dissolving and slowly stirring;
fourthly, stirring the mixed solution obtained in the third step until the mixed solution is uniformly mixed under the condition that the vacuum degree is not lower than-0.06 MPa, and avoiding the generation of bubbles; pouring the mixed solution into a forming mold, and cooling to form the hydrogel herbal plaster;
II, preparing a covering skin body: adding calcium peroxide into absolute ethyl alcohol according to the weight ratio of 1:1-3 according to the weight of the formula to prepare a suspension, and coating the suspension on one side of a support carrier.
6. The preparation method of herbal plaster for removing onychomycosis according to claim 5, wherein the herbal plaster comprises: the support carrier is non-woven fabric.
7. The preparation method of herbal plaster for removing onychomycosis according to claim 5, wherein the herbal plaster comprises: in the step (II), the water bath temperature is 70-85 ℃, and the water bath time is 1-1.5 h.
8. The preparation method of herbal plaster for removing onychomycosis according to claim 5, wherein the herbal plaster comprises: in the step (IV), the stirring speed is 65-75rpm, and the stirring time is 5-15 min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN202110471957.4A CN113230236A (en) | 2021-04-29 | 2021-04-29 | Plaster for removing onychomycosis and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110471957.4A CN113230236A (en) | 2021-04-29 | 2021-04-29 | Plaster for removing onychomycosis and preparation method thereof |
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| CN113230236A true CN113230236A (en) | 2021-08-10 |
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| CN202110471957.4A Pending CN113230236A (en) | 2021-04-29 | 2021-04-29 | Plaster for removing onychomycosis and preparation method thereof |
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| CN109498491A (en) * | 2018-12-27 | 2019-03-22 | 广州西科国际生物科技有限公司 | A kind of hydrogel Chinese herb medicine eye paste and its preparation process |
| CN112107675A (en) * | 2020-11-05 | 2020-12-22 | 赵垒垒 | Chinese herbal medicine ointment for preventing and treating onychomycosis and preparation method thereof |
| CN112677592A (en) * | 2020-12-28 | 2021-04-20 | 昆山亚比斯环保包装材料有限公司 | Carrier for fixing gasified substances and preparation method thereof |
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| WO2005002553A2 (en) * | 2003-07-02 | 2005-01-13 | EGIS Gyógyszergyár Rt. | Fluconazole capsules with improved release |
| CN109498491A (en) * | 2018-12-27 | 2019-03-22 | 广州西科国际生物科技有限公司 | A kind of hydrogel Chinese herb medicine eye paste and its preparation process |
| CN112107675A (en) * | 2020-11-05 | 2020-12-22 | 赵垒垒 | Chinese herbal medicine ointment for preventing and treating onychomycosis and preparation method thereof |
| CN112677592A (en) * | 2020-12-28 | 2021-04-20 | 昆山亚比斯环保包装材料有限公司 | Carrier for fixing gasified substances and preparation method thereof |
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